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T3535

Sigma-Aldrich

Calcitonin human

≥97% (HPLC), powder

Sinônimo(s):
Calcitonin M, human C carcinoma, Calcitonin, human reduced cyclic (1→7)-disulfide, hCT, Thyrocalcitonin
Empirical Formula (Hill Notation):
C151H226N40O45S3
Número CAS:
Peso molecular:
3417.85
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.32

Nível de qualidade

200

fonte biológica

synthetic (organic)

esterilidade

non-sterile

teor

≥97% (HPLC)

forma

powder

aplicação(ões)

cell culture | mammalian: suitable

solubilidade

1% acetic acid: 1.00-1.04 mg/mL, clear, colorless
water: 1.00-1.04 mg/mL, clear, colorless

nº de adesão UniProt

enviado em

ambient

temperatura de armazenamento

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc6ccc(O)cc6)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@@H]7CSSC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N7)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N8CCC[C@H]8C(N)=O

InChI

1S/C151H226N40O45S3/c1-17-75(8)118(144(229)163-67-114(205)183-117(74(6)7)143(228)162-64-112(203)165-77(10)150(235)190-50-29-38-106(190)124(158)209)185-125(210)76(9)166-145(230)120(79(12)194)186-131(216)92(45-47-109(155)200)170-142(227)107-39-30-51-191(107)151(236)103(58-85-35-25-20-26-36-85)180-148(233)122(81(14)196)188-139(224)99(59-87-63-159-71-164-87)176-133(218)96(55-83-31-21-18-22-32-83)174-128(213)90(37-27-28-49-152)168-136(221)101(61-111(157)202)177-134(219)97(56-84-33-23-19-24-34-84)175-137(222)102(62-116(207)208)178-129(214)91(44-46-108(154)199)171-147(232)121(80(13)195)187-138(223)98(57-86-40-42-88(198)43-41-86)179-146(231)119(78(11)193)184-115(206)66-161-127(212)94(53-72(2)3)172-130(215)93(48-52-237-16)169-141(226)105-70-239-238-69-89(153)126(211)160-65-113(204)167-100(60-110(156)201)135(220)173-95(54-73(4)5)132(217)181-104(68-192)140(225)189-123(82(15)197)149(234)182-105/h18-26,31-36,40-43,63,71-82,89-107,117-123,192-198H,17,27-30,37-39,44-62,64-70,152-153H2,1-16H3,(H2,154,199)(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,209)(H,159,164)(H,160,211)(H,161,212)(H,162,228)(H,163,229)(H,165,203)(H,166,230)(H,167,204)(H,168,221)(H,169,226)(H,170,227)(H,171,232)(H,172,215)(H,173,220)(H,174,213)(H,175,222)(H,176,218)(H,177,219)(H,178,214)(H,179,231)(H,180,233)(H,181,217)(H,182,234)(H,183,205)(H,184,206)(H,185,210)(H,186,216)(H,187,223)(H,188,224)(H,189,225)(H,207,208)/t75-,76-,77-,78+,79+,80+,81+,82+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,117-,118-,119-,120-,121-,122-,123-/m0/s1

InChI key

LDVRMNJZLWXJPL-JKQNMTHDSA-N

Gene Information

human ... CALCA(796)

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Amino Acid Sequence

Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 [Disulfide Bridge: 1−7]

Aplicação

Calcitonin human has been used to study its ability to stimulate cAMP production post transfection in mammalian cell by activating human CALCRL (calcitonin receptor like receptor gene)- receptor activity-modifying protein 1 (RAMP1) and CTR (calcitonin receptor).
Calcitonin human has been used as a positive control in in vivo study of HLA-A(*) 02.01 (HHD) mice injected with PTH-rP peptides. The product has also be used as a test compound for studying the effects of calcitonin deficiency and calcitonin substitution on particle-induced osteolysis in Calca -/- mice.

Ações bioquímicas/fisiológicas

Calcitonin, also referred to as thyrocalcitonin, is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compared to serum. It acts as a first messenger and hence regulates the the production of cAMP as well as mammalian sperm function. It also facilitates the regulation of different isoforms of adenylyl cyclase.
Hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes.

Outras notas

32 amino acid polypeptide, 8 of which are conserved across all species.
Lyophilized from 0.1% TFA in H2O

Nota de preparo

Calcitonin human dissolves in 1% acetic acid as well as in water at 1 mg/ml to yield a clear, colorless solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

Certificado de origem

Francesca Nunzi et al.
Molecules (Basel, Switzerland), 25(10) (2020-05-24)
The nature, strength, range and role of the bonds in adducts of noble gas atoms with both neutral and ionic partners have been investigated by exploiting a fine-tuned integrated phenomenological-theoretical approach. The identification of the leading interaction components in the...
Harshil K Renawala et al.
Biophysical journal, 120(1), 86-100 (2020-11-22)
Some therapeutic peptides self-assemble in solution to form ordered, insoluble, β-sheet-rich amyloid fibrils. This physical instability can result in reduced potency, cause immunogenic side effects, and limit options for formulation. Understanding the mechanisms of fibrillation is key to developing rational...
Kavitha Govarthanan et al.
Genomics, 112(2), 1384-1395 (2019-08-16)
Differentiation of Wharton's Jelly-Mesenchymal Stem cells (WJ-MSCs) into cardiomyocytes (CMs) in vitro has been reported widely although contradictions remain regarding the maturation of differentiated MSCs into fully functioning CMs. Studies suggest that use of epigenetic modifiers like 5'Azacytidine (5-AC) in...
Max D Kauther et al.
BMC musculoskeletal disorders, 12, 186-186 (2011-08-17)
Periprosthetic osteolysis is a major cause of aseptic loosening in joint arthroplasty. This study investigates the impact of CT (calcitonin) deficiency and CT substitution under in-vivo circumstances on particle-induced osteolysis in Calca -/- mice. We used the murine calvarial osteolysis...
Guido Francini et al.
Journal of immunology (Baltimore, Md. : 1950), 169(9), 4840-4849 (2002-10-23)
Parathyroid hormone-related protein (PTH-rP), a protein produced by prostate carcinoma and other epithelial cancers, is a key agent in the development of bone metastases. We investigated whether the protein follows the self-tolerance paradigm or can be used as a target...

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