T6397

3,3′,5-Triiodo-L-thyronine sodium salt

powder, BioReagent, suitable for cell culture

• Synonym(s): Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃
• Empirical Formula (Hill Notation): C₁₅H₁₁I₃NNaO₄
• CAS Number: 55-06-1
• Molecular Weight: 672.96
• Beilstein: 8179867
• Número EC: 200-223-5
• Número MDL: MFCD00002594
• ID de substância PubChem: 24900372
• NACRES: NA.77

Properties

• fonte biológica: synthetic
• Nível de qualidade: 200
• linha de produto: BioReagent
• teor: ≥95%
• forma: powder
• potência: 0.02-50 ng/mL (lit.)
• technique(s): cell culture | mammalian: suitable
• solubilidade: ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow
• enviado em: ambient
• temperatura de armazenamento: −20°C
• SMILES string: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
• InChI key: SBXXSUDPJJJJLC-YDALLXLXSA-M
• Gene Information: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Description

Descrição geral

3,3′,5′-Triiodo-L-thyronine (T₃) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T₄) serves as a precursor for T₃ and is generated in extrathyroidal tissues.

Aplicação

3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Embalagem

100, 250, 500 mg

1, 5 g

Ações bioquímicas/fisiológicas

3,3′,5′-Triiodo-L-thyronine (T₃) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T₃ regulates cell differentiation and protein expression. The interaction of T₃ with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T₃ hormone is reduced in hypothyroidism.

forma física

powder-20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Reconstituição

To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.

Safety Information

• Código de classe de armazenamento: 13 - Non Combustible Solids
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)