methanol: soluble 1.90-2.10 mg/mL, clear, colorless to faint yellow or tan
acetone: slightly soluble
benzene: slightly soluble
chloroform: slightly soluble
ethyl acetate: slightly soluble
lower alcohols: soluble
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11 - Combustible Solids
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
The product has a recommended retest date (similar to a shelf life date) of 2 years. The actual recommended retest date for each lot is on the Certificate of Analysis located at our website.
Trichostatin A is soluble in dimethyl sulfoxide (DMSO) and in ethanol, each at 1 mg/mL. It is also soluble in methanol at 2 mg/mL. It is insoluble in water. Additional solubility information can be found on the data sheet on our website.
Solutions at a concentration of 2 mg/mL in DMSO can be divided into aliquots and stored frozen at -20°C.
Product T8552 has not been tested for any endotoxin levels, nor has it been cell culture tested.
Trichostatin A inhibits histone deacetylase at nanomolar concentrations. Additional information may be found in the literature references cited on the product detail page for T8552.
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Ask a Scientist here.
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.
n proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparation for cell division occurs. Together, these three stages comprise the interphase phase of the cell cycle. Interphase is followed by the mitotic (M) phase.
Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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