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T8931

Sigma-Aldrich

Thyrotropic hormone from bovine pituitary

Synonym(s):
TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands
CAS Number:
Número MDL:
NACRES:
NA.32

fonte biológica

bovine pituitary glands

Nível de qualidade

200

forma

powder

embalagem

vial of 100 μg

technique(s)

cell culture | mammalian: suitable

nº de adesão UniProt

temperatura de armazenamento

2-8°C

Gene Information

cow ... TSHB(281552)
human ... TSHR(7253)

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Descrição geral

Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.

Aplicação

Thyrotropic hormone from bovine pituitary has been used:
  • to induce cAMP production in orbital fibroblasts.
  • as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
  • for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
  • for studying the thyrotropin involvement in photoperiodic signal transduction in mice.

Embalagem

1 vial in serum bottle
10 vials in serum bottle

Ações bioquímicas/fisiológicas

Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Qualidade

Contains phosphate buffer salts

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

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Certificate of Origin

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