Merck
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T9265

Sigma-Aldrich

Thyrotropic hormone from human pituitary

lyophilized powder, ≥6.2 IU/mg (immunoassay)

Synonym(s):
TSH, Thyroid stimulating hormone
CAS Number:
Número MDL:
NACRES:
NA.32

fonte biológica

human pituitary glands

Nível de qualidade

200

esterilidade

non-sterile

forma

lyophilized powder

specific activity

≥6.2 IU/mg (immunoassay)

technique(s)

cell culture | mammalian: suitable

Impurezas

HIV-1/HIV-2, tested negative

nº de adesão UniProt

enviado em

ambient

temperatura de armazenamento

−20°C

Gene Information

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Descrição geral

Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.

Aplicação

Thyrotropic hormone from human pituitary also referred to as TSH can be used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.

Ações bioquímicas/fisiológicas

In children, thyroid hormones are very much essential for the normal cognition and neurodevelopment. Thyroid-stimulating hormone (TSH) test is mainly used to diagnose thyroid function.
Thyrotropic hormone or Thyroid stimulating hormone (TSH) belongs to glycoprotein hormone family. The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Embalagem

Package size based on hormone

forma física

Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 1

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

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Certificate of Origin

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