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U0750

Sigma-Aldrich

Uracil

≥99.0%

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Sinônimo(s):
2,4(1H,3H)-Pyrimidinedione, 2,4-Dihydroxypyrimidine, 2,4-Pyrimidinediol
Fórmula empírica (Notação de Hill):
C4H4N2O2
Número CAS:
66-22-8
Peso molecular:
112.09
Beilstein:
507828
Número CE:
200-621-9
Número MDL:
MFCD00006016
Código UNSPSC:
41106305
ID de substância PubChem:
24900618
NACRES:
NA.51

fonte biológica

synthetic (organic)

Nível de qualidade

300

Ensaio

≥99.0%

forma

powder

pf

>300 °C (lit.)

cadeia de caracteres SMILES

O=C1NC=CC(=O)N1

InChI

1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

chave InChI

ISAKRJDGNUQOIC-UHFFFAOYSA-N

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Descrição geral

Uracil belongs to the pyrimidine nucleobase family. It is naturally occurring and is an important and active part of RNA.

Aplicação

Uracil has been used as:
  • a nucleotide standard to determine DNA methylation by high-performance liquid chromatography
  • a component of synthetic define medium for culturing Saccharomyces cerevisiae and its strain
  • a component of the amino acid supplement to culture Bacillus sp

Ações bioquímicas/fisiológicas

Uracil and its derivatives play an integral part in medicinal chemistry for the synthesis of cancer, viral infections, autosomal recessive disorder, thyroid, and diabetic drugs.

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Uridine ≥99%

Sigma-Aldrich

U3750

Uridine

Uracil-2-13C,15N2 99 atom % 13C, 98 atom % 15N

Sigma-Aldrich

608459

Uracil-2-13C,15N2

Uracil-2-13C 99 atom % 13C

Sigma-Aldrich

486264

Uracil-2-13C

Uracil-15N2,5,6-d2 98 atom % 15N, 91 atom % D

Sigma-Aldrich

685283

Uracil-15N2,5,6-d2

L-leucina reagent grade, ≥98% (HPLC)

Sigma-Aldrich

L8000

L-leucina

Comparative metabolite profiling of wild type and thermo-tolerant mutant of Saccharomyces cerevisiae
Kim S, et al.
Process Biochemistry (Oxford, United Kingdom), 111, 62-68 (2021)
Deepthi Ramesh et al.
European journal of medicinal chemistry, 207, 112801-112801 (2020-09-15)
Uracil is one of the most notable pharmacophores in medicinal chemistry as the pyrimidine nucleobase forms an integral part of many commercial drugs. Though the name uracil is usually associated with cancer drugs, there are many uracil-based compounds which can
Daisuke Katagiri et al.
Journal of the American Society of Nephrology : JASN, 24(12), 2034-2043 (2013-10-05)
Accumulating evidence of the beyond-glucose lowering effects of a gut-released hormone, glucagon-like peptide-1 (GLP-1), has been reported in the context of remote organ connections of the cardiovascular system. Specifically, GLP-1 appears to prevent apoptosis, and inhibition of dipeptidyl peptidase-4 (DPP-4)
Sandra M Carvalho et al.
PloS one, 8(3), e58492-e58492 (2013-03-19)
Links between carbohydrate metabolism and virulence in Streptococcus pneumoniae have been recurrently established. To investigate these links further we developed a chemically defined medium (CDM) and standardized growth conditions that allowed for high growth yields of the related pneumococcal strains
William B White et al.
The New England journal of medicine, 369(14), 1327-1335 (2013-09-03)
To assess potentially elevated cardiovascular risk related to new antihyperglycemic drugs in patients with type 2 diabetes, regulatory agencies require a comprehensive evaluation of the cardiovascular safety profile of new antidiabetic therapies. We assessed cardiovascular outcomes with alogliptin, a new
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