Merck
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V6629

Sigma-Aldrich

Vitamin B12

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

Sinônimo(s):
α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, Cyanocobalamin
Empirical Formula (Hill Notation):
C63H88CoN14O14P
Número CAS:
Peso molecular:
1355.37
Beilstein:
4122889
Número EC:
eCl@ss:
34058004
ID de substância PubChem:
NACRES:
NA.75

Nível de qualidade

200

fonte biológica

microbial

linha de produto

BioReagent

teor

≥98%

forma

powder

peso molecular

Mw 1355.37 g/mol

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

cor

red to brown

pH

6

solubilidade

water: soluble 50 mg/mL, dark red

temperatura de armazenamento

2-8°C

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

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Descrição geral

Cyanocobalamin (B12) is a water soluble vitamin, commonly called as cobalamins. Dairy products, meat and eggs are the major sources of this vitamin.

Aplicação

Vitamin B12 has been used:
  • as a component of Erdschreiber′s medium
  • as a supplement of Dulbecco′s modified Eagle′s medium used for the isolation of ventricular myocytes from neonatal and adult rats
  • orally administered to male quails to study its role in reducing the negative effects of sodium selenite intoxication, in vivo

Embalagem

1, 5 g in glass bottle
100, 250 mg in glass bottle

Ações bioquímicas/fisiológicas

Vitamin B12 is metabolized to its active form, methylcobalamin. Hindered vitamin B12 uptake is observed in pernicious anemia. Vitamin B12 is essential for erythroblast development. Pregnancy reduces the levels of vitamin B12. Aging reduces vitamin B12 absorption. It works as a coenzyme in fat, carbohydrate and protein metabolism. It is required for growth, genetic stability and survival of cells in vitro. Functions to support one-carbon metabolism. Present in many classical and serum-free formulations.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 1

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

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Certificado de origem

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Mais documentos

Quotes and Ordering

Selenium toxicosis assessment (in vivo and in vitro) and the protective role of vitamin B12 in male quail (Coturnix coturnix)
Gad MA and El-Twab SMA
Environmental Toxicology and Pharmacology, 27(1), 7-16 (2009)
miRNA-204 drives cardiomyocyte proliferation via targeting Jarid2
Liang D, et al.
International Journal of Cardiology, 201, 38-48 (2015)
Vitamins for chronic disease prevention in adults: clinical applications
Fletcher RH and Fairfield KM
JAMA : The Journal of the American Medical Association, 287(23), 3127-3129 (2002)
Effect of nutrients on growth and lipid accumulation in the green algae Dunaliella tertiolecta
Chen M, et al.
Bioresource Technology, 102(2), 1649-1655 (2011)
Vitamins, minerals and trace elements
Drugs During Pregnancy and Lactation (2015)

Artigos

Vitamin B12, Cobalamin, in Cell Culture

Importance and uses of Vitamin B12 in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell cultures

Folic Acid and Tetrahydrofolates in Cell Culture

Importance and uses of folic acid in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures. Folic acid and its reduced derivative(s), such as folinic acid, are an essential water soluble vitamins added to virtually all cell culture media.

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