Merck
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X4376

Sigma-Aldrich

Xanthine Oxidase from bovine milk

lyophilized powder, 0.4-1.0 units/mg protein

Synonym(s):
XOD, Xanthine:oxygen oxidoreductase
CAS Number:
Enzyme Commission number:
1.17.3.2.
Número EC:
Número MDL:
NACRES:
NA.54

fonte biológica

bovine milk

Nível de qualidade

300

forma

lyophilized powder

specific activity

0.4-1.0 units/mg protein

peso molecular

283 kDa

composição

Protein, 10.0-25.0%

temperatura de armazenamento

2-8°C

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Descrição geral

Formerly E.C. 1.1.3.22

Aplicação

Xanthine Oxidase from bovine milk has been used as a source for superoxide generation. It has also been used as a model enzyme in the internally calibrated electrochemical continuous enzyme assay (ICECEA).

Embalagem

5, 25, 50 units in poly bottle

Ações bioquímicas/fisiológicas

The isoflavanoid genistein was shown to inhibit xanthine oxidase at concentrations between 0.1-4.0 μM and then activate xanthine oxidase at concentrations higher than 5 μM.
Xanthine Oxidase acts as a potential biomarker for oxidative stress. It is also implicated in tissue and vascular injuries such as liver damage, inflammatory diseases and chronic heart failure.
Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.

Definição da unidade

One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.

forma física

Contains 0.5% sodium salicylate.

Nota de análise

Protein determined by biuret

Pictogramas

Health hazard

Palavra indicadora

Danger

Frases de perigo

Declarações de precaução

Classificações de perigo

Resp. Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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