Biomarker & Metabolite Standards

Metabolite and biomarker standards are critical for clinical and diagnostic testing, offering insights into metabolic states and disease progression. These standards enable precise diagnosis, prognosis, and personalized treatments. High-quality reference materials ensure accuracy, reproducibility, and reliability, supporting informed clinical decisions and research outcomes.

We provide a comprehensive range of metabolite and biomarker reference materials tailored for mass spectrometry-based metabolomics and biomarker testing. Our metabolite standards support applications such as metabolic panel testing, newborn screening, and inborn errors of metabolism screening. Biomarker reference materials are designed for diverse testing methods, including alcohol biomarkers, athlete biomarker tests, inflammatory biomarkers, and cancer biomarker assays.

Our portfolio includes Seraseq^® Oncology and NIPT DNA and RNA based reference materials, which set the standard for precision in clinical genomic testing. Seraseq^® Oncology materials are the most patient-like, highly multiplexed reference samples for pan-cancer profiling, disease monitoring, and immune-oncology biomarker validation. They enable the standardization and analytical validation of next-generation sequencing (NGS) and PCR applications. Seraseq^® NIPT products are patient-derived and preserve native fetal and maternal cfDNA characteristics. These materials are compatible with various assay technologies and platforms, including whole-genome (WG) and SNP-based fetal fraction estimation methods.

Our products also support metabolic profiling, novel biomarker identification, pharmaceutical research, and endocrinology studies. The collection features clinically significant endogenous compounds and key metabolites, including amino acids, lipids, carbohydrates, bile acids, vitamin D, catecholamines, neurotransmitters, and hormones related to male, female, neonatal, and thyroid health.

Seraseq^® NIPT Testing Reference Materials

Seraseq^® NIPT Reference Materials are high-quality, patient-like controls designed to support the entire Non-Invasive Prenatal Testing (NIPT) workflow, from assay development to routine quality control. Derived from maternal plasma and mimicking clinical samples, they preserve the native fetal and maternal cfDNA characteristics, to ensure compatibility with various assay technologies and platforms, including whole genome (WG) & SNP-based fetal fraction estimation methods. These reference materials provide extensive coverage, including common aneuploidies such as trisomy 21, 18, 13, and sex chromosome abnormalities like 22q11 microdeletion. Manufactured under cGMP compliance in ISO 13485-certified facilities, Seraseq^® NIPT reference materials ensure lot-to-lot consistency and have a long shelf life, providing stability and reliability. Also, the convenient single-vial format, simulating plasma, allows for easy integration into the NIPT testing workflow.

Seraseq^® Reference Materials for NGS Cancer Testing

Seraseq^® oncology products provide a comprehensive suite of reference materials designed to support the development, validation, and monitoring of next-generation sequencing (NGS) assays in precision oncology. These highly multiplexed, patient-like materials are available in various formats, including DNA, RNA, and circulating tumor DNA (ctDNA), and cover a wide range of variant types such as SNVs, INDELs, CNVs, SVs, and RNA fusions. Ideal for tumor profiling, immuno-oncology, liquid biopsy, and disease monitoring, Seraseq^® oncology reference materials ensure consistency, reproducibility, and confidence in results, making them a leading choice for advancing cancer diagnostics and personalized treatment strategies.

Reference Materials for Hormone Testing

Our wide selection of hormone reference materials includes Cerilliant^® certified reference material (CRM) solutions and VETRANAL^® analytical standards for the accurate and reproducible detection of hormone metabolites. These standards are available in both neat and solution forms, compatible with HPLC and GC analysis, ensuring reliable and precise results.

Reference Materials of Amino acid metabolites

We offer a wide selection of analytical standards and certified reference materials (CRMs) for amino acids, including both native and stable isotope-labeled internal standards. Our products are available as single solutions or multi-analyte mixes, optimized for use in GC/MS and LC/MS platforms.

Our TraceCERT^® certified reference materials provide consistent, reliable results for various quantitative applications such as preparing internal standards, system suitability tests, linearity verification, and proficiency testing. The stable, quantitative solution format ensures ease of use, reduced material waste, and increased efficiency, with certified concentration values delivering improved consistency and accuracy in clinical and research settings.

Reference Materials for Hydroxyvitamin D

25-Hydroxyvitamin D is a stable and widely recognized metabolite used to clinically assess vitamin D levels in the blood. Our range of 25-hydroxy vitamin D standards includes certified reference material solutions, available in both native and isotope-labeled forms, ensuring accuracy and reliability in clinical testing.

Reference Materials for Catecholamines and biogenic amines

Catecholamines are amines produced by the adrenal glands, acting as both hormones and neurotransmitters. Key catecholamines include dopamine, epinephrine (adrenaline), and norepinephrine (noradrenaline), all derived from the amino acid L-tyrosine. We provide a wide range of certified reference materials (CRMs) for catecholamine metabolites, available in both single- and multi-component solutions, to support accurate clinical analysis.