Kristina Xiao Liang et al.
EMBO molecular medicine, 12(10), e12146-e12146 (2020-08-26)
Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using patient cells carrying POLG mutations, we generated iPSCs and then neural