Showing 1-30 of 187 resultados for "


Mohamed Sherif El-Eskandarany et al.
Nanomaterials (Basel, Switzerland), 10(5) (2020-05-02)
Due to their outstanding mechanical properties and soft magnetic characteristics, cobalt-based metallic glassy alloys have stimulated much interesting research. These metastable ferromagnetic materials possess very small magnetocrystalline anisotropy, and almost zero magnetostriction. They reveal low coercivity, extremely low core loss...
Randy M Wadkins et al.
Journal of medicinal chemistry, 48(8), 2906-2915 (2005-04-15)
Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of selective inhibitors of these proteins has proved problematic. Using Telik's target-related affinity profiling (TRAP)...
Erik T Yukl et al.
Biochemistry, 52(52), 9447-9455 (2013-12-11)
The di-heme enzyme MauG catalyzes the oxidative biosynthesis of a tryptophan tryptophylquinone cofactor on a precursor of the enzyme methylamine dehydrogenase (preMADH). Reaction of H2O2 with the diferric form of MauG, or reaction of O2 with diferrous MauG, forms the...
Sanjeev Kumar et al.
Journal of medicinal chemistry, 51(6), 1706-1718 (2008-03-06)
Indoleamine 2,3-dioxygenase (IDO) is emerging as an important new therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression. While small molecule inhibitors of IDO exist, there remains a dearth of high-potency...
Parenteral iron as a cause of hypophosphataemia.
Francisco J Fernández-Fernández et al.
BMJ (Clinical research ed.), 349, g4616-g4616 (2014-07-17)
Tim M Conway et al.
Nature, 511(7508), 212-215 (2014-07-11)
Dissolved iron is an essential micronutrient for marine phytoplankton, and its availability controls patterns of primary productivity and carbon cycling throughout the oceans. The relative importance of different sources of iron to the oceans is not well known, however, and...
Darius J R Lane et al.
Biochimica et biophysica acta, 1845(2), 166-181 (2014-01-30)
Cancer is a major public health issue and, despite recent advances, effective clinical management remains elusive due to intra-tumoural heterogeneity and therapeutic resistance. Iron is a trace element integral to a multitude of metabolic processes, including DNA synthesis and energy...
Laura M van Staalduinen et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(14), 5171-5176 (2014-04-08)
The enzymes PhnY and PhnZ comprise an oxidative catabolic pathway that enables marine bacteria to use 2-aminoethylphosphonic acid as a source of inorganic phosphate. PhnZ is notable for catalyzing the oxidative cleavage of a carbon-phosphorus bond using Fe(II) and dioxygen...
Shaun D Wong et al.
Nature, 499(7458), 320-323 (2013-07-23)
Mononuclear non-haem iron (NHFe) enzymes catalyse a broad range of oxidative reactions, including halogenation, hydroxylation, ring closure, desaturation and aromatic ring cleavage reactions. They are involved in a number of biological processes, including phenylalanine metabolism, the production of neurotransmitters, the...
Wei Wang et al.
Journal of environmental sciences (China), 25(9), 1726-1735 (2014-02-14)
Bamboo charcoal (BC) was used as starting material to prepare Co-Fe binary oxideloaded adsorbent (Co-Fe-MBC) through its impregnation in Co(NO3)2, FeCl3 and HNO3 solutions simultaneously, followed by microwave heating. The low-cost composite was characterized and used as an adsorbent for...
Mak A Saito et al.
Science (New York, N.Y.), 345(6201), 1173-1177 (2014-09-06)
Marine primary productivity is strongly influenced by the scarcity of required nutrients, yet our understanding of these nutrient limitations is informed by experimental observations with sparse geographical coverage and methodological limitations. We developed a quantitative proteomic method to directly assess...
Zille Rubab et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 26(1), 19-25 (2015-01-13)
Patients on hemodialysis (HD) are usually anemic because of defective erythropoeisis. Hepcidin is a polypeptide that regulates iron homeostasis and could serve as an indicator of functional iron deficiency in patients with end-stage renal disease (ESRD); this may also aid...
Matthew Stroh et al.
Biochemical pharmacology, 88(4), 573-583 (2013-12-24)
A popular, if not centric, approach to the study of an event is to first consider that of the simplest cause. When dissecting the underlying mechanisms governing idiopathic diseases, this generally takes the form of an ab initio genetic approach....
Don-Kyu Kim et al.
Nature medicine, 20(4), 419-424 (2014-03-25)
In response to microbial infection, expression of the defensin-like peptide hepcidin (encoded by Hamp) is induced in hepatocytes to decrease iron release from macrophages. To elucidate the mechanism by which Salmonella enterica var. Typhimurium (S. typhimurium), an intramacrophage bacterium, alters...
L Iu Milovanova et al.
Terapevticheskii arkhiv, 85(6), 17-24 (2013-07-23)
To study the clinical significance of determining the serum concentration of phosphorus and calcium metabolism regulators--the morphogenetic proteins FGF-23 and Klotho in patients with different stages of chronic kidney disease (CKD). The serum levels of FGF-23 (a human FGF-23 ELISA...
Nicole Rietzschel et al.
Molecular and cellular biology, 35(2), 370-378 (2014-11-05)
Iron is an essential, yet at elevated concentrations toxic trace element. To date, the mechanisms of iron sensing by eukaryotic iron-responsive transcription factors are poorly understood. The Saccharomyces cerevisiae transcription factor Yap5, a member of the Yap family of bZIP...
I P Zaĭtseva et al.
Voenno-meditsinskii zhurnal, 334(3), 36-40 (2013-07-03)
According to examination, with the help of emission spectrum analysis method, of 24 cadets-athletes of different specialization it was determined that during physical exercise in summer and in winter loss of ferrum and copper with excrements exceeded the intake if...
Biotechnology: Against the grain.
Michael Eisenstein
Nature, 514(7524), S55-S57 (2014-11-05)
Samer R Abulateefeh et al.
Pharmaceutical development and technology, 19(7), 856-867 (2013-09-17)
The excellent gelling and safety profiles of alginic acid combined, however, with drawbacks of its ionotropically crosslinked beads (i.e. their quick release of loaded drugs) prompted us to chemically modify alginic acid. Alginic acid was chemically conjugated with four amines...
Caterina Borgna-Pignatti et al.
British journal of haematology, 167(1), 121-126 (2014-07-06)
The risk of developing hepatocellular carcinoma (HCC) in patients with thalassaemia is increased by transfusion-transmitted infections and haemosiderosis. All Italian Thalassaemia Centres use an ad hoc form to report all diagnoses of HCC to the Italian Registry. Since our last...
[R. J. Ulvik replies].
Rune J Ulvik
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 133(12-13), 1285-1285 (2013-07-03)
Nosratola D Vaziri
Nephrology news & issues, 28(2), 4-5 (2014-03-22)
Loss of blood associated with hemodialysis procedures and laboratory testing, together with impaired iron absorption due to elevation of hepcidin, invariably cause iron deficiency in end-stage renal disease patients. For this reason, nearly all ESRD patients require intravenous iron to...
Hypoferremia of infection: a double-edged sword?
Kristen L Lokken et al.
Nature medicine, 20(4), 335-337 (2014-04-09)
Femkje A M Jonker et al.
Journal of clinical pathology, 67(8), 717-723 (2014-06-12)
Iron deficiency is an important child health problem. Its diagnosis in areas of high infection exposure remains complicated as inflammation may interfere with the accuracy of peripheral iron markers. With this study, we aimed to validate the conventional iron markers...
Ocean chemistry: Fingerprints of a trace nutrient.
Joseph A Resing et al.
Nature, 511(7508), 164-165 (2014-07-11)
Microcytic anemia.
Shraga Aviner et al.
The New England journal of medicine, 371(26), 2536-2536 (2014-12-30)
Donglei Wu et al.
Environmental technology, 34(17-20), 2663-2669 (2014-02-18)
In this study, nanoscale zero-valent iron (NZVI) was synthesized by conventional liquid-phase chemical reduction methods without a support material and then characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The effect of NZVI particles...
Ocean Science. Microbial proteins and oceanic nutrient cycles.
C Mark Moore
Science (New York, N.Y.), 345(6201), 1120-1121 (2014-09-06)
Robert F Anderson et al.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 372(2019), 20130054-20130054 (2014-06-04)
Fluxes of lithogenic material and fluxes of three palaeo-productivity proxies (organic carbon, biogenic opal and alkenones) over the past 100,000 years were determined using the (230)Th-normalization method in three sediment cores from the Subantarctic South Atlantic Ocean. Features in the...
Joseph Marie Sieliechi et al.
Environmental technology, 35(13-16), 1831-1839 (2014-06-25)
In this study, spatial and seasonal variations of phosphorus fractions in Lake Bini sediments were evaluated using a sequential extraction method. The sampling of water and sediments (surface and coring) was carried out at seven sites around the lake during...