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Wei Qiu et al.
PloS one, 10(6), e0129772-e0129772 (2015-06-09)
ABCB10 (ATP binding cassette sub-family B10) is a mitochondrial inner-membrane ABC transporter. ABCB10 has been shown to protect the heart from the impact of ROS during ischemia-reperfusion and to allow for proper hemoglobin synthesis during erythroid development. ABC transporters are
Mohamad Nasir Shafiee et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(4), 286-290 (2014-12-17)
The aim of this proof-of-concept study was to determine the effects of three-month Metformin therapy on the expression of tumor-regulatory genes (p53, cyclin D2 and BCL-2) in the endometrium of women with polycystic ovary syndrome (PCOS). A total of 40
María C Ovejero-Benito et al.
Cell cycle (Georgetown, Tex.), 14(14), 2311-2322 (2015-05-07)
Nuclear DNA duplication in the absence of cell division (i.e. endoreplication) leads to somatic polyploidy in eukaryotic cells. In contrast to some invertebrate neurons, whose nuclei may contain up to 200,000-fold the normal haploid DNA amount (C), polyploid neurons in
Davide Povero et al.
PloS one, 9(12), e113651-e113651 (2014-12-04)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in both adult and children. Currently there are no reliable methods to determine disease severity, monitor disease progression, or efficacy of therapy, other than an invasive liver biopsy.
Courtney Reichhardt et al.
Eukaryotic cell, 14(11), 1064-1072 (2015-07-15)
Aspergillus fumigatus is commonly responsible for lethal fungal infections among immunosuppressed individuals. A. fumigatus forms biofilm communities that are of increasing biomedical interest due to the association of biofilms with chronic infections and their increased resistance to antifungal agents and
Mira Mooreville et al.
Obesity (Silver Spring, Md.), 23(4), 808-814 (2015-02-17)
Determine the association of children's susceptibility to large food portion sizes with appetite regulation and obesity. Normal-weight and obese non-Hispanic black children (n = 100) aged 5-6 years were observed in four dinner conditions of varying portion size; portions of all foods
Oluseye A Ogunbayo et al.
The FEBS journal, 281(3), 766-777 (2013-11-19)
Flavonoids are group of plant-derived hydroxylated polycyclic molecules found in fruit and vegetables. They are known to bio-accumulate within humans and are considered to have beneficial health effects, including cancer chemoprotection. One mechanism proposed to explain this is that they
Elizabeth A Wellberg et al.
Breast cancer research : BCR, 16(6), 481-481 (2014-12-05)
Spot14 (S14), encoded by the THRSP gene, regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland. We recently showed that S14 stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty
Daniel Sohmen et al.
Nature communications, 6, 6941-6941 (2015-04-24)
Ribosomal stalling is used to regulate gene expression and can occur in a species-specific manner. Stalling during translation of the MifM leader peptide regulates expression of the downstream membrane protein biogenesis factor YidC2 (YqjG) in Bacillus subtilis, but not in
Janna M Schurer et al.
The American journal of tropical medicine and hygiene, 90(6), 1184-1190 (2014-03-19)
Residents of remote and Indigenous communities might experience higher exposure to some zoonotic parasites than the general North American population. Human sero-surveillance conducted in two Saulteaux communities found 113 volunteers exposed as follows: Trichinella (2.7%), Toxocara canis (4.4%), Echinococcus (4.4%)
A Mühlstein et al.
Die Pharmazie, 69(7), 518-524 (2014-07-31)
Arylsulfatase A (ASA) deficiency is the cause of metachromatic leucodystrophy (MLD), a lysosomal storage disease associated with severe neurological disorders. Poly(butyl cyanoacrylate) (PBCA) nanoparticles overcoated with polysorbate 80 enabled the delivery of several drugs across the blood-brain barrier to the
Rangarajan Padmanabhan et al.
Journal of cell science, 128(9), 1773-1786 (2015-03-22)
The epithelial-to-mesenchymal transition (EMT) is important for the formation of migratory neural crest cells during development and is co-opted in human diseases such as cancer metastasis. Chick premigratory cranial neural crest cells lose intercellular contacts, mediated in part by Cadherin-6B
Corey Baimel et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(18), 7295-7303 (2015-05-08)
Dopamine neurons in the ventral tegmental area (VTA) are a key target of addictive drugs, and neuroplasticity in this region may underlie some of the core features of addiction. From the very first exposure, all drugs of abuse induce synaptic
Sujittra Chaiyadet et al.
International journal for parasitology, 45(12), 773-781 (2015-07-19)
Liver fluke infection caused by Opisthorchis viverrini remains a major public health problem in many parts of Asia including Thailand, Lao PDR, Vietnam and Cambodia, where there is a strikingly high incidence of cholangiocarcinoma (CCA - hepatic cancer of the
AhRan Kang et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(5), 1153-1161 (2015-03-11)
We investigated the effect of anticancer drug-loaded functional polymeric nanoparticles on drug resistance of three-dimensional (3D) breast tumor spheroids. 3D tumor models were built using concave microwells with different diameters (300-700μm) and nanoparticles were prepared using thermo-responsive poly(N-isopropylacrylamide) (PNIPAM)-co-acrylic acid
Lucie Peskova et al.
Stem cells (Dayton, Ohio) (2020-09-03)
MicroRNAs (miRNAs), a class of small, noncoding RNA molecules represent important regulators of gene expression. Recent reports have implicated their role in the cell specification process acting as "fine-tuners" to ensure the precise gene expression at the specific stage of
Gro S Johannessen et al.
International journal of environmental research and public health, 12(6), 6919-6932 (2015-06-20)
The aim of this study was to investigate the bacteriological quality of strawberries at harvest and to study risk factors such as irrigation water, soil and picker's hand cleanliness. Four farms were visited during the harvest season in 2012. Samples
Jing He et al.
Journal of cell science, 128(20), 3822-3836 (2015-08-27)
Mutations in the Pick1 gene cause globozoospermia, a male infertility disorder, in both mice and humans. PICK1 is crucial for vesicle trafficking, and its deficiency in sperm cells leads to abnormal vesicle trafficking from the Golgi to the acrosome. This
Maxime Bélanger et al.
Applied and environmental microbiology, 81(11), 3848-3855 (2015-03-31)
The lactococcal abortive phage infection mechanism AbiQ recently was classified as a type III toxin-antitoxin system in which the toxic protein (ABIQ) is regulated following cleavage of its repeated noncoding RNA antitoxin (antiQ). In this study, we investigated the role
Maria Dimopoulou et al.
Food microbiology, 53(Pt A), 10-17 (2015-11-28)
Oenococcus oeni (O. oeni), which is the main species that drives malolactic fermentation (FML), an essential step for wine microbial stabilization and quality improvement, is known to produce exopolysaccharides (EPS). Depending on the strain, these EPS can be soluble, remain
Vassilis Stratoulias et al.
Cellular and molecular life sciences : CMLS, 72(10), 1989-2004 (2014-12-17)
Glia are abundant cells in the brain of animals ranging from flies to humans. They perform conserved functions not only in neural development and wiring, but also in brain homeostasis. Here we show that by manipulating gene expression in glia
Astrid Lemire et al.
The ISME journal, 9(7), 1523-1531 (2014-12-10)
Disease in oysters has been steadily rising over the past decade, threatening the long-term survival of commercial and natural stocks. Our understanding and management of such diseases are of critical importance as aquaculture is an important aspect of dealing with
Jason R Potas et al.
Journal of immunological methods, 420, 38-49 (2015-04-04)
Macrophages play a key role in tissue regeneration following peripheral nerve injury by preparing the surrounding parenchyma for regeneration, however, they can be damaging if the response is excessive. Interleukin 10 (IL-10) is a cytokine that promotes macrophages toward an
Ronghua Wu et al.
PloS one, 10(5), e0127940-e0127940 (2015-05-30)
The 27.8 kDa membrane protein from flounder (Paralichthys olivaceus) gill (FG) cells was previously identified as a putative cellular receptor involved in lymphocystis disease virus (LCDV) infection. In this paper, the expression of receptor-27.8 kDa (27.8R) and LCDV loads in
Longhai Qiu et al.
Annals of biomedical engineering, 43(12), 2924-2940 (2015-05-28)
Our group pioneered the study of nerve regeneration in China and has successfully developed human "acellular nerve grafts (ACNGs)". However, our clinical studies revealed that the effects of ACNGs for long and large nerve defects are far from satisfactory. To
M Carolina Pilonieta et al.
mBio, 5(6), e02211-e02211 (2014-12-11)
Hemophagocytes are cells of the monocyte lineage that have engulfed erythrocytes and leukocytes. Hemophagocytes frequently accumulate in patients with severe acute bacterial infections, such as those caused by Salmonella enterica, Brucella abortus, and Mycobacterium tuberculosis. The relationship between hemophagocytosis and
Juan Manuel González-Rosa et al.
PloS one, 9(12), e115604-e115604 (2014-12-23)
While zebrafish embryos are amenable to in vivo imaging, allowing the study of morphogenetic processes during development, intravital imaging of adults is hampered by their small size and loss of transparency. The use of adult zebrafish as a vertebrate model
Chao Wang et al.
Nucleic acids research, 43(9), 4429-4446 (2015-04-18)
The genome-scale delineation of in vivo protein-DNA interactions is key to understanding genome function. Only ∼5% of transcription factors (TFs) in the Aspergillus genus have been identified using traditional methods. Although the Aspergillus oryzae genome contains >600 TFs, knowledge of
Lilia Clima et al.
Organic & biomolecular chemistry, 13(36), 9445-9456 (2015-08-08)
The complexes formed by DNA and polycations have received great attention owing to their potential application in gene therapy. In this study, the binding efficiency between double-stranded oligonucleotides (dsDNA) and branched polyethylenimine (B-PEI) has been quantified by processing of the
Majid Sakhi Jabir et al.
Autophagy, 11(1), 166-182 (2015-02-24)
The nucleotide-binding domain, leucine-rich repeat containing family caspase recruitment domain containing 4 (NLRC4) inflammasome can be activated by pathogenic bacteria via products translocated through the microbial type III secretion apparatus (T3SS). Recent work has shown that activation of the NLRP3
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