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Giovanni Forte et al.
Annali dell'Istituto superiore di sanita, 41(2), 213-216 (2005-10-26)
Although some studies suggested a link between exposure to trace elements and development of multiple sclerosis (MS), clear information on their role in the aetiology of MS is still lacking. In this study the concentrations of Al, Ba, Be, Bi
Dennis Sebastian et al.
Journal of AOAC International, 96(2), 251-259 (2013-06-19)
A 5-day method for determining the soluble silicon (Si) concentrations in nonliquid fertilizer products was developed using a sodium carbonate (Na2CO3)-ammonium nitrate (NH4NO3) extractant followed by visible spectroscopy with heteropoly blue analysis at 660 nm. The 5-Day Na2CO3-NH4NO3 Soluble Si
Mutlu Ozcan et al.
The journal of adhesive dentistry, 15(3), 211-214 (2013-05-24)
To evaluate the effect of nozzle distance, nozzle angle, and deposition duration on the silica content attained on zirconia by air abrasion. Disk-shaped zirconia (LAVA, 3M ESPE) (diameter: 10 mm, thickness: 2 mm) specimens (N = 54) were obtained. They
Keith R Martin
Metal ions in life sciences, 13, 451-473 (2014-01-29)
Silicon is the second most abundant element in nature behind oxygen. As a metalloid, silicon has been used in many industrial applications including use as an additive in the food and beverage industry. As a result, humans come into contact
Graham A Showell et al.
Drug discovery today, 8(12), 551-556 (2003-06-25)
During the lead optimization phase of drug discovery projects, the factors contributing to subsequent failure might include poor portfolio decision-making and a sub-optimal intellectual property (IP) position. The pharmaceutical industry has an ongoing need for new, safe medicines with a
Dae-Hee Kim et al.
Journal of nanoscience and nanotechnology, 13(5), 3564-3567 (2013-07-19)
The initial reaction of dimethylaluminum isopropoxide (Al(CH3)2OC3H7, DMAI) with a fully hydrogen-terminated Si (001) surface for aluminum oxide thin-film growth was investigated using density functional theory. Al-C and Al-O bonds of the adsorbed DMAI were easily broken to produce unimethylaluminum
Karyn L Jarvis et al.
Advances in colloid and interface science, 175, 25-38 (2012-04-24)
Porous silicon (pSi) has a number of unique properties that appoint it as a potential drug delivery vehicle; high loading capacity, controllable surface chemistry and structure, and controlled release properties. The native Si(y)SiH(x) terminated pSi surface is highly reactive and
Norbert W Lutz et al.
PloS one, 2(7), e595-e595 (2007-07-06)
Multiple sclerosis (MS), an inflammatory disease of the central nervous system, manifests itself in numerous forms and stages. A number of brain metabolic alterations have been reported for MS patients vs. control subjects. However, metabolite profiles of cerebrospinal fluid (CSF)
Emil Rudobeck et al.
Radiation research, 181(4), 407-415 (2014-03-15)
An unavoidable complication of space travel is exposure to radiation consisting of high-energy charged particles (HZE), such as Fe and Si nuclei. HZE radiation can affect neuronal functions at the level of the synapse or neuronal soma without inducing significant
C E Shaw et al.
Journal of neurology, 242(2), 53-58 (1995-01-01)
Magnetic resonance imaging of multiple sclerosis (MS) patients often shows active inflammatory lesions despite clinical remission. No immunological marker of disease activity has been identified in these patients. Concentrations of neopterin, interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R) and tumour necrosis
S Engelborghs et al.
Neurochemical research, 28(8), 1145-1150 (2003-07-02)
To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino acids, in cerebrospinal fluid of Parkinson's disease patients (n =
Xuyang Liu et al.
Environmental pollution (Barking, Essex : 1987), 184, 570-578 (2013-11-05)
Surface transformation can affect the stability, reactivity, and toxicity of titanium dioxide (TiO2) nanoparticles (NPs) in water environments. Herein, we investigated the release kinetics of Si impurity frequently introduced during NP synthesis and the resulting effect on TiO2 NP transformation
Guo-Jun Zhang et al.
Analytica chimica acta, 749, 1-15 (2012-10-06)
Over the past decade, silicon nanowire (SiNW) biosensors have been studied for the detection of biological molecules as highly sensitive, label-free, and electrical tools. Herein we present a comprehensive review about the fabrication of SiNW biosensors and their applications in
William Bains et al.
Current opinion in drug discovery & development, 6(4), 526-543 (2003-09-04)
The use of organosilicon chemistry in drug design is reviewed. The field of bioorganosilicon chemistry, which sprung up in the 1970s to exploit the opportunities of silicon for drug design, is currently being developed into a practical and commercial enterprise.
V Calabrese et al.
Neurochemical research, 28(9), 1321-1328 (2003-08-27)
Recent studies suggest that NO and its reactive derivative peroxynitrite are implicated in the pathogenesis of multiple sclerosis (MS). Patients dying with MS demonstrate increased astrocytic inducible nitric oxide synthase activity, as well as increased levels of iNOS mRNA. Peroxynitrite
Guohou Miao et al.
Materials science & engineering. C, Materials for biological applications, 33(7), 4236-4243 (2013-08-06)
Acid-catalyzed mesoporous bioactive glass microspheres (MBGMs-A) and acid-alkali co-catalyzed mesoporous bioactive glass microspheres (MBGMs-B) were successfully synthesized via combination of sol-gel and water-in-oil (W/O) micro-emulsion methods. The structural, morphological and textural properties of mesoporous bioactive glass microspheres (MBGMs) were characterized
P A LeWitt et al.
Neurology, 42(11), 2111-2117 (1992-11-01)
We used two analytic methods (a multichannel coulometric electrode array with high-performance liquid chromatography, and gas chromatography-mass spectrophotometry) to measure CSF dopamine (DA) and its metabolites in mildly affected, unmedicated subjects with Parkinson's disease (PD). The mean (+/- SD) concentration
Y Miura
The Kurume medical journal, 47(4), 267-272 (2001-02-24)
Plasma beta-phenylethylamine (PEA) levels were determined in 27 patients with Parkinson's disease (PD) in order to evaluate its relation with the severity or clinical course of PD. The plasma PEA concentrations in PD patients were significantly lower (mean +/- SD
V N Marty et al.
Radiation research, 182(6), 653-665 (2014-11-18)
The evaluation of potential health risks associated with neuronal exposure to space radiation is critical for future long duration space travel. The purpose of this study was to evaluate and compare the effects of low-dose proton and high-energy charged particle
Bo-Soon Kim et al.
Journal of nanoscience and nanotechnology, 13(5), 3622-3626 (2013-07-19)
A subwavelength structure (SWS) was formed via a simple chemical wet etching using a gold (Au) catalyst. Single nano-sized Au particles were fabricated by metallic self-aggregation. The deposition and thermal annealing of the thin metallic film were carried out. Thermal
K J Bär et al.
Neurobiology of aging, 24(2), 333-338 (2002-12-25)
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of
M Naoi et al.
Mechanisms of ageing and development, 111(2-3), 175-188 (2000-02-03)
Dopamine neurons in the substantia nigra of human brain are selectively vulnerable and the number decline by aging at 5-10% per decade. Enzymatic and non-enzymatic oxidation of dopamine generates reactive oxygen species, which induces apoptotic cell death in dopamine neurons.
Muhammad Ahsan Farooq et al.
Ecotoxicology and environmental safety, 96, 242-249 (2013-08-06)
Biotic systems face immense environmental hazards such as accumulation of heavy metals, particularly in agricultural ecosystems that might cause deterioration of yield and quality of crops. In this study, we evaluated the role of silicon (Si) in alleviating the heavy
Dean G Johnson et al.
Advances in chronic kidney disease, 20(6), 508-515 (2013-11-12)
The development of wearable or implantable technologies that replace center-based hemodialysis (HD) hold promise to improve outcomes and quality of life for patients with ESRD. A prerequisite for these technologies is the development of highly efficient membranes that can achieve
Prashanta Dhoj Adhikari et al.
Journal of nanoscience and nanotechnology, 13(7), 4587-4592 (2013-08-02)
Multi-walled carbon nanotubes (MWCNTs) were grown using iron oxide nanoclusters (Nc) assisted by self-assembled monolayer (SAM) on substrate. The amine-terminated SAM fabricated on silicon substrate (APTMS/SI) was carried out by UV-treatment and immersed into the FeCI3/HCI aqueous solution. Then, Nc
Anna Walter et al.
Neurobiology of aging, 25(10), 1299-1303 (2004-10-07)
Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF).
Hirohito Nishimura et al.
The Journal of cell biology, 202(6), 967-983 (2013-09-18)
Fluorescence microscopy is used extensively in cell-biological and biomedical research, but it is often plagued by three major problems with the presently available fluorescent probes: photobleaching, blinking, and large size. We have addressed these problems, with special attention to single-molecule
Cells under pressure.
Allison Doerr
Nature methods, 10(9), 818-819 (2013-10-22)
R K Sahoo et al.
Journal of nanoscience and nanotechnology, 14(6), 4595-4601 (2014-04-18)
The dewetting of a low melting point metal thin film deposited on silicon substrates was studied. The experimental results suggest that the change in the growth temperature affects the nanostructures that form. Based on the experimental results, the temperature which
Alexandra E Porter
Micron (Oxford, England : 1993), 37(8), 681-688 (2006-04-25)
Silicon plays an important role in bone mineralization and formation and is therefore incorporated into a wide variety of medical implants and bone grafts used today. The significance of silicon (Si) can be understood through an analysis of the mechanisms
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