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Mei-Lan Hong et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 30(8), 811-815 (2014-08-12)
A label-free fluorescent assay for the detection of trypsin by using oligonucleotide-templated silver nanoclusters (Ag NCs) and cytochrome c (Cyt c) has been demonstrated. When negatively charged Ag NCs and positively charged Cyt c are mixed, they tend to form
Xiang Yi Kong et al.
PloS one, 10(6), e0129402-e0129402 (2015-06-06)
Ablation of glycosylated lysosomal membrane protein (GLMP, formerly known as NCU-G1) has been shown to cause chronic liver injury which progresses into liver fibrosis in mice. Both lysosomal dysfunction and chronic liver injury can cause metabolic dysregulation. Glmp gt/gt mice
Ivan Sanchez-De Melo et al.
Journal of proteomics, 127(Pt B), 225-233 (2015-04-25)
The pharmaceutical market has entered an era in which the production of new therapeutics is being often replaced by "biosimilars", copies of already commercialized products waiting for the patents to expire in order to be distributed in a more competitive
Audrey J Majeske et al.
Journal of immunology (Baltimore, Md. : 1950), 193(11), 5678-5688 (2014-10-31)
Immune systems in animals rely on fast and efficient responses to a wide variety of pathogens. The Sp185/333 gene family in the purple sea urchin, Strongylocentrotus purpuratus, consists of an estimated 50 (±10) members per genome that share a basic
Jennifer Sealey-Voyksner et al.
Food chemistry, 194, 201-211 (2015-10-17)
Proteins unique to peanuts and various tree nuts have been extracted, subjected to trypsin digestion and analysis by liquid chromatography/quadrupole time-of-flight mass spectrometry, in order to find highly conserved peptides that can be used as markers to detect peanuts and
Pamela Di Tullo et al.
Analytical and bioanalytical chemistry, 407(30), 9029-9042 (2015-10-03)
Selenium is both essential and toxic for mammals; the range between the two roles is narrow and not only dose-dependent but also related to the chemical species present in foodstuff. Unraveling the metabolism of Se in plants as a function
Lin Hai Kurahara et al.
Inflammatory bowel diseases, 21(3), 496-506 (2015-02-04)
Intestinal fibrosis is a frequent complication of Crohn's disease (CD) and often leads to detrimental stricture formation. Myofibroblasts play active roles in mediating fibrotic changes in various tissues. We investigated whether transient receptor potential channels in intestinal myofibroblasts are involved
Patrícia Pereira et al.
Journal of chromatography. A, 1368, 173-182 (2014-12-03)
MicroRNA-based therapeutic applications have fostered a growing interest in the development of microRNAs purification processes in order to obtain the final product with high purity degree, good quality and biologically active. The pre-miR-29 deficiency or overexpression has been associated to
Verena Kriechbaumer
Bio-protocol, 6(9) (2017-02-10)
Auxin is a major growth hormone in plants and the first plant hormone to be discovered and studied (Darwin and Darwin, 1880). The auxin molecule in plants was first identified as indole-3-acetic acid (IAA) by Kögl et al. (1934). Active
Afshin Amini et al.
Journal of experimental & clinical cancer research : CR, 33, 92-92 (2014-11-27)
Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing compounds with good safety profiles which have been investigated for their benefits and application in health and disease for more than fifty years. As such, the potential values of these agents in cancer
M Rira et al.
Journal of animal science, 93(1), 334-347 (2015-01-09)
The objective of this work was to study nutritional strategies for decreasing methane production by ruminants fed tropical diets, combining in vitro and in vivo methods. The in vitro approach was used to evaluate the dose effect of condensed tannins
Mi-Young Kim et al.
Vaccine, 33(15), 1830-1838 (2015-03-03)
Dengue infection is on the rise in many endemic areas of the tropics. Vaccination remains the most realistic strategy for prevention of this potentially fatal viral disease but there is currently no effective vaccine that could protect against all four
Irene Moraleja et al.
Analytical and bioanalytical chemistry, 407(9), 2393-2403 (2015-01-27)
A shotgun approach including peptide-based OFFGEL-isoelectric focusing (IEF) fractionation has been developed with the aim of improving the identification of platinum-binding proteins in biological samples. The method is based on a filter-aided sample preparation (FASP) tryptic digestion under denaturing and
[Ketorolac tromethamine--with special reference to postoperative pain therapy].
S S Andersen et al.
Ugeskrift for laeger, 156(8), 1160-1163 (1994-02-21)
Natalie Cortes et al.
Journal of pharmaceutical and biomedical analysis, 102, 222-228 (2014-10-12)
Acetylcholinesterase (AChE) enzymatic inhibition is an important target for the management of Alzheimer disease (AD) and AChE inhibitors are the mainstay drugs for its treatment. In order to discover new sources of potent AChE inhibitors, a combined strategy is presented
Chulwon Kim et al.
Molecular carcinogenesis, 53(10), 793-806 (2013-06-15)
Constitutive activation of STAT3 is frequently observed and closely linked with proliferation, survival, invasion, metastasis and angiogenesis in tumor cells. In the present study, we investigated whether β-caryophyllene oxide (CPO), a sesquiterpene isolated primarily from the essential oils of medicinal
P A Mosier-Boss et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 153, 591-598 (2015-10-07)
SERS substrates were fabricated by filtering either Ag or Au colloidal particles onto rigid, ceramic filters - onto which suspensions of bacteria were then filtered. SERS spectra of the bacteria were obtained using a Raman spectrometer that has an 'orbital
Natalia A Stefanova et al.
Journal of pineal research, 59(2), 163-177 (2015-05-20)
Translational research on Alzheimer's disease (AD) has often focused on reducing the high cerebral levels of amyloid-β (Aβ) as a key characteristic of AD pathogenesis. There is, however, a growing body of evidence that synaptic dysfunction may be crucial for
Julieta Correa-Betanzo et al.
Journal of agricultural and food chemistry, 63(11), 2935-2946 (2015-03-03)
Biological activity of polyphenols is influenced by their uptake and is highly influenced by their interactions with the food matrix. This study evaluated the complex formation of blueberry polyphenols with fruit matrixes such as pectin and cellulose and their effect
David S Jones et al.
Molecular pharmaceutics, 12(8), 2928-2936 (2015-06-26)
This paper presents a novel strategy for the prevention of ventilator-associated pneumonia that involves coating poly(vinyl chloride, PVC) endotracheal tubes (ET) with hydrogels that may be subsequently used to entrap nebulized antimicrobial solutions. Candidate hydrogels were prepared containing a range
Lisa Mathiasen et al.
PloS one, 10(4), e0125789-e0125789 (2015-04-10)
Human PREP1 and PBX1 are homeodomain transcriptional factors, whose biochemical and structural characterization has not yet been fully described. Expression of full-length recombinant PREP1 (47.6 kDa) and PBX1 (46.6 kDa) in E. coli is difficult because of poor yield, high
Matthias C Truttmann et al.
Bio-protocol, 7(14) (2017-11-25)
Post-translational protein modifications (PTMs) orchestrate the activity of individual proteins and ensure their proper function. While modifications such as phosphorylation or glycosylation are well understood, more unusual modifications, including nitrosylation or AMPylation remain comparatively poorly characterized. Research on protein AMPylation-which
E O Farombi et al.
Andrologia, 46(8), 893-901 (2013-10-02)
The indiscriminate use, abuse and patients' noncompliance to normal prescription of artemisinin and its derivatives are a common practice during the treatment for drug-resistant malaria parasites in most developing countries. This study investigated the influence of artemisinin on the testicular
Wei Li et al.
Biosensors & bioelectronics, 70, 304-309 (2015-04-04)
DNA methylation catalyzed by methyltransferase (MTase) plays an important role in many biological processes, including gene transcription, genomic imprinting and cellular differentiation. Herein, a simple and novel homogeneous electrochemical strategy for ultrasensitive DNA MTase activity assay has been successfully developed
Qi-Bin Zhang et al.
Nature communications, 6, 8062-8062 (2015-08-22)
The South Asian Monsoon and mid-latitude Westerlies are two important controls on Tibetan Plateau (TP) fresh water resources. Understanding their interaction requires long-term information on spatial patterns in moisture variability on the TP. Here we develop a network of 23
Maria Sol Degese et al.
The Biochemical journal, 467(1), 77-90 (2015-01-15)
Mitogen-activated protein kinase (MAPK) pathways constitute key regulatory elements linking extracellular stimuli to nuclear gene expression. Immediate-early responsive genes (IEGs) of the activator protein 1 (AP-1) family, such as fos, achieve peak expression levels shortly after cells are stimulated with
M L Lima et al.
Transplantation proceedings, 44(8), 2326-2332 (2012-10-03)
There is a growing need to improve heart preservation benefit the performance of cardiac operations, decrease morbidity, and more important, increase the donor pool. Therefore, the objective of this study was to evaluate the cardioprotective effects of Krebs-Henseleit buffer (KHB)
Weifeng Liu et al.
Molecular biotechnology, 57(10), 914-922 (2015-07-24)
Many immune ligands and receptors are potential drug targets, which delicately manipulate a wide range of immune responses. We describe here the successful application of an efficient method to dramatically improve the heterologous expression levels in Drosophila Schneider 2 cells
Jennifer E Gilda et al.
PloS one, 10(8), e0135392-e0135392 (2015-08-20)
Western blotting is a commonly used technique in biological research. A major problem with Western blotting is not the method itself, but the use of poor quality antibodies as well as the use of different experimental conditions that affect the
R Mirmahmoudi et al.
Theriogenology, 82(7), 1012-1020 (2014-08-26)
Poor estrus expression and the difficulty encountered in predicting the time of ovulation compromise the reproductive efficiency of Murrah buffalo cows. Synchronization of ovulation and timed artificial insemination are able to precisely control the time of ovulation and thus avoid
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