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Lori S Tillmans et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 24(4), 713-719 (2015-02-05)
Cigarette smoking (smoking), hormone therapy (MHT), and folate intake (folate) are each thought to influence colorectal cancer risk, but the underlying molecular mechanisms remain incompletely defined. Expression of estrogen receptor β (ESR2) has been associated with colorectal cancer stage and
Yonghe Fei et al.
Food chemistry, 187, 385-390 (2015-05-16)
Three new monoterpene glycosides (1-3) and eleven known compounds (4-14) were isolated from seeds of Helianthus annuus L. (sunflower). Their structures were determined by spectroscopic and chemical methods. All the compounds were isolated from sunflower seeds for the first time.
Jay J Cao et al.
Calcified tissue international, 97(2), 145-155 (2015-04-24)
This study investigated whether exercise or antioxidant supplementation with vitamin C and E during exercise affects bone structure and markers of bone metabolism in obese rat. Sprague-Dawley rats, 6-week old, were fed a normal-fat diet (NF, 10 % kcal as
R Preston Mason et al.
Biochimica et biophysica acta, 1848(2), 502-509 (2014-12-03)
Lipid oxidation leads to endothelial dysfunction, inflammation, and foam cell formation during atherogenesis. Glucose also contributes to lipid oxidation and promotes pathologic changes in membrane structural organization, including the development of cholesterol crystalline domains. In this study, we tested the
Jian-Zhuang Tan et al.
Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)
The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:
Venkatakrishnan Kamesh et al.
Pharmaceutical biology, 52(10), 1327-1334 (2014-07-30)
Bacopa monniera L. (Scrophulariaceae) is used as a traditional medicine in India for various ailments such as epilepsy, mental disorders, and also as a cardio-tonic. However, its nephroprotective role is still unknown. The present study assesses the modulatory impact of
Jesús Crespo-Sanjuán et al.
Laboratory medicine, 46(2), 123-135 (2015-04-29)
To detect whether signs of oxidative stress appear at early stages of colorectal adenocarcinoma (CRC), particularly in the polyp stage. We also aimed to evaluate the specific entities myeloperoxidase (MPO) and oxidized low-density lipoprotein (oxLDL) as novel markers of oxidation
Logan K Townsend et al.
American journal of physiology. Cell physiology, 318(1), C137-C149 (2019-11-14)
Reactive oxygen species (ROS) are important signaling molecules mediating the exercise-induced adaptations in skeletal muscle. Acute exercise also drives the expression of genes involved in reesterification and glyceroneogenesis in white adipose tissue (WAT), but whether ROS play any role in
Yun Wang et al.
The Journal of nutritional biochemistry, 23(6), 602-608 (2011-07-19)
Eotaxin-3 (CCL-26), a potent chemokine for eosinophil recruitment and contributing significantly to the pathogenesis of asthma, is secreted by lung epithelial cells in response to T helper 2 cytokines including interleukin 13 (IL-13). Here we showed that vitamin E forms
C K Parr et al.
Journal of animal science, 93(5), 2165-2173 (2015-05-29)
An experiment was conducted to evaluate effects of 2 high-protein canola meals (canola meal A [CMA]: 45.69% CP and canola meal B [CMB]: 46.97% CP) and a conventional canola meal (CM-CV: 35.10% CP) on growth performance, organ weights, bone ash
Bénédicte M J Merle et al.
PloS one, 10(7), e0130816-e0130816 (2015-07-02)
Genetic susceptibility could be modified by environmental factors and may also influence differential responses to treatments for age-related macular degeneration (AMD). We investigated whether genotype could influence response to docosahexaenoic acid (DHA)-supplementation in the occurrence of choroidal new vessels (CNV).
G A Casas et al.
Journal of animal science, 93(7), 3441-3448 (2015-10-07)
The objectives of this experiment were to determine the apparent total tract digestibility (ATTD) and the standardized total tract digestibility (STTD) of P and the effect of microbial phytase on ATTD and STTD of P in full-fat rice bran (FFRB)
Yadong Sun et al.
Cell death & disease, 12(11), 1028-1028 (2021-10-31)
Ferroptosis is a form of regulated cell death that emerges to be relevant for therapy-resistant and dedifferentiating cancers. Although several lines of evidence suggest that ferroptosis is a type of autophagy-dependent cell death, the underlying molecular mechanisms remain unclear. Fin56
Hiroyuki Kitajima et al.
Acta paediatrica (Oslo, Norway : 1992), 104(2), e82-e89 (2014-11-11)
Methods to improve the mental development of extremely low birthweight (ELBW) children are currently lacking. We assessed the effects of long-term supplementation of alpha-tocopherol on the neurological development of 259 school-aged ELBW children. Extremely low birthweight participants were divided into
I A Alhidary et al.
Journal of animal science, 93(2), 576-588 (2015-05-29)
Forty-two 7-mo-old Australian Merino wethers were used in a 50-d trial to investigate the effects of Se and vitamin E on the performance and physiological responses of heat-stressed sheep. Sheep were exposed to thermoneutral conditions (maximum = 24°C and minimum
A Dalle Zotte et al.
Poultry science, 94(9), 2114-2123 (2015-07-29)
This study investigated the impact of 2 coccidiosis control systems (vaccine vs anticoccidial) and 2 feeding plans (standard energy vs low energy content, the latter supplemented with threonine and enzymes in the second half of the production cycle) on white
Nicolò Dossi et al.
Electrophoresis, 36(16), 1830-1836 (2015-04-22)
We propose here simple electrochemical cells assembled with electrodes pencil drawn on paper for conducting one-spot tests enabling olive oil to be easily distinguished from other vegetable oils. They consist of small circular pads of hydrophilic paper defined by hydrophobic
Jared D Hoffman et al.
Mutagenesis, 30(3), 421-430 (2015-02-15)
Isothiocyanates are plant-derived compounds that may be beneficial in the prevention of certain chronic diseases. Yet, by stimulating the production of reactive oxygen species (ROS), isothiocyanates can be genotoxic. Whether antioxidants influence isothiocyanate-induced genotoxicity is unclear, but this situation was
J C González-Vega et al.
Journal of animal science, 93(5), 2255-2264 (2015-05-29)
An experiment was conducted to test the hypothesis that differences in the apparent total tract digestibility (ATTD) and standardized total tract digestibility (STTD) of Ca exist among Ca supplements and that inclusion of microbial phytase increases the ATTD and STTD
J L Adolphe et al.
Journal of animal physiology and animal nutrition, 99(4), 767-776 (2014-12-06)
Peas are increasing in popularity as a source of carbohydrate, protein and fibre in extruded canine diets. The aim of this study was to test the health effects of two canine diets with identical macronutrient profiles, but containing either yellow
Jana Cela et al.
Plant & cell physiology, 52(8), 1389-1400 (2011-07-02)
Tocopherols are antioxidants found in chloroplasts of leaves, and it is a matter of current debate whether or not they can affect signaling and gene expression in plant cells. For insight into the possible effects of altered tocopherol composition in
Glycosphingolipids Prevent APAP and HMG-CoA Reductase Inhibitors-mediated Liver Damage: A Novel Method for ?Safer Drug? Formulation that Prevents Drug-induced Liver Injury
Mizrahi M, et al.
Journal of clinical and translational hepatology, 6(2), 1-8 (2018)
M Verdú et al.
Journal of animal science, 93(6), 3018-3033 (2015-06-27)
A total of 240 Holstein bulls (121 ± 2.0 kg initial BW; 99 ± 1.0 d of age), from 2 consecutive fattening cycles, were randomly allocated in 1 of 6 pens and assigned to 1 of the 3 treatments consisting
The two faces of α- and γ-tocopherols: an in vitro and ex vivo investigation into VLDL, LDL and HDL oxidation.
Nadeem N, Woodside JV, et al.
The Journal of Nutritional Biochemistry (2011)
Matthew Page et al.
Pharmacology, 96(3-4), 131-136 (2015-08-01)
To this date, the only available drugs for treating Alzheimer's disease are cognitive enhancers, which may improve the cognitive function of patients for a few years while the disease continues to progress. As such, there are intense investigations to develop
Suresh B Lakshminarayana et al.
Antimicrobial agents and chemotherapy, 59(2), 1200-1210 (2014-12-10)
Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone analogs and identify the PK-PD index
Shaban Y Shaban et al.
Dalton transactions (Cambridge, England : 2003), 44(31), 14110-14121 (2015-07-15)
A series of copper(ii) complexes, viz. [Tp(MeMe)Cu(Cl)(H2O)] (), [Tp(MeMe)Cu(OAc)(H2O)] (), [Tp(MeMe)Cu(NO3)] () and [Tp(MeMe)Cu(ClO4)] () containing tris(3,5-dimethylpyrazolyl)borate (KTp(MeMe)), have been synthesized and fully characterized. The substitution reaction of with thiourea was studied under pseudo-first-order conditions as a function of concentration
Mahmoud S Sharaf et al.
Free radical biology & medicine, 84, 142-153 (2015-04-07)
Zinc and calcium have highly interwoven functions that are essential for cellular homeostasis. Here we first present a novel real-time flow cytometric technique to measure mitochondrial redox state and show it is modulated by zinc and calcium, individually and combined.
Bernardino Alcázar Navarrete et al.
Clinical drug investigation, 35(9), 569-574 (2015-08-15)
To date, no evidence exists in the literature as to the effects of inhaled corticosteroids (ICs) on salivary composition in patients with bronchial asthma. The aim of this study was to assess the effect of ICs on salival composition. Adult
Alexandra C Weaver et al.
Toxins, 6(12), 3336-3353 (2014-12-24)
To evaluate the effects of the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA) on pigs and the benefits of two mycotoxin mitigation strategies, gilts (n = 84, 9.1 ± 0.1 kg) were allotted to four treatments: CON (control); MT (4.8 mg/kg
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