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Kiwamu Takahashi et al.
Anticancer research, 33(7), 2861-2866 (2013-06-20)
5-Aminolevulinic acid (ALA) is a precursor of heme. ALA is used as a photosensitive substance in photodynamic diagnosis (PDD) and photodynamic therapy (PDT) because heme metabolism is abnormal in tumor cells and a photosensitive metabolite of heme synthesis from ALA
Xiaomin Su et al.
Ultrasonics, 54(1), 275-284 (2013-08-28)
The present study aims to investigate apoptosis of human leukemia K562 cells induced by protoporphyrin IX (PpIX)-mediated sonodynamic therapy (PpIX-SDT). The uptakes of intracellular PpIX in K562 cells were detected by flow cytometry. The sub-cellular localization of PpIX was imaged
Chie Suzuki et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(10), 1671-1677 (2014-08-16)
Preoperative noninvasive imaging to estimate the quantity and spatial distribution of protoporphyrin IX (PpIX) accumulation in tumors induced by 5-aminolevulinic acid (ALA) administration is expected to improve the efficacy of ALA-based fluorescence-guided resection and photo- and sonodynamic therapies. PpIX synthesis
Vincent Oustric et al.
American journal of human genetics, 94(4), 611-617 (2014-04-01)
In 90% of people with erythropoietic protoporphyria (EPP), the disease results from the inheritance of a common hypomorphic FECH allele, encoding ferrochelatase, in trans to a private deleterious FECH mutation. The activity of the resulting FECH enzyme falls below the
Pablo A Valdés et al.
Scientific reports, 2, 798-798 (2012-11-16)
Intraoperative visual fluorescence imaging (vFI) has emerged as a promising aid to surgical guidance, but does not fully exploit the potential of the fluorescent agents that are currently available. Here, we introduce a quantitative fluorescence imaging (qFI) approach that converts
Georg Widhalm
Clinical neuropathology, 33(4), 260-278 (2014-07-06)
Precise histopathological diagnosis of brain tumors is essential for the correct patient management. Furthermore, complete resection of brain tumors is associated with an improved patient prognosis. However, histopathological undergrading and incomplete tumor removal are not uncommon, especially due to insufficient
Filippo Piffaretti et al.
Journal of biomedical optics, 17(11), 115007-115007 (2012-12-12)
Tissular oxygen concentration plays a key role during photodynamic therapy (PDT). Therefore, monitoring its local oxygen partial pressure (pO2) may help predict and/or control the outcome of a PDT treatment. The first real-time, in vivo measurements of the pO2 in
Carrie Hiser et al.
Biochemistry, 52(8), 1385-1396 (2013-01-29)
A conserved, crystallographically defined bile acid binding site was originally identified in the membrane domain of mammalian and bacterial cytochrome c oxidase (CcO). Current studies show other amphipathic molecules including detergents, fatty acids, steroids, and porphyrins bind to this site
Feng Li et al.
Nature medicine, 19(4), 418-420 (2013-03-12)
Co-therapy with rifampicin (RIF) and isoniazid (INH) used to treat tuberculosis in humans frequently causes liver injury. Here, using a pregnane X receptor (PXR)-humanized mouse model, we found that co-treatment with RIF and INH causes accumulation of the endogenous hepatotoxin
A A Potapov et al.
Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko, 76(5), 3-11 (2012-12-13)
Absence of well-defined borders of the glial tumor due to their infiltrative growth is one of the main issues in neurosurgery. A number of methods for intraoperative visualization are available today. The fluorescent metabolic navigation with 5-aminolevulinic acid (5-ALA) combined
S Samiullah et al.
Poultry science, 92(10), 2783-2788 (2013-09-21)
Protoporphyrin has been identified as the main eggshell pigment in brown-shelled eggs. However, there has been some uncertainty concerning the distribution of the pigment within the shell (and cuticle) in brown-shelled eggs. Most previous studies have suggested that the bulk
Carolina Loureiro da Silva et al.
Journal of nanoscience and nanotechnology, 13(10), 6533-6540 (2013-11-20)
Poly(D,L lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) are proposed for topical delivery of Protoporphyrin IX (PpIX) in Photodynamic Therapy of skin cancers. PpIX loaded into PLGA NPs showed nanometric average diameter (-280 nm), spherical forms and pH - 5.7, conditions
Beata Cunderlíková et al.
Biochimica et biophysica acta, 1830(3), 2750-2762 (2012-11-13)
Photodynamic therapy and photodiagnosis of cancer requires preferential accumulation of fluorescent photosensitizers in tumors. Clinical evidence documents feasibility of ALA-based photodiagnosis for tumor detection. However, false positive results and large variations in fluorescence intensities are also reported. Furthermore, selective accumulation
Tomonari Suzuki et al.
Journal of neurosurgery, 119(5), 1331-1339 (2013-09-10)
Gliomas contain aggressive malignant cancer, and resection rate remains an important factor in treatment. Currently, fluorescence-guided resection using orally administered 5-aminolevulinic acid (5-ALA) has proved to be beneficial in improving the prognosis of patients with gliomas. 5-ALA is metabolized to
Haiyan Xie et al.
Journal of biomedical optics, 19(7), 71408-71408 (2014-03-14)
Optical techniques for tissue diagnostics currently are experiencing tremendous growth in biomedical applications, mainly due to their noninvasive, inexpensive, and real-time functionality. Here, we demonstrate a hand-held fiber optic probe instrument based on fluorescence/reflectance spectroscopy for precise tumor delineation. It
Chi Zhang et al.
The Laryngoscope, 129(2), E80-E86 (2018-11-09)
To evaluate the feasibility of topical photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) for vocal fold leukoplakia. Ex vivo and in vivo. 5-ALA was applied topically as a 20% solution to ex vivo canine vocal folds. The penetration depth and
Sonodynamic effects of protoporphyrin IX disodium salt on isolated sarcoma 180 cells
Liu Q, et al.
Ultrasonics, 45(1-4), 56-60 (2006)
Naoko Ito et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(12), 1641-1643 (2014-01-08)
Cancer cells synthesize substantial amounts of protoporphyrin IX( PPIX) from aminolevulinic acid( ALA). PPIX emits red fluorescence when illuminated under blue light. Photodynamic diagnosis (PDD), based on this phenomenon, is currently used; however, various microorganisms also show the same fluorescence
Fluorescence spectroscopic characterization of salivary metabolites of oral cancer patients.
Yuvaraj M, et al.
Journal of Photochemistry and Photobiology. B, Biology, 130, 153-160 (2014)
Youzhong Guo et al.
Science (New York, N.Y.), 347(6221), 551-555 (2015-01-31)
Translocator proteins (TSPOs) bind steroids and porphyrins, and they are implicated in many human diseases, for which they serve as biomarkers and therapeutic targets. TSPOs have tryptophan-rich sequences that are highly conserved from bacteria to mammals. Here we report crystal
Pierre Martin et al.
Chimia, 67(4), 204-206 (2013-08-24)
The total synthesis of protoporphyrin IX and its disodium salt using a new alternative method to the classical MacDonald condensation is reported. The key step is the reaction of the new unsymmetrical diiodo dipyrrylmethane 1 with the known dipyrrylmethane 2.
Guoqing Ouyang et al.
Photodiagnosis and photodynamic therapy, 21, 396-403 (2018-01-23)
Photodynamic therapy (PDT) has been reported to be a promising therapy for colon cancer because of its substantial safety features and its ability to induce a systematic reaction rather than local effects on the focal lesion in the intestine. Autophagy
Hirotsugu Kobuchi et al.
PloS one, 7(11), e50082-e50082 (2012-11-29)
Accumulation of protoporphyrin IX (PpIX) in malignant cells is the basis of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy. We studied the expression of proteins that possibly affect ALA-mediated PpIX accumulation, namely oligopeptide transporter-1 and -2, ferrochelatase and ATP-binding cassette transporter G2
J Huang et al.
Cell proliferation, 46(5), 595-605 (2013-09-17)
The aim of this study was to explore mechanisms by which salvianolic acid A (SAA) revealed its anti-inflammatory activity, in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Nitric oxide (NO) concentration was determined by the Griess reaction and cell viability was assessed by
Xin Li et al.
The Journal of surgical research, 184(2), 1013-1021 (2013-04-30)
Treatments of infections are not always successful because of multi-antibiotic-resistant organisms. It is therefore particularly urgent to provide more effective anti-infective strategy against these organisms. 5-Aminolevulinic acid (ALA), with the chemical structure C5H9NO3, is the only photodynamic therapy agent that
Pan Wang et al.
Ultrasonics, 53(5), 935-942 (2013-02-19)
Protoporphyrin IX (PpIX) has been used as a sensitizer in photodynamic therapy (PDT) as well as in sonodynamic therapy (SDT). The photo-bleaching of PpIX has been well investigated in many experimental systems and some photo-products have also been identified in
Jinbo Zhu et al.
Chemical communications (Cambridge, England), 48(98), 11990-11992 (2012-11-08)
A special DNA calliper made of a split G-quadruplex was constructed to measure the length of DNA in a single-digit base number range between two selected sequences. The enhanced fluorescence of PPIX changed with the distance between two G-rich segments.
Yu-Hsing Lin et al.
FEBS letters, 587(19), 3202-3209 (2013-08-21)
Targeted inhibition of multidrug ABCG2 transporter is believed to improve cancer therapeutics. However, the consequences of ABCG2 inhibition have not been systematically evaluated since ABCG2 is expressed in several organs including the liver. Here, we demonstrate that ABCG2-deficient hepatocytes have
Guangqi Li et al.
Poultry science, 92(12), 3120-3124 (2013-11-16)
Protoporphyrin IX (PpIX), an immediate precursor of heme, is the main pigment resulting in the brown coloration of eggshell. The brownness and uniformity of the eggshell are important marketing considerations. In this study, 9 chickens laying darker brown shelled eggs
Kana Unuma et al.
PloS one, 8(2), e56526-e56526 (2013-03-05)
Lipopolysaccharide (LPS)-induced myocardial dysfunction is caused, at least in part, by mitochondrial dysfunction. Mitochondrial dysfunction and the oxidative damage associated with it are scavenged through various cellular defense systems such as autophagy to prevent harmful effects. Our recent study has
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