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On call. I have been experiencing strong muscle cramps that curl my fingers into a claw shape, which I can straighten only by using the other hand. How can I prevent this?
William Kormos
Harvard men's health watch, 17(8), 2-2 (2013-07-03)
Craig A Bayse et al.
Biochemistry, 53(30), 5034-5041 (2014-07-16)
Understanding the mechanism of prenyltransferases is important to the design of engineered proteins capable of synthesizing derivatives of naturally occurring therapeutic agents. CloQ is a Mg(2+)-independent aromatic prenyltransferase (APTase) that transfers a dimethylallyl group to 4-hydroxyphenylpyruvate in the biosynthetic pathway...
R Shukla et al.
The International journal of neuroscience, 116(12), 1391-1402 (2006-12-06)
Evidence from clinical and experimental studies supports the hypothesis of free radical-mediated damage of dopaminergic neurons in the pathology of Parkin's disease (PD). The present study was undertaken to evaluate the role of nitric oxide and oxidative stress in PD....
Katherine Brandao et al.
Cellular and molecular life sciences : CMLS, 71(24), 4853-4867 (2014-05-27)
The channel kinases TRPM6 and TRPM7 are both members of the melastatin-related transient receptor potential (TRPM) subfamily of ion channels and the only known fusions of an ion channel pore with a kinase domain. TRPM6 and TRPM7 form functional, tetrameric...
Chiung-Wei Huang et al.
Journal of cellular physiology, 229(11), 1703-1721 (2014-03-19)
In the Kir2.1 channel, the flow-dependent blocking effect of intracellular spermine (SPM) strongly indicates coupled movement of ions in a segment of the pore. We have shown that the bundle crossing region of M2 constitutes this critical segment of the...
Julia Matena et al.
International journal of molecular sciences, 16(6), 13287-13301 (2015-06-13)
Degradable implant material for bone remodeling that corresponds to the physiological stability of bone has still not been developed. Promising degradable materials with good mechanical properties are magnesium and magnesium alloys. However, excessive gas production due to corrosion can lower...
Mutsuko Demizu et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(7), 897-900 (2013-07-19)
Cetuximab is a monoclonal antibody that binds to the EGFR, and is used in patients with colorectal cancer. The most common toxicities associated with the use of cetuximab are rash and hypomagnesemia. Hypomagnesemia is a major adverse event, but it...
Wei Yang
Biochemistry, 53(17), 2793-2803 (2014-04-11)
Y-Family DNA polymerases specialize in translesion synthesis, bypassing damaged bases that would otherwise block the normal progression of replication forks. Y-Family polymerases have unique structural features that allow them to bind damaged DNA and use a modified template base to...
Shih-Hsin Chiu et al.
Journal of virology, 88(9), 4962-4975 (2014-02-21)
Epstein-Barr virus (EBV) lytic replication involves complex processes, including DNA synthesis, DNA cleavage and packaging, and virion egress. These processes require many different lytic gene products, but the mechanisms of their actions remain unclear, especially for DNA cleavage and packaging....
Reply to C.d. Atkins and a. Avan et Al.
Charles L Loprinzi et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(29), 3342-3343 (2014-08-20)
Christopher A Strulson et al.
Biochemistry, 52(46), 8187-8197 (2013-11-06)
In an effort to relate RNA folding to function under cellular-like conditions, we monitored the self-cleavage reaction of the human hepatitis delta virus-like CPEB3 ribozyme in the background of physiological ionic concentrations and various crowding and cosolute agents. We found...
Denise H M Heppe et al.
The American journal of clinical nutrition, 98(1), 224-232 (2013-05-31)
Maternal diet during pregnancy has been suggested to influence bone health in later life. We assessed the association of maternal first-trimester dietary intake during pregnancy with childhood bone mass. In a prospective cohort study in 2819 mothers and their children...
Ragnar Rylander
Journal of water and health, 12(1), 34-40 (2014-03-20)
Studies in many countries have demonstrated a relationship between drinking water mineral content and the risk of death in cardiovascular disease (CVD). Particularly strong relationships have been found for magnesium and it has been suggested that magnesium be added to...
The Grignard Reagents.
Seyferth D
Organometallics, 28(6), 1598-1605 (2009)
Andrea M P Romani
Metal ions in life sciences, 13, 49-79 (2014-01-29)
Mammalian cells tightly regulate cellular Mg(2+) content through a variety of transport and buffering mechanisms under the control of various hormones and cellular second messengers. The effect of these hormones and agents results in dynamic changes in the total content...
Wen Zhang et al.
The Analyst, 129(3), 229-234 (2004-02-24)
The fabrication and application of a novel electrochemical detector (ED) with nano crystalline Ce-doped lead dioxide film chemically modified electrode (CME) for liquid chromatography (LC) were described. The Ce-doped PbO(2) film was characterized by X-ray diffractometer (XRD) and scanning tunnel...
Yoon-Hyeong Choi et al.
The American journal of clinical nutrition, 99(1), 148-155 (2013-11-08)
The protective effects of antioxidant vitamins on hearing loss are well established in animal studies but in few human studies. Recent animal studies suggest that magnesium intake along with antioxidants may act in synergy to prevent hearing loss. We examined...
Ligia J Dominguez et al.
The American journal of clinical nutrition, 84(2), 419-426 (2006-08-10)
The role of magnesium in maintaining muscle integrity and function in older adults is largely unknown. We aimed to investigate the relation between serum magnesium concentrations and muscle performance in older subjects. Data are from the baseline examination conducted between...
W Vierling et al.
Deutsche medizinische Wochenschrift (1946), 138(22), 1165-1171 (2013-05-24)
Aim of the recommendations of the German Society for Magnesium Research: Recognition and compensation of magnesium deficiency in patients with risk factors for cardiac arrhythmias or manifest rhythm disturbances. Prevention of arrhythmias by administration of magnesium. Therapeutic administration of magnesium...
H U Shetty et al.
Clinical chemistry, 42(2), 298-302 (1996-02-01)
Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several other polyols in cerebrospinal fluid (CSF) and plasma from 10 AD subjects and 10 healthy...
D A Loeffler et al.
Journal of neural transmission. Parkinson's disease and dementia section, 9(1), 45-53 (1995-01-01)
Though depletion of CSF homovanillic acid (HVA) concentration has often been regarded as a direct indicator of dopamine (DA) deficiency in Parkinson's Disease (PD), CSF HVA is normal in mildly affected patients. To explore why, we measured DA and its...
Weifu Wang et al.
European urology, 48(3), 418-423 (2005-06-22)
To review and present the proposals or findings for a new approach about how to define and diagnose premature ejaculation (PE). Using Medline to search for international peer reviewed manuscripts published from 1996 to 2004 about the definition and diagnosis...
[The role of magnesium in neuroprotection and neuroplasticity].
E S Akarachkova et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(2), 80-83 (2013-05-15)
M A Raskind et al.
Biological psychiatry, 46(6), 756-765 (1999-09-24)
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid or increased release of NE into CNS extracellular fluid. Measuring CSF concentrations of the intraneuronal...
M O Kristensen et al.
Acta neurologica Scandinavica, 87(6), 475-481 (1993-06-01)
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite...
Yi Yin et al.
Zhongguo gu shang = China journal of orthopaedics and traumatology, 26(5), 423-428 (2013-08-14)
To investigate the tissue toxicity and degradation of ZK60 magnesium alloy with micro-arc oxidation coatings (MAO-ZK60), in order to discuss the possibility of its potential application for orthopedic implantation. Eighteen Sprague-Dawley rats were randomized equally to three groups of A...
Asger Granfeldt et al.
Critical care medicine, 42(5), e329-e344 (2014-02-22)
Currently, there is no effective small-volume fluid for traumatic hemorrhagic shock. Our objective was to translate small-volume 7.5% NaCl adenosine, lidocaine, and Mg hypotensive fluid resuscitation from the rat to the pig. Pigs (35-40 kg) were anesthetized and bled to...
Sebastiaan Werten et al.
Biochemistry, 53(50), 7990-7998 (2014-11-29)
Genes that render bacteria resistant to tetracycline-derived antibiotics are tightly regulated by repressors of the TetR family. In their physiologically relevant, magnesium-complexed form, tetracyclines induce allosteric rearrangements in the TetR homodimer, leading to its release from the promoter and derepression...
Alan S L Yu
Journal of the American Society of Nephrology : JASN, 26(1), 11-19 (2014-06-21)
Claudins are tight-junction membrane proteins that function as both pores and barriers in the paracellular pathway in epithelial cells. In the kidney, claudins determine the permeability and selectivity of different nephron segments along the renal tubule. In the proximal tubule...
Fawaz Al-Mousa et al.
Chemico-biological interactions, 207, 1-6 (2013-11-06)
Hexabromocyclododecane (HBCD) is a widely utilised brominated flame retardant (BFR). It has been shown to bio-accumulate within organisms, including man, and possibly cause neurological disorders. The acute neurotoxicity of HBCD, and six other unrelated BFRs, were assessed in SH-SY5Y human...