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Martin Gilar et al.
Journal of chromatography. A, 1381, 110-117 (2015-01-22)
Sample introduction in microfluidic liquid chromatography often generates wide zones rather than peaks, especially when a large sample volume (relative to column volume) is injected. Formation of wide injection zones can be further amplified when the sample is dissolved in
Yu Fu et al.
Analytical and bioanalytical chemistry, 406(20), 4987-4995 (2014-05-29)
Xanthine oxidase (XOD) is a key oxidative enzyme to the pathogenesis of hyperuricemia and certain diseases induced by excessive reactive oxygen species. XOD inhibitors could provide an important therapeutic approach to treat such diseases. A new method using affinity selection-based
Garrett R Ainslie et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 576-584 (2014-09-26)
Dietary substances, including herbal products and citrus juices, can perpetrate interactions with conventional medications. Regulatory guidances for dietary substance-drug interaction assessment are lacking. This deficiency is due in part to challenges unique to dietary substances, a lack of requisite human-derived
Chia-Jung Lee et al.
Biomedical chromatography : BMC, 28(6), 901-906 (2014-05-28)
The stem with hook of Uncaria rhynchophylla (Chinese herbal name Gou-Teng) is a traditional Chinese medicine that has been ethnopharmacologically used to extinguish wind and clean interior heat. Rhynchophylline (RHY), a tetracyclic oxindole alkaloid isolated from U. rhynchophylla, displays significant
Colby S Shemesh et al.
Pharmaceutical research, 32(5), 1604-1614 (2014-11-20)
The focus of this research was to formulate and evaluate a theranostic liposomal delivery system using indocyanine green (ICG) as a photosensitizer, triggered by near infrared (NIR) irradiation, for in vivo photodynamic therapy (PDT) of breast cancer. Cytotoxicity of PDT
M J Hilhorst et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 45-53 (2014-07-06)
A liquid chromatography-tandem mass spectrometry method is described for the quantitative determination of artemether (ART) and its metabolite dihydroartimisinin (DHA) in human plasma samples. Quantitation of ART and DHA in plasma is challenging due to the presence of malaria related
Qing-Yuan Zhou et al.
Asian Pacific journal of cancer prevention : APJCP, 15(13), 5417-5421 (2014-07-22)
The identification of cutaneous T cell lymphoma (CTCL) biomarkers may serve as a predictor of disease progression and treatment response. The aim of this study was to map potential biomarkers in CTCL plasma. Plasma metabolic perturbations between CTCL cases and
L Chiesa et al.
Analytica chimica acta, 852, 137-145 (2014-12-03)
The presence of β-boldenone II phase metabolites and prednisolone in urine samples, owing to endogenous or natural origin or illicit treatment, is under debate within the European Union. The detection of β-boldenone conjugates, α-boldenone conjugates at concentrations higher than 2
Carol L Cheatham et al.
Nutrients, 7(11), 9079-9095 (2015-11-06)
The aim was to explore the relation of human milk lutein; choline; and docosahexaenoic acid (DHA) with recognition memory abilities of six-month-olds. Milk samples obtained three to four months postpartum were analyzed for fatty acids, lutein, and choline. At six
Hanna Berkner et al.
PloS one, 9(10), e111691-e111691 (2014-10-31)
Birch pollen-allergic subjects produce polyclonal cross-reactive IgE antibodies that mediate pollen-associated food allergies. The major allergen Bet v 1 and its homologs in plant foods bind IgE in their native protein conformation. Information on location, number and clinical relevance of
Gabriella Klausz et al.
Biomedical chromatography : BMC, 29(12), 1859-1865 (2015-06-25)
A liquid chromatography-electrospray-mass spectrometry method (LC/MS) has been developed and validated for determination of praziquantel (PZQ), pyrantel (PYR), febantel (FBT), and the active metabolites fenbendazole (FEN) and oxfendazole (OXF), in dog plasma, using mebendazole as internal standard (IS). The method
Cynthia Stretch et al.
The Journal of nutrition, 142(1), 14-21 (2011-12-14)
Urine and plasma metabolites originate from endogenous metabolic pathways in different organs and exogenous sources (diet). Urine and plasma were obtained from advanced cancer patients and investigated to determine if variations in lean and fat mass, dietary intake, and energy
Wenping Tang et al.
Journal of agricultural and food chemistry, 63(44), 9722-9728 (2015-10-23)
The hepatoprotective activities of two different extracts, a hydroethanolic crude bulb extract (CB) and a steroidal glycoside-rich 1-butanol extract (BuOH), prepared from the bulbs of Easter lily (Lilium longiflorum Thunb.), were evaluated in a 24 week study in the female
C A Ledesma-Escobar et al.
Journal of mass spectrometry : JMS, 50(11), 1196-1205 (2015-10-28)
Eighty four metabolites (32 flavonoids, 15 amino acids, nine carboxylic acids, six coumarins, six sugars, five phenolic acids and 11 unclassified compounds) have been tentatively identified in a polar extract from lemon, without reference standards, based on their liquid chromatography-quadrupole-time-of-flight
Hongbin Liu et al.
Journal of pharmaceutical and biomedical analysis, 109, 142-149 (2015-03-17)
RP-HPLC has been demonstrated as a powerful tool to study antibody free thiol and disulfide variants. Recently, the introduction of UHPLC columns with wide pore size (300Å) and small particle size (1.7μm) offered the opportunity to further improve the separation
Matthias Schwebe et al.
Biochemical pharmacology, 94(2), 109-129 (2015-02-11)
The clinical efficiency of the highly potent antitumor agent doxorubicin is limited by cardiotoxic effects. In a murine doxorubicin cardiotoxicity model, increased endothelin-1 (ET-1) expression and cardioprotective effects of the dual ET-1 blocker bosentan were demonstrated. To date it is
Ru-Zhou Guo et al.
Journal of chromatography. A, 1422, 147-154 (2015-10-20)
Recently, screening of bioactive compounds by on-line ultra-high performance liquid chromatography (UHPLC) draws increasing attentions for the advantages of rapidity and intuition. Nevertheless, most on-line methods were limited to the shortcoming like low resolution and peak capacity, which could interfere
Xue Qiao et al.
Journal of chromatography. A, 1362, 157-167 (2014-09-01)
Herbal medicines contain a large number of minor constituents, which could contribute to their therapeutic effects and provide valuable lead compounds for drug discovery. However, to explore minor constituents from complicated herbal extracts is usually laborious and time-consuming. In order
Mohammad Mahdi Moein et al.
The Analyst, 140(6), 1939-1946 (2015-02-11)
In this work, a novel method based on in situ molecularly imprinted sol-gel for the surface modification of a polysulfone membrane (PSM) was developed. A modified molecularly imprinted sol-gel polysulfone membrane (MSM) was placed in a homemade plastic tube and
Lim Jeong et al.
International journal of nanomedicine, 9, 5277-5287 (2014-12-09)
One of the promising applications of silk fibroin (SF) in biomedical engineering is its use as a scaffolding material for skin regeneration. The purpose of this study was to determine the wound healing effect of SF nanofibrous matrices containing silver
Libo Zhao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1004, 37-45 (2015-10-08)
Penehyclidine hydrochloride (PHC) is an anticholinergic drug with both antimuscarinic and antinicotinic activity. In order to compare the pharmacokinetics of two administration routes (intravenous injection (i.v.) and intramuscular injection (i.m.)) of PHC, an improved High Performance Liquid Chromatography Tandem Mass
B Gómara et al.
Journal of chromatography. A, 1423, 86-95 (2015-11-11)
The retention behavior of nine MPAEs has been studied, using commercial LC columns with octadecylsilane (ODS), phenyl, and amide-type SPs. First, it was found that the use of methanol in the mobile phase is not advisable, because induce a transesterification
Clint M Alfaro et al.
Analytical chemistry, 86(21), 10639-10645 (2014-10-01)
With this study, we investigated why some small molecules demonstrate narrow dynamic ranges in electrospray ionization-mass spectrometry (ESI-MS) and sought to establish conditions under which the dynamic range could be extended. Working curves were compared for eight flavonoids and two
Agnes E Nystad et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(12), 1178-1186 (2014-05-28)
Vitamin D supplementation is increasingly recommended to patients with multiple sclerosis (MS). To study the effect of high-dose vitamin D on remyelination, female C57Bl/6 mice were demyelinated with dietary 0.2% cuprizone for 7 weeks. The mice received intraperitoneal injections of
Sabine Kokarnig et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 29, 83-90 (2014-07-27)
Selenium metabolic patterns in the human body originating from five distinct selenium dietary sources, selenate, selenite, selenomethionine (SeMet), methylselenocysteine (MeSeCys) and selenized yeast, were investigated by performing concurrent HPLC-mass spectrometric analysis of human serum and urine. Total selenium and selenium
Bin Han et al.
Journal of proteome research, 13(12), 5928-5943 (2014-09-30)
The proteins in royal jelly (RJ) play a pivotal role in the nutrition, immune defense, and cast determination of honeybee larvae and have a wide range of pharmacological and health-promoting functions for humans as well. Although the importance of post-translational
Xudong Tang et al.
International journal of molecular sciences, 15(12), 22011-22027 (2014-12-04)
Small ubiquitin-like modifier (SUMO) modification (SUMOylation) is an important and widely used reversible modification system in eukaryotic cells. It regulates various cell processes, including protein targeting, transcriptional regulation, signal transduction, and cell division. To understand its role in the model
Jamie O Lo et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 27(12), 1183-1188 (2013-10-10)
Proteomic analysis of four cervical-vaginal fluid (CVF) proteins to identify biomarkers of recurrent preterm birth (rPTB) in at-risk women prior to onset of preterm labor. Nested case control study from 2007 to 2011 of women with prior spontaneous preterm birth(s)
Cong Zha et al.
PloS one, 10(4), e0122322-e0122322 (2015-04-16)
Laryngeal cancer is the most frequent neoplasm in the head and neck region, with the vast majority of tumors originating from squamous cells. The survival rate of patients with laryngeal cancer has not improved substantially over the past 25 years.
Wenchu Yang et al.
Rapid communications in mass spectrometry : RCM, 28(13), 1489-1500 (2014-05-28)
A protein internal standard (IS) is essential and superior to a peptide IS to achieve reproducible results in the quantitation of protein therapeutics using immunoaffinity-liquid chromatography/tandem mass spectrometry (LC/MS/MS). Guanidination has been used as a protein post-modification technique for more
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