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Soomin Shin et al.
Journal of neuroimmunology, 271(1-2), 8-17 (2014-05-06)
Apolipoprotein E (ApoE) functions as a ligand in receptor-mediated endocytosis of lipoprotein particles and has been demonstrated to play a role in antigen presentation. To explore the contribution of ApoE during autoimmune central nervous system (CNS) demyelination, we examined the
Mathieu Quesnel-Vallières et al.
Genes & development, 29(7), 746-759 (2015-04-04)
Alternative splicing (AS) generates vast transcriptomic complexity in the vertebrate nervous system. However, the extent to which trans-acting splicing regulators and their target AS regulatory networks contribute to nervous system development is not well understood. To address these questions, we
Diogo Pestana et al.
Environmental research, 133, 170-177 (2014-06-21)
The role of persistent organic pollutants (POPs) with endocrine disrupting activity in the aetiology of obesity and other metabolic dysfunctions has been recently highlighted. Adipose tissue (AT) is a common site of POPs accumulation where they can induce adverse effects
Wan-Kuen Jo et al.
Chemosphere, 77(2), 236-241 (2009-08-12)
Unlike previous photocatalytic oxidation (PCO) studies incorporated with adsorption, this study investigates the feasibility of applying a tandem PCO-adsorption hybrid technique regarding low-level monoaromatic compound removal. The PCO efficiencies decreased as the hydraulic diameter (HD) increased. A PCO reactor of
Rajagopal N Aravalli et al.
World journal of gastroenterology, 21(7), 2011-2029 (2015-02-27)
To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells. In this study, we have used an immortal porcine liver stem cell line, PICM-19, to study the role of c-MYC in hepatocarcinogenesis.
Erin K Z Kirschmann et al.
Learning & memory (Cold Spring Harbor, N.Y.), 21(11), 606-615 (2014-10-18)
Conditioned stimuli (CS) can modulate reward-seeking behavior. This modulatory effect can be maladaptive and has been implicated in excessive reward seeking and relapse to drug addiction. We previously demonstrated that exposure to an appetitive CS causes an increase in the
Jun Xiao et al.
Nature communications, 5, 4572-4572 (2014-08-06)
Vernalization, sensing of prolonged cold, is important for seasonal flowering in eudicots and monocots. While vernalization silences a repressor (FLC, MADS-box transcription factor) in eudicots, it induces an activator (TaVRN1, an AP1 clade MADS-box transcription factor) in monocots. The mechanism
Ralf S Eschbach et al.
PloS one, 10(2), e0115543-e0115543 (2015-02-11)
To investigate a multimodal, multiparametric perfusion MRI / 18F-fluoro-deoxyglucose-(18F-FDG)-PET imaging protocol for monitoring regorafenib therapy effects on experimental colorectal adenocarcinomas in rats with immunohistochemical validation. Human colorectal adenocarcinoma xenografts (HT-29) were implanted subcutaneously in n = 17 (n = 10
J Lukas et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 122(5), 268-272 (2014-05-20)
Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumour. A common mutation of papillary thyroid carcinoma (PTC) is the somatic mutation of the BRAF (V600E) gene. The aim was to 1) determine the association of lymph node metastases
Sohaila Erfani et al.
Journal of molecular neuroscience : MN, 56(1), 237-243 (2015-01-22)
Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin (Nampt/PBEF/visfatin) is an adipocytokine. By synthesizing nicotinamide adenine dinucleotide (NAD(+)), Nampt/PBEF/visfatin functions to maintain an energy supply that has critical roles in cell survival. Cerebral ischemia leads to energy depletion and eventually neuronal death
Cheng-Xiong Yang et al.
Analytical chemistry, 83(18), 7144-7150 (2011-08-04)
The diverse structures and pore topologies, accessible cages and tunnels, and high surface areas make metal-organic frameworks attractive as novel media in separation sciences. Here we report the slurry-packed MIL-101(Cr) column for high-performance liquid chromatographic separation of substituted aromatics. The
Kenji Fukushima et al.
Nature communications, 6, 6450-6450 (2015-03-17)
Complex morphology is an evolutionary outcome of phenotypic diversification. In some carnivorous plants, the ancestral planar leaf has been modified to form a pitcher shape. However, how leaf development was altered during evolution remains unknown. Here we show that the
Xiang-Qian Wang et al.
Environmental technology, 34(17-20), 2691-2699 (2014-02-18)
In this study, performance evaluation for the gas-phase o-xylene removal using a xylene-acclimated biotrickling filter (BTF) was conducted. Substrate interactions during aerobic biodegradation of three poorly soluble compounds, both individually and in paired mixtures (namely, o-xylene and ethyl acetate, o-xylene
Marcia C da Silva Faria et al.
Chemico-biological interactions, 229, 119-131 (2015-02-11)
Both types of diabetes are associated with higher incidence of some types of cancer. Treating cancer in diabetic patients without aggravating diabetes-related complications is a challenge for clinicians. Additionally, little is known about how diabetes affects the treatment of cancer.
Song Nie et al.
Journal of proteome research, 14(2), 814-822 (2014-12-04)
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, with dismal survival outcomes. Recently, cancer stem cells (CSCs) have been demonstrated to play a role in therapeutic resistance and are considered to be the most likely cause of cancer relapse.
Filomena Aste Silveira et al.
Experimental and molecular pathology, 98(2), 308-311 (2015-01-13)
DNA methylation is the most important epigenetic change involved in the control of gene expression in human cells. Methylation of the p16(INK4a) gene occurs early in the development of cervical cancer. Low-grade squamous intraepithelial lesions (LSILs) are prevalent, and their
Jia-Ren Liu et al.
Shock (Augusta, Ga.), 42(6), 532-539 (2014-07-31)
Macrophage 1 antigen (Mac-1, CD11bCD18) is a leukocyte adhesion molecule that is involved in many functions including leukocyte recruitment, phagocytosis, and neutrophil apoptosis. The previous report of mild polymicrobial, abdominal sepsis showed that the administration of anti-CD11b-blocking antibody administration attenuated
Pennelope K Blakely et al.
Journal of neurovirology, 21(1), 43-55 (2014-11-02)
While alphaviruses spread naturally via mosquito vectors, some can also be transmitted as aerosols making them potential bioterrorism agents. One such pathogen, western equine encephalitis virus (WEEV), causes fatal human encephalitis via multiple routes of infection and thus presumably via
M Zuo et al.
British journal of cancer, 112(6), 1042-1051 (2015-03-06)
Activation of the PI3K/mTOR and Hedgehog (Hh) signalling pathways occurs frequently in biliary tract cancer (BTC). Crosstalk between these pathways occurs in other gastrointestinal cancers. The respective signalling inhibitors rapamycin and vismodegib may inhibit BTC synergistically and suppress cancer stem
Cecilia Bull et al.
Alcoholism, clinical and experimental research, 39(4), 650-658 (2015-04-04)
Prefrontal cortex (PFC) dysfunction is believed to contribute to the transition from controlled substance use to abuse. Because astrocytes have been suggested to play a key role in the development and maintenance of drug-seeking behaviors, we sought to determine whether
Gelei Xiao et al.
Oncology letters, 9(1), 235-240 (2014-12-02)
Wnt-1 inducible signaling pathway protein-2 (WISP-2) is a member of the CCN family, which is critical for the control of cell morphology, motion, adhesion and other processes involved in tumorigenesis. The expression pattern and clinical significance of WISP-2 in astrocytomas
Diana Pisa et al.
Journal of Alzheimer's disease : JAD, 43(2), 613-624 (2014-08-16)
Recently, we have reported the presence of fungal infections in patients with Alzheimer's disease (AD). Accordingly, fungal proteins and DNA were found in brain samples, demonstrating the existence of infection in the central nervous system. In the present work, we
Sousana Amptoulach et al.
Medical oncology (Northwood, London, England), 32(1), 416-416 (2014-12-06)
There is strong evidence that tumor growth is not only a result of uncontrolled cell proliferation but also of decreased apoptosis. Caspase-3 is a member of interleukin-1 beta-converting enzyme which is involved in the induction of apoptosis. Data on the
Yiting Tang et al.
Scientific reports, 5, 9476-9476 (2015-03-31)
Radioresistance has been an important factor in restricting efficacy of radiotherapy for non-small cell lung cancer (NSCLC) patients and new approaches to inhibit cancer growth and sensitize irradiation were warranted. Despite the important role of ubiquitin/proteasome system (UPS) during cancer
Beiyu Liu et al.
European journal of obstetrics, gynecology, and reproductive biology, 181, 171-175 (2014-08-26)
Histological dating has been used for decades to evaluate the histological maturation of the endometrium. Uterine natural killer cells are thought to play a significant role in pregnancy. While several studies have shown an increased number of uNK cells in
Julian C Lui et al.
Pediatric research, 77(3), 406-415 (2014-12-19)
In juvenile mammals, the epiphyses of long bones grow by chondrogenesis within the articular cartilage. A better understanding of the molecular mechanisms that regulate the growth of articular cartilage may give insight into the antecedents of joint disease, such as
Chunxiong Lu et al.
Molecules (Basel, Switzerland), 20(3), 4902-4914 (2015-03-20)
A novel annexin V derivative (Cys-Annexin V) with a single cysteine residue at its C-terminal has been developed and successfully labeled site-specifically with 18F-FBEM. 18F-FBEM was synthesized by coupling 18F-fluorobenzoic acid (18F-FBA) with N-(2-aminoethyl)maleimide using optimized reaction conditions. The yield
Andreas J Papoutsis et al.
Molecular carcinogenesis, 54(4), 261-269 (2013-10-19)
Studies with murine models suggest that maternal exposure to aromatic hydrocarbon receptor (AhR) agonists may impair mammary gland differentiation and increase the susceptibility to mammary carcinogenesis in offspring. However, the molecular mechanisms responsible for these perturbations remain largely unknown. Previously
Michael E Frohbergh et al.
Tissue engineering. Part A, 21(5-6), 970-981 (2014-10-23)
Our long-term goal is to develop smart biomaterials that can facilitate regeneration of critical-size craniofacial lesions. In this study, we tested the hypothesis that biomimetic scaffolds electrospun from chitosan (CTS) will promote tissue repair and regeneration in a critical size
Ahmed Anis Shiha et al.
Brain research bulletin, 111, 36-47 (2014-12-30)
The role of serotonin (5-hydroxytryptamine; 5-HT) in epileptogenesis still remains controversial. In this regard, it has been reported that serotonergic drugs can alter epileptogenesis in opposite ways. The main objective of this work was to investigate the effect of the
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