Search Within
Filtros aplicados
Exibindo 1-30 of 3446 resultados for "


" no prazo de Papéis
Carina Bäcktorp et al.
Journal of pharmaceutical sciences, 104(4), 1409-1420 (2015-02-26)
We have developed a predictive method, based on quantum chemical calculations, that qualitatively predicts N-oxidation by hydrogen peroxides in drug structures. The method uses linear correlations of two complementary approaches to estimate the activation barrier without calculating it explicitly. This
Navneeta Bansal et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 97-103 (2014-05-31)
To address the shortcomings of urine cytology and cystoscopy for screening and grading of urinary bladder cancer (BC) we applied a serum-based proteomics approach as a surrogate tactic for rapid BC probing. This study was performed on 90 sera samples
Preeti Singh et al.
World journal of microbiology & biotechnology, 31(12), 1923-1934 (2015-10-24)
Host cell interactions and invasion by Cryptosporidium is a complex process mediated by zoites ligand-host cell receptors. Knowledge of proteins involved in this process will enable entry level inhibitors to be tried as therapeutic agents. In the present study, invasion
Rebecca J Henry et al.
Journal of neuroimmunology, 276(1-2), 126-134 (2014-09-24)
The present study examined the effect of enhancing fatty acid amide hydrolase (FAAH) substrate levels in vivo on Toll-like receptor (TLR)3-induced neuroinflammation. Systemic and central (i.c.v.) administration of the FAAH inhibitor URB597 increased hippocampal levels of the N-acylethanolamines palmitoylethanolamide and
Yaqian Zhang et al.
Journal of dairy science, 98(12), 8433-8444 (2015-10-28)
A simple and rapid multi-class multi-residue analytical method was developed for the screening and quantification of veterinary drugs in milk by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). A total of 90 veterinary drugs investigated belonged to
Pradipbhai D Kalariya et al.
Journal of mass spectrometry : JMS, 50(11), 1222-1233 (2015-10-28)
Tinoridine is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity. However, metabolism of tinoridine has not been thoroughly investigated. To identify in vivo metabolites, the drug was administered to Sprague-Dawley rats (n = 5) at a dose
Ashish Soman et al.
Journal of chromatographic science, 52(5), 413-417 (2013-05-17)
Soluplus, a graft copolymer of polyethylene glycol, vinyl caprolactam and vinyl acetate, is designed to solubilize poorly soluble active pharmaceutical ingredients. A straightforward aqueous gel permeation chromatography method that exploits both size exclusion and adsorption modes of separation was used
Li Chu et al.
DNA and cell biology, 34(3), 178-188 (2015-01-22)
The traditional Chinese medicinal formula BDL301 has been used to inhibit inflammation for hundreds of years. The development of colorectal cancer and chronic inflammation are closely related. In this study, we investigated whether BDL301 could inhibit tumor growth. We found
Panfeng Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 55-61 (2014-04-29)
This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites
Esther See et al.
International journal of pharmaceutics, 473(1-2), 528-535 (2014-08-01)
To facilitate the development of a liposomal formulation for cancer therapy, the physicochemical properties of asulacrine (ASL), an anticancer drug candidate, were characterized. Nano-liposomes were prepared by thin-film hydration in conjugation with active drug loading using ammonium sulphate and post-insertion
Qiangwei Wang et al.
Aquatic toxicology (Amsterdam, Netherlands), 160, 163-171 (2015-02-01)
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant that is detectable in the environment and biota, prompting concern over its risk to wildlife and human health. Our objective was to investigate whether long-term exposure to low concentrations of TDCPP can
Kara Lea Vine et al.
Pharmaceutical research, 32(3), 1045-1054 (2014-09-19)
Overexpression of the serine protease urokinase (uPA) is recognised as an important biomarker of metastatic disease and a druggable anticancer target. Plasminogen activator inhibitor type-2 (PAI-2/SerpinB2) is a specific uPA inhibitor with proven potential for use in targeted therapy. However
Maria Peiris-Pagès et al.
Aging, 7(10), 816-838 (2015-11-06)
Cancer cells grow in highly complex stromal microenvironments, which through metabolic remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate metastasis and resistance to therapy. However, these changes in the metabolic profile of stromal cancer-associated fibroblasts and
Pius S Fasinu et al.
Malaria journal, 13, 507-507 (2014-12-19)
Primaquine, currently the only approved drug for the treatment and radical cure of Plasmodium vivax malaria, is still used as a racemic mixture. Clinical use of primaquine has been limited due to haemolytic toxicity in individuals with genetic deficiency in
Yan-xu Chang et al.
Journal of pharmaceutical and biomedical analysis, 117, 1-10 (2015-09-05)
A rapid, sensitive and selective high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of four phenolic acids (neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and ferulic acid) and seven alkaloids (berberine, epiberberine, coptisine
Thomas P Forbes et al.
Analytical chemistry, 86(15), 7788-7797 (2014-06-27)
We demonstrate the coupling of desorption electro-flow focusing ionization (DEFFI) with in-source collision induced dissociation (CID) for the mass spectrometric (MS) detection and imaging of explosive device components, including both inorganic and organic explosives and energetic materials. We utilize in-source
Zhuoyang Fan et al.
PloS one, 10(4), e0120129-e0120129 (2015-04-02)
Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)-a significant problem in the administration of PTX to cancer patients. To increase the
Juanjuan Pi et al.
Journal of separation science, 38(6), 886-893 (2015-01-08)
A rapid, sensitive, and reliable approach for analyzing five kinds of erythrocyte phospholipids in Sprague-Dawley rats was provided by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry with MassLynx(TM) MassFragment. Improving conventional high performance
Caroline Le Maréchal et al.
Journal of proteomics, 113, 447-461 (2014-08-26)
Propionibacterium freudenreichii is a beneficial bacterium used in the food industry as a vitamin producer, as a bio-preservative, as a cheese ripening starter and as a probiotic. It is known to adhere to intestinal epithelial cells and mucus and to
Joshua O Sestak et al.
The AAPS journal, 16(6), 1185-1193 (2014-09-07)
Presentation of antigen with immune stimulating "signal" has been a cornerstone of vaccine design for decades. Here, the antigen plus immune "signal" of vaccines is modified to produce antigen-specific immunotherapies (antigen-SITs) that can potentially reprogram the immune response toward tolerance
Marcello Locatelli et al.
Journal of chromatography. A, 1388, 79-86 (2015-02-24)
This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini
Chun-Xia Zhao et al.
Biotechnology and bioengineering, 112(5), 957-964 (2014-11-27)
Antimicrobial peptides, as a new class of antibiotics, have generated tremendous interest as potential alternatives to classical antibiotics. However, the large-scale production of antimicrobial peptides remains a significant challenge. This paper reports a simple and low-cost chromatography-free platform technology for
Hyun-Kyung Na et al.
Toxicology letters, 232(2), 429-437 (2014-12-03)
Tobacco smoking is a well-known cause of various diseases, however, its toxic mechanisms for diseases are not completely understood, yet. Therefore, we performed biological monitoring to find tobacco smoking-responsive mechanisms including oxidative stress in Korean men (N=36). Whole genome microarray
Nirupam Purkayastha et al.
Chemistry & biodiversity, 12(2), 179-193 (2015-02-14)
β(3) -Octaarginine chains were attached to the functional groups NH and CO2 H of the antibacterial fluoroquinolones ciprofloxacin (→1) and enrofloxacin (→2), respectively, in order to find out whether the activity increases by attachment of the polycationic, cell-penetrating peptide (CPP)
Thomas G Hammond et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 387-402 (2014-06-07)
Covalent protein modifications by electrophilic acyl glucuronide (AG) metabolites are hypothetical causes of hypersensitivity reactions associated with certain carboxylate drugs. The complex rearrangements and reactivities of drug AG have been defined in great detail, and protein adducts of carboxylate drugs
Zhe Gui et al.
Physical chemistry chemical physics : PCCP, 16(24), 12332-12340 (2014-05-16)
A redox exchange mechanism between potassium perruthenate (KRuO4) and the functional groups of selected polymers is used here to induce RuO2 into and onto conductive polymer nanowires by simply soaking the polymer nanowire arrays in KRuO4 solution. Conductive polymer nanowire
So Jung An et al.
Vaccine, 33(13), 1614-1619 (2015-02-11)
The majority of conjugate vaccines focus on inducing an antibody response to the polysaccharide antigen and the carrier protein is present primarily to induce a T-cell dependent response. In this study conjugates consisting of poly(ribosylribitolphosphate) (PRP) purified from Haemophilus influenzae
Francesca Scebba et al.
Ecotoxicology and environmental safety, 123, 45-52 (2015-09-02)
Quantum dots (QDs), namely semiconductor nanocrystals, due to their particular optical and electronic properties, have growing applications in device technology, biotechnology and biomedical fields. Nevertheless, the possible threat to human health and the environment have attracted increasing attention as the
Christopher J Stewart et al.
Scientific reports, 5, 17141-17141 (2015-11-26)
The development of the preterm gut microbiome is important for immediate and longer-term health following birth. We aimed to determine if modifications to the preterm gut on the neonatal intensive care unit (NICU) impacted the gut microbiota and metabolome long-term.
Ioannis Kasioulis et al.
Molecular biology of the cell, 25(8), 1216-1233 (2014-02-21)
The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its nuclear role in chromatin remodeling. Many histone-modifying enzymes have additional nonhistone substrates, as well as nonenzymatic functions, contributing to the full spectrum
Página 1 de 115
Página 1 de 115