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" no prazo de Papéis
Francesco Menichini et al.
Journal of enzyme inhibition and medicinal chemistry, 29(5), 677-685 (2013-10-10)
Cardiospermum halicacabum is widely used in traditional medicine. Previous studies have focused on the aerial parts, while the seeds have been poorly investigated. This work aimed to analyse the chemical composition of extracts from aerial parts and seeds obtained using
Xiao-Dong Wen et al.
Phytotherapy research : PTR, 28(6), 892-898 (2013-10-22)
Patients suffering from inflammatory bowel disease are at a high risk of developing colorectal cancer. To assess the anticancer potential of botanicals, in this study, we evaluated the effects of Panax notoginseng on azoxymethane/dextran sulfate sodium (DSS)-induced colitis. One week
Vinitha Ganesan et al.
Biochimica et biophysica acta, 1854(6), 592-600 (2014-12-04)
Immunoprecipitation (IP) is a widely used technique for identifying the binding partners of the target proteins of specific antibodies. Putative binding targets and their partners are usually in much lower amounts than the antibodies used to capture these target proteins.
Colin P Churchward et al.
The Journal of pharmacy and pharmacology, 67(3), 364-371 (2014-12-17)
Mycoplasma mycoides subspecies capri is one of the causative agents of contagious agalactia in goats. The disease is characterised by mastitis, pneumonia, arthritis, keratitis and in acute cases septicaemia. No vaccine is currently available that has been demonstrated to prevent
P G J ter Horst et al.
Journal of clinical pharmacy and therapeutics, 39(5), 541-544 (2014-07-06)
Depression during pregnancy is common and includes risks for mother and child. Pharmacokinetics of venlafaxine may be changed during pregnancy. This study aimed to describe changes in metabolic ratios and concentrations of venlafaxine and its main metabolite O-desmethylvenlafaxine during and
Joao N Dos Santos Pereira et al.
The AAPS journal, 16(6), 1247-1258 (2014-08-27)
Variations in influx transport at the blood-brain barrier might affect the concentration of psychotropic drugs at their site of action and as a consequence might alter therapy response. Furthermore, influx transporters in organs such as the gut, liver and kidney
Katarina Hostanska et al.
The Journal of pharmacy and pharmacology, 66(11), 1606-1614 (2014-09-02)
Extracts of the tubers of Harpagophytum procumbens (devil's claw, DC) inhibit different proinflammatory mediators important in the pathophysiology of osteoarthritis. Many plant-derived preparations interfere with cytochrome P450 liver enzymes, which influence their different biological activities. Therefore, the present study was
G Astrid Garzón et al.
Journal of agricultural and food chemistry, 63(6), 1803-1811 (2015-02-11)
The contents and profile of polyphenols were analyzed in edible petals of nasturtium flowers (Tropaeolum majus) of three colors, and their oxygen radical absorbance capacities (ORAC) were compared. Three primary anthocyanins (ACNs) and 15 non-ACN phenolic compounds including hydroxycinammic acids
Laura E Herring et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 166-174 (2015-03-18)
Phosphorylation is an important post-translational modification that is involved in regulating many signaling pathways. Of particular interest are the growth factor mediated Ras and phosphoinositide 3-kinase (PI3K) signaling pathways which, if misregulated, can contribute to the progression of cancer. Phosphoproteomic
Eugenia Mato et al.
Molecular and cellular endocrinology, 404, 37-45 (2015-01-27)
We investigated the role of VDAC2 in human epithelial thyroid tumours using proteomic 2D-DIGE analysis and qRT-PCR. We found a significant up-regulation of VDAC2 in thyroid tumours and in thyroid tumour cell lines (TPC-1 and CAL-62). We did not detect
Ying Zhou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 78-83 (2014-12-09)
A robust and validated method based on ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) has been developed for the simultaneous determination of remimazolam, which is a new chemical entity, and its major carboxylic acid metabolite (M1) in human
Xiaoping Li et al.
Fitoterapia, 95, 220-228 (2014-04-09)
In an effort to identify natural compounds with immunosuppressive activity, nine new flavonoids, including one isoflav-3-ene derivative (1), one coumaronochromone (2), two isoflavanones (3, 4), one isoflavone derivative (6), one isoflavone (7), three flavonols (8, 9, 10), as well as
Xiao-Cui Qian et al.
Journal of pharmaceutical and biomedical analysis, 105, 64-73 (2014-12-30)
Rhizoma coptidis (R.C.), a widely used traditional Chinese medicine, has been used for centuries in the treatment of hypertension, inflammation, dysentery and liver diseases, etc. Wine-processing is a specialized technology by sautéing crude herbal medicine using Chinese rice wine. This
Sifei Han et al.
Pharmaceutical research, 32(5), 1830-1844 (2014-12-03)
Recent studies have demonstrated the potential for a triglyceride (TG) mimetic prodrug to promote the delivery of mycophenolic acid (MPA) to the lymphatic system. Here, the metabolic pathways that facilitate the lymphatic transport of the TG prodrug (1,3-dipalmitoyl-2-mycophenoloyl glycerol, 2-MPA-TG)
John D Cooper et al.
Biochemistry, 53(31), 5060-5069 (2014-07-23)
In response to iron starvation, Staphylococcus aureus secretes both staphyloferrin A and staphyloferrin B, which are high-affinity iron-chelating molecules. The structures of both HtsA and SirA, the ferric-staphyloferrin A [Fe(III)-SA] and ferric-staphyloferrin B [Fe(III)-SB] receptors, respectively, have recently been determined.
Katarzyna E Stępnik et al.
Journal of chromatography. A, 1286, 127-136 (2013-03-20)
Biopartitioning Micellar Chromatography (BMC) is a mode of micellar liquid chromatography that uses C18 stationary phases and micellar mobile phases of Brij35 under adequate experimental conditions and can be useful to mimic human drug absorption, blood-brain barrier distribution or partitioning
Wolfram Lorenzen et al.
Journal of lipid research, 55(12), 2620-2633 (2014-10-22)
Analysis of whole cell lipid extracts of bacteria by means of ultra-performance (UP)LC-MS allows a comprehensive determination of the lipid molecular species present in the respective organism. The data allow conclusions on its metabolic potential as well as the creation
Di Bei et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 11-17 (2014-12-23)
5,7-Dimethoxyflavone (5,7-DMF), a natural flavonoid abundant in many plants, has been reported to have many beneficial pharmacological effects, including strong chemopreventive and chemosensitizing properties, anti-oxidant, cardiovascular protectant, and anti-inflammatory activities. However, to date 5,7-DMF was evaluated mainly in vitro and
Steven Carberry et al.
Biology, 2(4), 1438-1464 (2013-01-01)
In this article, we illustrate the application of difference in-gel electrophoresis for the proteomic analysis of dystrophic skeletal muscle. The mdx diaphragm was used as a tissue model of dystrophinopathy. Two-dimensional gel electrophoresis is a widely employed protein separation method
Yong-Wha Lee
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 11(3), 158-164 (2014-01-28)
The demand for rapid and broad clinical toxicology screening methods to identify drugs of abuse and medicinal drugs is increasing steadily. Liquid chromatography-tandem mass spectrometry (LC-TMS) is increasingly used to screen for drugs of abuse and to identify a wide
Jakub Dolata et al.
The EMBO journal, 34(4), 544-558 (2015-01-09)
The interconnection between transcription and splicing is a subject of intense study. We report that Arabidopsis homologue of spliceosome disassembly factor NTR1 is required for correct expression and splicing of DOG1, a regulator of seed dormancy. Global splicing analysis in
Yadollah Yamini et al.
Journal of separation science, 37(17), 2364-2371 (2014-06-26)
A new type of liquid-phase microextraction based on two immiscible organic solvents was optimized and validated for the quantification of lidocaine, ketamine, and cocaine in human urine samples. A hollow-fiber based microextraction technique followed by gas chromatography coupled with mass
Jeffery J Shaw et al.
Applied microbiology and biotechnology, 99(8), 3715-3728 (2015-02-13)
An endophytic fungus was isolated that produces a series of volatile natural products, including terpenes and odd chain polyenes. Phylogenetic analysis of the isolate using five loci suggests that it is closely related to Nigrograna mackinnonii CBS 674.75. The main
Jannet Kamoun et al.
Biochimica et biophysica acta, 1851(2), 129-140 (2014-12-03)
Yarrowia lipolytica is a lipolytic yeast possessing 16 paralog genes coding for lipases. Little information on these lipases has been obtained and only the major secreted lipase, namely YLLIP2, had been biochemically and structurally characterized. Another secreted lipase, YLLIP8, was
Peilin Yu et al.
Cell reports, 27(12), 3684-3695 (2019-06-20)
cADPR is a well-recognized signaling molecule by modulating the RyRs, but considerable debate exists regarding whether cADPR can bind to and gate the TRPM2 channel, which mediates oxidative stress signaling in diverse physiological and pathological processes. Here, we show that
Lea Ann Dailey et al.
Nanotoxicology, 9(1), 106-115 (2014-03-14)
Inhaled nanomaterials present a challenge to traditional methods and understanding of respiratory toxicology. In this study, a non-targeted metabolomics approach was used to investigate relationships between nanoparticle hydrophobicity, inflammatory outcomes and the metabolic fingerprint in bronchoalveolar fluid. Measures of acute
Antonina Gucciardi et al.
Biomedical chromatography : BMC, 28(8), 1131-1139 (2014-01-23)
Lysosomal storage disorders comprise a group of rare genetic diseases in which a deficit of specific hydrolases leads to the storage of undegraded substrates in lysosomes. Impaired enzyme activities can be assessed by MS/MS quantification of the reaction products obtained
Chen-Ching Yuan et al.
Archives of biochemistry and biophysics, 568, 16-27 (2015-01-21)
The flight muscles (DLM1) of the Hawkmoth, Manduca sexta are synchronous, requiring a neural spike for each contraction. Stress/strain curves of skinned DLM1 showed hysteresis indicating the presence of titin-like elastic proteins. Projectin and kettin are titin-like proteins previously identified
Eric Chabrol et al.
Biophysical journal, 108(3), 666-677 (2015-02-05)
Langerin, a trimeric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen receptor through the recognition of glycan motifs by its three carbohydrate recognition domains (CRD). In the context of HIV-1 (human immunodeficiency virus-1) transmission
T Trdan Lušin et al.
Die Pharmazie, 70(2), 94-96 (2015-05-23)
Bazedoxifene is used for the prevention and treatment of osteoporosis. After peroral application, bazedoxifene is metabolized by UDP-glucuronosyltransferases (UGTs) to bazedoxifene-4'-glucuronide (M4) and bazedoxifene-5-glucuronide (M5). It has already been shown that a relatively common UGT1A1*28 polymorphism can considerably affect raloxifene
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