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356018

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Dönem Avci et al.
Molecular cell, 56(5), 630-640 (2014-12-03)
Proteolysis by aspartyl intramembrane proteases such as presenilin and signal peptide peptidase (SPP) underlies many cellular processes in health and disease. Saccharomyces cerevisiae encodes a homolog that we named yeast presenilin fold 1 (Ypf1), which we verify to be an
Stefanie Grabrucker et al.
Brain : a journal of neurology, 137(Pt 1), 137-152 (2013-11-28)
Proteins of the ProSAP/Shank family act as major organizing scaffolding elements within the postsynaptic density of excitatory synapses. Deletions, mutations or the downregulation of these molecules has been linked to autism spectrum disorders, the related Phelan McDermid Syndrome or Alzheimer's
Caroline M Rufo et al.
Nature chemistry, 6(4), 303-309 (2014-03-22)
Enzymes fold into unique three-dimensional structures, which underlie their remarkable catalytic properties. The requirement to adopt a stable, folded conformation is likely to contribute to their relatively large size (>10,000 Da). However, much shorter peptides can achieve well-defined conformations through
Susan J Zunino et al.
The British journal of nutrition, 112(3), 369-380 (2014-05-17)
Obese individuals are at an increased risk of developing CVD, hypertension, type 2 diabetes, and bacterial and viral infections when compared with the normal-weight population. In a 9-week randomised, double-blind, cross-over study, twenty-four obese subjects aged between 20 and 60
Christoph Janiak et al.
Chimia, 67(6), 419-424 (2013-08-16)
Porous coordination polymers (PCPs)/metal-organic frameworks (MOFs) are inorganic-organic hybrid materials with a permanent three-dimensional porous metal-ligand network. PCPs or MOFs are inorganic-organic analogs of zeolites in terms of porosity and reversible guest exchange properties. Microporous water-stable PCPs with high water
S S Park et al.
Journal of wound care, 24(1), 23-33 (2014-12-30)
Wound healing is enhanced in the presence of an external electrical field. The purpose of this study was first to investigate whether microelectric potentials (EPs) can be generated when the innovative design of a silver (Ag)- and zinc (Zn)-printed wound
Ru Qiao et al.
Journal of nanoscience and nanotechnology, 13(6), 4247-4251 (2013-07-19)
In this paper, we report a preparation of CuZn dendritic microstructures through a tunable template-free electrochemical approach. By simply tunning the applied depositing current, the morphology of the product can be well controlled. The growth mechanism of CuZn dendritic alloys
L Eugene Arnold et al.
Journal of child and adolescent psychopharmacology, 15(4), 619-627 (2005-09-30)
The aim of this study was to review the published evidence for a role of zinc nutrition in attention-deficit/hyperactivity disorder (ADHD). A computer literature search was supplemented by the authors' knowledge. Numerous controlled studies report cross-sectional evidence of lower zinc
K Ryan Wessells et al.
The Journal of nutrition, 144(12), 2050-2058 (2014-11-21)
Biomarkers of iron [plasma ferritin (pF)], vitamin A [retinol binding protein (RBP)], and zinc status [plasma zinc (pZn)] are affected by the acute phase response, independent of micronutrient status. The objective of these analyses was to assess how asymptomatic malaria
Cristiane Cominetti et al.
Obesity surgery, 16(4), 448-453 (2006-04-13)
Previous researchers have found that the nutritional zinc status in obese and diabetic subjects is altered: low zinc concentrations in plasma and erythrocytes with high urinary zinc excretion were observed. This study assessed the influence of the Roux-en-Y gastric bypass
Wen-Lin An et al.
Brain research. Molecular brain research, 135(1-2), 40-47 (2005-04-29)
Zinc levels are increased in brain areas severely affected by Alzheimer's disease (AD) pathologies. Zinc has both protective and neurotoxic properties and can stimulate both phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. Several kinases related to these pathways
Georges Chreifi et al.
Biochemistry, 53(25), 4216-4223 (2014-05-14)
The nitric oxide synthase (NOS) dimer is stabilized by a Zn(2+) ion coordinated to four symmetry-related Cys residues exactly along the dimer 2-fold axis. Each of the two essential tetrahydrobiopterin (H4B) molecules in the dimer interacts directly with the heme
T Takagi et al.
Journal of chromatography, 272(2), 279-285 (1983-02-11)
The levels of putrescine, cadaverine, spermidine and spermine in uremic plasma were determined with an automatic polyamine analyzer with a 7.5 X 0.2 cm I.D. cation-exchange column using a stepwise sodium chloride gradient. All four polyamines were higher in ten
M A Lovell et al.
Archives of neurology, 58(3), 392-396 (2001-03-20)
Markers of oxidative stress are increased in cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), although none of those reported are appropriate diagnostic markers because of the overlap between patients with AD and control subjects. To determine the ratio
Sonia Melino et al.
The FEBS journal, 281(3), 657-672 (2013-11-14)
Natural antimicrobial peptides represent a primordial mechanism of immunity in both vertebrate and nonvertebrate organisms. Among them, histatins belong to a family of human salivary metal-binding peptides displaying potent antibacterial, antifungal and wound-healing activities. These properties, along with the ability
Osamu Oikawa et al.
Clinical and experimental nephrology, 11(4), 304-308 (2007-12-19)
Complications associated with atherosclerosis in dialysis patients are attracting attention. Fetuin-A, a circulating calcium-regulatory glycoprotein that inhibits vascular calcification, is associated with inflammation and outcome in dialysis patients. In this study, the relation between serum fetuin-A concentration and biochemical parameters
D Religa et al.
Neurology, 67(1), 69-75 (2006-07-13)
To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity. The authors measured zinc, copper, iron, manganese, and aluminum and Abeta levels in
Wolfgang Maret
Metal ions in life sciences, 13, 389-414 (2014-01-29)
The vast knowledge of the physiologic functions of zinc in at least 3000 proteins and the recent recognition of fundamental regulatory functions of zinc(II) ions released from cells or within cells links this nutritionally essential metal ion to numerous diseases.
Helena Stecka et al.
Environmental monitoring and assessment, 186(10), 6145-6155 (2014-05-30)
A simple and fast solid phase extraction procedure was developed to pre-concentrate traces of Cu and Zn prior to their determination in honey samples by flame atomic absorption spectrometry. The sample preparation included dissolution of honey samples and the passage
M E Kuyumcu et al.
European review for medical and pharmacological sciences, 17(11), 1467-1471 (2013-06-19)
Zinc is one of the most important elements for human body. Zinc deficiency can occur in any age, if it is seen in elderly its clinical results can be more harmful due to already diminished functions. Some studies showed zinc
E J Pappert et al.
Neurology, 47(4), 1037-1042 (1996-10-01)
To determine if ventricular cerebrospinal fluid (vCSF) alpha-tocopherol levels in Parkinson's disease (PD) patients can be increased by oral alpha-tocopherol supplementation and whether vCSF levels are linearly related to plasma alpha-tocopherol levels. In spite of its putative neuroprotective properties, alpha-tocopherol
Yanhui Shi et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9390-9395 (2014-07-01)
Multicomponent self-assembly, wherein two unique donor precursors are combined with a single metal acceptor instead of the more common two-component assembly, can be achieved by selecting Lewis-basic sites and metal nodes that select for heteroligated coordination spheres. Platinum(II) ions show
A Moser et al.
Journal of the neurological sciences, 131(2), 183-189 (1995-08-01)
We could identify the MPTP-like compound and isoquinoline derivative N-methyl-norsalsolinol (2-MDTIQ) in cerebrospinal fluid (CSF) of patients with Parkinson's disease. The presence of 2-MDTIQ negatively correlated with the disease duration. In order to study the relationship between presence of 2-MDTIQ
J A Molina et al.
Journal of neural transmission (Vienna, Austria : 1996), 109(7-8), 1035-1044 (2002-07-12)
Thiamine is an essential cofactor for several important enzymes involved in brain oxidative metabolism, such as the alpha-ketoglutarate dehydrogenase complex (KGDHC), pyruvate-dehydrogenase complex (PDHC), and transketolase. Some investigators reported decreased thiamine-diphosphate levels and decreased activities of KGDHC, pyruvate-dehydrogenase complex and
Peter Stenvinkel et al.
Clinical journal of the American Society of Nephrology : CJASN, 1(2), 281-287 (2007-08-21)
Myeloperoxidase (MPO), which is secreted during activation of neutrophils, may serve as one mechanistic link among persistent inflammation, oxidative stress, and cardiovascular disease. This study related MPO activity to inflammatory and oxidative stress biomarkers, comorbidity, and ongoing medication in prevalent
A Di Veroli et al.
Chemosphere, 112, 9-17 (2014-07-23)
Mouthpart deformities of Chironomus riparius larvae (Diptera) have been investigated to evaluate the toxic effects of contamination by heavy metals in the Genna Stream (Central Italy), situated in an area subjected to intensive swine farms (40000 heads). The livestock farming
Brittany L Mortensen et al.
Journal of bacteriology, 196(14), 2616-2626 (2014-05-13)
Acinetobacter baumannii is a leading cause of ventilator-associated pneumonia in intensive care units, and the increasing rates of antibiotic resistance make treating these infections challenging. Consequently, there is an urgent need to develop new antimicrobials to treat A. baumannii infections.
J-M Serot et al.
Journal of neurology, neurosurgery, and psychiatry, 76(11), 1585-1587 (2005-10-18)
Homocysteine may be involved in the pathogenesis of late onset Alzheimer's disease. It is implicated in the metabolism of several important pathways in the brain. Methylmalonic acid (MMA) is related to the metabolism of branched chained amino acids and fatty
M L Selley et al.
Neurobiology of aging, 23(3), 383-388 (2002-04-18)
There is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation that is increased in the ventricular fluid and brains of patients with Alzheimer's disease.
Jun-Hui Choi et al.
Journal of bioscience and bioengineering, 118(4), 372-377 (2014-04-22)
A thrombolytic protease named kitamase possessing anticoagulant property was purified from edible and medicinal plant Aster yomena (Kitam.) Honda. Kitamase showed a molecular weight of 50 kDa by SDS-PAGE and displayed a strong fibrin zymogram lysis band corresponding to the similar
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