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" no prazo de Papéis
Wardah M Din et al.
Natural product communications, 8(3), 375-380 (2013-05-18)
In the annals of biomedical theory perhaps no single class of natural product has enjoyed more ingenious speculation than antioxidants formally aimed at counteracting oxidative insults which are involved in the pathophysiology of Alzheimer's and Parkinson's disease, cancer, amyotrophic lateral
Wagner C Martins et al.
Neurotoxicity research, 28(1), 32-42 (2015-04-02)
Deposition of amyloid-β (Aβ) peptides into specific encephalic structures has been pointed as an important event related to Alzheimer's disease pathogenesis and associated with activation of glial cells, neuroinflammation, oxidative responses, and cognitive deficits. Aβ-induced pro-oxidative damage may regulate the
Xianfeng Wang et al.
Inflammation, 42(1), 156-169 (2018-09-12)
Obesity increases morbidity and mortality in acute illnesses such as sepsis and septic shock. We showed previously that the early/hyper-inflammatory phase of sepsis is exaggerated in obese mice with sepsis; sirtuin 2 (SIRT2) modulates sepsis inflammation in obesity. Evidence suggests
Iva Kulic et al.
The Journal of experimental medicine, 212(1), 37-52 (2014-12-17)
Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how expression or function of downstream elements in the Notch pathway affects tumor growth. Transcriptional regulation by Notch is dependent on interaction with the DNA-binding transcriptional repressor, RBPJ
Mario J Simirgiotis et al.
Molecules (Basel, Switzerland), 20(6), 11490-11507 (2015-06-26)
The antioxidant features, polyphenolic composition and chromatographic fingerprints of the aerial parts from three Chilean endemic plants from the Paposo Valley located on the cost of the Atacama Desert were investigated for the first time using high pressure liquid chromatography
Federico J Hernandez et al.
The Journal of chemical physics, 143(16), 164304-164304 (2015-11-02)
Small water clusters containing a single hydroxyl radical are synthesized in liquid helium droplets. The OH-H2O and OH(D2O)n clusters (n = 1-3) are probed with infrared laser spectroscopy in the vicinity of the hydroxyl radical OH stretch vibration. Experimental band
Daphne Yiu San Wong et al.
Neuroscience letters, 556, 221-226 (2013-10-29)
The native South American palm açaí berry (Euterpe oleraceae Mart.) has high polyphenolic and antioxidant levels. This study examined whether açaí berry extract afforded protection against β-amyloid (Aβ)-mediated loss of cell viability and oxidative stress associated with anti-fibrillar effects. PC12
Inorgorganica Chimica Acta, 357, 2237-2244 (2004)
Elena A Lapshina et al.
Cell biochemistry and function, 33(4), 202-210 (2015-05-13)
The present study was undertaken for further elucidation of the mechanisms of flavonoid biological activity, focusing on the antioxidative and protective effects of cranberry flavonoids in free radical-generating systems and those on mitochondrial ultrastructure during carbon tetrachloride-induced rat intoxication. Treatment
Noah Al Nakeeb et al.
Nanomaterials (Basel, Switzerland), 9(5) (2019-05-01)
The self-assembly of block copolymers in aqueous solution is an important field in modern polymer science that has been extended to double hydrophilic block copolymers (DHBC) in recent years. In here, a significant improvement of the self-assembly process of DHBC
Qiong Tang et al.
Ultrasonics sonochemistry, 20(5), 1168-1175 (2013-03-30)
This work investigated the ultrasonic assisted oxidative desulfurization of bunker-C oil with TBHP/MoO3 system. The operational parameters for the desulfurization procedure such as ultrasonic irradiation time, ultrasonic wave amplitude, catalyst initial concentration and oxidation agent initial concentration were studied. The
Yufang Zhong et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 50(8), 806-813 (2015-06-02)
To study the acute toxic effects of PCBs on airway exposure, the cell viability, apoptosis and mitochondrial functions of human lung cancer cell line A549 were measured and compared after Aroclor 1254 exposure for different time. The results showed that
Snežana D Marković et al.
General physiology and biophysics, 33(4), 393-401 (2014-08-26)
The effects of nitroglycerin (glyceryl trinitrate - GTN) are mediated by liberated nitric oxide (NO) and formed reactive nitrogen species, which induces oxidative stress during biotransformation in red blood cells (RBCs). The aim of this study was to evaluate effects
Muhammet Uyanik et al.
Science (New York, N.Y.), 345(6194), 291-294 (2014-07-19)
The diverse biological activities of tocopherols and their analogs have inspired considerable interest in the development of routes for their efficient asymmetric synthesis. Here, we report that chiral ammonium hypoiodite salts catalyze highly chemo- and enantioselective oxidative cyclization of γ-(2-hydroxyphenyl)ketones
Sung-Shin Hong et al.
Journal of ethnopharmacology, 168, 268-278 (2015-04-14)
Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced exercise mouse model.
Lei Cao et al.
Analytical and bioanalytical chemistry, 405(8), 2635-2642 (2013-02-05)
Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery. Detection of hepatic oxidative stress can be an early indicator of hepatotoxicity and benefits drug selection. The glutathione (GSH) and glutathione disulfide (GSSG)
Xiaoyue Sheng et al.
International journal of biological macromolecules, 56, 49-56 (2013-02-12)
In the present study, we reported fabrication and skin benefit of a novel vitamin E (VE)-loaded silk fibroin (SF) nanofibrous mats. RRR-α-Tocopherol polyethylene glycol 1000 succinate (VE TPGS), a water-soluble derivative of VE, was incorporated into SF nanofiber successfully by
Junho Kim et al.
Journal of cellular biochemistry, 114(3), 716-727 (2012-10-13)
Human mesenchymal stromal or stem cells (hMSCs) are being investigated for cell therapy in a wide range of diseases. MSCs are a potent source of trophic factors and actively remodel their immediate microenvironment through the secretion of bioactive factors in
Didier Betbeder et al.
International journal of nanomedicine, 10, 5355-5366 (2015-09-09)
Curcumin exhibits antioxidant properties potentially beneficial for human health; however, its use in clinical applications is limited by its poor solubility and relative instability. Nanoparticles exhibit interesting features for the efficient distribution and delivery of curcumin into cells, and could
Tingting Liu et al.
Rejuvenation research, 18(3), 225-233 (2015-01-09)
Resveratrol is a natural polyphenol derived mainly from the skin of grapes and from red wine. Resveratrol prolongs life span in several invertebrates, but this function is not found in mice. Our recently published paper demonstrated that resveratrol prolonged longevity
Adrian Flierl et al.
PloS one, 9(11), e112413-e112413 (2014-11-13)
Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies. Genetic predisposition, such as point mutations and copy number variants of the SNCA gene locus can
Marion Szelechowski et al.
Nature communications, 5, 5181-5181 (2014-10-22)
Mitochondrial dysfunction is a common feature of many neurodegenerative disorders, notably Parkinson's disease. Consequently, agents that protect mitochondria have strong therapeutic potential. Here, we sought to divert the natural strategy used by Borna disease virus (BDV) to replicate in neurons
María Belén Vecchione et al.
Scientific reports, 8(1), 6692-6692 (2018-04-29)
An estimated one third of the world's population is affected by latent tuberculosis (TB), which once active represents a leading cause of death among infectious diseases. Human immunodeficiency virus (HIV) infection is a main predisposing factor to TB reactivation. Individuals
Sangram Singh et al.
Journal of environmental biology, 33(5), 867-870 (2013-06-06)
Calcium ions play an importantrole in various physiological processes such as nerve impulse transmission, muscle contraction, hormone action, blood clotting. They ions act as an intracellular second messenger, relaying information within cells to regulate their activity. To understand the mechanism
Ewa Radzikowska et al.
Organic & biomolecular chemistry, 13(1), 269-276 (2014-11-05)
Chimeric oligonucleotides containing phosphodiester and phosphorothioate linkages have been obtained using the solid phase synthesis. The oligonucleotide parts possessing natural internucleotide phosphate bonds were assembled using commercially available nucleoside 3'-O-(2-cyanoethyl-N,N-diisopropylamino)phosphoramidites 7 whereas the phosphorothioate segment was built using nucleoside 3'-O-(2-thio-1,3,2-oxathiaphospholanes)
Laura Parma et al.
Cells, 9(2) (2020-02-07)
Unstable atherosclerotic plaques frequently show plaque angiogenesis which increases the chance of rupture and thrombus formation leading to infarctions. Hypoxia plays a role in angiogenesis and inflammation, two processes involved in the pathogenesis of atherosclerosis. We aim to study the
I V Mindukshev et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 99(1), 92-110 (2013-05-11)
Apoptosis is a common mechanism of programmed cell death in virtually all nucleated cells. In spite of the fact that platelets and erythrocytes are the only enucleated cells in mammals they contain most of the apoptosis machinery of other cells
Ludovic Peyre et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1916-1931 (2015-08-05)
Testing hepatotoxicity is a crucial step in the development and toxicological assessment of drugs and chemicals. Bio-activation can lead to the formation of metabolites which may present toxicity for the organism. Classical cytotoxic tests are not always appropriate and are
Fei Yang et al.
Journal of hazardous materials, 406, 124774-124774 (2020-12-15)
Futility of traditional advanced oxidation processes (AOPs) in saline wastewater treatment has stimulated the quest for novel "halotolerant" chemical oxidation technology. Acetylacetone (AA) has proven to be a potent photo-activator in the degradation of dyes, but the applicability of UV/AA
He Ren et al.
The journal of physical chemistry. A, 116(44), 10647-10655 (2012-10-19)
A dual-level direct dynamic method is employed to study the reaction mechanism of hydroxyl radical with (CH(3))(3)COOH and (CH(3))(2)CHOOH. Eight hydrogen abstraction channels are found for title reactions. The energy paths are optimized at the BH&H-HLYP/6-311G(d,p) level, and the energy
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