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Olfa Ben Said et al.
Environmental science and pollution research international, 22(20), 15319-15331 (2015-01-27)
Sediments from Bizerta lagoon were used in an experimental microcosm setup involving three scenarios for the bioremediation of anthracene-polluted sediments, namely bioaugmentation, biostimulation, and a combination of both bioaugmentation and biostimulation. In order to investigate the effect of the biotreatments
Marius F Ifrim et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(18), 7116-7130 (2015-05-08)
Fragile X syndrome (FXS) is caused by the loss of the fragile X mental retardation protein (FMRP), an RNA binding protein that regulates translation of numerous target mRNAs, some of which are dendritically localized. Our previous biochemical studies using synaptoneurosomes
Asis Khan et al.
PLoS neglected tropical diseases, 8(9), e3182-e3182 (2014-09-19)
Previous studies have stressed the genetic divergence and high pathogenicity of strains of T. gondii from French Guiana. Although strains from coastal, human adapted environments (so called anthropized) resemble those found in other regions of the Caribbean, strains collected from
Øystein Arlov et al.
Biomacromolecules, 16(11), 3417-3424 (2015-09-26)
Alginate is a promising polysaccharide for use in biomaterials as it is biologically inert. One way to functionalize alginate is by chemical sulfation to emulate sulfated glycosaminoglycans, which interact with a variety of proteins critical for tissue development and homeostasis.
Suhua Zhang et al.
Scientific reports, 5, 17711-17711 (2015-12-05)
As a multi-ethnic country, China has some indigenous population groups which vary in culture and social customs, perhaps as a result of geographic isolation and different traditions. However, upon close interactions and intermarriage, admixture of different gene pools among these
Qian Liang et al.
Thrombosis and haemostasis, 113(3), 585-592 (2014-12-17)
Mutations affecting splice sites comprise approximately 7.5 % of the known F8 gene mutations but only a few were verified at mRNA level. In the present study, 10 putative splice site mutations were characterised by mRNA analysis using reverse transcription PCR
Ji-young Kim et al.
Anti-cancer drugs, 25(9), 1061-1071 (2014-07-09)
To achieve a clinically rational regimen for cancer chemoprevention with improved efficacy and safety, the combination effect of celecoxib and newly developed oral angiogenesis inhibitor, LHD4, on chemoprevention was evaluated. The chemopreventive effects of celecoxib, LHD4, and the combination of
Evgeny Arons et al.
British journal of haematology, 166(5), 729-738 (2014-06-17)
Frequencies of human leucocyte antigens (HLA) were determined in 287 classic hairy cell leukaemia (HCL) patients. With respect to both population (n = 287) and allele (2n = 574) frequency respectively, the most common HLA class I and II antigens
Ryan S King et al.
BMC developmental biology, 13, 8-8 (2013-03-19)
The freshwater planarian Schmidtea mediterranea has emerged as a powerful model for studies of regenerative, stem cell, and germ cell biology. Whole-mount in situ hybridization (WISH) and whole-mount fluorescent in situ hybridization (FISH) are critical methods for determining gene expression
Brian J Beliveau et al.
Nature communications, 6, 7147-7147 (2015-05-13)
Fluorescence in situ hybridization (FISH) is a powerful single-cell technique for studying nuclear structure and organization. Here we report two advances in FISH-based imaging. We first describe the in situ visualization of single-copy regions of the genome using two single-molecule
Eva Wex et al.
PloS one, 9(12), e116166-e116166 (2014-12-30)
Mast cells are central effector cells in allergic asthma and are augmented in the airways of asthma patients. Attenuating mast cell degranulation and with it the early asthmatic response is an important intervention point to inhibit bronchoconstriction, plasma exudation and
Louela A Castrillo et al.
Fungal biology, 119(7), 595-604 (2015-06-11)
Sirex noctilio is a woodwasp of Eurasian origin that was inadvertently introduced to the southern hemisphere in the 1900s and to North America over a decade ago. Its larvae bore in Pinus spp. and can cause significant mortality in pine
Mirela Boca et al.
Scientific reports, 5, 17304-17304 (2015-11-28)
Microtubules are μm-long cylinders of about 25 nm in diameter which are present in the cytoplasm of eukaryotic cells. Here, we have developed a new method which uses these cylindrical structures as platforms to detect protein interactions in cells. The principle
Kyung-Yeon Park et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 213-216 (2015-03-18)
Although TNF-α possesses promising anticancer activity, clinical application is limited partly due to cardiovascular toxicities. TNF-α effects on vessels are likely related to vascular toxicity, but much remains poorly understood. Similarly, IL-2 is an attractive treatment option for cancers but
R.C. Ogden et al.
Methods in Enzymology, 152, 67-67 (1987)
S Malvezzi et al.
Analytical biochemistry, 478, 1-7 (2015-03-17)
The importance of DNA polymerases in biology and biotechnology, and their recognition as potential therapeutic targets, drives development of methods for deriving kinetic characteristics of polymerases and their propensity to perform polynucleotide synthesis over modified DNA templates. Among various polymerases
Fitsum G Tadesse et al.
Malaria journal, 14, 303-303 (2015-08-06)
Motivated by the success in malaria control that was documented over the last decade Ethiopia is aiming at malaria elimination by 2020 in selected districts. It is currently unknown if asymptomatic, submicroscopic malaria parasite carriage may form a hurdle to
Jian Wang et al.
Environmental science. Processes & impacts, 17(9), 1654-1660 (2015-07-29)
Environmental contamination caused by residual antibiotics and antibiotic resistance genes (ARGs) in concentrated animal feeding operations has drawn increasing attention. This study investigated the removal of oxytetracycline (OTC) and sulfamethazine (SMN) as well as the behavior of their corresponding ARGs
Federica Cesca et al.
PloS one, 10(4), e0125259-e0125259 (2015-04-29)
Abnormalities of intracellular Ca2+ homeostasis and signalling as well as the down-regulation of neurotrophic factors in several areas of the central nervous system and in peripheral tissues are hallmarks of Huntington's disease (HD). As there is no therapy for this
Laura Padrón-Barthe et al.
Blood, 124(16), 2523-2532 (2014-08-21)
The first blood and endothelial cells of amniote embryos appear in close association in the blood islands of the yolk sac (YS). This association and in vitro lineage analyses have suggested a common origin from mesodermal precursors called hemangioblasts, specified
Eunkyong Ko et al.
Biochemical and biophysical research communications, 447(2), 358-363 (2014-04-16)
Invasion, the representative feature of malignant tumors, leads to an increase in mortality. The malignant liver tumor - hepatocellular carcinoma (HCC) - has an enhanced invasive capacity that results in increased patient mortality. Moreover, this enhanced invasive capacity is due
Sarah E Johnstone et al.
Cell, 182(6), 1474-1489 (2020-08-26)
Widespread changes to DNA methylation and chromatin are well documented in cancer, but the fate of higher-order chromosomal structure remains obscure. Here we integrated topological maps for colon tumors and normal colons with epigenetic, transcriptional, and imaging data to characterize
Zhen Wang et al.
The Journal of pharmacology and experimental therapeutics, 352(1), 61-66 (2014-10-31)
Microvascular failure is hallmark of sepsis in humans and is recognized as a strong predictor of mortality. In the mouse subjected to cecal ligation and puncture (CLP) to induce a clinically relevant sepsis, renal microvascular permeability increases and peritubular capillary
Crystal M Han et al.
Lab on a chip, 14(16), 2958-2967 (2014-06-13)
We present an on-chip electrokinetic method to increase the reaction kinetics and sensitivity of DNA microarray hybridization. We use isotachophoresis (ITP) to preconcentrate target molecules in solution and transport them over the immobilized probe sites of a microarray, greatly increasing
Angelico Madaro et al.
The Journal of experimental biology, 218(Pt 16), 2538-2550 (2015-06-10)
Combinations of stressors occur regularly throughout an animal's life, especially in agriculture and aquaculture settings. If an animal fails to acclimate to these stressors, stress becomes chronic, and a condition of allostatic overload arises with negative results for animal welfare.
Belén Lledó et al.
Reproductive biomedicine online, 29(4), 509-515 (2014-08-19)
The human androgen receptor (AR) gene contains a highly polymorphic CAG repeat sequence within exon 1. In-vitro studies have shown a relationship between CAG repeats in the AR gene and its transactivation potential. This variation in length may play a
Tomoharu Yokooji et al.
International archives of allergy and immunology, 167(3), 193-202 (2015-09-04)
Aspirin (ASP)-facilitated absorption of ingested allergens is considered an exacerbating factor in the development of food allergy. Sodium cromoglycate (SCG) is used for the treatment of atopic dermatitis with food allergy, but the efficacy of SCG in ASP-exacerbated food-allergy reactions
Siele Ceuppens et al.
International journal of environmental research and public health, 12(8), 10171-10197 (2015-08-27)
Fresh herbs such as basil constitute an important food commodity worldwide. Basil provides considerable culinary and health benefits, but has also been implicated in foodborne illnesses. The naturally occurring bacterial community on basil leaves is currently unknown, so the epiphytic
Kosuke Nozaki et al.
Dental materials journal, 34(5), 671-678 (2015-10-07)
This study investigated the surface characteristics and antibacterial ability capacity of surface-improved dental glass-ceramics by an electrical polarization process. Commercially available dental glass-ceramic materials were electrically polarized to induce surface charges in a direct current field by heating. The surface
Stanislas Rebaudet et al.
PLoS neglected tropical diseases, 8(6), e2898-e2898 (2014-06-06)
Cholera is typically considered endemic in West Africa, especially in the Republic of Guinea. However, a three-year lull period was observed from 2009 to 2011, before a new epidemic struck the country in 2012, which was officially responsible for 7,350
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