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Alison C Macleod et al.
Molecular cancer therapeutics, 13(12), 2840-2851 (2014-09-26)
Resistant KIT mutations have hindered the development of KIT kinase inhibitors for treatment of patients with systemic mastocytosis. The goal of this research was to characterize the synergistic effects of a novel combination therapy involving inhibition of KIT and calcineurin
Ryan Salvador et al.
Infection and immunity, 82(9), 3687-3696 (2014-06-18)
The Chagas' disease parasite Trypanosoma cruzi elicits a potent inflammatory response in acutely infected hearts that keeps parasitism in check and triggers cardiac abnormalities. A most-studied mechanism underlying innate immunity in T. cruzi infection is Toll-like receptor (TLR) activation by
Catarina Mota et al.
Journal of immunology (Baltimore, Md. : 1950), 193(12), 5854-5862 (2014-11-05)
FOXP3-expressing regulatory T cells (Treg) are essential for the prevention of autoimmunity and were shown to be reduced and/or dysfunctional in several autoimmune diseases. Although Treg-based adoptive transfer represents a promising therapy, the large cell number required to achieve clinical
C M Lee et al.
Genes and immunity, 16(5), 356-361 (2015-04-24)
Epithelium-specific Ets transcription factor 1 (ESE-1) is a member of the E26 transformation-specific family of transcription factors that has an epithelial-restricted constitutive expression but is induced by inflammatory stimuli in non-epithelial cells. Here we report that ESE-1 is constitutively expressed
Filip Bochner et al.
Scientific reports, 5, 12446-12446 (2015-07-25)
The ovary is a dynamic organ that undergoes dramatic remodeling throughout the ovulatory cycle. Maturation of the ovarian follicle, release of the oocyte in the course of ovulation as well as formation and degradation of corpus luteum involve tightly controlled
Ina Kurth et al.
Oncotarget, 6(33), 34494-34509 (2015-10-16)
Despite recent advances in understanding of the molecular pathogenesis and improvement of treatment techniques, locally advanced head and neck squamous cell carcinoma (HNSCC) remains associated with an unfavorable prognosis. Compelling evidence suggests that cancer stem cells (CSC) may cause tumor
Jenni Küblbeck et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1759-1765 (2015-07-19)
Discovery of receptor-dependent mechanisms for regulation of drug metabolism has provided a new way to evaluate the propensity of drug candidates to cause induction of cytochrome P450 enzymes. Therefore, receptor-based reporter assays have become common in early stages of drug
D Fan et al.
Oncogene, 34(16), 2083-2093 (2014-06-10)
Leukemic lymphoblasts within different immunophenotypic populations possess stem cell properties. However, whether or not the self-renewal program is retained from stem cells or conferred on progenitors by leukemogenic molecules remains unknown. We have addressed the issue in the context of
Yiqing Qu et al.
Journal of experimental & clinical cancer research : CR, 33, 52-52 (2014-06-19)
Although the EGF receptor tyrosine kinase inhibitors (EGFR-TKI) gefitinib have shown dramatic effects against EGFR mutant lung cancer, patients become resistant by various mechanisms, including gatekeeper EGFR-T790M mutation, MET amplification, and KRAS mutation, thereafter relapsing. AZD6244 is a potent, selective
Rebecca L Dahlin et al.
Annals of biomedical engineering, 42(7), 1381-1390 (2013-07-12)
In this study, we investigated the effect of flow perfusion culture on the mineralization of co-cultures of human umbilical vein endothelial cells (HUVECs) and human mesenchymal stem cells (hMSCs). Osteogenically precultured hMSCs were seeded onto electrospun scaffolds in monoculture or
Jamie Rae Acosta et al.
PloS one, 9(6), e90572-e90572 (2014-06-10)
FUS mutations can occur in familial amyotrophic lateral sclerosis (fALS), a neurodegenerative disease with cytoplasmic FUS inclusion bodies in motor neurons. To investigate FUS pathology, we generated transgenic zebrafish expressing GFP-tagged wild-type or fALS (R521C) human FUS. Cell cultures were
Paulo Emílio C Leite et al.
Archivum immunologiae et therapiae experimentalis, 62(6), 483-491 (2014-05-17)
Sustained chronic inflammation induces activation of genes involved in cellular proliferation and apoptosis, thereby causing skeletal muscle degeneration. To investigate in vitro effects of isolated pentacyclic triterpenes from Eugenia punicifolia (Ep-CM) upon signaling pathways involved in the regulation of skeletal
E Bart Tarbet et al.
The Journal of antimicrobial chemotherapy, 69(8), 2164-2174 (2014-04-30)
Emerging drug resistance to antiviral therapies is an increasing challenge for the treatment of influenza virus infections. One new antiviral compound, BTA938, a dimeric derivative of the viral neuraminidase inhibitor zanamivir, contains a 14-carbon linker bridging two zanamivir moieties. In
Silvia Alvarez et al.
Nature communications, 6, 8548-8548 (2015-10-13)
Replicative stress during embryonic development influences ageing and predisposition to disease in adults. A protective mechanism against replicative stress is provided by the licensing of thousands of origins in G1 that are not necessarily activated in the subsequent S-phase. These
Xinying Zhou et al.
Journal of hepatology, 61(4), 746-754 (2014-05-27)
Humans are frequently exposed to hepatitis E virus (HEV). Nevertheless, the disease mainly affects pregnant women and immunocompromised individuals. Organ recipients receiving immunosuppressants, such as rapalogs, to prevent rejection have a high risk for developing chronic hepatitis following HEV infection.
Christina L Wilson et al.
Nanoscale, 7(44), 18477-18488 (2015-08-15)
Titanium dioxide (TiO2) nanoparticles are currently the second most produced engineered nanomaterial in the world with vast usage in consumer products leading to recurrent human exposure. Animal studies indicate significant nanoparticle accumulation in the brain while cellular toxicity studies demonstrate
Margit Mutso et al.
PloS one, 10(6), e0128686-e0128686 (2015-06-04)
The inhibitory potency of an antisense oligonucleotide depends critically on its design and the accessibility of its target site. Here, we used an RNA interference-guided approach to select antisense oligonucleotide target sites in the coding region of the highly structured
Kathryne E Taylor et al.
Journal of virology, 89(19), 9841-9852 (2015-07-17)
It has recently been proposed that the herpes simplex virus (HSV) protein ICP0 has cytoplasmic roles in blocking antiviral signaling and in promoting viral replication in addition to its well-known proteasome-dependent functions in the nucleus. However, the mechanisms through which
Jochen A Ackermann et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4650-4656 (2015-04-12)
Signals from the BCR are required for Ag-specific B cell recruitment into the immune response. Binding of Ag to the BCR induces phosphorylation of immune receptor tyrosine-based activation motifs in the cytoplasmic domains of the CD79a and CD79b signaling subunits
L N Moro et al.
Reproduction in domestic animals = Zuchthygiene, 50(5), 849-857 (2015-09-04)
The aim of this study was to evaluate three different cloning strategies in the domestic cat (Felis silvestris) and to use the most efficient to generate wild felid embryos by interspecific cloning (iSCNT) using Bengal (a hybrid formed by the
M Jesús Corral et al.
The Journal of antimicrobial chemotherapy, 69(12), 3268-3274 (2014-08-07)
To evaluate the efficacy of the combination of allicin and amphotericin deoxycholate (AmB) in the chemotherapy of Leishmania infantum infection with the final aim of reducing the dose of AmB in the chemotherapy of visceral leishmaniasis. Hamsters were intraperitoneally (ip)
Sandeep Sampangi et al.
PloS one, 10(7), e0134688-e0134688 (2015-08-01)
Proximal tubule epithelial cells (PTEC) of the kidney line the proximal tubule downstream of the glomerulus and play a major role in the re-absorption of small molecular weight proteins that may pass through the glomerular filtration process. In the perturbed
Ana Beatriz DePaula-Silva et al.
Virology, 477, 10-17 (2015-01-27)
Vpr and Vpx are a group of highly related accessory proteins from primate lentiviruses. Despite the high degree of amino acid homology within this group, these proteins can be highly divergent in their functions. In this work, we constructed chimeric
Justin L Eddy et al.
Cellular immunology, 290(1), 120-130 (2014-07-01)
Although glucocorticoids are well known for their capacity to suppress the immune response, glucocorticoids can also promote immune responsiveness. It was the purpose of this investigation to evaluate the molecular basis for this apparent dichotomous immunologic effect. Glucocorticoid treatment of
Fatma Demir Duman et al.
Nanoscale, 7(26), 11352-11362 (2015-06-13)
The development of non-toxic theranostic nanoparticles capable of delivering a therapeutic cargo and providing a means for diagnosis is one of the most challenging tasks in nano-biotechnology. Gene therapy is a very important mode of therapy and polyethyleneimine (PEI) is
Ying Liu et al.
Clinica chimica acta; international journal of clinical chemistry, 446, 171-174 (2015-04-30)
Classic galactosemia (CG) is a potentially lethal genetic disorder that results from profound loss of galactose-1-phosphate uridylyltransferase (GALT). CG is detected by newborn screening (NBS) in many countries; however, conclusive diagnosis can be complex due to broad and overlapping ranges
Roya M Dayam et al.
Traffic (Copenhagen, Denmark), 16(9), 1010-1026 (2015-05-27)
Macrophages internalize and sequester pathogens into a phagosome. Phagosomes then sequentially fuse with endosomes and lysosomes, converting into degradative phagolysosomes. Phagosome maturation is a complex process that requires regulators of the endosomal pathway including the phosphoinositide lipids. Phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate
Karina Sánchez-Reyes et al.
BioMed research international, 2014, 683068-683068 (2014-10-14)
Cervical cancer (CC) is the second most common cancer among women worldwide. Infection with human papillomavirus (HPV) is the main risk factor for developing CC. Macrophages are important immune effector cells; they can be differentiated into two phenotypes, identified as
Sahar A Alshalchi et al.
Archives of microbiology, 197(2), 135-145 (2014-09-01)
Bacterial biofilms are an important cause of nosocomial infections. Microorganisms such as Pseudomonas aeruginosa colonize biotic and abiotic surfaces leading to chronic infections that are difficult to eradicate. To characterize novel genes involved in biofilm formation, we identified the lpxD
Xingliang Dai et al.
Oncology reports, 34(6), 2997-3006 (2015-09-24)
Solid tumors are abnormal tissues containing tumor and non-tumor cells, also known as tumor stromal cells. However, the malignant potential of tumor stromal cells remains largely unknown. The aim of the present study was to investigate the malignant potential of
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