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Exibindo 1-30 of 3448 resultados para "49781" no prazo de Papéis
Dennis H M Kusters et al.
PloS one, 10(6), e0130484-e0130484 (2015-06-20)
To investigate therapeutic effects of annexin A1 (anxA1) on atherogenesis in LDLR-/- mice. Human recombinant annexin A1 (hr-anxA1) was produced by a prokaryotic expression system, purified and analysed on phosphatidylserine (PS) binding and formyl peptide receptor (FPR) activation. Biodistribution of
Michitaka Suzuki et al.
Molecular biology of the cell, 26(12), 2333-2342 (2015-04-24)
Adipocyte triglyceride lipase (ATGL) is the major enzyme involved in the hydrolysis of triglycerides. The Arf1-coat protein complex I (COPI) machinery is known to be engaged in the recruitment of ATGL to lipid droplets (LDs), but the regulatory mechanism has
Tonya Kueck et al.
PLoS pathogens, 11(8), e1005141-e1005141 (2015-09-01)
HIV-1 Vpu prevents incorporation of tetherin (BST2/ CD317) into budding virions and targets it for ESCRT-dependent endosomal degradation via a clathrin-dependent process. This requires a variant acidic dileucine-sorting motif (ExxxLV) in Vpu. Structural studies demonstrate that recombinant Vpu/tetherin fusions can
Hongtao Wang et al.
Kidney international, 87(5), 948-962 (2015-01-08)
Reactive oxygen species (ROS) have an important pathogenic role in the development of many diseases, including kidney disease. Major ROS generators in the glomerulus of the kidney are the p47(phox)-containing NAPDH oxidases NOX1 and NOX2. The cytosolic p47(phox) subunit is
Atrayee Chattopadhyay et al.
FEMS yeast research, 15(4), fov013-fov013 (2015-03-26)
The repressor activator protein1 (Rap1) has been studied over the years as a multifunctional regulator in Saccharomyces cerevisiae. However, its role in storage lipid accumulation has not been investigated. This report documents the identification and isolation of a putative transcription
Mohamed Elgendy et al.
Nature communications, 5, 5637-5637 (2014-12-05)
Mcl-1 is a unique Bcl-2 family member that plays crucial roles in apoptosis. Apoptosis-unrelated functions of Mcl-1 are however emerging, further justifying its tight regulation. Here we unravel a novel mechanism of Mcl-1 regulation mediated by the haplo-insufficient tumour suppressor
Miku Hirane et al.
Biochemical and biophysical research communications, 441(1), 47-52 (2013-10-19)
Reactive oxygen species (ROS) are known to mediate a variety of biological responses, including cell motility. Recently, we indicated that lysophosphatidic acid (LPA) receptor-3 (LPA3) increased cell motile activity stimulated by hydrogen peroxide. In the present study, we assessed the
Duncan M Gascoyne et al.
PloS one, 10(6), e0128513-e0128513 (2015-06-04)
Mutations of the forkhead transcription factor FOXP2 gene have been implicated in inherited speech-and-language disorders, and specific Foxp2 expression patterns in neuronal populations and neuronal phenotypes arising from Foxp2 disruption have been described. However, molecular functions of FOXP2 are not
Xuan-thanh Mai et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(7), 561-568 (2015-04-01)
A 15-mer cationic α-helical antimicrobial peptide HPRP-A1 was used as the parent peptide to study the effects of peptide secondary structure on the biophysical properties and biological activities. Without changing the amino acid composition of HPRP-A1, we designed two α-helical
Izabela Waclawska et al.
Biological chemistry, 396(9-10), 1117-1126 (2015-07-07)
The trimeric transporter BetP counteracts hyperosmotic stress by a fast increase in transport rate in order to accumulate the compatible solute betaine. The positively charged α-helical C-terminal domain acts as an osmosensor perceiving the increase in the internal potassium (K+)
Bruno M Andrade et al.
PloS one, 10(6), e0127561-e0127561 (2015-06-04)
Skeletal muscle injury is the most common problem in orthopedic and sports medicine, and severe injury leads to fibrosis and muscle dysfunction. Conventional treatment for successive muscle injury is currently controversial, although new therapies, like cell therapy, seem to be
Steven L Roseno et al.
Nutrition & metabolism, 12, 39-39 (2015-11-06)
A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals. The purpose of this study was
Mie Bech Lukassen et al.
Marine drugs, 13(7), 4331-4343 (2015-07-18)
Scopularide A is a promising potent anticancer lipopeptide isolated from a marine derived Scopulariopsis brevicaulis strain. The compound consists of a reduced carbon chain (3-hydroxy-methyldecanoyl) attached to five amino acids (glycine, l-valine, d-leucine, l-alanine, and l-phenylalanine). Using the newly sequenced
Sarath Vijayakumar et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 26(3-4), 154-172 (2015-02-04)
A/J mice develop progressive hearing loss that begins before 1 month of age and is attributed to cochlear hair cell degeneration. Screening tests indicated that this strain also develops early onset vestibular dysfunction and has otoconial deficits. The purpose of this
Ilse Timmerman et al.
Journal of cell science, 128(16), 3041-3054 (2015-06-28)
Endothelial cell-cell junctions maintain a restrictive barrier that is tightly regulated to allow dynamic responses to permeability-inducing angiogenic factors, as well as to inflammatory agents and adherent leukocytes. The ability of these stimuli to transiently remodel adherens junctions depends on
Adriana María Belén Abiuso et al.
The Journal of endocrinology, 223(3), 241-253 (2014-09-26)
The histamine H4 receptor (HRH4), discovered only 13 years ago, is considered a promising drug target for allergy, inflammation, autoimmune disorders and cancer, as reflected by a steadily growing number of scientific publications and patent applications. Although the presence of
Michael Tscherner et al.
PLoS pathogens, 11(10), e1005218-e1005218 (2015-10-17)
Human fungal pathogens like Candida albicans respond to host immune surveillance by rapidly adapting their transcriptional programs. Chromatin assembly factors are involved in the regulation of stress genes by modulating the histone density at these loci. Here, we report a
Claus Brandt et al.
Metabolism: clinical and experimental, 64(2), 283-295 (2014-12-03)
Follistatin-like 3 (fstl3), a natural inhibitor of members of the TGF-β family, increases during resistance training in human plasma. Fstl3 primarily binds myostatin and activin A, and thereby inhibits their functions. We hypothesize that blocking myostatin and activin A signalling
Di Jia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1371-1382 (2015-01-01)
We have previously identified a zinc finger transcription factor, ZNF24 (zinc finger protein 24), as a novel inhibitor of tumor angiogenesis and have demonstrated that ZNF24 exerts this effect by repressing the transcription of VEGF in breast cancer cells. Here
David M Anderson et al.
Journal of bacteriology, 197(3), 529-541 (2014-11-19)
Phospholipase A2 enzymes are ubiquitously distributed throughout the prokaryotic and eukaryotic kingdoms and are utilized in a wide array of cellular processes and physiological and immunological responses. Several patatin-like phospholipase homologs of ExoU from Pseudomonas aeruginosa were selected on the
Laure B Bindels et al.
PloS one, 10(6), e0131009-e0131009 (2015-06-23)
We tested the hypothesis that changing the gut microbiota using pectic oligosaccharides (POS) or inulin (INU) differently modulates the progression of leukemia and related metabolic disorders. Mice were transplanted with Bcr-Abl-transfected proB lymphocytes mimicking leukemia and received either POS or
Nilay Yogeshkumar Thakar et al.
Stem cells and development, 24(16), 1888-1900 (2015-03-21)
The molecular mechanisms that orchestrate the exit from pluripotency, cell cycle progression, and lineage-specific differentiation in human pluripotent stem cells (hPSCs) are poorly understood. RELB, a key protein in the noncanonical nuclear factor-kappaB (NFκB) signaling pathway, was previously implicated in
Chunyan Wang et al.
International journal of clinical and experimental pathology, 8(5), 4715-4724 (2015-07-21)
Spontaneous intracerebral hemorrhage (ICH) is a common and fatal subtype of stroke, with hypertension the most common cause of this disorder. Bone marrow derived mesenchymal stem cells (BM-MSCs) have been shown to elicit protective properties in stroke models. In the
Magdalena Dudek et al.
PloS one, 10(10), e0141327-e0141327 (2015-10-28)
The search for drugs with anorectic activity, acting within the adrenergic system has attracted the interest of researchers. Partial α2-adrenoceptor agonists might offer the potential for effective and safe treatment of obesity. We compared the effectiveness and safety of α2-adrenoceptor
Jacqueline J Dimatelis et al.
Journal of molecular neuroscience : MN, 56(3), 696-707 (2015-02-11)
Attention deficit hyperactivity disorder (ADHD) is a heterogeneous behavioural disorder that affects 3-15 % of children worldwide. Spontaneously hypertensive rats (SHR) display the major symptoms of ADHD (hyperactivity, impulsivity and poor performance in tasks that require sustained attention) and are
Jeannette G Lumaban et al.
Human molecular genetics, 24(8), 2175-2184 (2015-01-02)
Fragile X syndrome results from loss of FMR1 expression. Individuals with the disorder exhibit not only intellectual disability, but also an array of physical and behavioral abnormalities, including sleep difficulties. Studies in mice demonstrated that Fmr1, along with its paralog
Oriane Guillermin et al.
Developmental biology, 405(2), 202-213 (2015-06-27)
Brain development goes through phases of proliferative growth and differentiation to ensure the formation of correct number and variety of neurons. How and when naïve neuroepithelial cells decide to enter a differentiation pathway remains poorly understood. In the Drosophila visual
Son Hoang Minh et al.
Microbiology and immunology, 59(3), 114-122 (2015-02-04)
Shiga toxin producing Escherichia coli (STEC) are dangerous foodborne pathogens. Foods are considered as important sources for STEC infection in human. In this study, STEC contamination of raw meats was investigated and the virulence factors of 120 clinical STEC strains
Giuseppe Fiume et al.
Scientific reports, 5, 13864-13864 (2015-09-08)
Immune activation and chronic inflammation are hallmark features of HIV infection causing T-cell depletion and cellular immune dysfunction in AIDS. Here, we addressed the issue whether HIV-1 Tat could affect T cell development and acute inflammatory response by generating a
Harriet P Lo et al.
The Journal of cell biology, 210(5), 833-849 (2015-09-02)
Dysfunction of caveolae is involved in human muscle disease, although the underlying molecular mechanisms remain unclear. In this paper, we have functionally characterized mouse and zebrafish models of caveolae-associated muscle disease. Using electron tomography, we quantitatively defined the unique three-dimensional
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