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Evangelia Terzopoulou et al.
Environmental science and pollution research international, 22(2), 1095-1112 (2014-08-12)
A multi-residue method, based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS), has been developed for the determination of 70 organic micropollutants from various chemical classes (organochlorinated, organophosphorous, triazines, carbamate and urea, polycyclic aromatic hydrocarbons, polychlorinated biphenyls, pharmaceuticals, phenols...
Antonella Liantonio et al.
The American journal of pathology, 184(10), 2803-2815 (2014-08-02)
Hypertension is often associated with skeletal muscle pathological conditions related to function and metabolism. The mechanisms underlying the development of these pathological conditions remain undefined. Because calcium homeostasis is a biomarker of muscle function, we assessed whether it is altered...
Kirti Kumar Tiwari et al.
Biochemical and biophysical research communications, 450(4), 1345-1350 (2014-07-06)
Caffeine is used to prevent bronchopulmonary dysplasia (BPD) in premature neonates. Hyperoxia contributes to the development of BPD, inhibits cell proliferation and decreases cell survival. The mechanisms responsible for the protective effect of caffeine in pulmonary oxygen toxicity remain largely...
Yong-Cheng Ma et al.
Toxicology and applied pharmacology, 282(2), 227-236 (2014-12-03)
Jaridonin, a novel diterpenoid from Isodon rubescens, has been shown previously to inhibit proliferation of esophageal squamous cancer cells (ESCC) through G2/M phase cell cycle arrest. However, the involved mechanism is not fully understood. In this study, we found that...
Maria Dobrinas et al.
Pharmacogenetics and genomics, 23(5), 286-292 (2013-03-16)
There is a high interindividual variability in cytochrome P4501A2 (CYP1A2) activity and in its inducibility by smoking, only poorly explained by known CYP1A2 polymorphisms. We aimed to study the contribution of other regulatory pathways, including transcription factors and nuclear receptors...
M Gajewska et al.
Toxicology letters, 227(3), 189-202 (2014-04-16)
The application of physiologically based toxicokinetic (PBTK) modelling in route-to-route (RtR) extrapolation of three cosmetic ingredients: coumarin, hydroquinone and caffeine is shown in this study. In particular, the oral no-observed-adverse-effect-level (NOAEL) doses of these chemicals are extrapolated to their corresponding...
Anna Casey et al.
The British journal of nutrition, 112(7), 1175-1184 (2014-08-15)
The use of supplements is widespread at all levels of civilian sport and a prevalence of 60-90 % is reported among high-performance UK athletes, including juniors. The prevalence of supplement use among UK-based British Army personnel is not known. The aim...
Daniel Caldeira et al.
Heart (British Cardiac Society), 99(19), 1383-1389 (2013-09-07)
Atrial fibrillation (AF) is the most prevalent sustained arrhythmia, and risk factors are well established. Caffeine exposure has been associated with increased risk of AF, but heterogeneous data exist in the literature. To evaluate the association between chronic exposure to...
Cody Ramin et al.
Occupational and environmental medicine, 72(2), 100-107 (2014-09-28)
We examined the association of night shift work history and age when night shift work was performed with cancer and cardiovascular disease risk factors among 54 724 women in the Nurses' Health Study (NHS) II. We calculated age-adjusted and socioeconomic status-adjusted...
Combined butalbital/acetaminophen/caffeine overdose: case files of the Robert Wood Johnson Medical School Toxicology Service.
Christopher Bryczkowski et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(4), 424-431 (2012-09-27)
Katherine Booker et al.
Organic & biomolecular chemistry, 12(37), 7201-7210 (2014-06-28)
The selectivity and rebinding capacity of molecularly imprinted polymers selective for propranolol (1) using the room temperature ionic liquids [BMIM][BF4], [BMIM][PF6], [HMIM][PF6] and [OMIM][PF6] and CHCl3 were examined. The observed IF (imprinting factor) values for MIPBF4, MIPPF6 and MIPCHCl3 were...
Douglas D Lemon et al.
FEBS letters, 589(10), 1080-1088 (2015-03-31)
PKD-mediated phosphorylation of class IIa HDACs frees the MEF2 transcription factor to activate genes that govern muscle differentiation and growth. Studies of the regulation and function of this signaling axis have involved MC1568 and Gö-6976, which are small molecule inhibitors...
Gaber Hashem Gaber Ahmed et al.
Talanta, 132, 252-257 (2014-12-06)
Herein we describe an easy one step synthesis of carbon nanodots (C-dots) by thermal carbonization of 6-bromohexylboronic acid using two different amine compounds, polyethyleneglycol bis(3-aminopropyl (PEGA) and 1,2-aminopropane (DPA), at 180 °C in atmospheric oxygen. The as-synthesized C-dots were characterized...
Mariana N Batista et al.
Archives of virology, 160(2), 399-407 (2014-12-11)
Hepatitis C is considered the major cause of cirrhosis and hepatocellular carcinoma. Conventional treatment is not effective against some hepatitis C virus (HCV) genotypes; therefore, new treatments are needed. Coffee and, more recently, caffeine, have been found to have a...
Koichi Takita et al.
Respiratory physiology & neurobiology, 207, 14-21 (2014-12-17)
In a previous study, we showed that in an in vitro en bloc preparation of newborn rats perfused with standard [K(+)] (6.2mM) and high [K(+)] (11.2mM) artificial cerebrospinal fluid (aCSF), nociceptin/orphanin FQ (N/OFQ) suppresses bursting of pre-inspiratory neurons with 1:1...
S Uccella et al.
British journal of cancer, 109(7), 1908-1913 (2013-09-12)
Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases. Type I...
[How much coffee is healthy?].
Franziska Etter
Praxis, 103(25), 1531-1532 (2014-12-11)
Martin Kronschläger et al.
Experimental eye research, 127, 179-183 (2014-08-12)
The aim of the present study was to examine if topically applied caffeine influences pupil size in ketamine/xylazine anesthetized animals. Two experiments were carried out. In the first experiment, caffeine was topically applied to one of the eyes of 10...
Qi Wang et al.
International immunopharmacology, 25(2), 340-352 (2015-02-24)
Alcoholic liver fibrosis (ALF) is characterized by hyperplasia of extracellular matrix under long-term alcohol stimulation. Hepatic stellate cell (HSC) activation plays an important role in promoting hepatic fibrogenesis. Caffeine, as the main active component of coffee and tea, was widely...
Pieter M M De Kesel et al.
Clinical pharmacokinetics, 53(8), 763-771 (2014-07-02)
Dried blood spot (DBS) sampling has gained wide interest in bioanalysis during the last decade and has already been successfully applied in pharmacokinetic and phenotyping studies. However, all of the available phenotyping studies used small datasets and did not include...
S Picone et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 25 Suppl 3, 11-14 (2012-10-04)
The efficacy of caffeine in an episode of Apnoea of Prematurity (AOP) has been known for over thirty years. Its use over long periods of time has not only found it to be manageable within the field of neonatology, but...
Rachel Beckerman et al.
Genes & development, 23(11), 1364-1377 (2009-06-03)
We reported previously that when cells are arrested in S phase, a subset of p53 target genes fails to be strongly induced despite the presence of high levels of p53. When DNA replication is inhibited, reduced p21 mRNA accumulation is...
Yasuhiro Uno et al.
Biochemical pharmacology, 91(2), 242-248 (2014-07-19)
CYP2C19 (formerly known as CYP2C75), highly homologous to human CYP2C19, has been identified in cynomolgus and rhesus macaques, non-human primate species widely used in drug metabolism studies. CYP2C19 is predominantly expressed in liver and encodes a functional drug-metabolizing enzyme. Genetic...
N Inui et al.
Clinical pharmacology and therapeutics, 94(6), 702-708 (2013-08-27)
Cytochrome P450 (CYP) 1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A are major factors involved in the metabolism of clinically prescribed drugs. Because the time course after drug treatment discontinuation has received little attention, we aimed to clarify the chronological changes of...
Junho Choe et al.
Nucleic acids research, 42(14), 9334-9349 (2014-07-14)
Histone biogenesis is tightly controlled at multiple steps to maintain the balance between the amounts of DNA and histone protein during the cell cycle. In particular, translation and degradation of replication-dependent histone mRNAs are coordinately regulated. However, the underlying molecular...
Jitendriya Mishra et al.
Pharmacological reports : PR, 66(6), 1148-1155 (2014-12-03)
Chronic quinolinic acid (QA) lesions in rats closely resemble Huntington's disease like conditions. Oxidative stress and mitochondrial dysfunction have long been implicated in the neurotoxic effects of QA acting through N-methyl-d-aspartate (NMDA) receptors. Reports suggest that inhibition of adenosine A2A...
Paula L Diaz-Sylvester et al.
Molecular pharmacology, 85(4), 564-575 (2014-01-16)
Eudistomin D (EuD) and penaresin (Pen) derivatives are bioactive alkaloids from marine sponges found to induce Ca(2+) release from striated muscle sarcoplasmic reticulum (SR). Although these alkaloids are believed to affect ryanodine receptor (RyR) gating in a "caffeine-like" manner, no...
Adam D Collier et al.
Progress in neuro-psychopharmacology & biological psychiatry, 55, 16-25 (2014-06-03)
Addiction and substance abuse are found ubiquitously throughout human society. In the United States, these disorders are responsible for amassing hundreds of billions of dollars in annual costs associated with healthcare, crime and lost productivity. Efficacious treatments remain few in...
Hsien-Tsung Yao et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 70, 120-127 (2014-05-13)
The effect of commercially available green tea (GT) and black tea (BT) drinks on drug metabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory chow diet and GT or BT drink for...
F Ariu et al.
Cryo letters, 35(6), 530-536 (2015-01-15)
Molecules that stabilize protein kinases may be useful in overcoming the deleterious effects of cryopreservation. To evaluate the effect of caffeine treatment before vitrification of in vitro matured ovine oocytes on the activity of MPF and MAPK as well as...
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