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" no prazo de Papéis
Stefanie Grabrucker et al.
Brain : a journal of neurology, 137(Pt 1), 137-152 (2013-11-28)
Proteins of the ProSAP/Shank family act as major organizing scaffolding elements within the postsynaptic density of excitatory synapses. Deletions, mutations or the downregulation of these molecules has been linked to autism spectrum disorders, the related Phelan McDermid Syndrome or Alzheimer's
Dönem Avci et al.
Molecular cell, 56(5), 630-640 (2014-12-03)
Proteolysis by aspartyl intramembrane proteases such as presenilin and signal peptide peptidase (SPP) underlies many cellular processes in health and disease. Saccharomyces cerevisiae encodes a homolog that we named yeast presenilin fold 1 (Ypf1), which we verify to be an
L Eugene Arnold et al.
Journal of child and adolescent psychopharmacology, 15(4), 619-627 (2005-09-30)
The aim of this study was to review the published evidence for a role of zinc nutrition in attention-deficit/hyperactivity disorder (ADHD). A computer literature search was supplemented by the authors' knowledge. Numerous controlled studies report cross-sectional evidence of lower zinc
S S Park et al.
Journal of wound care, 24(1), 23-33 (2014-12-30)
Wound healing is enhanced in the presence of an external electrical field. The purpose of this study was first to investigate whether microelectric potentials (EPs) can be generated when the innovative design of a silver (Ag)- and zinc (Zn)-printed wound
Cristiane Cominetti et al.
Obesity surgery, 16(4), 448-453 (2006-04-13)
Previous researchers have found that the nutritional zinc status in obese and diabetic subjects is altered: low zinc concentrations in plasma and erythrocytes with high urinary zinc excretion were observed. This study assessed the influence of the Roux-en-Y gastric bypass
Wen-Lin An et al.
Brain research. Molecular brain research, 135(1-2), 40-47 (2005-04-29)
Zinc levels are increased in brain areas severely affected by Alzheimer's disease (AD) pathologies. Zinc has both protective and neurotoxic properties and can stimulate both phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. Several kinases related to these pathways
Georges Chreifi et al.
Biochemistry, 53(25), 4216-4223 (2014-05-14)
The nitric oxide synthase (NOS) dimer is stabilized by a Zn(2+) ion coordinated to four symmetry-related Cys residues exactly along the dimer 2-fold axis. Each of the two essential tetrahydrobiopterin (H4B) molecules in the dimer interacts directly with the heme
Zinc and copper toxicity in host defense against pathogens: Mycobacterium tuberculosis as a model example of an emerging paradigm.
Olivier Neyrolles et al.
Frontiers in cellular and infection microbiology, 3, 89-89 (2013-12-19)
Włodzimierz Opoka et al.
Acta poloniae pharmaceutica, 70(6), 961-965 (2014-01-05)
Zinc is an interesting target for detection as it is one of the elements necessary for the proper functioning of the human body, its excess and deficiency can cause several symptoms. Several techniques including electrochemistry have been developed but require
Eleni Kouremenou-Dona et al.
The Science of the total environment, 359(1-3), 76-81 (2005-06-16)
Serum copper and zinc concentrations of 506 (414 males and 92 females) apparently healthy Greek blood donors aged 18-60 years old were determined by flame atomic absorption spectrometry. The mean copper and zinc concentrations were 115.46+/-23.56 microg/dl and 77.11+/-17.67 microg/dl
Najjapak Sooksawat et al.
Journal of environmental sciences (China), 25(3), 596-604 (2013-08-08)
The ability for usage of common freshwater charophytes, Chara aculeolata and Nitella opaca in removal of cadmium (Cd), lead (Pb) and zinc (Zn) from wastewater was examined. C. aculeolata and N. opaca were exposed to various concentrations of Cd (0.25
Johan Hattne et al.
Nature methods, 11(5), 545-548 (2014-03-19)
X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and without radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous
M E Kuyumcu et al.
European review for medical and pharmacological sciences, 17(11), 1467-1471 (2013-06-19)
Zinc is one of the most important elements for human body. Zinc deficiency can occur in any age, if it is seen in elderly its clinical results can be more harmful due to already diminished functions. Some studies showed zinc
T Takagi et al.
Journal of chromatography, 272(2), 279-285 (1983-02-11)
The levels of putrescine, cadaverine, spermidine and spermine in uremic plasma were determined with an automatic polyamine analyzer with a 7.5 X 0.2 cm I.D. cation-exchange column using a stepwise sodium chloride gradient. All four polyamines were higher in ten
Yanhui Shi et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9390-9395 (2014-07-01)
Multicomponent self-assembly, wherein two unique donor precursors are combined with a single metal acceptor instead of the more common two-component assembly, can be achieved by selecting Lewis-basic sites and metal nodes that select for heteroligated coordination spheres. Platinum(II) ions show
Ru Qiao et al.
Journal of nanoscience and nanotechnology, 13(6), 4247-4251 (2013-07-19)
In this paper, we report a preparation of CuZn dendritic microstructures through a tunable template-free electrochemical approach. By simply tunning the applied depositing current, the morphology of the product can be well controlled. The growth mechanism of CuZn dendritic alloys
Rebecca G Mitchell et al.
Environmental pollution (Barking, Essex : 1987), 187, 162-169 (2014-02-08)
Urban gardens provide affordable fresh produce to communities with limited access to healthy food but may also increase exposure to lead (Pb) and other soil contaminants. Metals analysis of 564 soil samples from 54 New York City (NYC) community gardens
Sonia Melino et al.
The FEBS journal, 281(3), 657-672 (2013-11-14)
Natural antimicrobial peptides represent a primordial mechanism of immunity in both vertebrate and nonvertebrate organisms. Among them, histatins belong to a family of human salivary metal-binding peptides displaying potent antibacterial, antifungal and wound-healing activities. These properties, along with the ability
Kohei Takeshita et al.
Nature structural & molecular biology, 21(4), 352-357 (2014-03-04)
The voltage-gated proton channel Hv1 (or VSOP) has a voltage-sensor domain (VSD) with dual roles of voltage sensing and proton permeation. Its gating is sensitive to pH and Zn(2+). Here we present a crystal structure of mouse Hv1 in the
Marcella C Galvão et al.
Life sciences, 120, 54-60 (2014-12-03)
Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 μg/kg, intraperitoneally) on gestation day (GD) 9.5 in rats, which mimics infections by Gram-negative bacteria, induces short- and long-term behavioral and neuroimmune changes in the offspring.
Beatriz Garrido-Rodriguez et al.
Chemosphere, 107, 379-385 (2014-01-29)
Batch type and column experiments were used to study competitive adsorption-desorption and transport for Cd, Cu, Ni and Zn in a mine soil, both un-amended and amended with mussel shell. Batch type experiments showed that adsorption was affected by the
Xiang Sheng et al.
Biochemistry, 53(27), 4455-4466 (2014-06-26)
Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to produce oxaloacetate. Its activity is directly related to insulin release and thus PC has recently attracted great interest as a potential target for diabetes treatment. In this article, the catalytic mechanism
Wolfgang Maret
Metal ions in life sciences, 13, 389-414 (2014-01-29)
The vast knowledge of the physiologic functions of zinc in at least 3000 proteins and the recent recognition of fundamental regulatory functions of zinc(II) ions released from cells or within cells links this nutritionally essential metal ion to numerous diseases.
Christian Fleck et al.
Clinica chimica acta; international journal of clinical chemistry, 336(1-2), 1-12 (2003-09-23)
NO synthesis is inhibited by the dimethylarginine (DMA) ADMA, which accumulates, similar to SDMA, in the plasma of patients suffering from chronic renal failure (CRF). ADMA and possibly SDMA contribute to hypertension and atherosclerosis in patients with chronic renal disease:
M A Lovell et al.
Archives of neurology, 58(3), 392-396 (2001-03-20)
Markers of oxidative stress are increased in cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), although none of those reported are appropriate diagnostic markers because of the overlap between patients with AD and control subjects. To determine the ratio
Metals: setting a trap for copper.
Valeria Culotta
Nature chemical biology, 10(12), 986-987 (2014-10-27)
E J Pappert et al.
Neurology, 47(4), 1037-1042 (1996-10-01)
To determine if ventricular cerebrospinal fluid (vCSF) alpha-tocopherol levels in Parkinson's disease (PD) patients can be increased by oral alpha-tocopherol supplementation and whether vCSF levels are linearly related to plasma alpha-tocopherol levels. In spite of its putative neuroprotective properties, alpha-tocopherol
Osamu Oikawa et al.
Clinical and experimental nephrology, 11(4), 304-308 (2007-12-19)
Complications associated with atherosclerosis in dialysis patients are attracting attention. Fetuin-A, a circulating calcium-regulatory glycoprotein that inhibits vascular calcification, is associated with inflammation and outcome in dialysis patients. In this study, the relation between serum fetuin-A concentration and biochemical parameters
Brittany L Mortensen et al.
Journal of bacteriology, 196(14), 2616-2626 (2014-05-13)
Acinetobacter baumannii is a leading cause of ventilator-associated pneumonia in intensive care units, and the increasing rates of antibiotic resistance make treating these infections challenging. Consequently, there is an urgent need to develop new antimicrobials to treat A. baumannii infections.
Peter Stenvinkel et al.
Clinical journal of the American Society of Nephrology : CJASN, 1(2), 281-287 (2007-08-21)
Myeloperoxidase (MPO), which is secreted during activation of neutrophils, may serve as one mechanistic link among persistent inflammation, oxidative stress, and cardiovascular disease. This study related MPO activity to inflammatory and oxidative stress biomarkers, comorbidity, and ongoing medication in prevalent
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