Showing 1-30 of 50 resultados for "


Rachel Binet et al.
Antimicrobial agents and chemotherapy, 51(12), 4267-4275 (2007-10-03)
Azithromycin is a major drug used in the treatment and prophylaxis of chlamydial infections. Spontaneous azithromycin-resistant mutants of Chlamydia psittaci 6BC were isolated in vitro in the plaque assay at a frequency of about 10(-8). Isogenic clonal variants with A(2058)C...
Giuseppe Alessio Messano et al.
Igiene e sanita pubblica, 67(6), 697-706 (2012-04-18)
Antibiotic resistance is an emerging public health problem especially due to the continuous use of antibiotics that selects more aggressive and resistant species. In the present study the authors determined the antibiotic sensitivity of 128 Mycoplasma hominis strains obtained from...
Fragmentation pathways of new aza derivatives of 16-membered macrolide antibiotic--analog of Josamycin investigated by ESI and FAB mass spectrometric methods.
Piotr Przybylski et al.
Journal of mass spectrometry : JMS, 44(9), 1395-1401 (2009-07-02)
U Colombo et al.
Minerva ginecologica, 50(11), 491-497 (1999-01-12)
The macrolides are among the most effective antibiotics against infections due to Chlamydia and Mycoplasma. The drug in such cases must have marked antibacterial activity, good oral bioavailability, and high intracellular diffusion--indispensable for instance with Chlamydia infection. Rokitamycin, a macrolide...
Biyang Deng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 859(1), 125-130 (2007-10-12)
A novel determination method for josamycin (JOS) based on capillary electrophoresis-electrochemiluminescence detection has been described. In this study, platinum disk electrode (300 microm in diameter) was used as a working electrode and the conditions affecting separation and detection were investigated...
Maki Kanda et al.
Journal of AOAC International, 98(1), 230-247 (2015-04-11)
Residues of 37 polar veterinary drugs belonging to six families (quinolones, tetracyclines, macrolides, lincosamides, sulfonamides, and others) in livestock and fishery products were determined using a validated LC-MS/MS method. There were two key points in sample preparation. First, extraction was...
I V Andreeva et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 57(5-6), 32-40 (2012-11-20)
The aim of the study was to estimate the diagnostic and treatment patterns in the management of acute nongonococcal urethritis (NGU) in males in some cities of Russia. Retrospective cross-sectional study was conducted in 2009 in 5 centers of 4...
Lihong Gao et al.
Environmental science and pollution research international, 22(15), 11360-11371 (2015-03-26)
The recycling of reclaimed wastewater for irrigation and road cleaning is an important strategy to minimize water scarcity in megacities. However, little is known regarding the potential accumulation of antibiotics contained in reclaimed wastewater in urban soil. We investigated the...
Wenhui Li et al.
Environmental science. Processes & impacts, 17(9), 1611-1619 (2015-08-08)
The occurrence and distribution of 22 antibiotics, including eight fluoroquinolones, nine sulfonamides and five macrolides, were investigated in the urban surface waters in Beijing, China. A total of 360 surface water samples were collected from the main rivers and lakes...
Two unusual glandular presentations of tick-borne tularemia.
P Charles et al.
Medecine et maladies infectieuses, 38(3), 159-161 (2008-01-15)
Yun Zhou et al.
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 25(3), 201-204 (2011-10-08)
To explore the effects of mycoplasma and chlamydia infections on tubal infertilityand to assess the antibiotic susceptibility and resistance of female urogenital, and consequently to guide clinical rational drug use. 327 tubal infertility women as infertility group and 286 healthy...
Xue-Mei Ou et al.
Respirology (Carlton, Vic.), 13(1), 63-72 (2008-01-17)
To examine the effect of a 14-membered ring macrolide on airway mucus hypersecretion in rats treated with LPS. Mucus hypersecretion in rat airways was induced by intratracheal instillation of LPS. Rats treated with or without LPS were administered roxithromycin (1-10...
Lisa K Smith et al.
Antimicrobial agents and chemotherapy, 52(5), 1703-1712 (2008-02-27)
The methyltransferase genes erm(B) and cfr are adjacent to each other in the chromosome of methicillin-resistant Staphylococcus aureus strain CM05. Analyses of the transcriptional organization of the erm(B) and cfr genes in the chromosome of strain CM05 showed that the...
I V Khamaganova et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (1)(1), 90-93 (2011-03-31)
To study efficacy of complex therapy of urogenital infections caused by Chlamydia and Mycoplasma using immunomodulator Superlimph. Fifty males and thirty six females ages 22 - 47 years old with chronic urogenital infections--cervicitis and vulvovaginitis (females), prostatitis (males)--were studied. PCR...
Outcome of very preterm infants with Mycoplasma/Ureaplasma airway colonization treated with josamycine.
H See et al.
Acta paediatrica (Oslo, Norway : 1992), 99(4), 625-626 (2010-01-09)
M Weidlich et al.
Letters in applied microbiology, 46(2), 155-159 (2007-11-22)
Evaluation of the activity profiles of standard prokaryotic translation inhibitors with different physicochemical properties under whole-cell and cell-free conditions. The minimal inhibitory concentration values (cell-free/whole-cell microg ml(-1)) for three aminoglycosides (neomycin, 0.01/6.92; paromomycin, 0.7/1.96; streptomycin 1.45/1.57), three macrolides (erythromycin, 1.53/56.9;...
Takeshi Shimizu et al.
Mediators of inflammation, 2012, 265714-265714 (2012-05-12)
To examine the in vivo effects of the 15-member macrolide, azithromycin (AZM), on mucus hypersecretion, we induced hypertrophic and metaplastic changes of goblet cells in rat nasal epithelium by intranasal instillation of ovalbumin (OVA) in OVA-sensitized rats, or by intranasal...
Christopher A Elkins et al.
Antimicrobial agents and chemotherapy, 51(3), 923-929 (2007-01-11)
AcrAB-TolC is the major, constitutively expressed tripartite multidrug efflux system in Escherichia coli that recognizes various structurally unrelated molecules, including many antibiotics, dyes, and steroids. The AcrB inner membrane pump portion of the efflux system has been shown in recent...
Piotr Przybylski et al.
Magnetic resonance in chemistry : MRC, 48(4), 286-296 (2010-02-27)
Four new hydroxy-aminoalkyl derivatives of alpha,beta-unsaturated macrolide-josamycin (2-5) have been synthesised and their structures have been studied by means of (1)H and (13)C NMR and FT-IR methods. Complete assignment of resonances in the (1)H and (13)C NMR spectra has been...
Qiang Xue et al.
Environmental science and pollution research international, 22(21), 16857-16867 (2015-06-25)
An optimized solid-phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray tandem mass spectrometry (UPLC-MS/MS) method was developed for the effective analysis of 35 antibiotics including sulfonamides (SAs), quinolones (QLs), tetracyclines (TCs), macrolides (MALs), lincomycin (LIN), and chloramphenicol (CAP). The addition...
Iu N Perlamutrov et al.
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury, (3)(3), 45-51 (2013-07-04)
The prevalence of cytomegalovirus infection (CMVI) dictates the necessity of its in-depth investigation in the patients presenting with the signs of chronic inflammatory diseases of sexual organs. The objective of the present study was to estimate the effectiveness of combined...
Yu-Hong Min et al.
Archives of pharmacal research, 31(3), 377-380 (2008-04-15)
Frequencies of spontaneous mutation from inducible resistance to constitutive resistance were determined for the four clinical isolates of erythromycin-resistant enterococci, including one isolate with ermB gene and three clinical isolates with ermA gene. The rate of ermB mutation was higher...
Martin Lovmar et al.
Biochimie, 91(8), 989-995 (2009-05-26)
Macrolide antibiotics block the entrance of nascent peptides to the peptide exit tunnel of the large ribosomal subunit. Expression of specific cis-acting peptides confers low-level macrolide-resistance. We show that, in the case of josamycin, peptide expression does not eject josamycin...
[A tick bite and lymphadenosis benigna cutis in childhood. Their treatment with josamycin].
I Querol Nasarre et al.
Anales espanoles de pediatria, 39(3), 251-254 (1993-09-01)
Deli Xin et al.
Antimicrobial agents and chemotherapy, 53(5), 2158-2159 (2009-03-11)
Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point...
Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro.
K Morikawa, F Oseko, et al.
Antimicrobial Agents and Chemotherapy, 38, 2634-2647 (1994)
Pushp R Nepal et al.
International journal of pharmaceutics, 341(1-2), 85-90 (2007-05-09)
The aim of this study was to develop floating microspheres with practical applications to fish farming. Each microsphere with a central hollow cavity was prepared using a solvent diffusion and evaporation method with Eudragit E100. Various manufacturing parameters were investigated...
Yang Liu et al.
Antimicrobial agents and chemotherapy, 53(5), 2160-2162 (2009-03-11)
Fifty-three Mycoplasma pneumoniae strains were isolated from pediatric patients in Shanghai, China, from October 2005 to February 2008. Of 53 clinical isolates, 44 (83%) were resistant to erythromycin (MICs of >128 microg/ml for all 44 strains), azithromycin, and clarithromycin. All...
Tatsuya Tsuda et al.
Antimicrobial agents and chemotherapy, 52(4), 1538-1541 (2008-01-24)
The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes. Those macrolides may attenuate the protease-activated receptor...
Elena Ortega et al.
The Journal of antimicrobial chemotherapy, 53(2), 367-370 (2004-01-20)
The aim of this study was to determine whether pre-incubation of peritoneal or splenic cells with different doses of the macrolides erythromycin A (14-membered ring), azithromycin (15-membered ring) and josamycin (16-membered ring) affects their phagocytic activity or cytokine production. Peritoneal...