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Blagovesta Popova et al.
PloS one, 10(9), e0136778-e0136778 (2015-09-12)
A major challenge in gene library generation is to guarantee a large functional size and diversity that significantly increases the chances of selecting different functional protein variants. The use of trinucleotides mixtures for controlled randomization results in superior library diversity
Maciej Jarosz et al.
Analytica chimica acta, 851, 72-77 (2014-12-03)
Electrospray ionization mass spectrometry (ESI-MS) techniques have been used to characterize the speciation of a Ru(III) anticancer drug, indazolium trans-[tetrachloridobis(1H-indazole) ruthenate(III)], upon its binding to transferrin and the impact of cellular reducing components on drug-transferrin adducts. Using time-of-flight ESI-MS, the
Vidula Kolhatkar et al.
Pharmaceutical research, 32(1), 196-210 (2014-08-06)
An oligonucleotide termed 'T-oligo' having sequence homology with telomere overhang has shown cytotoxicity in multiple cancers. We have demonstrated that T-oligo can induce apoptosis in androgen independent prostate cancer cell line DU-145. In this report, we evaluate the use of
S Astals et al.
Water research, 81, 208-215 (2015-06-13)
Despite the importance of quantifying inhibitory capacity of compounds in anaerobic digestion, there is currently no well-defined method to assess it. Experimental methods in literature are frequently time-consuming and resource intensive. As a result, detailed inhibition testing rarely forms part
Panfeng Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 55-61 (2014-04-29)
This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites
Małgorzata Cebo et al.
Analytical and bioanalytical chemistry, 406(30), 8013-8020 (2014-10-31)
Isotope exchange at the histidine C2 atom of imidazole in D2O solution is well known to occur at a significantly slower rate than the exchange of amide protons. Analysis of the kinetics of this isotope-exchange reaction is proposed herein as
T T H Pham et al.
Biochimie, 107 Pt A, 143-153 (2014-06-22)
Visceral leishmaniasis is a life-threatening disease that affects nearly a million people every year. The emergence of Leishmania strains resistant to existing drugs complicates its treatment. The purpose of this study was to develop a new lipid formulation based on
Hui Peng et al.
Environmental science & technology, 49(5), 2999-3006 (2015-01-27)
Ultra-High Resolution LC/mass spectrometry (LC-UHRMS; Thermo Fisher Q-Exactive) was used to identify two novel isomers of hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-TBPH) which were unexpectedly observed in a commercial standard of TBPH. By combining ultra-high resolution (UHR) mass spectra (MS(1)), mass errors to
Javad Tashkhourian et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 152, 119-125 (2015-07-24)
A rapid, simple and inexpensive spectrofluorimetric sensor for determination of doxycycline based on its interaction with thioglycolic acid-capped cadmium telluride quantum dots (TGA/CdTe QDs) has been developed. Under the optimum experimental conditions, the sensor exhibited a fast response time of
Nahid Dayyani et al.
European journal of medicinal chemistry, 98, 190-202 (2015-05-30)
Novel pH-sensitive, biocompatible and biodegradable magneto-dendrimers with OH and/or NH2 functional groups based on poly amino-ester were synthesized for delivery of anti-cancer drugs. Magnetite nanoparticles (MNPs) were synthesized by the co-precipitation method and their surfaces were modified by 3-aminopropyl triethoxysilane.
M Isabel Barba et al.
Talanta, 147, 111-116 (2015-11-26)
This paper proposes a methodology based on short-wave near-infrared spectroscopy to determine the ammonia content of ammonia/water mixtures with ammonia mass fraction in the range 0.35-0.65. Establishing this methodology meant modeling the relationship between the pressure bar (15-25)bar, temperature (20-50)°C
Yifen Wen et al.
Colloids and surfaces. B, Biointerfaces, 133, 246-253 (2015-06-30)
Polysaccharide-based crosslinked nanogles (bionanogels) exhibiting multiple stimuli-responsive release of encapsulated therapeutics hold a great potential as tumor-targeting intracelluar durg delivery nanocarriers. Herein, we report the synthesis of monodisperse dual temperature/acidic pH-responsive bionanogels (DuR-BNGs) by aqueous crosslinking polymerization through temperature-induced self-association
Amir Behzadnia et al.
Journal of photochemistry and photobiology. B, Biology, 149, 103-115 (2015-06-10)
Here, a simple processing route is introduced for preparation of N-doped nano structure ZnO at 75-80°C using in-situ sonosynthesis method through hydrolysis of zinc acetate at pH≈9-10 adjusting with ammonia. Synthesis and fabrication of nano N-doped ZnO were carried out
Kazuo Hotta et al.
Anticancer research, 35(9), 4681-4689 (2015-08-09)
We investigated whether hepatic multidrug resistance-associated protein 2 (ABCC2) is involved in the hepatobiliary excretion of regorafenib, a novel multi-kinase inhibitor, using Sprague-Dawley (SD) rats and Eisai hyperbilirubinemic rats (EHBR) lacking the efflux transporter ABCC2. The involvement of organic anion-transporting
Laurie Bruzzese et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(2), 140-147 (2015-05-23)
The nucleoside adenosine acts on the nervous and cardiovascular systems via the A2A receptor (A2AR). In response to oxygen level in tissues, adenosine plasma concentration is regulated in particular via its synthesis by CD73 and via its degradation by adenosine
A Wallner et al.
Nature communications, 6, 5956-5956 (2015-01-21)
Half of the heavy elements including all actinides are produced in r-process nucleosynthesis, whose sites and history remain a mystery. If continuously produced, the Interstellar Medium is expected to build-up a quasi-steady state of abundances of short-lived nuclides (with half-lives
Luqman Atanda et al.
ChemSusChem, 8(17), 2907-2916 (2015-08-05)
A water-THF biphasic system containing N-methyl-2-pyrrolidone (NMP) was found to enable the efficient synthesis of 5-hydroxymethylfurfural (HMF) from a variety of sugars (simple to complex) using phosphated TiO2 as a catalyst. Fructose and glucose were selectively converted to HMF resulting
Yossi Shemesh et al.
Nucleosides, nucleotides & nucleic acids, 34(11), 753-762 (2015-10-01)
Carboxylates and dicarboxylates are important phosphate mimics. Herein, we present a simple synthetic route for the preparation of RNA carboxylate/dicarboxylate conjugates, starting from suitably protected NH2- and COOH-containing molecules that are coupled to the RNA on the solid support. The
Varongsiri Kemsawasd et al.
Applied microbiology and biotechnology, 99(23), 10191-10207 (2015-08-11)
In this study, the influence of twenty different single (i.e. 19 amino acids and ammonium sulphate) and two multiple nitrogen sources (N-sources) on growth and fermentation (i.e. glucose consumption and ethanol production) performance of Saccharomyces cerevisiae and of four wine-related
Marion Vallet et al.
Kidney international, 88(1), 137-145 (2015-03-12)
Recent studies suggest that alkalinizing treatments improve the course of chronic kidney disease (CKD), even in patients without overt metabolic acidosis. Here, we tested whether a decreased ability in excreting urinary acid rather than overt metabolic acidosis may be deleterious
Susana Sadler Simões et al.
Forensic science international, 243, 117-125 (2014-08-16)
An UPLC-MS/MS method using ESI+ionization and MRM was developed and fully validated according to international guidelines for the qualitative and quantitative analysis of nine synthetic cannabinoids and/or their metabolites in urine samples (1mL). Prior to extraction the samples were subjected
Vernal N Richards et al.
Nuclear medicine and biology, 42(6), 530-535 (2015-03-26)
A proof of concept study was undertaken where non-carrier added (186 g)Re was produced from the cyclotron bombardment of (186)WC. (186)WC was carbo-thermally generated from a novel precursor synthesized from (186)WO3, aqueous ammonia and hexamethyltetramine. The inherent high electrical and
Lina Zuluaga-Idárraga et al.
Journal of pharmaceutical and biomedical analysis, 95, 200-206 (2014-04-01)
One of the most important aspects regarding the therapeutic efficacy of antimalarials is its quantification in biologic fluids. The detection and measurement of antimalarial drug levels is important for demonstrating (1) adequate absorption of the drug being given, (2) compliance
Andrea Speltini et al.
Journal of chromatography. A, 1379, 9-15 (2015-01-07)
This work presents a novel analytical method based on graphene for the determination of five widely used fluoroquinolones (FQs) in aqueous matrices. The procedure entails solid-phase extraction (SPE) on graphene-derivatized silica (200mg), followed by liquid chromatography with fluorescence detection. Monolayer
Bahram Ebrahimi et al.
Journal of AOAC International, 98(3), 822-827 (2015-06-19)
A sensitive and low cost SPE method for the extraction, preconcentration, and flame atomic absorption spectrometric determination of nickel at ng/mL levels is described. Parameters governing the extraction efficiency including pH of the solution, eluent type, sample volume, and matrix
Wei Sun et al.
International immunopharmacology, 23(1), 247-253 (2014-09-15)
Resolvin D1 (RvD1), an endogenous lipid mediator derived from docosahexaenoic acid, has been reported to promote a biphasic activity in anti-inflammatory response and regulate inflammatory resolution. The present study aimed to determine the endogenous expression pattern of RvD1 in a
Mahesh Kumar Joshi et al.
Journal of colloid and interface science, 453, 159-168 (2015-05-20)
In this study, a fly ash based composite, Ag-iron oxide/fly ash, was synthesized via a facile one-pot hydrothermal process using fly ash, ferrous chloride, and silver nitrate as precursors. Field emission scanning electron microscopy (FE-SEM), EDX, transmission electron microscopy (TEM)
Wenpei Fan et al.
Biomaterials, 35(32), 8992-9002 (2014-08-12)
To achieve the accurate diagnosis and efficient in situ therapy of malignant tumors is encouraging but still remains a big challenge. The integration of upconversion nanoparticles and mesoporous silica that can combine the diagnostic/therapeutic functions within a single platform, may
Yuan-long Wang et al.
Foodborne pathogens and disease, 12(8), 693-703 (2015-08-11)
A precise and simplified method of sample preparation for the simultaneous quantification of the antibiotics β-lactam, macrolide, tetracycline, sulfonamide, and quinolone in bovine milk was developed. The central composite design of response surface methodology was used to design and optimize
Han Yao et al.
Journal of pharmaceutical and biomedical analysis, 117, 232-239 (2015-09-18)
L-asparaginase is an effective anti-tumor agent for acute lymphoblastic leukemia. This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality control purposes, in accordance with analytical Quality by Design principles. Critical method attributes, the absorbance
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