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Muriel Babey et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(6), 1064-1076 (2014-12-17)
The primary goal of this study was to determine whether the IGF1R in mature osteoblasts and osteocytes was required for the catabolic actions of continuous parathyroid hormone (cPTH). Igf1r was deleted from male and female FVN/B mice by breeding with
F Munarin et al.
International journal of biological macromolecules, 72, 199-209 (2014-08-12)
Pectin-based biocomposite hydrogels were produced by internal gelation, using different hydroxyapatite (HA) powders from commercial source or synthesized by the wet chemical method. HA possesses the double functionality of cross-linking agent and inorganic reinforcement. The mineralogical composition, grain size, specific
Dariusz Wawro et al.
International journal of molecular sciences, 12(11), 7286-7300 (2011-12-17)
This paper describes a method for preparing chitosan fibers modified with hydroxyapatite (HAp), tricalcium phosphate (β-TCP), and HAp/β-TCP nanoparticles. Fiber-grade chitosan derived from the northern shrimp (Pandalus borealis) and nanoparticles of tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) suspended in a
Weihong Qu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 15-22 (2015-04-05)
Column chromatography has been widely used as a scalable purification strategy for recombinant adeno-associated virus (rAAV) vectors. The rAAV1, 2, 4, 5, 6, 8 and 9 serotypes could be separated using affinity resins, ion exchange resins or other types of
Ruixue Yin et al.
Materials science & engineering. C, Materials for biological applications, 46, 239-245 (2014-12-11)
In this work, hydroxyapatite (HA) was first dispersed into cyclic acetal unit based monomers (EHD), and then EHD/HA composites were obtained by in-situ photopolymerization. FTIR and XRD analyses were used to successfully confirm the chemical composition of this composite. Real-time
Jing Yao et al.
Journal of controlled release : official journal of the Controlled Release Society, 170(3), 414-420 (2013-06-25)
Anti-herpes simplex virus (HSV) drug acyclovir (ACV) is phosphorylated by the viral thymidine kinase (TK), but not the cellular TK. Phosphorylated ACV inhibits cellular DNA synthesis and kills the infected cells. We hypothesize that ACV monophosphate (ACVP), which is an
A I Espirito Santo et al.
Biochemical and biophysical research communications, 464(4), 1145-1150 (2015-07-26)
The treatment of autoimmune disorders has been revolutionised by the introduction of biologics such as anti-tumour necrosis factor (anti-TNF). Although in rheumatoid arthritis patients a bone sparing effect of anti-TNF has been shown, the mechanism is not fully understood. Anti-TNF
David Pastorino et al.
Acta biomaterialia, 28, 205-214 (2015-09-20)
Characterization of the intricate pore structure of calcium phosphate cements is a key step to successfully link the structural properties of these synthetic bone grafts with their most relevant properties, such as in vitro or in vivo behaviour, drug loading
Giulia Pavani et al.
Blood, 124(7), 1157-1165 (2014-06-25)
Recombinant activated human factor VII (rhFVIIa) is an established hemostatic agent in hemophilia, but its mechanism of action remains unclear. Although tissue factor (TF) is its natural receptor, rhFVIIa also interacts with the endothelial protein C receptor (EPCR) through its
Shih-Yeh Lin et al.
Biotechnology and bioengineering, 112(10), 2005-2015 (2015-05-23)
Enterovirus 71 (EV71) is responsible for the outbreaks of hand-foot-and-mouth disease in the Asia-Pacific region. To produce the virus-like particle (VLP) vaccine, we previously constructed recombinant baculoviruses to co-express EV71 P1 polypeptide and 3CD protease using the Bac-to-Bac(®) vector system.
Betul Kul Babur et al.
Cell and tissue research, 361(3), 755-768 (2015-05-01)
Engineered biphasic osteochondral tissues may have utility in cartilage defect repair. As bone-marrow-derived mesenchymal stem/stromal cells (MSC) have the capacity to make both bone-like and cartilage-like tissues, they are an ideal cell population for use in the manufacture of osteochondral
Ana Maria S Simão et al.
Calcified tissue international, 93(3), 222-232 (2013-08-15)
During endochondral bone formation, chondrocytes and osteoblasts synthesize and mineralize the extracellular matrix through a process that initiates within matrix vesicles (MVs) and ends with bone mineral propagation onto the collagenous scaffold. pH gradients have been identified in the growth
Lyndon F Charles et al.
Experimental gerontology, 64, 62-69 (2015-02-15)
There is an age-associated reduction in the bone healing activity of bone morphogenetic protein-2 (BMP-2) that is currently addressed by administering higher doses of BMP-2 in elderly patients. The unwanted medical complications from high dose BMP-2 motivated this investigation to
Priscila Tomie Leme Ike et al.
SpringerPlus, 4, 654-654 (2015-11-07)
In this work we have identified, using mass spectrometry, two laccases produced by Leucoagaricus gongylophorus. One of them, Lac1Lg, was isolated, purified and characterized. Lac1Lg, a monomeric enzyme, was studied using ABTS and syringaldazine substrates. Lac1Lg presented kcat/Km almost threefold
Niladri Nath Panda et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(5), 971-982 (2014-09-02)
This study evaluated the mechanical properties and osteogenic potential of a silk fibroin scaffold prepared from a 70:30 blend of Eri (Philosamia ricini) and Tasar (Antheraea mylitta) silk, respectively (ET scaffolds). An electrospinning process was used to prepare uniformly blended
Jie Deng et al.
Oral oncology, 51(9), 824-831 (2015-07-23)
Concurrent chemoradiation (CCR) therapy is a standard treatment for patients with locally advanced head and neck cancer (HNC). It is well documented that CCR causes profound acute and late toxicities. Xerostomia (the symptom of dry mouth) and hyposalivation (decreased salivary
Yoshikuni Goto et al.
Journal of biochemistry, 157(6), 439-449 (2015-01-13)
In this study, we examined the role of aminopeptidases with reference to endoplasmic reticulum aminopeptidase 1 (ERAP1) in nitric oxide (NO) synthesis employing murine macrophage cell line RAW264.7 cells activated by lipopolysaccharide (LPS) and interferon (IFN)-γ and LPS-activated peritoneal macrophages
R Osorio et al.
Journal of dental research, 93(12), 1258-1263 (2014-09-18)
To obtain more durable adhesion to dentin, and to protect collagen fibrils of the dentin matrix from degradation, calcium- and phosphate-releasing particles have been incorporated into the dental adhesive procedure. The aim of the present study was to incorporate zinc-loaded
Takaya Kurokawa et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1218-1225 (2015-05-17)
Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyldiltiazem to diltiazem
Hideyuki Arimitsu et al.
Microbiology and immunology, 59(2), 71-81 (2014-12-19)
Shiga toxin 2 (Stx2)-specific mAb-producing hybridoma clones were generated from mice. Because mice tend to produce small amounts of B subunit (Stx2B)-specific antibodies at the polyclonal antibody level after immunization via the parenteral route, mice were immunized intranasally with Stx2
Shoji Ohgami et al.
Plant physiology, 168(2), 464-477 (2015-04-30)
Tea plants (Camellia sinensis) store volatile organic compounds (VOCs; monoterpene, aromatic, and aliphatic alcohols) in the leaves in the form of water-soluble diglycosides, primarily as β-primeverosides (6-O-β-D-xylopyranosyl-β-D-glucopyranosides). These VOCs play a critical role in plant defenses and tea aroma quality
Hyun Wook Huh et al.
Carbohydrate polymers, 126, 130-140 (2015-05-03)
A biomineralized hydrogel system containing hyaluronic acid (HA) and poloxamer composed of a poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) (PEO-PPO-PEO) block copolymer was developed as a biomimetic thermo-responsive injectable hydrogel system for bone regeneration. Using HA and poloxamer macromers with polymerizable residues
Aysel Koç et al.
Journal of biomaterials applications, 29(5), 748-760 (2014-07-27)
Bone tissue is dependent on an efficient blood supply to ensure delivery of nutrients and oxygen. One method to acquire a vascular-engineered bone tissue could be the use of an angiogenic gene-activated scaffold. In the current study, porous chitosan/hydroxyapatite (C/HA)
Craig J van Dolleweerd et al.
The Journal of infectious diseases, 210(2), 200-208 (2014-02-11)
Rabies post-exposure prophylaxis (PEP) currently comprises administration of rabies vaccine together with rabies immunoglobulin (RIG) of either equine or human origin. In the developing world, RIG preparations are expensive, often in short supply, and of variable efficacy. Therefore, we are
Taichi Inui et al.
Applied and environmental microbiology, 81(16), 5471-5476 (2015-06-07)
Carbohydrate availability shifts when bacteria attach to a surface and form biofilm. When salivary planktonic bacteria form an oral biofilm, a variety of polysaccharides and glycoproteins are the primary carbon sources; however, simple sugar availabilities are limited due to low
E Buraka et al.
Chemico-biological interactions, 220, 200-207 (2014-07-13)
The ability to intercalate between DNA strands determines the cytotoxic activity of numerous anticancer drugs. Strikingly, intercalating activity was also reported for some compounds considered to be antimutagenic. The aim of this study was to determine the mode of interaction
Chen Li et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 114, 575-578 (2013-07-03)
Eu(2+)-Yb(3+) co-doped transparent glass-ceramic containing nano-Ca5(PO4)3F (FAP) was prepared in reducing atmosphere. XRD and TEM analysis indicated that nano-FAP about 40 nm precipitated homogeneously in glass matrix after heat treatment. Confirmed by spectroscopy measurements, the crystal-like absorption and emission of
Radosław Olkowski et al.
Journal of materials science. Materials in medicine, 26(12), 270-270 (2015-10-30)
Calcium phosphate cements (CPC) are valuable bone fillers. Recently they have been also considered as the basis for drug-, growth factors- or cells-delivery systems. Broad possibilities to manipulate CPC composition provide a unique opportunity to obtain materials with a wide
Lawrence M Kauvar et al.
Antimicrobial agents and chemotherapy, 59(3), 1558-1568 (2014-12-24)
Human cytomegalovirus (HCMV) is the most common infection causing poor outcomes among transplant recipients. Maternal infection and transplacental transmission are major causes of permanent birth defects. Although no active vaccines to prevent HCMV infection have been approved, passive immunization with
Shin-Woo Ha et al.
Biomaterials, 65, 32-42 (2015-07-05)
Hydroxyapatite (HA) is the primary structural component of the skeleton and dentition. Under biological conditions, HA does not occur spontaneously and therefore must be actively synthesized by mineralizing cells such as osteoblasts. The mechanism(s) by which HA is actively synthesized
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