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Shuying Huo et al.
Dalton transactions (Cambridge, England : 2003), 43(41), 15328-15336 (2014-07-31)
L-Selenomethionine (SeMet), the predominant form of selenium acquired from the diet by humans, has been used as a supplement, and exhibit some important functions like cancer prevention and antioxidative defense. Its interactions with Pt(II) anticancer drugs have been characterized, but...
Michael S Young et al.
Journal of AOAC International, 97(6), 1737-1741 (2015-01-30)
An SPE-based cleanup protocol was developed for ultra-performance LC (UPLC)/MS/MS determination of residues of the common aminoglycoside antibiotics streptomycin, dihydrostreptomycin, neomycin, and gentamicin in bovine milk, kidney, and muscle. Recoveries for all compounds except neomycin ranged from 80 to 104%...
Eagleson M.
Concise Encyclopedia Chemistry, 887-887 (1994)
O Chudomel et al.
Neurochemical research, 40(4), 747-757 (2015-02-04)
Previous studies have shown that the pharmacologic effects of GABAergic drugs and the postsynaptic phasic GABAAergic inhibitory responses in the anterior part of the rat substantia nigra pars reticulata (SNRA) are age- and sex-specific. Here, we investigate whether there are...
Songsong Zhu et al.
Cell transplantation, 23(6), 715-727 (2014-04-26)
In cartilage tissue engineering using stem cells, it is important to stimulate proliferation and control the differentiation of stem cells to specific lineages. Here we reported a combined technique for articular cartilage repair, consisting of bone marrow mesenchymal stem cells...
Henriette Franz et al.
Oncotarget, 6(7), 4773-4789 (2015-03-10)
The histone code reader Spindlin1 (SPIN1) has been implicated in tumorigenesis and tumor growth, but the underlying molecular mechanisms remain poorly understood. Here, we show that reducing SPIN1 levels strongly impairs proliferation and increases apoptosis of liposarcoma cells in vitro...
Christina Lamparter et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 59-67 (2014-06-11)
Exposure to the anticonvulsant drug valproic acid (VPA) is associated with an increased risk of congenital malformations. Although the mechanisms contributing to its teratogenicity are poorly understood, VPA has been shown to induce DNA double strand breaks (DSB) and to...
Abida Siddiqa et al.
Viruses, 6(7), 2762-2777 (2014-07-19)
Cervical cancer is the third most common cause of cancer-related death in women worldwide. Infection with high-risk human papillomavirus (HPV) is established as the cause of cervical carcinoma, therefore, high risk HPV detection may have prognostic significance for the women...
Marcello Clerici et al.
Nature communications, 5, 5399-5399 (2014-11-19)
Ubiquitin-specific protease USP4 is emerging as an important regulator of cellular pathways, including the TGF-β response, NF-κB signalling and splicing, with possible roles in cancer. Here we show that USP4 has its catalytic triad arranged in a productive conformation. Nevertheless...
Avnika A Ruparelia et al.
Acta neuropathologica, 128(6), 821-833 (2014-10-03)
Mutations in the co-chaperone Bcl2-associated athanogene 3 (BAG3) can cause myofibrillar myopathy (MFM), a childhood-onset progressive muscle disease, characterized by the formation of protein aggregates and myofibrillar disintegration. In contrast to other MFM-causing proteins, BAG3 has no direct structural role...
Fumihiro Ito et al.
MicrobiologyOpen, 3(6), 922-936 (2014-10-11)
Molecular chaperones function in various important physiological processes. Null mutants of genes for the molecular chaperone ClpB (Hsp104), and those that encode J-domain proteins (DnaJ, CbpA, and DjlA), which may act as Hsp40 co-chaperones of DnaK (Hsp70), were constructed from...
Kristy L Hentchel et al.
Journal of bacteriology, 197(2), 314-325 (2014-11-05)
Protein and small-molecule acylation reactions are widespread in nature. Many of the enzymes catalyzing acylation reactions belong to the Gcn5-related N-acetyltransferase (GNAT; PF00583) family, named after the yeast Gcn5 protein. The genome of Salmonella enterica serovar Typhimurium LT2 encodes 26...
Jessica J Buchanan et al.
Environmental technology, 34(5-8), 695-701 (2013-07-11)
Coal seam gas (CSG) is being touted as a transition fuel as the world moves towards low-carbon economies. However, the development of CSG reserves will generate enormous volumes of saline water. In this work, we investigate the potential of using...
Nawal Bahia El Idrissi et al.
Acta neuropathologica, 129(5), 653-667 (2015-03-17)
Peripheral nerve damage is the hallmark of leprosy pathology but its etiology is unclear. We previously identified the membrane attack complex (MAC) of the complement system as a key determinant of post-traumatic nerve damage and demonstrated that its inhibition is...
Adam Mechler et al.
Biochimica et biophysica acta, 1838(11), 2939-2946 (2014-08-17)
Lipid-mimetic metallosurfactant based luminophores are promising candidates for labeling phospholipid membranes without altering their biophysical characteristics. The metallosurfactants studied exhibit high structural and physicochemical similarity to phospholipid molecules, designed to incorporate into the membrane structure without the need for covalent...
Franca Vulinovic et al.
Human mutation, 35(9), 1114-1122 (2014-06-17)
A three-nucleotide (GAG) deletion (ΔE) in TorsinA (TOR1A) has been identified as the most common cause of dominantly inherited early-onset torsion dystonia (DYT1). TOR1A encodes a chaperone-like AAA+-protein localized in the endoplasmic reticulum. Currently, only three additional, likely mutations have...
Kiranj K Chaudagar et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 36(8), 557-566 (2014-02-05)
Telmisartan possesses endothelial protective effects due to angiotensin II type 1 receptor antagonist, peroxisome proliferator-activated receptor γ (PPARγ) agonist and antioxidant action. Therefore, our objective was to study effect of telmisartan on angiogenic responsiveness of coronary endothelial cells (cECs) of...
M C Pérez et al.
Applied microbiology and biotechnology, 99(1), 19-32 (2014-05-07)
The removal of styrene was studied using two biofilters packed with peat and coconut fibre (BF1-P and BF2-C, respectively) and one biotrickling filter (BTF) packed with plastic rings. Two inoculation procedures were applied: an enriched culture with strain Pseudomonas putida...
Julia Müller et al.
Basic research in cardiology, 109(6), 440-440 (2014-09-23)
Interleukin-6 (IL-6) is a multifunctional cytokine that orchestrates the immune response to a wide variety of pathophysiologic challenges but also contributes to tissue homeostasis. Furthermore, IL-6 is elevated in patients with acute myocardial infarction. Hyaluronan (HA) is an extracellular carbohydrate...
Dandan Zhang et al.
The Plant cell, 26(7), 2939-2961 (2014-07-19)
Tapetal programmed cell death (PCD) is a prerequisite for pollen grain development in angiosperms, and cysteine proteases are the most ubiquitous hydrolases involved in plant PCD. We identified a papain-like cysteine protease, CEP1, which is involved in tapetal PCD and...
G L Erre et al.
Clinical rheumatology, 33(12), 1725-1729 (2014-05-27)
Little is known regarding the environmental factors at play in igniting rheumatoid arthritis (RA) autoimmunity, although an association between Mycobacteria and RA has been documented. This pilot study focused on examining a possible involvement of Mycobacterium tuberculosis (MTB) and Mycobacterium...
Julieta L Mateos et al.
Genome biology, 16, 31-31 (2015-04-09)
The initiation of flowering is an important developmental transition as it marks the beginning of the reproductive phase in plants. The MADS-box transcription factors (TFs) FLOWERING LOCUS C (FLC) and SHORT VEGETATIVE PHASE (SVP) form a complex to repress the...
María Llorián-Salvador et al.
The Prostate, 75(1), 70-83 (2014-09-30)
Pain due to bone metastases of prostatic origin is a relevant clinical issue. We study here the nociceptive responses obtained in mice receiving the intratibial inoculation of RM1 prostate cancer cells. 10(2) -10(5) RM1 cells were inoculated to C57BL/6 mice...
Joaquín Giner-Lamia et al.
MicrobiologyOpen, 4(1), 167-185 (2014-12-30)
Copper resistance system in the cyanobacterium Synechocystis sp. PCC 6803 comprises two operons, copMRS and copBAC, which are expressed in response to copper in the media. copBAC codes for a heavy-metal efflux-resistance nodulation and division (HME-RND) system, while copMRS codes...
Helena Pětrošová et al.
Applied and environmental microbiology, 80(19), 6091-6103 (2014-07-27)
Leptospira spp. are spirochete bacteria comprising both pathogenic and free-living species. The saprophyte L. biflexa is a model bacterium for studying leptospiral biology due to relative ease of culturing and genetic manipulation. In this study, we constructed a library of...
Kenta Nishimura et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1432-1437 (2014-07-06)
This study was performed to identify genetic polymorphisms in multidrug and toxin extrusion 2-K (MATE2-K, SLC47A2), a proton/organic cation antiporter that plays a role in the transport of organic cations across the apical membrane in kidney epithelial cells into the...
Angelika Varga et al.
Pflugers Archiv : European journal of physiology, 466(7), 1421-1435 (2013-10-12)
The endogenous lipid agent N-arachidonoylethanolamine (anandamide), among other effects, has been shown to be involved in nociceptive processing both in the central and peripheral nervous systems. Anandamide is thought to be synthesised by several enzymatic pathways both in a Ca(2+)-sensitive...
Hiroshi Yoneyama et al.
Anti-cancer drugs, 26(1), 90-100 (2014-09-05)
The efficacy of gemcitabine (GEM), a standard treatment agent for pancreatic cancer, is insufficient because of primary or acquired resistance to this drug. Patients with tumors intrinsically sensitive to GEM gradually acquire resistance and require a shift to second agents...
B Li et al.
Free radical research, 48(7), 758-768 (2014-04-12)
Stromal interaction molecule (STIM) proteins are parts of elaborate eukaryotic Ca(2+) signaling systems and are considered to be important players in regulating neuronal Ca(2+) homeostasis under normal ageing and pathological conditions. Here, we investigated the potential role of STIM1 in...
Richard M Allen et al.
Drug and alcohol dependence, 147, 137-143 (2014-12-20)
Blocking N-methyl-d-aspartate (NMDA) glutamate receptors (NMDARs) prevents cocaine locomotor sensitization, but facilitates escalation of cocaine self-administration and produces ambiguous effects on acquisition of cocaine self-administration. This study used a recently described model of acquisition and escalation to test the hypothesis...
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