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Yunqing Zhu et al.
ACS nano, 8(7), 6644-6654 (2014-06-17)
The facile loading of sensitive and fragile biomacromolecules, such as glucose oxidase, hemoglobin, and ribonucleic acid (RNA), via synthetic vehicles directly in pure aqueous media is an important technical challenge. Inspired by the nucleus pore complex that connects the cell...
Stephan Schmidt et al.
Beilstein journal of organic chemistry, 11, 720-729 (2015-07-01)
Many biological functions at cell level are mediated by the glycocalyx, a dense carbohydrate-presenting layer. In this layer specific interactions between carbohydrate ligands and protein receptors are formed to control cell-cell recognition, cell adhesion and related processes. The aim of...
Chong-Ki Lee et al.
Pharmacological reports : PR, 67(1), 44-51 (2015-01-07)
This study aimed to investigate the effects of HMG-CoA reductase inhibitors on the pharmacokinetics of nifedipine in rats. We determined the pharmacokinetic parameters of nifedipine and dehydronifedipine in rats after oral and intravenous administration of nifedipine without and with HMG-CoA...
Sry D Hujaya et al.
Pharmaceutical research, 32(9), 3066-3086 (2015-04-09)
To investigate the properties of phenylboronic acid-functional poly(amido amine) polymers (BA-PAA) in forming multilayered thin films with poly(vinyl alcohol) (PVA) and chondroitin sulfate (ChS), and to evaluate their compatibility with COS-7 cells. Copolymers of phenylboronic acid-functional poly(amido amine)s, differing in...
Hideki Mizusako et al.
Journal of pharmaceutical sciences, 104(9), 2934-2940 (2015-05-06)
Active drug targeting is an effective therapeutic approach for the treatment of malignant cancers and novel types of drug carriers have been developed. In this study, we developed a cyclodextrin (CD)-based novel carrier-drug conjugate, called per-FOL-β-CD-ss-DOX, which has folic acid...
Laura Jaime et al.
Journal of the science of food and agriculture, 95(4), 722-729 (2014-06-17)
In this work three different techniques were applied to extract dry leaves of spinach (Spinacia oleracea): solid-liquid extraction (SLE), pressurised liquid extraction (PLE) and supercritical fluid extraction (SFE) to investigate the influence of extraction solvent and technique on extracts composition...
Toshiki Matsui et al.
Acta biomaterialia, 13, 32-41 (2014-12-03)
Polylactic acid (PLA) is a candidate material to prepare scaffolds for 3-D tissue regeneration. However, cells do not adhere or proliferate well on the surface of PLA because it is hydrophobic. We report a simple and rapid method for inducing...
Arik Dahan et al.
Molecular pharmaceutics, 11(12), 4385-4394 (2014-11-05)
The efficacy of chemotherapeutic drugs is often offset by severe side effects attributable to poor selectivity and toxicity to normal cells. Recently, the enzyme dipeptidyl peptidase IV (DPPIV) was considered as a potential target for the delivery of chemotherapeutic drugs....
Carolina Kato Prado et al.
Food additives & contaminants. Part B, Surveillance, 8(2), 81-84 (2014-09-24)
The aim of this study was to investigate the presence of tetracycline residues in pasteurised cow's milk using high-performance liquid chromatography coupled with UV/VIS detection to determine the exposure of Brazilian's population to antibiotic residues. One hundred samples collected from...
David Cipolla et al.
Journal of aerosol medicine and pulmonary drug delivery, 28(6), 411-422 (2015-10-16)
Previously we showed that the release properties of a liposomal ciprofloxacin (CFI) formulation could be attenuated by incorporation of drug nanocrystals within the vesicles. Rather than forming these drug nanocrystals during drug loading, they were created post manufacture simply by...
Sang-Bae Lee et al.
Biomacromolecules, 16(8), 2265-2275 (2015-07-16)
This study reports a synthetic polymer functionalized with catechol groups as dental adhesives. We hypothesize that a catechol-functionalized polymer functions as a dental adhesive for wet dentin surfaces, potentially eliminating the complications associated with saliva contamination. We prepared a random...
Wei Feng et al.
Scientific reports, 5, 17422-17422 (2015-12-04)
Photothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes...
J S Seo et al.
Journal of veterinary pharmacology and therapeutics, 38(1), 86-92 (2014-09-18)
The study was aimed at investigating the pharmacokinetics of amoxicillin trihydrate (AMOX) in olive flounder (Paralichthys olivaceus) following oral, intramuscular, and intravenous administration, using high-performance liquid chromatography following. The maximum plasma concentration (Cmax ), following oral administration of 40 and...
Dariela Almeda et al.
Biomaterials, 41, 37-44 (2014-12-20)
Liposomes may be engineered to target inflamed endothelium by mimicking ligand-receptor interactions between leukocytes and cytokine-activated endothelial cells (ECs). The upregulation and assembly of vascular cell adhesion molecule-1 (VCAM1) and E-selectin on the cell membrane upon exposure to cytokines have...
Marek Janko et al.
Biomacromolecules, 16(7), 2179-2187 (2015-06-24)
The properties of paper sheets can be tuned by adjusting the surface or bulk chemistry using functional polymers that are applied during (online) or after (offline) papermaking processes. In particular, polymers are widely used to enhance the mechanical strength of...
Ádám Tölgyesi et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(9), 1512-1522 (2015-07-28)
Alternaria toxins and citrinin are mycotoxins produced by fungi growing on different raw materials and agricultural commodities. Maximum levels of these toxins in foods are currently under consideration by the European Commission as a risk management measure. In this study...
Wesley A Hoffert et al.
Acta crystallographica. Section E, Structure reports online, 67(Pt 7), m853-m854 (2011-08-13)
In the title compound, trans,trans-[μ-(m-phenyl-ene)bis-(ethyne-1,2-di-yl)]bis-[chlorido(1,4,8,11-tetra-aza-cyclo-tetra-deca-ne)cobalt(III)]-trans,trans-[μ-(5-bromo-m-phenyl-ene)bis-(ethyne-1,2-di-yl)]bis-[chlorido(1,4,8,11-tetra-aza-cyclo-tetra-deca-ne)cobalt(III)]-tetra-phenyl-borate-acetone (0.88/0.12/2/4), [Co(2)(C(12)H(4))Cl(2)(C(10)H(24)N(4))(2)](0.88)[Co(2)(C(10)H(3)Br)Cl(2)(C(10)H(24)N(4))(2)](0.12)(C(24)H(20)B)(2)·4C(3)H(6)O, with the exception of the acetyl-ene and bromine groups, all atomic postitions are the same in the two compounds and are modeled at full occupancy. The Co(III) ions are six-coordinate with acetyl-ide and...
S Khoee et al.
Nanoscale, 7(9), 4134-4148 (2015-02-11)
The aim of this study is to investigate the effect of polymer nature on the morphology of synthesized nanoparticles. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared by co-precipitation method and then reacted with (3-mercaptopropyl) trimethoxysilane to obtain thiol-decorated SPIONs....
Patrick R Visperas et al.
The Biochemical journal, 465(1), 149-161 (2014-10-08)
Zeta-chain associated protein of 70 kDa (ZAP-70) and spleen tyrosine kinase (Syk) are non-receptor tyrosine kinases that are essential for T-cell and B-cell antigen receptor signalling respectively. They are recruited, via their tandem-SH2 (Src-homology domain 2) domains, to doubly phosphorylated immunoreceptor...
Si Wang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 78-89 (2014-06-15)
In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenicity, i.e., other...
Settimio Pacelli et al.
International journal of biological macromolecules, 72, 1335-1342 (2014-12-03)
In this work, a natural polysaccharide gellan gum (GG) has been modified with methacrylic groups (GG-MA) and combined with polyethylene glycol dimethacrylate (PEG-DMA) in order to create novel injectable hydrogels that can be easily delivered through a needle and photocross-linked...
Hadi Hajiali et al.
Biomacromolecules, 16(3), 936-943 (2015-02-07)
The broad utilization of electrospun scaffolds of sodium alginate in tissue engineering is strongly limited by their high solubility in aqueous environments and by the difficulty to adjust their degradation dynamics. Here, an alternative strategy to enhance the stability and...
F Hetmann et al.
Acta anaesthesiologica Scandinavica, 59(6), 740-748 (2015-04-25)
Persistent post-surgical pain is recognised as a major problem. Prevalence after different surgical procedures has been reported to range from 5% up to 85%. Limb amputation and thoracotomy have the highest reported prevalence. Prediction of persistent post-surgical pain has over...
Jingjing Zhang et al.
Biomedical materials (Bristol, England), 10(3), 035016-035016 (2015-06-25)
Macroporous hydrogels have shown great promise as scaffolds for cartilage engineering by facilitating nutrition transport and tissue in growth. Cell-matrix adhesion-a fundamental process in tissue engineering-has shown a profound effect on subsequent cell phenotype, extracellular matrix (ECM) accumulation, and tissue...
A Rúbies et al.
Food chemistry, 181, 57-63 (2015-03-22)
We present a simple method for extracting avermectines from meat, based on a QuEChERS approach followed by liquid chromatography (LC) coupled to triple quadrupole (QqQ) tandem mass spectrometry (MS/MS). The compounds considered are ivermectin, abamectin, emamectin, eprinomectin, doramectin and moxidectin....
Sâmia R Caruso et al.
Biotechnology progress, 30(4), 889-895 (2014-02-28)
Human mesenchymal stromal cells (hMSCs) cells are attractive for applications in tissue engineering and cell therapy. Because of the low availability of hMSCs in tissues and the high doses of hMSCs necessary for infusion, scalable and cost-effective technologies for in...
Susan Kashanian et al.
Monoclonal antibodies in immunodiagnosis and immunotherapy, 34(4), 270-274 (2015-08-25)
A monoclonal antibody (MAb) was produced by immunization of a BALB/c mouse with a conjugated morphine C6-hemisuccinated derivative (MHS) to cationized bovine serum albumin (cBSA). The hybridoma clones were screened by indirect ELISA using MHS-BSA. The best hybridoma clone was...
A Lesniak et al.
Faraday discussions, 175, 189-201 (2014-10-01)
Multifunctional nanoparticles that actively target specific cells are promising tools for cancer diagnosis and therapy. In this article we review the synthesis and surface chemistry of Fe-Au nanorods and their characterization using microscopy. The diameter of the rods used in...
Xinshuai Zhang et al.
Angewandte Chemie (International ed. in English), 51(29), 7282-7286 (2012-06-15)
A matter of protection: The outcome of a divergent organocatalytic aza-Michael/aldol cascade process toward quinolines and 1,4-dihydroquinolines depends on the choice of the N-protecting group (see scheme; TEA = triethylamine, TMS = trimethylsilyl). Use of an electron-donating sulfonyl group results...
MinHui Wang et al.
International journal of pharmaceutics, 468(1-2), 243-249 (2014-04-09)
Light- and temperature-responsive liposomes were prepared by immobilizing cinnamoyl Pluronic F127 (CP F127) on the surface of egg phosphatidylcholine liposomes. CP F127 was prepared by a condensation reaction, and the molar ratio of cinnamoyl group to Pluronic F127 was calculated...
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