Search Within
Applied Filters:
Showing 1-30 of 467 results for "


" within Papers
Sort by Relevance
Patrick O Wagers et al.
Antimicrobial agents and chemotherapy, 59(9), 5494-5502 (2015-07-01)
We present a novel family of small-molecule urinary bladder exfoliants that are expected to be of great value in preclinical studies of urologic conditions and have improved potential for translation compared with prior agents. There is broad urologic interest in
Mette D Mosgaard et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 493-500 (2015-07-15)
To develop a high-throughput in vitro intestinal lipolysis (HTP) model, without any means of pH-stat-titration, to enable a fast evaluation of lipid-based drug delivery systems (LbDDS). The HTP model was compared to the traditionally used dynamic in vitro lipolysis (DIVL)
Gyeong Jin Lee et al.
Macromolecular bioscience, 15(11), 1595-1604 (2015-07-18)
Crosslinked bioreducible polypropylenimine-cystaminebisacrylamides (PPI-CBAs) were synthesized for gene delivery systems. They formed nano-sized polyplexes with high stability even in reducing condition probably due to the re-crosslinking. PPI-CBAs displayed high transfection efficiency comparable to PEI25k in serum condition. However, cytotoxicity increase
Adhiraj Roy et al.
PloS one, 10(3), e0121985-e0121985 (2015-03-31)
The transport of glucose across the plasma membrane is mediated by members of the glucose transporter family. In this study, we investigated glucose uptake through the yeast hexose transporter 1 (Hxt1) by measuring incorporation of 2-NBDG, a non-metabolizable, fluorescent glucose
Abir Bhattacharya et al.
Journal of pharmaceutical and biomedical analysis, 70, 280-287 (2012-08-11)
Tris(hydroxymethyl) aminomethane (tris) salt of API ramipril was synthesized, and characterized by FTIR, TG-DSC and ab initio X-ray powder structure analysis. The compound, ramipril-tris (II), crystallizes in the monoclinic space group P2(1) with a=24.3341(15), b=6.4645(5), c=9.5357(7) Å, β=96.917(3)° and V=1489.1(3)
Michele Bellesi et al.
BMC biology, 13, 66-66 (2015-08-26)
Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral
Meijuan Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(5), 679-690 (2015-02-12)
DanHong injection is a Danshen (Salvia miltiorrhiza roots)-based injectable solution for treatment of coronary artery disease and ischemic stroke. Danshen catechols are believed to be responsible for the injection's therapeutic effects. This study aimed to characterize systemic exposure to and
Vadapalli Chandrasekhar et al.
Inorganic chemistry, 51(16), 8664-8666 (2012-08-08)
A new water-soluble, multisite-coordinating ligand LH(7) was prepared by the condensation of tris(hydroxymethyl)aminomethane with 2,6-diformyl-p-cresol. LH(7) is a selective chemosensor for Cu(2+), under physiological conditions, with visual detection limits of 20 ppm (ambient light conditions) and 4 ppm (UV light
Xue Fu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 139(2), 432-451 (2014-03-13)
Regulation of cellular copper (Cu) homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7B. The question as to how these Cu-ATPases in brain barrier systems transport Cu, i.e., toward brain parenchyma, cerebrospinal fluid (CSF), or blood, remained unanswered. This study
P J Noy et al.
Oncogene, 34(47), 5821-5831 (2015-03-10)
We previously identified CLEC14A as a tumour endothelial marker. Here we show that CLEC14A is a regulator of sprouting angiogenesis in vitro and in vivo. Using a human umbilical vein endothelial cell spheroid-sprouting assay, we found CLEC14A to be a
Anna Miodek et al.
Sensors (Basel, Switzerland), 15(10), 25015-25032 (2015-10-02)
An aptasensor with enhanced anti-fouling properties has been developed. As a case study, the aptasensor was designed with specificity for human thrombin. The sensing platform was developed on screen printed electrodes and is composed of a self-assembled monolayer made from
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Celia Fernández-Blanco et al.
Toxicology letters, 235(2), 61-66 (2015-04-02)
Oxidative stress occurs as a consequence of an imbalance between the prooxidant/antioxidant systems, causing an increase of intracellular generation of reactive oxygen species. Alternariol (AOH), a mycotoxin produced by Alternaria sp. can alter the action of glutathione (GSH) and the
Masashi Ohno et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(10), 979-986 (2015-10-16)
Changes in the interfacial tension of a lipid monolayer membrane formed at the water/chloroform interface upon DNA addition were measured using the quasi-elastic laser scattering (QELS) method. A cationic lipid, N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTAP), as well as zwitterionic lipids, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
E Halevas et al.
Journal of inorganic biochemistry, 147, 99-115 (2015-04-30)
Among the various roles of vanadium in the regulation of intracellular signaling, energy metabolism and insulin mimesis, its exogenous activity stands as a contemporary challenge currently under investigation and a goal to pursue as a metallodrug against Diabetes mellitus II.
Enze Wang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 152, 327-335 (2015-08-02)
A dual-function optical chemosensor (RBF) was designed and easily synthesized by condensation reaction of 5-Hydroxymethylfurfural and rhodamine B hydrazide. RBF exhibited highly sensitive, highly selective and quick response to acidic pH. The fluorescence intensity of RBF exhibited a more than
H L Bleich et al.
The New England journal of medicine, 274(14), 782-787 (1966-04-07)
It has been the purpose of this discussion to review critically the physiologic considerations and clinical evidence regarding the use of Tris buffer in the treatment of acid-base disorders. It is concluded that there is little current evidence, theoretical, experimental
Shih-Hao Hu et al.
Biotechnology progress, 28(6), 1443-1449 (2012-08-24)
A peptide, N-Ac-Phe-Tyr-NH(2) , with angiotensin I-converting enzyme (ACE) inhibitor activity was synthesized by an α-chymotrypsin-catalyzed condensation reaction of N-acetyl phenylalanine ethyl ester (N-Ac-Phe-OEt) and tyrosinamide (Tyr-NH(2) ). Three kinds of solvents: a Tris-HCl buffer (80 mM, pH 9.0), dimethylsulfoxide
Alfred N Fonteh et al.
PloS one, 10(5), e0125597-e0125597 (2015-05-06)
Sphingolipids are important in many brain functions but their role in Alzheimer's disease (AD) is not completely defined. A major limit is availability of fresh brain tissue with defined AD pathology. The discovery that cerebrospinal fluid (CSF) contains abundant nanoparticles
M Vergara-Barberán et al.
Food chemistry, 169, 28-33 (2014-09-23)
The improvement of protein extraction from olive leaves using an enzyme-assisted protocol has been investigated. Using a cellulase enzyme (Celluclast® 1.5L), different parameters that affect the extraction process, such as the influence and amount of organic solvent, enzyme amount, pH
Ryosuke Shimizu et al.
Journal of pharmacokinetics and pharmacodynamics, 42(1), 67-77 (2014-11-08)
Second-generation antisense oligonucleotides (ASOs) demonstrate excellent biological stability and in vitro/in vivo potency, and thus are considered to be attractive candidates for drugs to treat various diseases. A pharmacokinetic-pharmacodynamic (PK-PD) model of ASOs is desired for the design of appropriate
Lourdes Infantes et al.
Journal of molecular biology, 423(4), 503-514 (2012-08-28)
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen. It colonizes different tissues by the utilization of diverse mechanisms. One of these may involve the breakdown of the host cell membrane through the sequential action of hemolytic phospholipase C and phosphorylcholine phosphatase
R.C. Ogden et al.
Methods in Enzymology, 152, 65-65 (1987)
N Boknäs et al.
Thrombosis and haemostasis, 112(3), 558-565 (2014-07-06)
Thrombin-induced platelet activation via PAR1 and PAR4 is an important event in haemostasis. Although the underlying mechanisms responsible for ensuring efficient PAR1 activation by thrombin have been extensively studied, the potential involvement of recognitions sites outside the active site of
Chitra Rani et al.
Tuberculosis (Edinburgh, Scotland), 95(6), 664-677 (2015-09-01)
N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is a pivotal bifunctional enzyme, its N and C terminal domains catalyzes uridyltransferase and acetyltransferase activities, respectively. Final product of GlmU catalyzed reaction, uridine-diphospho-N-acetylglucosamine (UDP-GlcNAc), acts as sugar donor providing GlcNAc residues in the synthesis of peptidoglycan
Peng Guo et al.
Theranostics, 6(1), 1-13 (2016-01-02)
Lipocalin 2 (Lcn2) is a promising therapeutic target as well as a potential diagnostic biomarker for breast cancer. It has been previously shown to promote breast cancer progression by inducing the epithelial to mesenchymal transition in breast cancer cells as
Magnus Rogeberg et al.
Biochimie, 105, 216-220 (2014-07-11)
Deposition of insoluble amyloid plaques is one of the known hallmarks of Alzheimer's disease. Amyloid beta 1-42 is the main component in these plaques, and the soluble oligomers of this peptide are believed to contribute to synaptic degradation and dementia.
Noelia Purroy et al.
Oncotarget, 6(10), 7632-7643 (2014-12-30)
Chronic lymphocytic leukemia (CLL) cells residing in the bone marrow (BM) and in secondary lymphoid tissues receive survival and proliferative signals from the microenvironment, resulting in persistence of residual disease after treatment. In this study, we characterized primary CLL cells
Marlies De Boeck et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 151-157 (2015-07-28)
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay (comet assay), p-phenylenediamine dihydrochloride (PPD), o-phenylphenol sodium salt (OPP), and 2,4-diaminotoluene (2,4-DAT), were analyzed in this laboratory
Emilien Folzer et al.
Journal of pharmaceutical sciences, 104(9), 2824-2831 (2015-05-27)
Oxidation of methionine and tryptophan are common degradation pathways for monoclonal antibodies and present major analytical challenges in biotechnology. Generally, protein oxidation is detectable in stability and/or stressed samples (e.g., exposed to hydrogen peroxide, UV light, or metal ions). The
Page 1 of 16
Page 1 of 16