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Editorial Commentary: Enterococcus faecalis infective endocarditis: is it time to abandon aminoglycosides?
Jose M Munita et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(9), 1269-1272 (2013-02-09)
K A S N Shanaka et al.
Fish & shellfish immunology, 92, 655-666 (2019-06-30)
Viperin, also known as RSAD2 (Radical S-adenosyl methionine domain containing 2), is an interferon-induced endoplasmic reticulum-associated antiviral protein. Previous studies have shown that viperin levels are elevated in the presence of viral RNA, but it has rarely been characterized in...
Benjamin Ezraty et al.
Science (New York, N.Y.), 340(6140), 1583-1587 (2013-07-03)
All bactericidal antibiotics were recently proposed to kill by inducing reactive oxygen species (ROS) production, causing destabilization of iron-sulfur (Fe-S) clusters and generating Fenton chemistry. We find that the ROS response is dispensable upon treatment with bactericidal antibiotics. Furthermore, we...
Xiao Zhu et al.
Toxicology, 321, 62-72 (2014-04-12)
Drug-induced liver injury (DILI) is one of the most common drug-induced adverse events (AEs) leading to life-threatening conditions such as acute liver failure. It has also been recognized as the single most common cause of safety-related post-market withdrawals or warnings....
Chishih Chu et al.
Foodborne pathogens and disease, 10(3), 256-262 (2013-03-16)
A total of 117 mastitis-associated Staphylococcus aureus isolates from cow, goat, and human patients were analyzed for differences in antibiotic susceptibility, virulence genes, and genotypes using accessory gene regulator (agr) typing, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST)....
Jianhua Yin et al.
PloS one, 8(3), e60460-e60460 (2013-04-05)
Shewanella oneidensis is a facultative anaerobic γ-proteobacterium possessing remarkably diverse respiratory capacities for reducing various organic and inorganic substrates. As a veteran research model for investigating redox transformations of environmental contaminants the bacterium is well known to be a naturally...
Robin A Sorg et al.
Nature communications, 6, 8773-8773 (2015-10-31)
The human pathogen Streptococcus pneumoniae shows alarming rates of antibiotic resistance emergence. The basic requirements for de novo resistance emergence are poorly understood in the pneumococcus. Here we systematically analyse the impact of antibiotics on S. pneumoniae at concentrations that...
Letian Xu et al.
Microbial ecology, 70(4), 1012-1023 (2015-05-20)
Bark beetles are the most important mortality agent in coniferous forests, and pheromones play important roles in their management. Dendroctonus valens LeConte was introduced from North America to China and has killed millions of healthy pines there. Trapping with semiochemicals...
Yuraporn Sahasakul et al.
The British journal of nutrition, 112(3), 408-415 (2014-06-17)
Lactobacilli are indigenous microbes of the stomach of rodents, with much lower numbers being present in mice fed a purified diet than in those fed a non-purified diet. We postulated that gastric emptying (GE) is responsible for the different colonisation...
Eugene A Yurtsev et al.
Molecular systems biology, 9, 683-683 (2013-08-07)
Inactivation of β-lactam antibiotics by resistant bacteria is a 'cooperative' behavior that may allow sensitive bacteria to survive antibiotic treatment. However, the factors that determine the fraction of resistant cells in the bacterial population remain unclear, indicating a fundamental gap...
Gaurav Jawa et al.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 8(1), 134-136 (2013-02-05)
Group B Streptococcus is a known cause of neonatal sepsis, being more common in the early period by maternal genital tract transmission and less so in the late neonatal period, ascribed to intestinal colonization or horizontal transmission. Although breastmilk transmission...
Hitoshi Tsugawa et al.
PLoS biology, 18(9), e3000813-e3000813 (2020-09-30)
Short-chain fatty acids (SCFAs) produced by gastrointestinal microbiota regulate immune responses, but host molecular mechanisms remain unknown. Unbiased screening using SCFA-conjugated affinity nanobeads identified apoptosis-associated speck-like protein (ASC), an adaptor protein of inflammasome complex, as a noncanonical SCFA receptor besides...
Combination therapy for enterococcal endocarditis.
Michael S Gelfand et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 57(5), 767-767 (2013-05-25)
Snehal N Chaudhari et al.
Cell host & microbe, 29(3), 408-424 (2021-01-13)
Bariatric surgery is the most effective treatment for type 2 diabetes and is associated with changes in gut metabolites. Previous work uncovered a gut-restricted TGR5 agonist with anti-diabetic properties-cholic acid-7-sulfate (CA7S)-that is elevated following sleeve gastrectomy (SG). Here, we elucidate...
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds...
Jonathan A Cohen et al.
Cell, 178(4), 919-932 (2019-07-30)
Cutaneous TRPV1+ neurons directly sense noxious stimuli, inflammatory cytokines, and pathogen-associated molecules and are required for innate immunity against some skin pathogens. Important unanswered questions are whether TRPV1+ neuron activation in isolation is sufficient to initiate innate immune responses and...
Marta Putrinš et al.
Infection and immunity, 83(3), 1056-1067 (2015-01-07)
Uropathogenic strains of Escherichia coli (UPEC) are the major cause of bacteremic urinary tract infections. Survival in the bloodstream is associated with different mechanisms that help to resist serum complement-mediated killing. While the phenotypic heterogeneity of bacteria has been shown...
Andrew J Renuart et al.
PloS one, 8(3), e57776-e57776 (2013-03-08)
The microbiology and epidemiology of UTI pathogens are largely unknown in Botswana, a high prevalence HIV setting. Using laboratory data from the largest referral hospital and a private hospital, we describe the major pathogens causing UTI and their antimicrobial resistance...
V Mozzetti et al.
Beneficial microbes, 3(4), 261-272 (2012-12-14)
A central issue in the use of probiotics in food and food supplements is their sensitivity to many environmental stress factors. The resistance of probiotic cells to lethal stress can be improved by application of homologous or heterologous sub-lethal stress...
Angela Bisio et al.
Phytochemistry, 110, 120-132 (2014-12-02)
From the aerial parts of Salvia adenophora Fernald four derivatives of 12-oxo-phytodienoic acid (1-4) together with five clerodane diterpenoids (5, 6, 8-10), and one known diterpene (7) have been isolated. Compounds 1-6 and 8-10 are described for the first time....
An unusual presentation of altered mental status after orthotopic liver transplantation: Listeria brain abscess.
Jennifer Tseng et al.
Transplantation, 95(12), e72-e73 (2013-06-19)
Maolida Nihemaiti et al.
Water research, 182, 115921-115921 (2020-07-07)
This study investigated the degradation and deactivation of an extracellular ampicillin resistance gene (ampR) encoded in plasmid pUC19 during exposure to UV254, •OH (generated by UV>290/H2O2), and combined exposure to UV254 and •OH (and/or SO4•-) using UV254/H2O2 and UV254/S2O82-. The...
Pinky Mal et al.
Indian journal of experimental biology, 50(10), 677-689 (2012-12-12)
Effects of ampicillin (Amp) in combination with riboflavin on septic arthritis in mice infected with Staphylococcus aureus have been reported. Ampicillin was given at 100 mg/kg after 24 h of infection, followed by riboflavin (Ribo) at 20 mg/kg body wt...
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Andrew Goodyear et al.
The American journal of tropical medicine and hygiene, 89(5), 973-982 (2013-09-26)
Burkholderia pseudomallei is a Gram-negative environmental bacterium found in tropical climates that causes melioidosis. Culture remains the diagnostic gold standard, but isolation of B. pseudomallei from heavily contaminated sites, such as fecal specimens, can be difficult. We recently reported that...
Mohamed F Mohamed et al.
Antimicrobial agents and chemotherapy, 58(7), 4113-4122 (2014-05-07)
The seriousness of microbial resistance combined with the lack of new antimicrobials has increased interest in the development of antimicrobial peptides (AMPs) as novel therapeutics. In this study, we evaluated the antimicrobial activities of two short synthetic peptides, namely, RRIKA...
Samira Bibi et al.
Journal of health, population, and nutrition, 30(4), 487-490 (2013-01-12)
The study evaluated the commonly-used drugs for the management of sepsis and their outcome among under-five children. We evaluated the hospital-records of all paediatric sepsis patients (n = 183) in the intensive care unit (ICU) and longer-stay unit (LSU) of...
Yuanyuan Liu et al.
Science (New York, N.Y.), 339(6124), 1210-1213 (2013-03-09)
Recent observations have suggested that classic antibiotics kill bacteria by stimulating the formation of reactive oxygen species (ROS). If true, this notion might guide new strategies to improve antibiotic efficacy. In this study, the model was directly tested. Contrary to...
Duccio Conti et al.
eLife, 8 (2019-12-07)
Microtubules segregate chromosomes by attaching to macromolecular kinetochores. Only microtubule-end attached kinetochores can be pulled apart; how these end-on attachments are selectively recognised and stabilised is not known. Using the kinetochore and microtubule-associated protein, Astrin, as a molecular probe, we...
Seth T Housman et al.
The Journal of antimicrobial chemotherapy, 68(10), 2296-2304 (2013-05-28)
Multidrug resistance is common among Acinetobacter baumannii, limiting the available options used to treat infections caused by this organism. The objective of this study was to compare monotherapy and combination therapy with ampicillin/sulbactam, doripenem and tigecycline against multidrug-resistant A. baumannii...
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