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Bin Huang et al.
Ecotoxicology and environmental safety, 174, 377-383 (2019-03-09)
17β-estradiol (E2) is a steroid estrogen able to affect the reproduction of aquatic organisms even at extremely low concentrations. The behavior of E2 in the presence of chlorella algae was investigated in laboratory experiments. The results showed that the algae's
Enriqueta Garcia-Gutierrez et al.
Applied microbiology and biotechnology, 104(9), 3869-3884 (2020-03-15)
Bacteriocins are antimicrobial peptides produced by bacteria, and their production is regarded as a desirable probiotic trait. We found that Lactobacillus gasseri LM19, a strain isolated from human milk, produces several bacteriocins, including a novel bacteriocin, gassericin M. These bacteriocins
Changfeng Li et al.
Developmental cell, 46(4), 441-455 (2018-08-14)
Pancreatic cancer is an aggressive malignancy with changes in the tumor microenvironment. Here, we demonstrate that PINK1 and PARK2 suppressed pancreatic tumorigenesis through control of mitochondrial iron-dependent immunometabolism. Using mouse models of spontaneous pancreatic cancer, we show that depletion of Pink1 and Park2
Mel F Bedi et al.
Bioorganic & medicinal chemistry, 25(20), 5598-5602 (2017-09-21)
Oxidative events that take place during regular oxygen metabolism can lead to the formation of organic or inorganic radicals. The interaction of these radicals with macromolecules in the organism and with DNA in particular is suspected to lead to apoptosis
Sang-Ah Kim et al.
Molecular cell, 78(5), 903-914 (2020-05-13)
LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase discovered, regulates cell-fate determination and is overexpressed in multiple cancers. LSD1 demethylates histone H3 Lys4, an epigenetic mark for active genes, but requires the CoREST repressor to act
Fan Yang et al.
Oncotarget, 8(19), 31626-31637 (2017-04-19)
Iron overload induces severe damage to several vital organs such as the liver, heart and bone, and thus contributes to the dysfunction of these organs. The aim of this study is to investigate whether iron overload causes the apoptosis and
Berta Capella Roca et al.
Biotechnology progress, 36(3), e2954-e2954 (2019-12-19)
While reliable transfection methods are essential for Chinese hamster ovary (CHO) cell line engineering, reduced transfection efficiencies have been observed in several commercially prepared media. In this study, we aimed to assess common media additives that impede efficiency mediated by
Scott R Suter et al.
Organic & biomolecular chemistry, 15(47), 10029-10036 (2017-11-23)
SiRNAs can cause unintended gene silencing due to miRNA-like effects because of the similarity in function of an siRNA guide strand and a miRNA. Here we evaluate the effect on miRNA-like off targeting of introducing the adenosine derivative 7-EAA and
J M Baena et al.
Experimental biology and medicine (Maywood, N.J.), 244(1), 13-21 (2019-01-12)
3D bioprinting represents a novel advance in the area of regenerative biomedicine and tissue engineering for the treatment of different pathologies, among which are those related to cartilage. Currently, the use of different thermoplastic polymers, such as PLA or PCL
Sharmistha Samanta Koruri et al.
Archives of microbiology, 197(7), 955-963 (2015-07-15)
The present investigation deals with the optimization of cell growth rate of the candidate probiotic Pediococcus acidilactici in the presence of the specific prebiotic inulin. Three independent variables viz. concentration of inulin, concentration of glucose and pH have been selected
Oreoluwa Adedoyin et al.
American journal of physiology. Renal physiology, 314(5), F702-F714 (2017-05-19)
Ferroptosis is an iron-dependent form of regulated nonapoptotic cell death, which contributes to damage in models of acute kidney injury (AKI). Heme oxygenase-1 (HO-1) is a cytoprotective enzyme induced in response to cellular stress, and is protective against AKI because
Nikhita Anand et al.
Neurobiology of disease, 139, 104786-104786 (2020-02-08)
Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neurodegeneration as a potential
Jin Zhang et al.
Journal of colloid and interface science, 511, 296-306 (2017-10-17)
In this study, a novel N-CQDs/Bi
Yang Yang et al.
International journal of pharmaceutics, 533(1), 49-61 (2017-09-25)
Control of crystal size and shape is crucially important for crystallization process development in the pharmaceutical industries. In general crystals of large size and low aspect ratio are desired for improved downstream manufacturability. It can be extremely challenging to design
Yucen Xie et al.
Applied and environmental microbiology, 87(3) (2020-11-08)
Salmonella spp. are resilient bacterial pathogens in low-moisture foods. There has been a general lack of understanding of critical factors contributing to the enhanced thermal tolerance of Salmonella spp. in dry environments. In this study, we hypothesized that the moisture
Masaki Miyazawa et al.
RNA (New York, N.Y.), 24(4), 468-479 (2018-01-04)
Intracellular iron is tightly regulated by coordinated expression of iron transport and storage genes, such as transferrin receptor-1 (TfR1) and ferritin. They are primarily regulated by iron through iron-induced dissociation of iron-regulatory proteins (IRPs) from iron-responsive elements (IREs) in the
Cristine M Quiason et al.
Journal of the American Society for Mass Spectrometry, 26(6), 967-973 (2015-04-05)
Matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry has been adopted in the pharmaceutical industry as a useful tool to detect xenobiotic distribution within tissues. A unique sample preparation approach for MALDI imaging has been described here for the extraction
Shane M Buker et al.
SLAS discovery : advancing life sciences R & D, 25(4), 361-371 (2019-10-06)
A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation. Methylation of adenosine at the N6 position (m6A) in messenger RNA (mRNA) is currently the most well-studied RNA modification and is
Samantha M Sarett et al.
Journal of biomedical materials research. Part A, 103(9), 3107-3116 (2015-02-03)
Clinical translation of siRNA therapeutics has been limited by the inability to effectively overcome the rigorous delivery barriers associated with intracellular-acting biologics. Here, to address both potency and longevity of siRNA gene silencing, pH-responsive micellar nanoparticle (NP) carriers loaded with
NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells.
Gryzik, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1868, 118913-118913 (2021)
Chiara Raggi et al.
Scientific reports, 7(1), 17667-17667 (2017-12-17)
Cholangiocarcinoma (CCA) is a devastating liver tumour arising from malignant transformation of bile duct epithelial cells. Cancer stem cells (CSC) are a subset of tumour cells endowed with stem-like properties, which play a role in tumour initiation, recurrence and metastasis.
Laura Perea-Sanz et al.
Meat science, 147, 100-107 (2018-09-17)
Slow fermented sausages with reduced ingoing amounts of sodium nitrate (control, 15% and 25% reduction) were stored under vacuum up to three months. Changes in microbiology, chemical parameters and volatile compounds were studied. Residual nitrate was not affected by vacuum
Ranran Wang et al.
Neurochemistry international, 125, 127-135 (2019-02-25)
α-Synuclein plays a central role in synucleinopathies pathogenesis such as Parkinson's disease (PD). Phosphorylation is the most common and important protein modification linked to α-synuclein pathologies. There is mounting evidence suggested iron and α-synuclein are closely related in PD. We
Elena Gammella et al.
Molecular biology of the cell, 32(2), 98-108 (2020-11-26)
The posttranslational regulation of transferrin receptor (TfR1) is largely unknown. We investigated whether iron availability affects TfR1 endocytic cycle and protein stability in HepG2 hepatoma cells exposed to ferric ammonium citrate (FAC). NH4Cl and bafilomycin A1, but not the proteasomal
Taous Saraoui et al.
Food microbiology, 53(Pt A), 70-78 (2015-11-28)
Listeria monocytogenes is a pathogenic Gram positive bacterium and the etiologic agent of listeriosis, a severe food-borne disease. Lactococcus piscium CNCM I-4031 has the capacity to prevent the growth of L. monocytogenes in contaminated peeled and cooked shrimp. To investigate
Chunyu Kang et al.
Journal of food protection, 83(12), 2158-2166 (2020-07-22)
As demand for fresh-cut produce increases, minimizing the risk of salmonellosis becomes critical for the produce industry. Sanitizers are routinely used during commercial flume washing of fresh-cut produce to minimize cross-contamination from the wash water. This study assessed the efficacy
Hye Young Kim et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(9), 12354-12366 (2020-07-29)
Although previous studies have shown that the administration of fibroblast growth factor 21 (FGF21) reverses hepatic steatosis, the mechanism by which FGF21 exerts a therapeutic effect on nonalcoholic fatty liver disease (NAFLD) is not yet entirely understood. We previously demonstrated
Trang Thi Mai et al.
Nature chemistry, 9(10), 1025-1033 (2017-09-25)
Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal properties and the capacity to seed tumours. CSCs are typically refractory to conventional treatments and have been associated to metastasis and relapse. Salinomycin operates as a
Mimouna Madaoui et al.
Chembiochem : a European journal of chemical biology, 21(23), 3433-3448 (2020-07-24)
Galacto- and fuco-clusters conjugated with one to three catechol or hydroxamate motifs were synthesised to target LecA and LecB lectins of Pseudomonas aeruginosa (PA) localised in the outer membrane and inside the bacterium. The resulting glycocluster-pseudosiderophore conjugates were evaluated as
Indranil Sinha et al.
Angewandte Chemie (International ed. in English), 54(12), 3603-3606 (2015-01-30)
The first parallel-stranded DNA duplex with Hoogsteen base pairing that readily incorporates an Ag(+) ion into an internal mispair to form a metal-mediated base pair has been created. Towards this end, the highly stabilizing 6 FP-Ag(+)-6 FP base pair comprising the artificial
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