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Qifan Zheng et al.
Neuro-oncology, 16(9), 1229-1243 (2014-05-28)
As a commonly mutated form of the epidermal growth factor receptor, EGFRvIII strongly promotes glioblastoma (GBM) tumor invasion and progression, but the mechanisms underlying this promotion are not fully understood. Through gene manipulation, we established EGFRvIII-, wild-type EGFR-, and vector-expressing...
Adil Mohamed et al.
Journal of virology, 94(4) (2019-11-22)
Little is known about how genetic variations in viruses affect their success as therapeutic agents. The type 3 Dearing strain of Mammalian orthoreovirus (T3D) is undergoing clinical trials as an oncolytic virotherapy. Worldwide, studies on reovirus oncolysis use T3D stocks...
Olivia Abigail Robles-Rodríguez et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 25(1), 543-548 (2020-04-12)
To compare the antitumor effect of adenoviruses that express mutant variants of the protein E7 from HPV-16 fused to calreticulin. Recombinant adenoviruses were generated to express calreticulin fused to mutant versions of E7 (CRT/E7m and CRT/E7dm). Western blot and immunofluorescence...
Tomoya Narawa et al.
Biological & pharmaceutical bulletin, 38(4), 545-551 (2015-04-04)
The stereoselective transport of methotrexate (L-amethopterin, L-MTX) and its enantiomer (D-amethopterin, D-MTX) by the rat proton-coupled folate transporter (rPCFT) were examined using rPCFT-expressing HEK293 cells. The initial rate of uptake of [3H]-L-MTX by the rPCFT followed Michaelis-Menten kinetics, with a...
Zedong Jiang et al.
Bioscience, biotechnology, and biochemistry, 83(11), 2065-2074 (2019-06-28)
In this study, a sulfated polysaccharide (BFP) was isolated from the edible red alga Bangia fusco-purpurea. Gel-filtration and thin layer chromatographically analyses suggested that BFP was a homogenous polysaccharide. The chemical structural analysis revealed that BFP mainly consisted of galactose...
Arianna Crespi et al.
The Journal of investigative dermatology, 135(1), 192-201 (2014-08-02)
By means of morphological and biochemical criteria, we here provide evidence for the localization and function of premature ovarian failure, 1B (POF1B) in desmosomes. In monolayers of Caco-2 intestinal cells and in stratified HaCaT keratinocytes, endogenous POF1B colocalized with desmoplakin...
Hany E S Marei et al.
Journal of cellular physiology, 230(7), 1614-1629 (2014-12-24)
Parkinson's disease (PD) is a neurological disorder characterized by the loss of midbrain dopaminergic (DA) neurons. Neural stem cells (NSCs) are multipotent stem cells that are capable of differentiating into different neuronal and glial elements. The production of DA neurons...
Xue Yang et al.
Journal of cellular physiology, 235(3), 2009-2022 (2019-09-13)
Renal fibrosis is a common pathway for the progression of all chronic kidney diseases to end-stage kidney disease. Studies show that WNT1-inducible signaling pathway protein-1 (WISP-1) is involved in the fibrosis of various organs. The aim of the study was...
David E Place et al.
PLoS pathogens, 16(3), e1008364-e1008364 (2020-03-10)
Innate immunity responds to pathogens by producing alarm signals and activating pathways that make host cells inhospitable for pathogen replication. The intracellular bacterium Burkholderia thailandensis invades the cytosol, hijacks host actin, and induces cell fusion to spread to adjacent cells...
Hua Zhang et al.
Journal of virology, 89(19), 10031-10043 (2015-07-24)
Enterovirus 71 (EV71) recruits various cellular factors to assist in the replication and translation of its genome. Identification of the host factors involved in the EV71 life cycle not only will enable a better understanding of the infection mechanism but...
Bianca Del B Sahm et al.
Frontiers in chemistry, 8, 110-110 (2020-03-21)
The TBX2 transcription factor plays critical roles during embryonic development and it is overexpressed in several cancers, where it contributes to key oncogenic processes including the promotion of proliferation and bypass of senescence. Importantly, based on compelling biological evidences, TBX2...
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.
Fowler, et al.
Human Molecular Genetics, 29, 2882-2898 (2020)
D C Eustice et al.
Antimicrobial agents and chemotherapy, 26(1), 53-60 (1984-07-01)
Tetrahymena thermophila is a eucaryotic organism that is highly susceptible to growth inhibition by aminoglycoside antibiotics. Concentrations of paromomycin, gentamicin G418, and hygromycin B at 22, 10, and 17 microM, respectively, inhibited growth by 50%. A combination of in vitro...
Saskia Willenbrock et al.
PloS one, 9(6), e98788-e98788 (2014-06-11)
The architectural transcription factor HMGA2 is abundantly expressed during embryonic development. In several malignant neoplasias including prostate cancer, high re-expression of HMGA2 is correlated with malignancy and poor prognosis. The let-7 miRNA family is described to regulate HMGA2 negatively. The...
Frederik Walter et al.
PloS one, 15(9), e0239369-e0239369 (2020-10-01)
Cancer vaccinations sensitize the immune system to recognize tumor-specific antigens de novo or boosting preexisting immune responses. Dendritic cells (DCs) are regarded as the most potent antigen presenting cells (APCs) for induction of (cancer) antigen-specific CD8+ T cell responses. Chitosan...
Fei Liu et al.
International journal of oncology, 53(5), 2241-2257 (2018-09-19)
The miR-17-92 cluster plays either an oncogenic or anti-oncogenic role in cancer progression in diverse human cancers. However, the underlying mechanisms of the miR-17-92 cluster in gastric cancer have not yet been fully elucidated. In this study, the function of...
Yukinobu Kodama et al.
Biological & pharmaceutical bulletin, 37(8), 1274-1281 (2014-08-05)
We developed a novel small interfering RNA (siRNA) delivery system using a ternary complex with polyethyleneimine (PEI) and γ-polyglutamic acid (γ-PGA), which showed silencing effect and no cytotoxicity. The binary complexes of siRNA with PEI were approximately 73-102 nm in...
G H Wagman et al.
Antimicrobial agents and chemotherapy, 6(2), 144-149 (1974-08-01)
Antibiotic G-418 is a new aminoglycoside produced as the major component by a new species of Micromonospora, M. rhodorangea NRRL 5326. The antibiotic is prepared by submerged fermentation in a soybean-dextrin medium. Antibiotic G-418 is adsorbed on a cationic-exchange resin...
Ruo-Yu Chen et al.
Cell death and differentiation, 27(4), 1259-1273 (2019-09-13)
Centrosomal P4.1-associated protein (CPAP) is overexpressed in hepatocellular carcinoma (HCC) and positively correlated with recurrence and vascular invasion. Here, we found that CPAP plays an important role in HCC malignancies. Functional characterization indicated that CPAP overexpression increases tumor growth, angiogenesis...
Yun Hong et al.
Biochemical and biophysical research communications, 461(3), 513-518 (2015-04-23)
Chronic infection with hepatitis B virus (HBV) plays an important role in the etiology of hepatocellular carcinoma (HCC). Signal transducer and activator of transcription 3 (STAT3) inactivation could inhibit the tumor growth of HCC. In this study, differential antiproliferative effect...
Christopher D Whitewoods et al.
Science (New York, N.Y.), 367(6473), 91-96 (2019-11-23)
Leaves vary from planar sheets and needle-like structures to elaborate cup-shaped traps. Here, we show that in the carnivorous plant Utricularia gibba, the upper leaf (adaxial) domain is restricted to a small region of the primordium that gives rise to...
Chuan-Feng Yeh et al.
Cells, 9(6) (2020-06-24)
Single-cell cloning (SCC) is a critical step in generating monoclonal cell lines, which are widely used as in vitro models and for producing proteins with high reproducibility for research and the production of therapeutic drugs. In monoclonal cell line generation...
JianPing Lu et al.
Journal of neurochemistry, 98(6), 1908-1919 (2006-09-02)
Hereditary spastic paraplegia describes a diverse group of disorders characterized by progressive paraparesis primarily affecting lower limbs. In Troyer syndrome, an autosomal recessive form of hereditary spastic paraplegia, patients have dysarthria, distal amyotrophy, developmental delay and short stature in addition...
Luis M Molinos-Albert et al.
Retrovirology, 11, 44-44 (2014-06-10)
The MPER region of the HIV-1 envelope glycoprotein gp41 is targeted by broadly neutralizing antibodies. However, the localization of this epitope in a hydrophobic environment seems to hamper the elicitation of these antibodies in HIV infected individuals.We have quantified and...
Benoit Briard et al.
Nature microbiology, 4(2), 316-327 (2018-12-05)
Invasive pulmonary aspergillosis causes substantial mortality in immunocompromised individuals. Recognition of Aspergillus fumigatus by the host immune system leads to activation of the inflammasome, which provides protection against infection. However, regulation of inflammasome activation at the molecular level is poorly...
Vibha Singh et al.
Cell cycle (Georgetown, Tex.), 19(3), 363-375 (2020-01-10)
The TLK1/Nek1 axis contributes to cell cycle arrest and implementation of the DDR to mediate survival upon DNA damage. However, when the damage is too severe, the cells typically are forced into apoptosis, and the contribution of TLKs in this...
Annie Turkieh et al.
Cell death & disease, 10(8), 608-608 (2019-08-14)
Clusterin (CLU) is induced in many organs after tissue injury or remodeling. Recently, we show that CLU levels are increased in plasma and left ventricle (LV) after MI, however, the mechanisms involved are not yet elucidated. On the other hand...
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