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Progress in studies on the role of gamma-aminobutyric acid.
Xing-fang Li et al.
Chinese medical journal, 125(7), 1322-1330 (2012-05-23)
Alexandra Tikidji-Hamburyan et al.
Nature neuroscience, 18(1), 66-74 (2014-12-09)
The collective activity pattern of retinal ganglion cells, the retinal code, underlies higher visual processing. How does the ambient illuminance of the visual scene influence this retinal output? We recorded from isolated mouse and pig retina and from mouse dorsal
Cortical inhibition, gamma-aminobutyric acid, and major depression: there is plenty of smoke but is there fire?
Gerard Sanacora
Biological psychiatry, 67(5), 397-398 (2010-02-18)
Satoshi Shibuta et al.
Neuroscience research, 98, 9-16 (2015-05-03)
The neurotoxic effects of anesthetics on the developing brain are a concern. Although most of the anesthetics are GABAA agonists or NMDA antagonists, the differences in these effects on prospective glutamate-neurotoxicity in the brain is not fully understood. We examined
D Rating et al.
Journal of neurology, 230(4), 217-225 (1983-01-01)
In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined. While the mean for CSF GABA concentrations for all epileptic children was unchanged [144 (range: 73-285) pmol/ml; controls:
H K Knych et al.
Journal of veterinary pharmacology and therapeutics, 38(2), 113-122 (2014-08-19)
The anti-anxiety and calming effects following activation of the GABA receptor have been exploited in performance horses by administering products containing GABA. The primary goal of the study reported here was to describe endogenous concentrations of GABA in horses and
Benzodiazepines: revealing of the secrets of GABAA-mediated immunosuppression: GABAA subtype-specific benzodiazepines are the hope.
Gyorgy Frendl
Critical care medicine, 41(7), 1807-1808 (2013-06-19)
Maria Luisa Gelmi et al.
Journal of medicinal chemistry, 49(18), 5571-5577 (2006-09-01)
A novel class of 3-demethoxy-3-glycosylaminothiocolchicines (7) was prepared and tested for muscle relaxant activity. The syntheses were performed starting from the new 3-amino-3-demethoxythiocolchicine (5) prepared in good yield from 3-O-demethylthiocolchicine (1c) using the Buchwald-Hartwig reaction. The condensation of 5 with
V Martinez et al.
Anaesthesia, 69(1), 46-52 (2013-12-11)
Ketamine and pregabalin each provide postoperative analgesia, although the combination has yet to be evaluated. One hundred and forty-two patients undergoing total hip arthroplasty were randomly assigned to receive ketamine alone, pregabalin alone, ketamine and pregabalin combined, or placebo. Pain
Martin D Haustein et al.
Neuron, 82(2), 413-429 (2014-04-20)
The spatiotemporal activities of astrocyte Ca²⁺ signaling in mature neuronal circuits remain unclear. We used genetically encoded Ca²⁺ and glutamate indicators as well as pharmacogenetic and electrical control of neurotransmitter release to explore astrocyte activity in the hippocampal mossy fiber
Stephen West et al.
Current opinion in organ transplantation, 19(2), 201-208 (2014-02-21)
The use of corticosteroids is increasing, and while the physical complications of their use are well known, the neuropsychiatric consequences are not. This review focuses on preventing these neuropsychiatric complications. Although there are limited data on this subject, it is
Frank Richter et al.
Annals of neurology, 76(1), 43-53 (2014-05-07)
Brain damage and ischemia often trigger cortical spreading depression (CSD), which aggravates brain damage. The proinflammatory cytokine tumor necrosis factor (TNF) is significantly upregulated during brain damage, but it is unknown whether TNF influences spreading depression in cerebral cortex in
G Mark Freeman et al.
Neuron, 78(5), 799-806 (2013-06-15)
Systems of coupled oscillators abound in nature. How they establish stable phase relationships under diverse conditions is fundamentally important. The mammalian suprachiasmatic nucleus (SCN) is a self-sustained, synchronized network of circadian oscillators that coordinates daily rhythms in physiology and behavior.
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and
V N Marty et al.
Radiation research, 182(6), 653-665 (2014-11-18)
The evaluation of potential health risks associated with neuronal exposure to space radiation is critical for future long duration space travel. The purpose of this study was to evaluate and compare the effects of low-dose proton and high-energy charged particle
Donald Mann et al.
Epilepsia, 55(12), 1934-1943 (2014-11-08)
To evaluate the safety, tolerability, and pharmacokinetics (PK) of pregabalin as adjunctive therapy in children with refractory partial seizures. This was a phase 1, randomized, placebo-controlled, parallel-group, escalating-dose, multiple-dose study comprising a 7-day, double-blind treatment period and a single-blind, single
Drugs for neuropathic pain.
Eija Kalso et al.
BMJ (Clinical research ed.), 347, f7339-f7339 (2013-12-21)
Maria Luisa Gelmi et al.
Journal of medicinal chemistry, 50(9), 2245-2248 (2007-04-07)
New 3-O-glycosyl-3-demethylthiocolchicines containing natural and unnatural sugar moieties were prepared and tested on gamma-aminobutyric acid (GABA) and strychnine-sensitive glycine receptors present in rat brain and spinal cord. Two different synthetic approaches were used with the readily available 3-O-demethylthiocolchicine (1b) and
Young Seok Lee et al.
Cancer genomics & proteomics, 12(3), 153-166 (2015-05-16)
Despite great effort to elucidate the process of acquired gefitinib resistance (AGR) in order to develop successful chemotherapy, the precise mechanisms and genetic factors of such resistance have yet to be elucidated. We performed a cross-platform meta-analysis of three publically
Daniel M Tassone et al.
Clinical therapeutics, 29(1), 26-48 (2007-03-24)
The US Food and Drug Administration (FDA) approved pregabalin in December 2004 for the treatment of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Pregabalin is the first drug approved in the United States and in Europe for
Michael J Buys et al.
Anesthesia and analgesia, 119(2), 481-488 (2014-06-11)
The anticonvulsant drugs pregabalin and gabapentin are often used systemically to treat some forms of chronic neuropathic pain. However, many patients report side effects serious enough to cause discontinuation of the drug. Here we present evidence that pregabalin may block
Roman Tyzio et al.
Science (New York, N.Y.), 343(6171), 675-679 (2014-02-08)
We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism. During delivery and subsequently, hippocampal neurons in these models have elevated intracellular chloride levels, increased
Neuroscience: Dissecting appetite.
Bijal P Trivedi
Nature, 508(7496), S64-S65 (2014-04-18)
[Narrowly missing internal exsanguination].
H S Füessl
MMW Fortschritte der Medizin, 156(21-22), 50-50 (2015-01-23)
Ulrike Klenke et al.
Endocrinology, 155(5), 1851-1863 (2014-02-26)
Metabolic dysfunctions are often linked to reproductive abnormalities. Adiponectin (ADP), a peripheral hormone secreted by white adipose tissue, is important in energy homeostasis and appetite regulation. GnRH neurons are integral components of the reproductive axis, controlling synthesis, and release of
Antonio Rodríguez-Núñez et al.
Brain & development, 25(2), 102-106 (2003-02-13)
To determine the effects of meningitis on cerebral energy metabolism, cerebrospinal fluid concentrations of adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine and urate were determined by high-performance liquid chromatography, and neuron-specific enolase by an enzyme immunoassay
Gaetano Zaccara et al.
Epilepsia, 55(7), 1048-1057 (2014-06-07)
To assess the comparative efficacy and safety of pregabalin and levetiracetam for the reduction of seizure frequency in patients with partial seizures. This was a randomized, double-blind, flexible-dose, parallel-group noninferiority study of pregabalin and levetiracetam (randomized 1:1) as adjunctive treatment
Margarita V Glazova et al.
Journal of neurochemistry, 132(2), 218-229 (2014-10-30)
It has recently been proposed that extracellular signal-regulated kinases 1 and 2 (ERK1/2) are one of the factors mediating seizure development. We hypothesized that inhibition of ERK1/2 activity could prevent audiogenic seizures by altering GABA and glutamate release mechanisms. Krushinsky-Molodkina
Richard A E Edden et al.
Magnetic resonance in medicine, 68(3), 657-661 (2012-07-11)
Edited magnetic resonance spectroscopy makes possible noninvasive studies of the role of the inhibitory neurotransmitter GABA in the healthy brain and in disease processes. A major limitation of the methodology is coediting of macromolecular signals. Although it has previously been
May-Yun Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(8), 2503-2508 (2015-02-13)
Insulin monotherapy can neither maintain normoglycemia in type 1 diabetes (T1D) nor prevent the long-term damage indicated by elevated glycation products in blood, such as glycated hemoglobin (HbA1c). Here we find that hyperglycemia, when unaccompanied by an acute increase in
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