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Hemant Mittal et al.
International journal of biological macromolecules, 79, 8-20 (2015-05-03)
Biodegradable hydrogels of gum ghatti (Gg) with a co-polymer mixture of acrylamide (AAm) and methacrylic acid (MAA) (termed as Gg-cl-P(AAm-co-MAA)) were synthesised by microwave-assisted free radical graft co-polymerisation technique. The hydrogel polymer was characterized by FTIR, SEM, and Brunauer-Emmett-Teller techniques.
Dongfeng Wei et al.
Carbohydrate polymers, 125, 161-168 (2015-04-11)
Beta-amyloid (Aβ) peptide, the hallmark of Alzheimer's disease, invokes oxidative damage to neurons and eventually leads to neuronal death. Selenylation modification of polysaccharide obtained from Radix hedysari (RHP) was studied to access antioxidant activities and neuroprotective effects against oxidative stress
Hannah E Da Silva et al.
Journal of the Academy of Nutrition and Dietetics, 114(8), 1181-1194 (2014-03-19)
Poor diet and a sedentary lifestyle can contribute to nonalcoholic fatty liver disease (NAFLD). Our aim was to compare diet and physical activity of patients with NAFLD and healthy controls with current recommendations. This was a cross-sectional study. Seventy-four patients
Basavaraj Girennavar et al.
Bioorganic & medicinal chemistry, 15(11), 3684-3691 (2007-04-03)
Grapefruit juice has been shown to increase the oral bioavailability of several clinically important drugs by inhibiting first pass metabolism. Several compounds in grapefruit juice have shown different biological activities. Unique among them are furocoumarins with potent inhibitory activity against
Fiona Allum et al.
Nature communications, 6, 7211-7211 (2015-05-30)
Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach, methylC-capture sequencing (MCC-Seq), for
Yi-Chun Kuo et al.
PloS one, 6(7), e22382-e22382 (2011-08-06)
Surface plasmon resonance (SPR) biosensors have been recognized as a useful tool and widely used for real-time dynamic analysis of molecular binding affinity because of its high sensitivity to the change of the refractive index of tested objects. The conventional
Larissa Nelson et al.
Cartilage, 5(4), 203-214 (2015-06-13)
Osteoarthritis (OA) is a debilitating disease affecting more than 4 million people in the United Kingdom. Despite its prevalence, there is no successful cell-based therapy currently used to treat patients whose cartilage is deemed irrecoverable. The present study aimed to
Pratima Tripathi et al.
Indian journal of biochemistry & biophysics, 50(2), 99-104 (2013-06-01)
Increased production of oxygen free radicals and decreased oxidant capacity occur in coronary artery diseases (CAD) This pro-oxidant shift in intracellular redox state may induce cell death by either direct cell membrane damage by lipic peroxidation or apoptosis through activation
Henriette Jülke et al.
Cell transplantation, 24(6), 1111-1125 (2013-12-18)
The purpose of this study was to evaluate the use of three different superparamagnetic iron oxide (SPIO) particles for labeling of ovine and equine bone marrow (BM)-derived multipotent stromal cells (MSCs) in vitro. MSCs were obtained from five adult sheep
Partha Pratim Roy et al.
Bioorganic chemistry, 56, 1-7 (2014-06-03)
The objective of the present work was tantamount to explain the antiperoxidative potential and structural requirements of twenty-eight structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation. Both experimental and computational approaches were taken to the work. The experiments were
Hyoung Ja Kim et al.
Journal of natural products, 69(4), 600-603 (2006-04-29)
Bioassay-directed chromatographic fractionation of an ethyl acetate extract of Gardenia jasminoides (Gardeniae Fructus) afforded a new vanillic acid 4-O-beta-d-(6'-sinapoyl)glucopyranoside (1) and five new quinic acid derivatives, methyl 5-O-caffeoyl-3-O-sinapoylquinate (2), ethyl 5-O-caffeoyl-3-O-sinapoylquinate (3), methyl 5-O-caffeoyl-4-O-sinapoylquinate (4), ethyl 5-O-caffeoyl-4-O-sinapoylquinate (5), and methyl
Chih-Chiang Chen et al.
Journal of dermatological science, 75(1), 55-62 (2014-05-08)
EGb-761 is an antioxidant and anticarcinogen; however, its role as a photoprotector remains unknown. To determine whether EGb-761 photoprotects human dermal fibroblasts and BALB/c mice skin against ultraviolet B (UVB) light irradiation. To simulate chronic photodamage, shaved BALB/c mice were
Hiroki Teraoka et al.
Aquatic toxicology (Amsterdam, Netherlands), 154, 19-26 (2014-05-27)
The cardiovascular system is one of the most characteristic and important targets for developmental toxicity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in fish larvae. However, knowledge of the mechanism of TCDD-induced edema after heterodimerization of aryl hydrocarbon receptor type 2 (AHR2) and AHR
Qin-Hua Gu et al.
Nature communications, 6, 6789-6789 (2015-04-11)
Long-term potentiation (LTP) is a form of synaptic plasticity that results in enhanced synaptic strength. It is associated with the formation and enlargement of dendritic spines-tiny protrusions accommodating excitatory synapses. Both LTP and spine remodelling are crucial for brain development
Shigeyuki Chaki et al.
Pharmacology, biochemistry, and behavior, 135, 154-168 (2015-06-06)
Melanin-concentrating hormone receptor 1 (MCH1 receptor) is known to be involved in the control of mood and stress, in addition to the regulation of feeding. Here, we report further evidence that the blockade of the MCH1 receptor exhibits antidepressant and
A Maqbool et al.
eLife, 4 (2015-08-26)
Plants have evolved intracellular immune receptors to detect pathogen proteins known as effectors. How these immune receptors detect effectors remains poorly understood. Here we describe the structural basis for direct recognition of AVR-Pik, an effector from the rice blast pathogen
[Recent advance in the study of ascorbic acid in photosynthe-sizing organisms].
Takahiro Ishikawa
Seikagaku. The Journal of Japanese Biochemical Society, 83(9), 838-841 (2011-11-25)
Antônio Carlos Lopes Câmara et al.
PloS one, 10(11), e0143708-e0143708 (2015-11-26)
Gossypol, a polyphenol compound produced by cotton plant, has proven reproductive toxicity, but the effects of gossypol on sheep ovaries are unknown. This study was aimed to determine the in vitro and in vivo effects of gossypol on the ovarian
Bing-jiao Zhao et al.
Fundamental & clinical pharmacology, 28(5), 583-592 (2013-10-12)
Periodontal ligament stem cells (PDLSCs) are considered as potential mesenchymal stem cell sources for future clinical applications in periodontal regeneration therapy. Simvastation, widely used for lowering serum cholesterol, is known to have a bone stimulatory effect. However, it is not
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Xia Xiang et al.
Talanta, 141, 182-187 (2015-05-13)
We have developed a label-free fluorescence sensor for caffeic acid (CA) by the use of CdTe:Zn(2+) quantum dots (CdTe:Zn(2+) QDs) as an output signal. The principle of sensor is based on the fluorescence quenching and binding properties of Fe(2+) toward
Mei-Lin Yang et al.
Journal of natural products, 74(9), 1996-2000 (2011-08-19)
In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has
Loyal A Goff et al.
Experimental hematology, 36(10), 1354-1369 (2008-07-29)
Human multipotent mesenchymal stromal cells (MSC) have the potential to differentiate into multiple cell types, although little is known about factors that control their fate. Differentiation-specific microRNAs may play a key role in stem cell self-renewal and differentiation. We propose
Juliane Meyer et al.
Aesthetic surgery journal, 35(8), 1030-1039 (2015-05-27)
In recent years the therapeutic application of extracted adipose tissue for autologous fat grafting and the application of adipose tissue-derived mesenchymal stem cells (adMSC) isolated thereof has progressed. Water-jet assisted liposuction (WAL) is 1 procedure for harvesting adipose tissue and
Martin Spickenreither et al.
Bioorganic & medicinal chemistry letters, 16(20), 5313-5316 (2006-08-16)
Previously, we identified ascorbic acid 6-O-hexadecanoate as an up to 1500 times more potent inhibitor of bacterial and bovine hyaluronidases than the parent compound, vitamin C, and determined a crystal structure of hyaluronidase from Streptococcus pneumoniae in complex with the
Wei-Ming Chai et al.
Journal of agricultural and food chemistry, 63(33), 7381-7387 (2015-08-11)
Proanthocyanidins were purified from avocado (Persea americana) fruit, and their structures were analyzed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and high-performance liquid chromatography-electrospray ionization-QTRAP mass spectrometry (HPLC-ESI-QTRAP MS) techniques. The results obtained from mass spectrometry (MS) analysis demonstrated
Marylhi Mora et al.
Investigacion clinica, 54(2), 161-170 (2013-08-21)
In the present study we compared the effects of minocycline and ascorbic acid in the life span, motor activity and lipid peroxidation of Drosophila melanogaster, in an effort to find a substance capable of providing protection against oxidative stress in
Yalin Wu et al.
Journal of natural products, 71(2), 241-245 (2008-01-12)
The structure of an antiradical arabinoglucogalactan ( 1) from Panax notoginseng roots was determined. This polymeric carbohydrate was obtained through successive phosphate buffer (pH 7.0) extraction after cold-water pretreatment and purification by ion-exchange and gel-filtration chromatography. Monosaccharide analysis, permethylation analysis
Feng Shi et al.
Bioorganic & medicinal chemistry letters, 19(19), 5565-5568 (2009-09-05)
The green chemoselective synthesis of thiazolo[3,2-a]pyridine derivatives was achieved in water via microwave-assisted three-component reactions of malononitrile, aromatic aldehydes and 2-mercaptoacetic acid with molar ratios of 2:1:1.5 and 2:2.2:1, respectively. These compounds were subject to the experiments of antioxidant activity
Lean-Teik Ng et al.
Bioorganic & medicinal chemistry, 17(13), 4360-4366 (2009-06-02)
Deoxybenzoins (DOBs) are one-pot synthetic precursors of isoflavones with feature analogous to those beneficial polyphenols such as resveratrol (stilbene) and phloretin (dihydrochalcone). In this study, seventeen polyphenolic DOBs were synthesized and evaluated by various antioxidant assays and tyrosinase inhibitory effect
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