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Matteo Bassetti et al.
Clinical drug investigation, 31(11), 745-758 (2011-09-06)
Invasive fungal infections are associated with a poor outcome and their incidence is rising. Amphotericin B has for a long time been the gold standard for treatment of these infections, but the conventional formulation is associated with a high incidence
Manica Balasegaram et al.
Expert opinion on emerging drugs, 17(4), 493-510 (2012-11-22)
Leishmaniasis is a parasitic disease transmitted by phlebotomine sandflies. Between 700,000 and 1.2 million cases of cutaneous leishmaniasis and between 200,000 and 400,000 cases of visceral leishmaniasis (VL), which is fatal if left untreated, occur annually worldwide. Liposomal amphotericin B
Amparo Estepa et al.
Fish & shellfish immunology, 47(1), 264-270 (2015-09-13)
While exploring the molecular mechanisms behind the fin hemorrhages that follow zebrafish (Danio rerio) early infection with viral haemorrhagic septicemia virus (VHSV), we discovered that most serpin (serine protease inhibitor) gene transcripts were upregulated, except those of serpine1. Surprisingly, only
Haruka Takahashi et al.
Human cell, 28(3), 143-153 (2015-02-26)
The squamous cell carcinoma cell lines Nialym was successfully established from metastatic foci of lymph nodes from a 48-year-old male Japanese patient with squamous cell carcinoma of the tongue. In addition, the Nialymx cell line was established from a transplanted
Pirouz M Daftarian et al.
The Journal of infectious diseases, 208(11), 1914-1922 (2013-08-01)
Amphotericin B (AmB), the most effective drug against leishmaniasis, has serious toxicity. As Leishmania species are obligate intracellular parasites of antigen presenting cells (APC), an immunopotentiating APC-specific AmB nanocarrier would be ideally suited to reduce the drug dosage and regimen
Angela S Loo et al.
Expert opinion on drug safety, 12(6), 881-895 (2013-08-13)
Amphotericin B (AmB) was first approved by the US Food and Drug Administration in 1959 with sodium deoxycholate (DAmB, Fungizone®). Extensive toxicities associated with the drug led to the development of lipid formulations of AmB, including liposomal amphotericin B (L-AmB
Chitralekha Mohanty et al.
Anticancer research, 34(6), 2801-2806 (2014-06-13)
The use of ion radiation therapy is growing due to the continuously increasing positive clinical experience obtained. Therefore, there is a high interest in radio-biological experiments comparing the relative efficiency in cell killing of ions and photons as photons are
Marco Scarpa et al.
Oncotarget, 6(24), 20058-20069 (2015-01-18)
In patients with ulcerative colitis (UC) the cumulative risk of colon cancer is lower than the actual rate of dysplasia suggesting an efficient immune surveillance mechanism. Since the co-stimulatory molecule CD80 is overexpressed in dysplastic colonic mucosa of UC patients
Richard J Hamill
Drugs, 73(9), 919-934 (2013-06-04)
Because of the increasing prevalence and changing microbiological spectrum of invasive fungal infections, some form of amphotericin B still provides the most reliable and broad spectrum therapeutic alternative. However, the use of amphotericin B deoxycholate is accompanied by dose-limited toxicities
Masaki Fujita et al.
The Japanese journal of antibiotics, 66(1), 37-43 (2013-06-20)
We report a case of pulmonary aspergillosis in lung transplant recipient who was successfully treated with inhalation administration of anti-fungal agent. The case was 33-year-old female. Two years ago, she had received lung transplant because of lymphangioleiomyomatosis. One year ago
Afaq Ahmad Khan et al.
Journal of the Indian Medical Association, 110(7), 499-500 (2013-03-26)
Non-Hodgkin's lymphoma (NHL) is predominantly a disease of lymph nodes, but extranodal involvement is not very uncommon. Palatal involvement by NHL is rare. Mucormycosis is a devastating fungal infection commonly seen in immunocompromised individuals, including those with NHL, but it
Jeremy N Day et al.
The New England journal of medicine, 368(14), 1291-1302 (2013-04-05)
Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment for cryptococcal meningitis but has not been shown to reduce mortality, as compared with amphotericin B alone. We performed a randomized, controlled trial to determine whether combining flucytosine
Daniel J Mullen et al.
PLoS genetics, 16(9), e1009023-e1009023 (2020-09-15)
Lung cancer is the leading cause of cancer-related death and lung adenocarcinoma is its most common subtype. Although genetic alterations have been identified as drivers in subsets of lung adenocarcinoma, they do not fully explain tumor development. Epigenetic alterations have
Michael Klepser
Journal of critical care, 26(2), 225-225 (2010-10-19)
Over the last 20 years, there has been an increase in the total number of invasive fungal infections (IFIs) and in infections caused by rare and emerging pathogens. This is due in part to the growing population of immunocompromised patients
Review: voriconazole for prevention or treatment of invasive fungal infections in cancer with neutropenia.
Andrew M Morris
Annals of internal medicine, 161(2), JC8-JC8 (2014-07-16)
Surjit Lidder et al.
Journal of the Royal Army Medical Corps, 159(2), 123-125 (2013-05-31)
Infection is the third commonest cause of total hip arthroplasty failure. Infections of the hip with Candida species are extremely rare with only a few reports in the literature. A case of a 76-year-old female subject is presented illustrating both
John E Linley
Methods in molecular biology (Clifton, N.J.), 998, 149-157 (2013-03-27)
Perforated whole-cell patch-clamp is a variant of the patch-clamp technique used to measure the sum activity of ion channels in the plasma membrane of a single cell. Its defining feature is that electrical access to the cell is obtained through
E Martínez-León et al.
Human reproduction (Oxford, England), 30(9), 2138-2151 (2015-06-26)
Does fibronectin (Fn) stimulate the sperm capacitation process in humans? Fibronectin stimulates human sperm capacitation. Capacitation is a process that occurs in the oviduct. It has been suggested that some molecules present in the oviductal fluid and cells as well
Noelle Layer et al.
JAMA ophthalmology, 132(7), 832-837 (2014-05-03)
Optisol-GS, the most common corneal storage medium in the United States, contains antibacterial but no antifungal supplementation. Most postkeratoplasty endophthalmitis and keratitis cases are now of a fungal origin. To assess the efficacy and safety of voriconazole and amphotericin B
Stefanie Schrauwen et al.
Gynecologic oncology, 138(2), 378-382 (2015-06-09)
New treatment options for advanced and recurrent endometrial carcinoma (EC) are necessary. Epidemiological studies showed that diabetic patients using metformin have reduced risks of endometrial cancer (EC) incidence. Moreover, pre- and clinical studies demonstrated an antitumor effect by metformin, with
Treating cryptococcal meningitis in people with HIV.
BMJ (Clinical research ed.), 346, f2203-f2203 (2013-04-12)
Konstantin A Krychtiuk et al.
Thrombosis and haemostasis, 113(2), 350-362 (2014-10-03)
Levosimendan is a positive inotropic drug for the treatment of acute decompensated heart failure (HF). Clinical trials showed that levosimendan was particularly effective in HF due to myocardial infarction. Myocardial necrosis induces a strong inflammatory response, involving chemoattractants guiding polymorphonuclear
D Standaert et al.
Acta clinica Belgica, 68(2), 124-127 (2013-08-24)
Leishmaniasis, an intracellular protozoal infection in which tissue macrophages are targeted, is transmitted by female sandfly bite and occurs in 98 countries. Visceral leishmaniasis (VL) is the clinical form of leishmaniasis most frequently associated with HIV, especially in Europe. Both
Alyse N Douglass et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(5), 857-865 (2015-02-05)
Eliminating malaria parasites during the asymptomatic but obligate liver stages (LSs) of infection would stop disease and subsequent transmission. Unfortunately, only a single licensed drug that targets all LSs, Primaquine, is available. Targeting host proteins might significantly expand the repertoire
Ermias Diro et al.
Tropical medicine & international health : TM & IH, 20(1), 8-16 (2014-10-21)
Visceral leishmaniasis (VL) in north-west Ethiopia is causing an overwhelming case load among adult migrant workers that masked the disease burden in children. This study describes the clinical profile and explores comorbidities in paediatric VL patients. A prospective study at
Patrícia L N Néris et al.
Experimental parasitology, 135(2), 307-313 (2013-07-31)
Leishmaniasis' treatment is based mostly on pentavalent antimonials or amphotericin B long-term administration, expensive drugs associated with severe side effects. Considering these aforementioned, the search for alternative effective and safe leishmaniasis treatments is a necessity. This work evaluated a neolignan
Dale M Walker et al.
Environmental and molecular mutagenesis, 54(4), 268-280 (2013-04-05)
The events or factors that lead from normal cell function to conditions and diseases such as aging or cancer reflect complex interactions between cells and their environment. Cellular stress responses, a group of processes involved in homeostasis and adaptation to
Tatiane F P de Mello et al.
Experimental parasitology, 136, 27-34 (2013-11-26)
The treatment of American cutaneous leishmaniasis (ACL) is based on a small group of compounds that were developed decades ago, all of which are highly toxic and have a high rate of treatment failure. The chalcones show leishmanicidal activity, yet
Shannon M Reilly et al.
The Journal of clinical investigation, 131(10) (2021-04-07)
The protein kinases IKKε and TBK1 are activated in liver and fat in mouse models of obesity. We have previously demonstrated that treatment with the IKKε/TBK1 inhibitor amlexanox produces weight loss and relieves insulin resistance in obese animals and patients.
Perplexity of a fungus in the sinus.
Radhika Dasararaju et al.
The American journal of medicine, 127(1), e1-e2 (2013-11-26)
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