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Guoliang Zou et al.
Cell cycle (Georgetown, Tex.), 18(24), 3432-3441 (2019-11-19)
Oxidative stress is considered as a major pathogenesis in myocardial damage; however, effective therapies are limited so far. The present study aimed to investigate the in vitro antioxidative mechanism of Catalpol in cardiomyocytes. The results indicated that Catalpol attenuated high
Kyoung-Jin Min et al.
Oncotarget, 8(47), 83195-83206 (2017-11-16)
Sorafenib is approved for the treatment of hepatocellular carcinoma (HCC) and advanced renal cell carcinoma (RCC). However, low tumor response and side effects have been widely reported. Therefore, to improve the efficacy of sorafenib, we investigated whether combined treatment with
Tamalika Paul et al.
Anti-cancer drugs, 30(2), 167-178 (2018-11-13)
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of cytokine superfamily, induces apoptosis in a number of tumor cells through the activation of extrinsic apoptotic pathway but shows little or no cytotoxicity toward normal cells. However some tumor cells
Sha Huang et al.
Translational lung cancer research, 9(6), 2337-2355 (2021-01-26)
The therapeutic efficacy of cisplatin-based chemotherapy for non-small cell lung cancer (NSCLC) is limited by drug resistance. In NSCLC, hyperactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) counteracts oxidative stress to promote chemoresistance. Metformin-mediated downregulation of Nrf2 plays a
Peng Mou et al.
Journal of cellular biochemistry (2018-12-16)
To evaluate the predictive efficacy and prognostic value of rs7435335 located in the UGT2B7 gene as a genetic marker in breast cancer patients receiving neoadjuvant chemotherapy (NAC). A total of 190 patients with breast cancer treated with NAC were enrolled to
Bo Ra You et al.
Molecular carcinogenesis, 56(12), 2566-2577 (2017-07-02)
Histone deacetylase (HDAC) inhibitors, especially suberoylanilide hydroxamic acid (SAHA) induce apoptosis in various cancer cells. Here, we investigated the effect of SAHA on apoptosis in lung cancer cells and addressed the role of reactive oxygen species (ROS), glutathione (GSH), and
Min Seung Lee et al.
Biology, 10(2) (2021-03-07)
Proteasome inhibitors, such as bortezomib (BZ) and carfilzomib (CFZ), have been suggested as treatments for various cancers. To utilize BZ and/or CFZ as effective therapeutics for treating melanoma, we studied their molecular mechanisms using B16-F1 melanoma cells. Flow cytometry of
Wenjing Dong et al.
Chemical research in toxicology, 32(6), 1051-1057 (2019-04-13)
Polychlorinated biphenyls (PCBs) are one of the most refractory environmental pollutants. Because of their ubiquitous existence in the biological systems (including human body), it is important to investigate their toxic behavior. Our previous findings demonstrated that a high reactive metabolite
Ni Hou et al.
Anti-cancer drugs, 28(1), 59-65 (2016-09-08)
Chlorogenic acid (CGA) is one of the polyphenols identified in the human diet. Previous studies have shown that CGA plays a protective role against liver diseases. The colon plays a pivotal role in CGA metabolism. However, little is known about
Vikas Saini et al.
Pharmacological reports : PR, 69(4), 813-821 (2017-06-08)
Diallyl disulfide (DADS), a principal organosulfur component of garlic, is known for its medicinal properties including anti-cancer activity. Prior studies have demonstrated that the compounds containing Diallyl disulfide moieties exhibited diverse therapeutic potential with promising biological activities. In the present
Ha Na Kim et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 69(2), 233-244 (2020-01-08)
Recently, Rodgersia podophylla has been reported to exhibit anti-inflammatory activity. However, little is known about the potential mechanisms about its anti-inflammatory activity. We elucidated the anti-inflammatory mechanisms of leaves extracts from Rodgersia podophylla (RP-L) in RAW264.7 cells. LPS-induced NO was
Woo Hyun Park
Oncology reports, 37(2), 1277-1283 (2016-12-31)
Gallic acid (GA; 3,4,5-triphydroxyl-benzoic acid) is widely dispersed in various plants, fruits and foods and it shows various biological properties including anticancer effects. This study investigated the effects of GA on HeLa cervical cancer cells in relation to cell death
Marlen B Espinoza et al.
Journal of cellular biochemistry, 118(4), 718-725 (2016-08-27)
Cortisol is an essential regulator of neuroendocrine stress responses in teleosts. Cortisol predominantly affects target tissues through the genomic pathway, which involves interacting with cytoplasmic glucocorticoid receptors, and thereby, modulating stress-response gene expressions. Cortisol also produces rapid effects via non-genomic
Yi-Chun Liao et al.
Archives of toxicology, 89(11), 1971-1979 (2014-09-10)
Inorganic arsenite (iAs) is a human carcinogen. Numerous studies have shown that mutation-activated H-Ras is frequently observed in human urothelial carcinomas. The interaction between iAs, an environmental factor, and H-Ras, an oncogene, is not clear. In this study, we explored
Francesca Cottini et al.
Cancer discovery, 5(9), 972-987 (2015-06-18)
Ongoing DNA damage is a common feature of epithelial cancers. Here, we show that tumor cells derived from multiple myeloma, a disease of clonal plasma cells, demonstrate DNA-replicative stress, leading to DNA damage. We identified a poor-prognosis subset of multiple
Chia-Yi Tseng et al.
PloS one, 10(7), e0131911-e0131911 (2015-07-07)
Exposure to diesel exhaust particles (DEP) is associated with pulmonary and cardiovascular diseases. Previous studies using in vitro endothelial tubes as a simplified model of capillaries have found that DEP-induced ROS increase vascular permeability with rearrangement or internalization of adherens
Apei Jiang et al.
Journal of cellular biochemistry, 116(8), 1553-1562 (2015-02-05)
Ubiquitin activating enzyme E1-like (UBE1L) is the activating enzyme for ISG15ylation (ISG15, interferon stimulated gene 15). UBE1L is thought to be a candidate tumor suppressor gene and has positive activity against stress responses such as viral infections. Both type I
Brittany L Murphy et al.
Annals of surgical oncology, 25(8), 2241-2248 (2018-05-23)
While breast cancer has historically been treated with surgery followed by adjuvant chemotherapy (AC) and radiation when indicated, neoadjuvant chemotherapy (NAC) use is thought to be increasing; however, the trends of its use in various biological subtypes have not been
Sun Young Kim et al.
Toxicological sciences : an official journal of the Society of Toxicology, 148(1), 167-182 (2015-08-12)
Cadmium (Cd(2+)) is a major environmental pollutant that induces cytotoxicity by heavy-metal accumulation. Prolonged Cd(2+) exposure leads to cell damage by oxidative stress mainly in the kidneys, a critical organ for detoxification. To identify reliable on invasive protein biomarkers for
Wei-Lin Hu et al.
Frontiers in cellular and infection microbiology, 7, 471-471 (2017-12-01)
Leptospirosis is a global zoonotic infectious disease caused by pathogenic
Evelyn A Carrillo-Bermejo et al.
Journal of plant research, 133(6), 897-909 (2020-10-24)
Climate change has caused serious problems related to the productivity of agricultural crops directly affecting human well-being. Plants have evolved to produce molecular mechanisms in response to environmental stresses, such as transcription factors (TFs), to cope with abiotic stress. The
Lukas Feil et al.
Cancers, 12(4) (2020-04-29)
Cold atmospheric plasma (CAP) treatment is developing as a promising option for local anti-neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Currently, high-frequency electrosurgical argon plasma sources are available and well established for clinical use. In this study, we
Zhong-Jie Liu et al.
Oxidative medicine and cellular longevity, 2015, 683197-683197 (2015-07-15)
Hyperglycemia can inhibit expression of the 8-oxoG-DNA glycosylase (OGG1) which is one of the key repair enzymes for DNA oxidative damage. The effect of hyperglycemia on OGG1 expression in response to local anesthetics-induced DNA damage is unknown. This study was
Soo Ah Jeong et al.
Oncotarget, 6(25), 21173-21192 (2015-06-09)
The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9(11)-dien-C28-methyl ester (CDDO-Me) is considered a promising anti-tumorigenic compound. In this study, we show that treatment with CDDO-Me induces progressive endoplasmic reticulum (ER)-derived vacuolation in various breast cancer cells and ultimately kills these cells by
Li Hu et al.
Neuroscience bulletin, 36(5), 475-492 (2020-04-04)
Increased microglial activation and neuroinflammation within autonomic brain regions such as the rostral ventrolateral medulla (RVLM) have been implicated in stress-induced hypertension (SIH). Prorenin, a member of the brain renin-angiotensin system (RAS), can directly activate microglia. The present study aimed
Gabriele Gut et al.
Science (New York, N.Y.), 361(6401) (2018-08-04)
Obtaining highly multiplexed protein measurements across multiple length scales has enormous potential for biomedicine. Here, we measured, by iterative indirect immunofluorescence imaging (4i), 40-plex protein readouts from biological samples at high-throughput from the millimeter to the nanometer scale. This approach
Yue Wang et al.
Molecular medicine reports, 19(3), 1654-1664 (2018-12-29)
Derivatives of 1,4‑naphthoquinone have excellent anti‑cancer effects, but their use has been greatly limited due to their serious side effects. To develop compounds with decreased side effects and improved anti‑cancer activity, two novel types of 1,4‑naphthoquinone derivatives, 2,3‑dihydro‑2,3‑epoxy‑2‑propylsulfonyl‑5,8‑dimethoxy‑1,4‑naphthoquinone (EPDMNQ) and
Vamsi Krishna Kommalapati et al.
Molecular and cellular biochemistry, 468(1-2), 21-34 (2020-03-09)
Neuroblastoma (NB) is the common pediatric tumor of the sympathetic nervous system characterized by poor prognosis. Owing to the challenges such as high tumor heterogeneity, multidrug resistance, minimal residual disease, etc., there is an immediate need for exploring new therapeutic
Vlad C Sandulache et al.
Molecular cancer therapeutics, 14(12), 2901-2908 (2015-09-18)
Ionizing radiation is the primary nonsurgical treatment modality for solid tumors. Its effectiveness is impacted by temporal constraints such as fractionation, hypoxia, and development of radioresistant clones. Biomarkers of acute radiation response are essential to developing more effective clinical algorithms.
S J Han et al.
Cell death & disease, 6, e1863-e1863 (2015-08-28)
High-mobility group box 1 (HMGB1) functions as a transcription-enhancing nuclear protein as well as a crucial cytokine that regulates inflammation. This study demonstrated that secretion of HMGB1 due to ultraviolet (UV) radiation inducing ocular surface inflammation-mediated reactive oxygen species (ROS)
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