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Sha Huang et al.
Translational lung cancer research, 9(6), 2337-2355 (2021-01-26)
The therapeutic efficacy of cisplatin-based chemotherapy for non-small cell lung cancer (NSCLC) is limited by drug resistance. In NSCLC, hyperactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) counteracts oxidative stress to promote chemoresistance. Metformin-mediated downregulation of Nrf2 plays a
Peng Mou et al.
Journal of cellular biochemistry (2018-12-16)
To evaluate the predictive efficacy and prognostic value of rs7435335 located in the UGT2B7 gene as a genetic marker in breast cancer patients receiving neoadjuvant chemotherapy (NAC). A total of 190 patients with breast cancer treated with NAC were enrolled to
Bo Ra You et al.
Molecular carcinogenesis, 56(12), 2566-2577 (2017-07-02)
Histone deacetylase (HDAC) inhibitors, especially suberoylanilide hydroxamic acid (SAHA) induce apoptosis in various cancer cells. Here, we investigated the effect of SAHA on apoptosis in lung cancer cells and addressed the role of reactive oxygen species (ROS), glutathione (GSH), and
Min Seung Lee et al.
Biology, 10(2) (2021-03-07)
Proteasome inhibitors, such as bortezomib (BZ) and carfilzomib (CFZ), have been suggested as treatments for various cancers. To utilize BZ and/or CFZ as effective therapeutics for treating melanoma, we studied their molecular mechanisms using B16-F1 melanoma cells. Flow cytometry of
Wenjing Dong et al.
Chemical research in toxicology, 32(6), 1051-1057 (2019-04-13)
Polychlorinated biphenyls (PCBs) are one of the most refractory environmental pollutants. Because of their ubiquitous existence in the biological systems (including human body), it is important to investigate their toxic behavior. Our previous findings demonstrated that a high reactive metabolite
Ni Hou et al.
Anti-cancer drugs, 28(1), 59-65 (2016-09-08)
Chlorogenic acid (CGA) is one of the polyphenols identified in the human diet. Previous studies have shown that CGA plays a protective role against liver diseases. The colon plays a pivotal role in CGA metabolism. However, little is known about
Vikas Saini et al.
Pharmacological reports : PR, 69(4), 813-821 (2017-06-08)
Diallyl disulfide (DADS), a principal organosulfur component of garlic, is known for its medicinal properties including anti-cancer activity. Prior studies have demonstrated that the compounds containing Diallyl disulfide moieties exhibited diverse therapeutic potential with promising biological activities. In the present
Ha Na Kim et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 69(2), 233-244 (2020-01-08)
Recently, Rodgersia podophylla has been reported to exhibit anti-inflammatory activity. However, little is known about the potential mechanisms about its anti-inflammatory activity. We elucidated the anti-inflammatory mechanisms of leaves extracts from Rodgersia podophylla (RP-L) in RAW264.7 cells. LPS-induced NO was
Marzena Szwed et al.
Journal of nanobiotechnology, 18(1), 5-5 (2020-01-08)
Lipid nanocapsules (LNCs) are promising vehicles for drug delivery. However, since not much was known about cellular toxicity of these nanoparticles in themselves, we have here investigated the mechanisms involved in LNC-induced intoxication of the three breast cancer cell lines
Jie Zhou et al.
Biomedicines, 8(8) (2020-07-29)
Oligodendrocytic injury by oxidative stress can lead to demyelination, contributing to neurodegeneration. We investigated the mechanisms by which an antioxidant, N-acetylcysteine (NAC), reduces oxidative stress in murine oligodendrocytes. We used normal 158N and mutant 158JP cells with endogenously high reactive
Tommaso Di Palma et al.
Zygote (Cambridge, England), 28(4), 300-307 (2020-04-15)
Information on donkey sperm bioenergetics, kinetics and oxidative status is scarce even though crucial for development of reproductive technologies and germplasm conservation. For these reasons, it is interesting to monitor sperm kinetics, bioenergetics, and oxidative status during sperm storage at
Poornima Ramburrun et al.
Biomedical materials (Bristol, England), 14(6), 065015-065015 (2019-09-19)
The focus of significance in neuronal repair strategies is the design of scaffold systems capable of promoting neuronal regeneration and directional guidance via provision of a biomimetic environment resemblance of native neural tissue. The purpose of this study was to
Pankaj Borgohain et al.
Protoplasma, 256(4), 1065-1077 (2019-03-29)
Plant NAC (NAM, ATAF, and CUC) transcription factors (TF) have important roles to play in abiotic stress responses through activation of a battery of functional genes/transcriptional regulators responsible for stress tolerance. Here we report the cloning of a novel Solanum
Hyun-Kyoung Kim et al.
Redox biology, 40, 101853-101853 (2021-01-15)
Chalcone is a polyphenolic compound found abundantly in natural plant components. They have been acclaimed as potential antitumor compounds in multiple tumor cells. However, not much attention has been paid to elucidate its antitumor mechanism of action. Here, chalcone was
Ovie Utuama et al.
Annals of surgical oncology, 28(4), 1939-1949 (2021-01-09)
Upfront surgery is the current standard for resectable intrahepatic cholangiocarcinoma (ICC) despite high treatment failure with this approach. We sought to examine the use of neoadjuvant chemotherapy (NAC) as an alternative strategy for this population. The National Cancer Database was
Shresh Pathak et al.
Immunologic research, 63(1-3), 236-245 (2015-09-24)
Autoimmune inner ear disease (AIED) is a poorly understood disease marked by bilateral, rapidly progressive hearing loss triggered by unknown stimuli, which is corticosteroid responsive in 60 % of patients. Although the mechanism of the disease is not precisely understood, a
Julia M Broström et al.
Toxicology and applied pharmacology, 287(3), 222-231 (2015-06-15)
Diisocyanates are industrial chemicals which have a wide range of applications in developed and developing countries. They are notorious lung toxicants and respiratory sensitizers. However, the mechanisms behind their adverse effects are not adequately characterized. Autotaxin (ATX) is an enzyme
Woo Hyun Park
Oncology reports, 37(2), 1277-1283 (2016-12-31)
Gallic acid (GA; 3,4,5-triphydroxyl-benzoic acid) is widely dispersed in various plants, fruits and foods and it shows various biological properties including anticancer effects. This study investigated the effects of GA on HeLa cervical cancer cells in relation to cell death
Marlen B Espinoza et al.
Journal of cellular biochemistry, 118(4), 718-725 (2016-08-27)
Cortisol is an essential regulator of neuroendocrine stress responses in teleosts. Cortisol predominantly affects target tissues through the genomic pathway, which involves interacting with cytoplasmic glucocorticoid receptors, and thereby, modulating stress-response gene expressions. Cortisol also produces rapid effects via non-genomic
Yi-Chun Liao et al.
Archives of toxicology, 89(11), 1971-1979 (2014-09-10)
Inorganic arsenite (iAs) is a human carcinogen. Numerous studies have shown that mutation-activated H-Ras is frequently observed in human urothelial carcinomas. The interaction between iAs, an environmental factor, and H-Ras, an oncogene, is not clear. In this study, we explored
Francesca Cottini et al.
Cancer discovery, 5(9), 972-987 (2015-06-18)
Ongoing DNA damage is a common feature of epithelial cancers. Here, we show that tumor cells derived from multiple myeloma, a disease of clonal plasma cells, demonstrate DNA-replicative stress, leading to DNA damage. We identified a poor-prognosis subset of multiple
Chia-Yi Tseng et al.
PloS one, 10(7), e0131911-e0131911 (2015-07-07)
Exposure to diesel exhaust particles (DEP) is associated with pulmonary and cardiovascular diseases. Previous studies using in vitro endothelial tubes as a simplified model of capillaries have found that DEP-induced ROS increase vascular permeability with rearrangement or internalization of adherens
Apei Jiang et al.
Journal of cellular biochemistry, 116(8), 1553-1562 (2015-02-05)
Ubiquitin activating enzyme E1-like (UBE1L) is the activating enzyme for ISG15ylation (ISG15, interferon stimulated gene 15). UBE1L is thought to be a candidate tumor suppressor gene and has positive activity against stress responses such as viral infections. Both type I
Brittany L Murphy et al.
Annals of surgical oncology, 25(8), 2241-2248 (2018-05-23)
While breast cancer has historically been treated with surgery followed by adjuvant chemotherapy (AC) and radiation when indicated, neoadjuvant chemotherapy (NAC) use is thought to be increasing; however, the trends of its use in various biological subtypes have not been
Guoliang Zou et al.
Cell cycle (Georgetown, Tex.), 18(24), 3432-3441 (2019-11-19)
Oxidative stress is considered as a major pathogenesis in myocardial damage; however, effective therapies are limited so far. The present study aimed to investigate the in vitro antioxidative mechanism of Catalpol in cardiomyocytes. The results indicated that Catalpol attenuated high
Kyoung-Jin Min et al.
Oncotarget, 8(47), 83195-83206 (2017-11-16)
Sorafenib is approved for the treatment of hepatocellular carcinoma (HCC) and advanced renal cell carcinoma (RCC). However, low tumor response and side effects have been widely reported. Therefore, to improve the efficacy of sorafenib, we investigated whether combined treatment with
Tamalika Paul et al.
Anti-cancer drugs, 30(2), 167-178 (2018-11-13)
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of cytokine superfamily, induces apoptosis in a number of tumor cells through the activation of extrinsic apoptotic pathway but shows little or no cytotoxicity toward normal cells. However some tumor cells
Beverly Giam et al.
Scientific reports, 7(1), 17718-17718 (2017-12-20)
Mechanisms underlying the renal pathology in cardiorenal syndrome (CRS) type 2 remain elusive. We hypothesised that renal glutathione deficiency is central to the development of CRS type 2. Glutathione precursor, N-acetylcysteine (NAC;40 mg/kg/day; 8 weeks) or saline were administered to transgenic
Sun Young Kim et al.
Toxicological sciences : an official journal of the Society of Toxicology, 148(1), 167-182 (2015-08-12)
Cadmium (Cd(2+)) is a major environmental pollutant that induces cytotoxicity by heavy-metal accumulation. Prolonged Cd(2+) exposure leads to cell damage by oxidative stress mainly in the kidneys, a critical organ for detoxification. To identify reliable on invasive protein biomarkers for
Evelyn A Carrillo-Bermejo et al.
Journal of plant research, 133(6), 897-909 (2020-10-24)
Climate change has caused serious problems related to the productivity of agricultural crops directly affecting human well-being. Plants have evolved to produce molecular mechanisms in response to environmental stresses, such as transcription factors (TFs), to cope with abiotic stress. The
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