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A2942

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Guo-Kai Wang et al.
In vivo (Athens, Greece), 35(1), 325-332 (2021-01-07)
Salvia miltiorrhiza is a medical herb for human disorders including cardiovascular diseases and cancer. However, the interactions between Salvia miltiorrhiza and its endophytes are largely unknown. The current study aimed at identifying its endophytic fungi and examining their inhibitory effects...
Richard C Condit et al.
Virology, 482, 147-156 (2015-04-13)
Vaccinia virus mutants in which expression of the virion core protein gene E6R is repressed are defective in virion morphogenesis. E6 deficient infections fail to properly package viroplasm into viral membranes, resulting in an accumulation of empty immature virions and...
Carlo Cifani et al.
Acta bio-medica : Atenei Parmensis, 83(2), 154-163 (2013-02-12)
Amphotericin B is a polyene macrolide derived from Streptomyces nodosus. Introduced into therapy in 1957, for decades amphotericin B has been the "gold standard" for fighting systemic fungal infections. In order to facilitate its systemic use, much attention has been...
Diana Vargas-Hurtado et al.
Current biology : CB, 29(18), 2993-3005 (2019-09-10)
A functional bipolar spindle is essential to segregate chromosomes correctly during mitosis. Across organisms and cell types, spindle architecture should be optimized to promote error-free divisions. However, it remains to be investigated whether mitotic spindle morphology adapts to changes in...
Shankar P Parajuli et al.
American journal of physiology. Cell physiology, 305(2), C207-C214 (2013-05-25)
Large conductance voltage- and Ca(2+)-activated K(+) (BK) channels are key regulators of detrusor smooth muscle (DSM) contraction and relaxation during urine voiding and storage. Here, we explored whether BK channels are regulated by muscarinic receptors (M-Rs) in native freshly isolated...
Anna Turkova et al.
Current opinion in infectious diseases, 24(2), 163-171 (2011-02-09)
The aim is to compare the available evidence on the efficacy and safety of deoxycholate and lipid amphotericin B formulations (AMBF) in the treatment of invasive fungal disease (IFD) in neonates. The review also aims to summarize current practices and...
Guangwei Wang et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 19(39), 12938-12942 (2013-09-17)
Highly stereoselective: A highly efficient, stereoselective and practical synthesis of the C21-C37 fragment of amphotericin B was realized in 25 % overall yield in eight longest linear steps from commercially available ethyl (S)-3-hydroxybutyrate by using Fráter-Seebach alkylation, Brown crotylboration, Negishi coupling, Heck...
Francesca Caccuri et al.
Journal of translational medicine, 18(1), 362-362 (2020-09-25)
Since the first outbreak of SARS-CoV-2, the clinical characteristics of the Coronavirus Disease 2019 (COVID-19) have been progressively changed. Data reporting a viral intra-host and inter-host evolution favouring the appearance of mild SARS-CoV-2 strains are since being accumulating. To better...
J Bolard et al.
Biochemistry, 30(23), 5707-5715 (1991-06-11)
The inducement of K+ permeability through membranes by the polyene antibiotic amphotericin B (AmB) has been analyzed as a measure of the antibiotic activity. Dose-response curves have been obtained with cholesterol- and ergosterol-containing egg yolk phosphatidylcholine large unilamellar vesicles (LUVs)...
Kristopher R Genschmer et al.
Cell, 176(1-2), 113-126 (2019-01-12)
Here, we describe a novel pathogenic entity, the activated PMN (polymorphonuclear leukocyte, i.e., neutrophil)-derived exosome. These CD63+/CD66b+ nanovesicles acquire surface-bound neutrophil elastase (NE) during PMN degranulation, NE being oriented in a configuration resistant to α1-antitrypsin (α1AT). These exosomes bind and...
Kausar Sadia Fakhruddin et al.
BMC microbiology, 20(1), 95-95 (2020-04-17)
The microbiome of Severe-Early Childhood Caries (S-ECC), is characterized by an ecosystem comprising bacterial and fungal species, with a predominance of Candida species. Hence, an anti-cariogen effective against both bacteria and fungi would be valuable in the management of S-ECC....
Greta Klejborowska et al.
Bioorganic & medicinal chemistry, 32, 116014-116014 (2021-01-20)
Colchicine is a plant alkaloid with a broad spectrum of biological and pharmacological properties. It has found application as an anti-inflammatory agent and also shows anticancer effects through its ability to destabilize microtubules by preventing tubulin dimers from polymerizing leading...
Michael Klepser
Journal of critical care, 26(2), 225-225 (2010-10-19)
Over the last 20 years, there has been an increase in the total number of invasive fungal infections (IFIs) and in infections caused by rare and emerging pathogens. This is due in part to the growing population of immunocompromised patients...
Niven A Salih et al.
Tropical medicine & international health : TM & IH, 19(2), 146-152 (2014-01-18)
The aim of this study was to report the patient profile and treatment outcomes, including relapses, of patients with visceral leishmaniasis (VL) treated with liposomal amphotericin B (AmBisome) in Gedaref, Sudan. AmBisome was offered to two groups of patients: primary...
A patient with rheumatoid arthritis, cryoglobulinaemia, and an "accidental" finding.
Konstantinos Liapis et al.
BMJ (Clinical research ed.), 348, g2701-g2701 (2014-04-16)
Mariusz Dyląg et al.
Biochemical and biophysical research communications, 434(2), 322-327 (2013-04-02)
We have investigated the antifungal activity of the pyruvic acid analogue: 3-bromopyruvate (3-BP). Growth inhibition by 3-BP of 110 strains of yeast-like and filamentous fungi was tested by standard spot tests or microdilution method. The human pathogen Cryptococcus neoformans exhibited...
Iman Karimzadeh et al.
European journal of clinical pharmacology, 69(7), 1351-1368 (2013-01-31)
To collect available clinical data to define the role of diuretics and lipid formulations in the prevention of amphotericin B (AmB)-induced nephrotoxicity (AIN) in human populations. A literature search was performed in the following databases: Scopus, Medline, Embase, Cochrane Central...
E Martínez-León et al.
Human reproduction (Oxford, England), 30(9), 2138-2151 (2015-06-26)
Does fibronectin (Fn) stimulate the sperm capacitation process in humans? Fibronectin stimulates human sperm capacitation. Capacitation is a process that occurs in the oviduct. It has been suggested that some molecules present in the oviductal fluid and cells as well...
Noelle Layer et al.
JAMA ophthalmology, 132(7), 832-837 (2014-05-03)
Optisol-GS, the most common corneal storage medium in the United States, contains antibacterial but no antifungal supplementation. Most postkeratoplasty endophthalmitis and keratitis cases are now of a fungal origin. To assess the efficacy and safety of voriconazole and amphotericin B...
Ulisse Garbin et al.
Mediators of inflammation, 2008, 367590-367590 (2008-04-26)
The endothelium plays a key role in the development of atherogenesis and its inflammatory and proliferative status influences the progression of atherosclerosis. The aim of this study is to compare the effects of two beta blockers such as nebivolol and...
Hee Chan Yoo et al.
Cell metabolism, 31(2), 267-283 (2019-12-24)
Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism, the mitochondrial glutamine transporter has long been unknown. Here, we show that the SLC1A5 variant plays...
Treating cryptococcal meningitis in people with HIV.
BMJ (Clinical research ed.), 346, f2203-f2203 (2013-04-12)
Ana Amaral et al.
Animals : an open access journal from MDPI, 10(5) (2020-05-21)
Neutrophil extracellular traps (NETs) fight endometritis, and elastase (ELA), a protease found in NETs, might induce collagen type I (COL1) accumulation in equine endometrium. Metallopeptidases (MMPs) are involved in extracellular matrix balance. The aim was to evaluate the effects of...
Deniz Gulfem Ozturk et al.
Autophagy, 15(3), 375-390 (2018-10-07)
Macroautophagy (autophagy) is an evolutionarily conserved recycling and stress response mechanism. Active at basal levels in eukaryotes, autophagy is upregulated under stress providing cells with building blocks such as amino acids. A lysosome-integrated sensor system composed of RRAG GTPases and...
R Scott Pearsall et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(19), 7082-7087 (2008-05-08)
Diseases that affect the regulation of bone turnover can lead to skeletal fragility and increased fracture risk. Members of the TGF-beta superfamily have been shown to be involved in the regulation of bone mass. Activin A, a TGF-beta signaling ligand...
Katrina A Brandis et al.
The Journal of biological chemistry, 288(50), 35703-35713 (2013-11-01)
Mobilization of plasma membrane (PM) cholesterol to the endoplasmic reticulum is essential for cellular cholesterol homeostasis. The mechanisms regulating this retrograde, intermembrane cholesterol transfer are not well understood. Because mutant cells with defects in PM to endoplasmic reticulum cholesterol trafficking...
Saira Tabassum et al.
BMC complementary and alternative medicine, 19(1), 256-256 (2019-09-16)
Arisaema jacquemontii is traditionally used in treatment of different diseases. In this study, phytochemical, in vitro biological and chemo-preventive screening of A. jacquemontii was carried out to explore its pharmacological potential. The dried tuber of A. jacquemontii was extracted in...
D Standaert et al.
Acta clinica Belgica, 68(2), 124-127 (2013-08-24)
Leishmaniasis, an intracellular protozoal infection in which tissue macrophages are targeted, is transmitted by female sandfly bite and occurs in 98 countries. Visceral leishmaniasis (VL) is the clinical form of leishmaniasis most frequently associated with HIV, especially in Europe. Both...
Maria Teresa Montagna et al.
Journal of medical microbiology, 63(Pt 12), 1638-1643 (2014-09-12)
We determined the in vitro antifungal activity of liposomal amphotericin B (L-AmB) against 604 clinical yeast isolates. Amphotericin B deoxycholate (D-AmB) was tested in parallel against all the isolates. Susceptibility testing was performed according to the Clinical and Laboratory Standards...
Patrícia L N Néris et al.
Experimental parasitology, 135(2), 307-313 (2013-07-31)
Leishmaniasis' treatment is based mostly on pentavalent antimonials or amphotericin B long-term administration, expensive drugs associated with severe side effects. Considering these aforementioned, the search for alternative effective and safe leishmaniasis treatments is a necessity. This work evaluated a neolignan...
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