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A5955

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Maria João Carvalho et al.
Pathology oncology research : POR, 25(3), 1163-1174 (2018-12-01)
This study aimed to characterize endometrial cancer regarding cancer stem cells (CSC) markers, regulatory and differentiation pathways, tumorigenicity and glucose metabolism. Endometrial cancer cell line ECC1 was submitted to sphere forming protocols. The first spheres generation (ES1) was cultured in...
Irene Anton-Sales et al.
Biomaterials science, 8(10), 2921-2930 (2020-04-22)
Corneal trauma and ulcerations are leading causes of corneal blindness around the world. These lesions require attentive medical monitoring since improper healing or infection has serious consequences in vision and quality of life. Amniotic membrane grafts represent the common solution...
Anna Piaszyk-Borychowska et al.
Frontiers in immunology, 10, 1253-1253 (2019-06-25)
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ), and dendritic cells (DC) play a crucial role in vascular inflammation and atherosclerosis. Interferon (IFN)α, IFNγ, and Toll-like...
Huan Qu et al.
Journal of animal science, 96(5), 1724-1735 (2018-04-17)
Heat stress (HS) leads to increased lipid storage and expression of cytosolic phosphoenolpyruvate carboxykinase (PCK1) in pig adipocytes. However, the importance of PCK1 activation and lipid storage in the adaptive response to HS is unknown. Therefore, in vitro experiments were...
Ana Sofia Coelho et al.
Odontology, 108(2), 260-270 (2019-10-19)
The aim of this study was to evaluate the cytotoxic effects of an enzymatic mouthwash and of a chlorhexidine mouthwash on human gingival fibroblasts. The metabolic activity of the fibroblasts exposed to each mouthwash was assessed by the MTT assay...
Inês Ferreira et al.
Molecules (Basel, Switzerland), 25(18) (2020-09-24)
The sealers used for root canal treatment should be biocompatible for the peri-radicular tissues, to evaluate the cytotoxic effects of GuttaFlow® bioseal sealer and to compare them with AH26® epoxy resin. Culture media were conditioned with the GuttaFlow® bioseal and...
Maria Masnata et al.
Acta neuropathologica, 137(6), 981-1001 (2019-02-23)
In recent years, evidence has accumulated to suggest that mutant huntingtin protein (mHTT) can spread into healthy tissue in a prion-like fashion. This theory, however, remains controversial. To fully address this concept and to understand the possible consequences of mHTT spreading...
Genevieve Saw et al.
Glia, 68(3), 656-669 (2019-11-09)
Microglia are the main form of immune defense in the central nervous system. Microglia express phosphatidylinositol 3-kinase (PI3K), which has been shown to play a significant role in synaptic plasticity in neurons and inflammation via microglia. This study shows that...
Alessandro Taloni et al.
Scientific reports, 7(1), 3748-3748 (2017-06-18)
Classification of morphological features in biological samples is usually performed by a trained eye but the increasing amount of available digital images calls for semi-automatic classification techniques. Here we explore this possibility in the context of acrosome morphological analysis during...
Seetharam Deepa et al.
Nanotoxicology, 13(2), 240-257 (2019-01-22)
The present study analyzed the effects of zinc oxide nanoparticles (ZnO-NPs) and zinc sulfate (ZnSO4) in the testis of six-month-old common carp Cyprinus carpio exposed to three different doses, viz., 10, 50, and 100 μg/L for 21 days. Characterization of ZnO-NPs was...
Wassamon Boonying et al.
Journal of neurochemistry, 150(3), 312-329 (2019-02-09)
Loss of function mutations in the PTEN-induced putative kinase 1 (Pink1) gene have been linked with an autosomal recessive familial form of early onset Parkinson's disease (PD). However, the underlying mechanism(s) responsible for degeneration remains elusive. Presently, using co-immunoprecipitation in...
Cristian Alfredo Segura-Cerda et al.
Tuberculosis (Edinburgh, Scotland), 115, 42-48 (2019-04-06)
Tuberculosis (TB) is the most prevalent infectious disease worldwide, with no fully effective vaccine yet available. Considering that BCG strains devoid of the BCG1416c or BCG1419c genes afforded protection in mice versus highly virulent M. tuberculosis challenge, or in chronic...
Lyda Espitia-Pérez et al.
Chemosphere, 206, 203-216 (2018-05-12)
During coal surface mining, several activities such as drilling, blasting, loading, and transport produce large quantities of particulate matter (PM) that is directly emitted into the atmosphere. Occupational exposure to this PM has been associated with an increase of DNA...
Hidetoshi Yamada et al.
PloS one, 6(7), e21952-e21952 (2011-07-16)
Pacific Krill (Euphausia pacifica) are small, red crustaceans, similar to shrimp, that flourish in the North Pacific and are eaten in Japan. We investigated the effect of a water-soluble extract of Pacific Krill on adipocytes and discovered that this extract...
Seiichiro Ishihara et al.
Cancer research, 77(22), 6179-6189 (2017-10-04)
In response to chemical stimuli from cancer cells, mesenchymal stem cells (MSC) can differentiate into cancer-associated fibroblasts (CAF) and promote tumor progression. How mechanical stimuli such as stiffness of the extracellular matrix (ECM) contribute to MSC phenotype in cancer remains...
Lucas Oliveira Sousa et al.
Epigenomics, 12(6), 475-485 (2020-04-09)
Aim: Histone acetylation and methylation control gene expression. We investigated the impact of SET knockdown on histone methylation status and the consequences for the miRNAs levels in oral squamous cell carcinoma (OSCC). Methods: OSCC cells with and without SET knockdown...
Helen R Murphy et al.
Journal of food protection, 80(7), 1133-1144 (2017-06-08)
Cyclospora cayetanensis is a protozoan parasite that causes human diarrheal disease associated with the consumption of fresh produce or water contaminated with C. cayetanensis oocysts. In the United States, foodborne outbreaks of cyclosporiasis have been linked to various types of...
Mohammed H A Almarzoug et al.
Environmental toxicology, 35(9), 930-941 (2020-04-21)
Platinum nanoparticles (PtNPs) attract much attention due to their excellent biocompatibility and catalytic properties, but their toxic effects on normal (CHANG) and cancerous (HuH-7) human liver cells are meagre. The cytotoxic and apoptotic effects of PtNPs (average size, 3 nm) were...
Sina Naddaf Dezfuli et al.
Journal of the mechanical behavior of biomedical materials, 67, 74-86 (2016-12-18)
In our previous study, we developed Mg-matrix composites with bredigite as the reinforcing phase and achieved improved degradation resistance in comparison with Mg. However, the effects of materials processing method and process parameters on the mechanical behavior of the composites...
Nina Strah et al.
BMC biology, 18(1), 34-34 (2020-03-29)
The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in skeletal...
Agnes Schröder et al.
Alcohol (Fayetteville, N.Y.), 77, 59-70 (2018-10-20)
Consumption of toxic substances such as alcohol is widespread in the general population and thus also in patients receiving orthodontic treatment. Since human periodontal ligament (hPDL) fibroblasts play a key role in orthodontic tooth movement (OTM) by expressing cytokines and...
Kaja Kostyrko et al.
Biotechnology and bioengineering, 114(2), 384-396 (2016-10-27)
Untargeted plasmid integration into mammalian cell genomes remains a poorly understood and inefficient process. The formation of plasmid concatemers and their genomic integration has been ascribed either to non-homologous end-joining (NHEJ) or homologous recombination (HR) DNA repair pathways. However, a...
S Tian et al.
Gene therapy, 16(10), 1260-1270 (2009-09-04)
Dendritic cells (DC) engineered in vitro by DNA encoding OVAhsp70 and IL-15 up-regulated their expressions of CD80, CD86, CCR7 and IL-15Ralpha and promoted their productions of IL-6, IL-12 and TNF-alpha. Transcriptional IL-15-directed in vivo DC targeting DNA vaccine encoding OVAhsp70...
Grethel León-Mejía et al.
Environmental science and pollution research international, 27(16), 20516-20526 (2020-04-05)
Diesel engine exhaust (DEE) is a complex mixture of toxic gases, halogenated aromatic hydrocarbons, alkyl polycyclic aromatic hydrocarbons, polycyclic aromatic hydrocarbons, benzene derivatives, metals and diesel exhaust particles (DEPs) generated from the incomplete combustion of diesel fuel. Many of the...
Annika de Jong et al.
Thrombosis and haemostasis, 120(11), 1569-1579 (2020-08-18)
Von Willebrand disease (VWD) is the most common inherited bleeding disorder and is mainly caused by dominant-negative mutations in the multimeric protein von Willebrand factor (VWF). These mutations may either result in quantitative or qualitative defects in VWF. VWF is...
Helen R Murphy et al.
Food microbiology, 69, 170-178 (2017-09-25)
A collaborative validation study was performed to evaluate the performance of a new U.S. Food and Drug Administration method developed for detection of the protozoan parasite, Cyclospora cayetanensis, on cilantro and raspberries. The method includes a sample preparation step in...
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Susan Walker et al.
PloS one, 9(9), e106262-e106262 (2014-09-04)
In human adults, and animals, the Apelin-APJ ligand-receptor system is emerging as having a role in the pathogenesis of cardiovascular function and heart failure. The aim was to investigate expression, and regulation by oxygen, of the Apelin APJ receptor (APJ)...
Grethel León-Mejía et al.
Ecotoxicology and environmental safety, 171, 264-273 (2019-01-07)
Diesel engine exhaust (DEE), which is the product of diesel combustion, is considered carcinogenic in humans. It comprises toxic gases, polycyclic aromatic hydrocarbons (PAHs) and particulate matter which can reach the pulmonary parenchyma and trigger various diseases, including cancer. The...
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