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Lívia C Magalhães et al.
Biopreservation and biobanking, 15(5), 463-468 (2017-09-19)
The brown brocket deer Mazama gouazoubira is 1 of the 10 recognized brocket deer of the Neotropical region. Recently, this species has suffered a population decline due to current threats, mainly poaching and habitat loss. Several studies have shown that
Nhat Quang Bui et al.
Physics in medicine and biology, 62(2), 501-516 (2016-12-22)
Macrophages are excellent imaging targets for detecting atherosclerotic plaques as they are involved in all the developmental stages of atherosclerosis. However, no imaging technique is currently capable of visualizing macrophages inside blood vessel walls. The current study develops an intravascular
Alfeu Zanotto-Filho et al.
Molecular cancer therapeutics, 15(12), 3000-3014 (2016-09-18)
Alkylating agents are a commonly used cytotoxic class of anticancer drugs. Understanding the mechanisms whereby cells respond to these drugs is key to identify means to improve therapy while reducing toxicity. By integrating genome-wide gene expression profiling, protein analysis, and
Monireh Kouhi et al.
Journal of biomedical materials research. Part A, 107(6), 1154-1165 (2019-01-13)
Guided bone regeneration (GBR) has been established to be an effective method for the repair of defective tissues, which is based on isolating bone defects with a barrier membrane for faster tissue reconstruction. The aim of the present study is
Yao-Kuang Huang et al.
Microbial pathogenesis, 128, 69-74 (2018-12-26)
Salmonella is a common foodborne and zoonotic pathogen. Only a few serovars carry a virulence plasmid (pSV), which enhances the pathogenicity of the host. Here, we investigated the pathogenicity roles of the pSVs among wild-type, plasmid-less, and complemented S. Typhimurium
Agnes Schröder et al.
Immunology and cell biology, 99(1), 84-96 (2020-09-06)
Myeloid cells regulate bone density in response to increased salt (NaCl) intake via the osmoprotective transcription factor, nuclear factor of activated T cells-5 (NFAT-5). Because orthodontic tooth movement (OTM) is a pseudoinflammatory immunological process, we investigated the influence of NaCl
Mohammad Golam Sabbir
The Journal of steroid biochemistry and molecular biology, 191, 105376-105376 (2019-05-09)
Progesterone (P4) is a major steroid hormone that has important effects on metabolism. The progesterone receptor membrane component 1 (PGRMC1) is a non-canonical P4 binding protein. The biological functions affected by PGRMC1 include cholesterol/steroid biosynthesis and metabolism, iron homeostasis and
Dikla Raz-Ben Aroush et al.
Current biology : CB, 27(19), 2963-2973 (2017-10-03)
Actin turnover is the central driving force underlying lamellipodial motility. The molecular components involved are largely known, and their properties have been studied extensively in vitro. However, a comprehensive picture of actin turnover in vivo is still missing. We focus on fragments
PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.
Di Paolo, et al.
RNA, 26, 1637-1653 (2021)
Sara Balbuena-Pecino et al.
International journal of molecular sciences, 21(16) (2020-08-23)
Soybeans are one of the most used alternative dietary ingredients in aquafeeds. However, they contain phytoestrogens like genistein (GE), which can have an impact on fish metabolism and health. This study aimed to investigate the in vitro and in vivo
Mariafrancesca Hyeraci et al.
ChemMedChem, 15(15), 1464-1472 (2020-06-04)
Platinum(II) complexes of the type [Pt(Cl)(PPh3 ){(κ2 -N,O)-(1{C(R)=N(OH)-2(O)C6 H4 })}] with R=Me, H, (1 and 2) were synthesized and characterized. Single-crystal X-ray diffraction confirmed the proposed (SP4-3) configuration for 1. Study of the antiproliferative activity, performed on a panel of
Laura Silvana Pérez-Restrepo et al.
Archives of virology, 164(1), 149-158 (2018-10-10)
Dengue is the second most prevalent vector-borne disease after malaria in Colombia. It is caused by dengue virus, an arbovirus that exhibits high epidemic power, which is evidenced by its occurrence in more than 80% of the country, largely because
Jaouad Anter et al.
Journal of medicinal food, 14(3), 276-283 (2010-12-25)
Medicinal plants represent an important resource in new drug research. Antioxidant properties of plants can help to scavenge reactive oxygen species. The objective of this work was to evaluate the genotoxic, antigenotoxic, tumoricidal, and apoptotic effect of some major phenols
Paula Benny et al.
Tissue engineering. Part A, 21(1-2), 183-192 (2014-07-25)
Skin is one of the most accessible tissues for experimental biomedical sciences, and cultured skin cells represent one of the longest-running clinical applications of stem cell therapy. However, culture-generated skin mimetic multicellular structures are still limited in their application by
Yuenmu Chen et al.
American journal of physiology. Lung cellular and molecular physiology, 291(3), L378-L385 (2006-05-09)
We have demonstrated that VEGF-induced dilation of bovine pulmonary arteries is associated with activation of cytochrome P-450 family 4 (CYP4) enzymes and eNOS. We hypothesized that VEGF and the CYP4 product 20-HETE would trigger common downstream pathways of intracellular signaling
Ute Nazet et al.
Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie (2021-06-19)
Apart from other risk factors, mechanical stress on joints can promote the development of osteoarthritis (OA), which can also affect the temporomandibular joint (TMJ), resulting in cartilage degeneration and synovitis. Synovial fibroblasts (SF) play an important role in upkeeping joint
Maria João Carvalho et al.
Pathology oncology research : POR, 25(3), 1163-1174 (2018-12-01)
This study aimed to characterize endometrial cancer regarding cancer stem cells (CSC) markers, regulatory and differentiation pathways, tumorigenicity and glucose metabolism. Endometrial cancer cell line ECC1 was submitted to sphere forming protocols. The first spheres generation (ES1) was cultured in
Agnes Schröder et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Orthodontic treatment to correct dental malocclusions leads to the formation of pressure zones in the periodontal ligament resulting in a sterile inflammatory reaction, which is mediated by periodontal ligament fibroblasts (PDLF). Leptin levels are elevated in obesity and chronic inflammatory
Ander Egimendia et al.
Pharmaceutics, 13(7) (2021-07-03)
Ex vivo models for the noninvasive study of myelin-related diseases represent an essential tool to understand the mechanisms of diseases and develop therapies against them. Herein, we assessed the potential of multimodal imaging traceable myelin-targeting liposomes to quantify myelin in
Mohammed H A Almarzoug et al.
Environmental toxicology, 35(9), 930-941 (2020-04-21)
Platinum nanoparticles (PtNPs) attract much attention due to their excellent biocompatibility and catalytic properties, but their toxic effects on normal (CHANG) and cancerous (HuH-7) human liver cells are meagre. The cytotoxic and apoptotic effects of PtNPs (average size, 3 nm) were
Andrew S Flies et al.
Bio-protocol, 10(13), e3696-e3696 (2021-03-05)
This protocol provides a step-by-step method to create recombinant fluorescent fusion proteins that can be secreted from mammalian cell lines. This builds on many other recombinant protein and fluorescent protein techniques, but is among the first to harness fluorescent fusion
Genevieve Saw et al.
Glia, 68(3), 656-669 (2019-11-09)
Microglia are the main form of immune defense in the central nervous system. Microglia express phosphatidylinositol 3-kinase (PI3K), which has been shown to play a significant role in synaptic plasticity in neurons and inflammation via microglia. This study shows that
Su Yeon Kim et al.
Mediators of inflammation, 2011, 945123-945123 (2011-08-09)
The effects of dietary protein and fat on renal function-related blood and urine parameters, such as albumin, urinary protein,and inflammatory cytokines were investigated in adriamycin- (ADR) induced nephrotic syndrome rats. ADR (2 mg/kg BW) was injected i.p. weekly for six weeks
Kinue Aihara et al.
Kidney international, 64(4), 1283-1291 (2003-09-13)
Crystal formation and retention are critical events for the formation of kidney stones. Oxalate and calcium oxalate (CaOx) crystals are injurious to renal epithelium, and membranes of injured cells promote crystal adherence and retention. Calcium phosphate (CaP) is the most
Wassamon Boonying et al.
Journal of neurochemistry, 150(3), 312-329 (2019-02-09)
Loss of function mutations in the PTEN-induced putative kinase 1 (Pink1) gene have been linked with an autosomal recessive familial form of early onset Parkinson's disease (PD). However, the underlying mechanism(s) responsible for degeneration remains elusive. Presently, using co-immunoprecipitation in
Cristian Alfredo Segura-Cerda et al.
Tuberculosis (Edinburgh, Scotland), 115, 42-48 (2019-04-06)
Tuberculosis (TB) is the most prevalent infectious disease worldwide, with no fully effective vaccine yet available. Considering that BCG strains devoid of the BCG1416c or BCG1419c genes afforded protection in mice versus highly virulent M. tuberculosis challenge, or in chronic
Lyda Espitia-Pérez et al.
Chemosphere, 206, 203-216 (2018-05-12)
During coal surface mining, several activities such as drilling, blasting, loading, and transport produce large quantities of particulate matter (PM) that is directly emitted into the atmosphere. Occupational exposure to this PM has been associated with an increase of DNA
Inês Ferreira et al.
Molecules (Basel, Switzerland), 25(18) (2020-09-24)
The sealers used for root canal treatment should be biocompatible for the peri-radicular tissues, to evaluate the cytotoxic effects of GuttaFlow® bioseal sealer and to compare them with AH26® epoxy resin. Culture media were conditioned with the GuttaFlow® bioseal and
Huan Qu et al.
Journal of animal science, 96(5), 1724-1735 (2018-04-17)
Heat stress (HS) leads to increased lipid storage and expression of cytosolic phosphoenolpyruvate carboxykinase (PCK1) in pig adipocytes. However, the importance of PCK1 activation and lipid storage in the adaptive response to HS is unknown. Therefore, in vitro experiments were
Anna Piaszyk-Borychowska et al.
Frontiers in immunology, 10, 1253-1253 (2019-06-25)
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ), and dendritic cells (DC) play a crucial role in vascular inflammation and atherosclerosis. Interferon (IFN)α, IFNγ, and Toll-like
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