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Adeleye J Afolayan et al.
The Journal of biological chemistry, 292(6), 2369-2378 (2016-12-29)
Stress-inducible heat shock protein 70 (hsp70) interacts with superoxide dismutase 2 (SOD2) in the cytosol after synthesis to transfer the enzyme to the mitochondria for subsequent activation. However, the structural basis for this interaction remains to be defined. To map...
Ilan Y Benador et al.
Cell metabolism, 27(4), 869-885 (2018-04-05)
Mitochondria associate with lipid droplets (LDs) in fat-oxidizing tissues, but the functional role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of interscapular brown adipose tissue reveals that PDM have unique protein composition and cristae structure and remain adherent...
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila.
Bjedov, et al.
PLoS Genetics, 16, e1009083-e1009083 (2021)
Sahar Elouej et al.
Nature communications, 11(1), 4589-4589 (2020-09-13)
Mandibuloacral dysplasia syndromes are mainly due to recessive LMNA or ZMPSTE24 mutations, with cardinal nuclear morphological abnormalities and dysfunction. We report five homozygous null mutations in MTX2, encoding Metaxin-2 (MTX2), an outer mitochondrial membrane protein, in patients presenting with a severe...
Marten Szibor et al.
The Journal of biological chemistry, 295(14), 4383-4397 (2020-02-26)
Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activation of matrix dehydrogenases, thereby matching OXPHOS substrate supply...
Maximiliano Tourmente et al.
Reproduction (Cambridge, England), 154(4), 341-354 (2017-07-06)
Whereas a broad link exists between nucleotide substitutions in the mitochondrial genome (mtDNA) and a range of metabolic pathologies, exploration of the effect of specific mtDNA genotypes is on-going. Mitochondrial DNA mutations are of particular relevance for reproductive traits, since...
Riccardo M Betto et al.
Nature genetics, 53(2), 215-229 (2021-02-03)
Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such developmental plasticity is associated with genome hypomethylation. Here, we show that LIF-Stat3 signaling induces genomic hypomethylation via metabolic reconfiguration. Stat3-/- ESCs show decreased α-ketoglutarate production...
Ming Zhuo et al.
Free radical biology & medicine, 99, 20-31 (2016-10-23)
To meet energy demands, dorsal root ganglion (DRG) neurons harbor high mitochondrial content, which renders them acutely vulnerable to disruptions of energy homeostasis. While neurons typically rely on mitochondrial energy production and have not been associated with metabolic plasticity, new...
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Saar Vandekeere et al.
Cell metabolism, 28(4), 573-587 (2018-07-19)
The role of phosphoglycerate dehydrogenase (PHGDH), a key enzyme of the serine synthesis pathway (SSP), in endothelial cells (ECs) remains poorly characterized. We report that mouse neonates with EC-specific PHGDH deficiency suffer lethal vascular defects within days of gene inactivation...
ATP production in isolated mitochondria of procyclic Trypanosoma brucei
Mitochondria, 379-387 (2007)
Essam A Assali et al.
Nature communications, 11(1), 3347-3347 (2020-07-06)
A sharp increase in mitochondrial Ca2+ marks the activation of brown adipose tissue (BAT) thermogenesis, yet the mechanisms preventing Ca2+ deleterious effects are poorly understood. Here, we show that adrenergic stimulation of BAT activates a PKA-dependent mitochondrial Ca2+ extrusion via...
Rio Sebori et al.
Oxidative medicine and cellular longevity, 2018, 9179270-9179270 (2018-12-05)
We previously showed that treatment with resveratrol (3,5,4'-trihydroxy-trans-stilbene), an activator of the NAD+-dependent deacetylase SIRT1 at 4 g/kg food for 32 weeks, significantly decreased the muscular reactive oxygen species (ROS) levels and ameliorated the pathology of mdx mice, an animal model...
Chantell S Evans et al.
eLife, 9 (2020-01-15)
Mitophagy, the selective removal of damaged mitochondria, is thought to be critical to maintain neuronal homeostasis. Mutations of proteins in the pathway cause neurodegenerative diseases, suggesting defective mitochondrial turnover contributes to neurodegeneration. In primary rat hippocampal neurons, we developed a...
Pingping Wu et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 9294605-9294605 (2020-02-28)
Zhibaidihuang decoction (ZBDHD) is a Chinese herbal formula, which is used in Chinese traditional medicine to treat symptoms of Yinxuhuowang (Yin deficiency and high fire) syndrome. This study elucidates the mechanism of ZBDHD on oral ulcers, one Yinxuhuowang syndrome. Simultaneously...
Jussemara Souza da Silva et al.
Molecular neurobiology, 57(11), 4790-4809 (2020-08-14)
Amyloid-β oligomers (AβOs) toxicity causes mitochondrial dysfunction, leading to synaptic failure in Alzheimer's disease (AD). Considering presynaptic high energy demand and tight Ca2+ regulation, impairment of mitochondrial function can lead to deteriorated neural activity and cell death. In this study...
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Haiyang Yu et al.
Science (New York, N.Y.), 371(6529) (2020-12-19)
The RNA binding protein TDP-43 forms intranuclear or cytoplasmic aggregates in age-related neurodegenerative diseases. In this study, we found that RNA binding-deficient TDP-43 (produced by neurodegeneration-causing mutations or posttranslational acetylation in its RNA recognition motifs) drove TDP-43 demixing into intranuclear...
Jiacheng Deng et al.
Cellular and molecular life sciences : CMLS, 77(24), 5299-5320 (2020-03-14)
Stem/progenitor cells (SPCs) have been implicated to participate in vascular repair. However, the exact role of SPCs in endothelial repair of large vessels still remains controversial. This study aimed to delineate the cellular heterogeneity and possible functional role of endogenous...
Alexandre Moquin et al.
ACS nano, 7(11), 9585-9598 (2013-10-11)
Although caspase-1 is a key participant in inflammation, there is no sensitive assay to measure its enzymatic activity in real time in cells or animals. Here we describe a nanosensor for caspase-1 ratiometric measurements, consisting of a rhodamine-labeled, caspase-1 cleavable...
Alexandros K Kanellopoulos et al.
Cell, 180(6), 1178-1197 (2020-03-24)
Social impairment is frequently associated with mitochondrial dysfunction and altered neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it remains unknown whether mitochondrial disruption contributes to social behavioral deficits. Here, we show that Drosophila mutants in the homolog of...
Jia Sun et al.
Redox biology, 39, 101811-101811 (2020-12-29)
Vascular complications of diabetes are a serious challenge in clinical practice, and effective treatments are an unmet clinical need. Acidic fibroblast growth factor (aFGF) has potent anti-oxidative properties and therefore has become a research focus for the treatment of diabetic...
Site of Mitochondrial ROS Production in Skeletal Muscle of COPD and its Relationship with Exercise Oxidative Stress
Puente-Maestu, L., et al.
American Journal of Respiratory Cell and Molecular Biology, doi: 10-doi: 10 (2012)
Ji Young Lee et al.
Pulmonary circulation, 7(4), 777-792 (2017-08-26)
Pulmonary artery, capillary, and vein endothelial cells possess distinctive structures and functions, which represent a form of vascular segment specific macroheterogeneity. However, within each of these segmental populations, individual cell functional variability represents a poorly characterized microheterogeneity. Here, we hypothesized...
Fangyuan Shao et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(23), 2001914-2001914 (2020-12-12)
Resistance to therapeutic drugs occurs in virtually all types of cancers, and the tolerance to one drug frequently becomes broad therapy resistance; however, the underlying mechanism remains elusive. Combining a whole whole-genome-wide RNA interference screening and an evolutionary drug pressure...
Pamela J Yao et al.
iScience, 23(9), 101514-101514 (2020-09-18)
Mitochondrial function relies on multiple quality control mechanisms, including the release of mitochondrial vesicles. To investigate the ultrastructure and prevalence of mitochondrial membranous protrusions (and, by extension, vesicles) in neurons, we surveyed mitochondria in rat and planarian brains using transmission...
Yotaro Kudo et al.
Cancer cell, 38(2), 247-262 (2020-06-27)
Oxidative stress plays a critical role in liver tissue damage and in hepatocellular carcinoma (HCC) initiation and progression. However, the mechanisms that regulate autophagy and metabolic reprogramming during reactive oxygen species (ROS) generation, and how ROS promote tumorigenesis, still need...
Dennis Ma et al.
Scientific reports, 7, 42957-42957 (2017-02-22)
Enhanced mitochondrial stability and decreased dependence on oxidative phosphorylation confer an acquired resistance to apoptosis in cancer cells, but may present opportunities for therapeutic intervention. The compound pancratistatin (PST) has been shown to selectively induce apoptosis in cancer cells. However...
Yong-Woo Jun et al.
Animal cells and systems, 23(3), 164-169 (2019-06-25)
Phosphatidylinositol-4-phosphate (PI4P) plays a crucial role in cellular functions, including protein trafficking, and is mainly located in the cytoplasmic surface of intracellular membranes, which include the trans-Golgi network (TGN) and the plasma membrane. However, many PI4P-binding domains of membrane-associated proteins...
Andrea Dlasková et al.
Biochimica et biophysica acta. Bioenergetics, 1860(8), 659-678 (2019-06-28)
Hypoxia causes mitochondrial cristae widening, enabled by the ~20% degradation of Mic60/mitofilin, with concomitant clustering of the MICOS complex, reflecting the widening of crista junctions (outlets) (Plecitá-Hlavatá et al. FASEB J., 2016 30:1941-1957). Attempting to accelerate metabolism by the addition...
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