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" no prazo de Papéis
Afaq Ahmad Khan et al.
Journal of the Indian Medical Association, 110(7), 499-500 (2013-03-26)
Non-Hodgkin's lymphoma (NHL) is predominantly a disease of lymph nodes, but extranodal involvement is not very uncommon. Palatal involvement by NHL is rare. Mucormycosis is a devastating fungal infection commonly seen in immunocompromised individuals, including those with NHL, but it
Jeremy N Day et al.
The New England journal of medicine, 368(14), 1291-1302 (2013-04-05)
Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment for cryptococcal meningitis but has not been shown to reduce mortality, as compared with amphotericin B alone. We performed a randomized, controlled trial to determine whether combining flucytosine
Moises A Huaman et al.
Frontiers in immunology, 11, 607957-607957 (2021-01-05)
Tuberculosis has been associated with increased risk of atherosclerotic cardiovascular disease. To examine whether mycobacterial infection exacerbates atherosclerosis development in experimental conditions, we infected low-density lipoprotein receptor knockout (Ldlr -/-) mice with Mycobacterium bovis Bacille-Calmette-Guérin (BCG), an attenuated strain of
Manica Balasegaram et al.
Expert opinion on emerging drugs, 17(4), 493-510 (2012-11-22)
Leishmaniasis is a parasitic disease transmitted by phlebotomine sandflies. Between 700,000 and 1.2 million cases of cutaneous leishmaniasis and between 200,000 and 400,000 cases of visceral leishmaniasis (VL), which is fatal if left untreated, occur annually worldwide. Liposomal amphotericin B
Michael Klepser
Journal of critical care, 26(2), 225-225 (2010-10-19)
Over the last 20 years, there has been an increase in the total number of invasive fungal infections (IFIs) and in infections caused by rare and emerging pathogens. This is due in part to the growing population of immunocompromised patients
Matteo Bassetti et al.
Clinical drug investigation, 31(11), 745-758 (2011-09-06)
Invasive fungal infections are associated with a poor outcome and their incidence is rising. Amphotericin B has for a long time been the gold standard for treatment of these infections, but the conventional formulation is associated with a high incidence
Takuo Hojo et al.
Theriogenology, 128, 193-200 (2019-02-19)
Necroptosis is an alternative form of programmed cell death regulated by receptor-interacting protein kinase (RIPK) 1 and 3-dependent. In the present study, to clarify if necroptosis in luteal endothelial cells (LECs) participates and contributes for bovine luteolysis, we investigated RIPK1
Stefanie Schrauwen et al.
Gynecologic oncology, 138(2), 378-382 (2015-06-09)
New treatment options for advanced and recurrent endometrial carcinoma (EC) are necessary. Epidemiological studies showed that diabetic patients using metformin have reduced risks of endometrial cancer (EC) incidence. Moreover, pre- and clinical studies demonstrated an antitumor effect by metformin, with
Haruka Takahashi et al.
Human cell, 28(3), 143-153 (2015-02-26)
The squamous cell carcinoma cell lines Nialym was successfully established from metastatic foci of lymph nodes from a 48-year-old male Japanese patient with squamous cell carcinoma of the tongue. In addition, the Nialymx cell line was established from a transplanted
Treating cryptococcal meningitis in people with HIV.
BMJ (Clinical research ed.), 346, f2203-f2203 (2013-04-12)
Pirouz M Daftarian et al.
The Journal of infectious diseases, 208(11), 1914-1922 (2013-08-01)
Amphotericin B (AmB), the most effective drug against leishmaniasis, has serious toxicity. As Leishmania species are obligate intracellular parasites of antigen presenting cells (APC), an immunopotentiating APC-specific AmB nanocarrier would be ideally suited to reduce the drug dosage and regimen
Patrícia L N Néris et al.
Experimental parasitology, 135(2), 307-313 (2013-07-31)
Leishmaniasis' treatment is based mostly on pentavalent antimonials or amphotericin B long-term administration, expensive drugs associated with severe side effects. Considering these aforementioned, the search for alternative effective and safe leishmaniasis treatments is a necessity. This work evaluated a neolignan
Ermias Diro et al.
Tropical medicine & international health : TM & IH, 20(1), 8-16 (2014-10-21)
Visceral leishmaniasis (VL) in north-west Ethiopia is causing an overwhelming case load among adult migrant workers that masked the disease burden in children. This study describes the clinical profile and explores comorbidities in paediatric VL patients. A prospective study at
L Pagano et al.
Journal of chemotherapy (Florence, Italy), 23(1), 5-8 (2011-04-13)
The proportion of patients with cancers who develop invasive fungal infections has increased dramatically over the past few decades. Most of these infections are diagnosed in patients with hematological malignancies, mainly in patients with acute myeloid leukemia and those undergoing
Successful treatment of cutaneous zygomycosis with intravenous amphotericin B followed by oral posaconazole in a multivisceral transplant recipient.
Liat Ashkenazi-Hoffnung et al.
Transplantation, 90(10), 1133-1135 (2011-03-24)
Ptosis, erythema, and rapidly decreasing vision.
Adam Zanation et al.
JAMA, 309(22), 2382-2383 (2013-06-13)
Angela S Loo et al.
Expert opinion on drug safety, 12(6), 881-895 (2013-08-13)
Amphotericin B (AmB) was first approved by the US Food and Drug Administration in 1959 with sodium deoxycholate (DAmB, Fungizone®). Extensive toxicities associated with the drug led to the development of lipid formulations of AmB, including liposomal amphotericin B (L-AmB
Surjit Lidder et al.
Journal of the Royal Army Medical Corps, 159(2), 123-125 (2013-05-31)
Infection is the third commonest cause of total hip arthroplasty failure. Infections of the hip with Candida species are extremely rare with only a few reports in the literature. A case of a 76-year-old female subject is presented illustrating both
Thomas M Anderson et al.
Nature chemical biology, 10(5), 400-406 (2014-04-01)
For over 50 years, amphotericin has remained the powerful but highly toxic last line of defense in treating life-threatening fungal infections in humans with minimal development of microbial resistance. Understanding how this small molecule kills yeast is thus critical for
Ji Hong Hwang et al.
Biochimie, 95(10), 1917-1922 (2013-07-03)
In this study, the antifungal activity and mode of action(s) of hibicuslide C derived from Abutilon theophrasti were investigated. Antifungal susceptibility testing showed that hibicuslide C possessed potent activities toward various fungal strains and less hemolytic activity than amphotericin B.
Efficiently killing a sugar-coated yeast.
John R Perfect
The New England journal of medicine, 368(14), 1354-1356 (2013-04-05)
Dale M Walker et al.
Environmental and molecular mutagenesis, 54(4), 268-280 (2013-04-05)
The events or factors that lead from normal cell function to conditions and diseases such as aging or cancer reflect complex interactions between cells and their environment. Cellular stress responses, a group of processes involved in homeostasis and adaptation to
Tatiane F P de Mello et al.
Experimental parasitology, 136, 27-34 (2013-11-26)
The treatment of American cutaneous leishmaniasis (ACL) is based on a small group of compounds that were developed decades ago, all of which are highly toxic and have a high rate of treatment failure. The chalcones show leishmanicidal activity, yet
Pu-Ting Dong et al.
Science advances, 7(2) (2021-02-02)
Ergosterol-targeting amphotericin B (AmB) is the first line of defense for life-threatening fungal infections. Two models have been proposed to illustrate AmB assembly in the cell membrane; one is the classical ion channel model in which AmB vertically forms transmembrane
R Bini et al.
Annals of the Royal College of Surgeons of England, 96(5), e31-e33 (2014-07-06)
Mucormycosis is a life threatening condition caused by invasion of fungi of the order Mucorales. Gastrointestinal invasion is very rare and often lethal, particularly in disseminated mucormycosis. We present the case of a 26-year-old woman from North Africa with type
Iman Karimzadeh et al.
Expert opinion on drug safety, 11(6), 969-983 (2012-09-07)
Nephrotoxicity is generally considered as the most clinically significant adverse reaction of amphotericin B, and has been reported in up to 80% of amphotericin B recipients during the first 2 weeks of treatment. Numerous experimental and clinical investigations have been
Elżbieta Łopieńska-Biernat et al.
Pathogens (Basel, Switzerland), 9(12) (2020-12-16)
Anisakis simplex (s.l.) is a complex of three sibling (biological) species of parasitic nematodes of marine mammals, including A. berlandi, A. pegreffii and A. simplex (s.s.). It is characterized by a complex life cycle in which humans can become accidental
A patient with rheumatoid arthritis, cryoglobulinaemia, and an "accidental" finding.
Konstantinos Liapis et al.
BMJ (Clinical research ed.), 348, g2701-g2701 (2014-04-16)
Sóstenes Mistro et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54(12), 1774-1777 (2012-04-12)
This meta-analysis of 13 studies revealed that amphotericin B delivered as a locally prepared lipid emulsion or in liposomes reduced nephrotoxicity to a similar degree, by 18.4% (relative risk [RR], 0.40 [99% confidence interval, .25-.64]; n = 459) and 18.1% (RR, 0.48
Breakthrough Fusarium solani infection in a patient with acute myeloid leukemia receiving posaconazole prophylaxis.
Cheng-Han Wu et al.
Annals of hematology, 93(6), 1079-1081 (2013-10-31)
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