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B3259
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Palavra-chave:'B3259'
Exibindo 1-30 of 63 resultados para "B3259" no prazo de Papéis
Bing-Wen Soong et al.
American journal of human genetics, 92(3), 422-430 (2013-02-26)
Charcot-Marie-Tooth disease (CMT) is a heterogeneous group of inherited neuropathies. Mutations in approximately 45 genes have been identified as being associated with CMT. Nevertheless, the genetic etiologies of at least 30% of CMTs have yet to be elucidated. Using a
Alexander S Easton
Advances in experimental medicine and biology, 763, 1-19 (2013-02-12)
The blood-brain barrier refers to the very low permeability across microvessels in the Central Nervous System (CNS), created by the interaction between vascular endothelial cells and surrounding cells of the neurovascular unit. Permeability can be modulated (increased and decreased) by
Haptotaxis is cell type specific and limited by substrate adhesiveness
Wen JH, et al.
Cellular and Molecular Bioengineering, 8(4), 530-542 (2015)
Hsin-I Tong et al.
PloS one, 11(4), e0154022-e0154022 (2016-04-27)
The ability of monocytes and monocyte-derived macrophages (MDM) to travel towards chemotactic gradient, traverse tissue barriers, and accumulate precisely at diseased sites makes them attractive candidates as drug carriers and therapeutic gene delivery vehicles targeting the brain, where treatments are
Adrien Marchand et al.
Analytical chemistry, 89(23), 12674-12681 (2017-11-14)
Ion mobility spectrometry allows one to determine ion collision cross sections, which are related to ion size and shape. Collision cross sections (CCS) are usually discussed based on the peak center, yet the width of each peak contains further information
Pranjali Beri et al.
APL bioengineering, 7(2), 026104-026104 (2023-05-19)
Asthma is often characterized by tissue-level mechanical phenotypes that include remodeling of the airway and an increase in airway tightening, driven by the underlying smooth muscle. Existing therapies only provide symptom relief and do not improve the baseline narrowing of
Katrin N Sander et al.
Placenta, 88, 12-19 (2019-10-02)
The function of the placental vasculature differs considerably from other systemic vascular beds of the human body. A detailed understanding of the normal placental vascular physiology is the foundation to understand perturbed conditions potentially leading to placental dysfunction. Behaviour of
Alain Mazé et al.
Nature chemical biology, 16(2), 179-187 (2019-12-18)
Augmenting live cells with new signal transduction capabilities is a key objective in genetic engineering and synthetic biology. We showed earlier that two-component signaling pathways could function in mammalian cells, albeit while losing their ligand sensitivity. Here, we show how
Matias Wagner et al.
Nature communications, 10(1), 4790-4790 (2019-10-23)
Alterations of Ca2+ homeostasis have been implicated in a wide range of neurodegenerative diseases. Ca2+ efflux from the endoplasmic reticulum into the cytoplasm is controlled by binding of inositol 1,4,5-trisphosphate to its receptor. Activated inositol 1,4,5-trisphosphate receptors are then rapidly
Yacine Tabet et al.
American journal of physiology. Lung cellular and molecular physiology, 304(8), L562-L569 (2013-02-19)
Epoxyeicosanoids (EETs) are produced by cytochrome P-450 epoxygenase; however, it is not yet known what triggers their endogenous production in epithelial cells. The relaxing effects of bradykinin are known to be related to endogenous production of epithelial-derived hyperpolarizing factors (EpDHF).
C L Boyajian et al.
The Journal of biological chemistry, 266(8), 4995-5003 (1991-03-15)
The modulation of neuronal adenylylcyclase by Ca2+, acting via calmodulin, is a long-established example of a positive interaction between the Ca2(+)-mobilizing and cAMP-generating systems. In the present study, concentrations of Ca2+ that stimulate brain adenylylcyclase inhibit the adenylylcyclase of NCB-20
Edith D V Guaytima et al.
Journal of cellular physiology, 233(8), 6173-6195 (2018-01-14)
It is known that bradykinin (BK) B2 receptor (B2R) is expressed in the collecting duct (CD) cells of the newborn rat kidney, but little is known about its role during early postnatal life. Therefore, we hypothesize that BK could participate
Jillian N Noblet et al.
Basic research in cardiology, 111(3), 25-25 (2016-03-16)
Leptin has been implicated as a key upstream mediator of pathways associated with coronary vascular dysfunction and disease. The purpose of this investigation was to test the hypothesis that leptin modifies the coronary artery proteome and promotes increases in coronary
D T Johnston et al.
MMW Fortschritte der Medizin, 155 Suppl 1, 1-5 (2013-05-18)
Hereditary angioedema (HAE) is a rare type of angioedema caused by a quantitative or functional deficit of C1 inhibitor (C1 INH) that leads to excess production of bradykinin, which can result in acute localized swelling attacks in the skin or
Nisha S Patel et al.
Allergy and asthma proceedings, 34(1), 72-77 (2013-02-15)
Acquired C1 inhibitor (C1-INH) deficiency exposes patients to angioedema recurrences (acquired angioedema [AAE]) mediated by bradykinin pathway activation. C1-INH replacement and specific inhibition of plasma kallikrein with ecallantide have been successful in the treatment of hereditary angioedema (HAE), a more
Mei-Hui Liao et al.
PloS one, 8(2), e56331-e56331 (2013-03-05)
RhoA/Rho-kinase (RhoA/ROK) pathway promotes vasoconstriction by calcium sensitivity mechanism. LPS causes nitric oxide (NO) overproduction to induce vascular hyporeactivity. Thus, we tried to examine the role of RhoA/ROK and NO in the regulation of vascular reactivity in different time-point of
Marcus Maurer et al.
PloS one, 8(2), e53773-e53773 (2013-02-08)
Attacks of hereditary angioedema (HAE) are unpredictable and, if affecting the upper airway, can be lethal. Icatibant is used for physician- or patient self-administered symptomatic treatment of HAE attacks in adults. Its mode of action includes disruption of the bradykinin
Giovanna Baron et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-01-28)
The aim of the study is to compare the qualitative and semi-quantitative profile of the polyphenol fraction purified from the leaf (BLPF) and fruit (BFPF) of bergamot (Citrus bergamia), and to evaluate their antioxidant and anti-inflammatory activity. The analytical qualitative
Louis Potier et al.
The Journal of pharmacology and experimental therapeutics, 346(1), 23-30 (2013-04-18)
Cardiac ischemia is a leading cause of death, especially in diabetic patients. The diabetic ischemic heart is resistant experimentally to established cardioprotective treatments. New pharmacological approaches to cardiac protection are warranted. The kallikrein-kinin system is involved in myocardial protection in
Patrice Cunningham et al.
PloS one, 17(6), e0270338-e0270338 (2022-06-24)
Cancer patients can develop visceral, somatic, and neuropathic pain, largely due to the malignancy itself and its treatments. Often cancer patients and survivors turn to the use of complementary and alternative medicine (CAM) to alleviate pain and fatigue. Thus, it
Bob Geng et al.
Allergy and asthma proceedings, 34(1), 13-18 (2013-02-15)
This review on hereditary angioedema (HAE) focuses on special topics regarding HAE in female patients. HAE is a bradykinin-mediated disorder, and the role of hormonal regulation of disease expression will be discussed focusing on the effect of estrogen on disease
Fatih Dal et al.
Acta cirurgica brasileira, 35(4), e202000402-e202000402 (2020-06-25)
To investigate the effects of bradykinin on reperfusion injury in an experimental intestinal ischemia reperfusion model. We used 32 Wistar-Albino rats. We composed 4 groups each containing 8 rats. Rats in sham group were sacrified at 100 minutes observation after
Hepato-and nephroprotective effects of bradykinin potentiating factor from scorpion (Buthus occitanus) venom on mercuric chloride-treated rats
Salman M, et al.
EXCLI Journal , 15, 807-807 (2016)
Valentina Lo Sardo et al.
Cell, 175(7), 1796-1810 (2018-12-12)
The 9p21.3 cardiovascular disease locus is the most influential common genetic risk factor for coronary artery disease (CAD), accounting for ∼10%-15% of disease in non-African populations. The ∼60 kb risk haplotype is human-specific and lacks coding genes, hindering efforts to
Novel bradykinin signaling in adult rat cardiac myocytes through activation of p21-activated kinase.
Yunbo Ke et al.
American journal of physiology. Heart and circulatory physiology, 298(4), H1283-H1289 (2010-02-16)
Although bradykinin (BK) is known to exert effects on the myocardium, its intracellular signaling pathways remain poorly understood. Experiments in other cell types indicated that p21-activated kinase-1 (Pak1), a Ser/Thr kinase downstream of small monomeric G proteins, is activated by
Joaquim Bobi et al.
Journal of the American Heart Association, 9(3), e014035-e014035 (2020-02-06)
Background Hypothermia has been associated with therapeutic benefits including reduced mortality and better neurologic outcomes in survivors of cardiac arrest. However, undesirable side effects have been reported in patients undergoing coronary interventions. Using a large animal model of temperature management
The nebulous diagnosis of type III hereditary angioedema.
Suran L Fernando
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(1), 65-66 (2013-06-29)
Henriette Farkas
Expert opinion on pharmacotherapy, 14(5), 571-586 (2013-03-14)
Bradykinin-mediated angioedema is characterized by subcutaneous and/or submucosal edema formation without wheals and pruritus. It is linked to bradykinin-enhanced vascular permeability and, therefore, it does not respond to conventional measures, but requires specific therapy. This summary briefly reviews the different
Nan Gu et al.
Molecular brain, 15(1), 86-86 (2022-10-28)
Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial processes interact with neuronal elements constantly on the order of minutes. The functional significance of this acute microglia-neuron interaction and its potential role in the context of
A Ca2+-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics.
Ratajczyk, et al.
Cells, 11 (2023)
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