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Xiao-Dong Liu et al.
Neuroscience letters, 494(1), 10-13 (2011-03-01)
It is well known that hippocampus plays important roles in learning and memory. Both calcitonin gene-related peptide (CGRP) and CGRP receptors are found in hippocampus. In the present study we explored the influence of CGRP on long term potentiation (LTP)
Muhammad Zaki et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(8), G715-G722 (2013-02-09)
Acute Helicobacter pylori infection produces hypochlorhydria. The decrease in acid facilitates survival of the bacterium and its colonization of the stomach. The present study was designed to identify the pathways in oxyntic mucosa by which acute H. pylori infection inhibits
Adrenomedullin enhances the progressive motility and zona pellucida-binding capacity of spermatozoa from normozoospermic but not asthenozoospermic men.
Philip C N Chiu et al.
Molecular reproduction and development, 79(2), 76-76 (2011-10-13)
N Liu et al.
Minerva anestesiologica, 77(8), 789-796 (2011-07-07)
The cardioprotective effects of the calcitonin gene-related peptide (CGRP) are known; however, the profiles of CGRP given pre- and postischemia as a therapeutic agent in acute myocardial ischemia and reperfusion remain elusive. The effects of CGRP on cardiac performance in
Petra Hartmann et al.
Naunyn-Schmiedeberg's archives of pharmacology, 383(2), 179-189 (2010-12-25)
We have shown that ischaemic preconditioning ameliorates both the local periosteal and the systemic leukocyte activation evoked by limb ischaemia-reperfusion. We hypothesized that the activation of chemosensitive afferent nerves by transient ischaemia contributes to the protective mechanisms of ischaemic preconditioning
Peng Li et al.
Peptides, 47, 1-6 (2013-07-03)
Direct administration of intermedin (IMD) into the brain elicits cardiovascular effects different from the systemic administration. Nucleus tractus solitarii (NTS) is an important region for the cardiovascular regulation. The present study was designed to determine the effect of IMD on
Regulation of pulpal microcirculation by calcitonin gene-related peptide
Kim S K, et al.
The Journal of Korean Academy of Prosthodontics, 30(6), 470-476 (2005)
Hisashi Shinbara et al.
Acupuncture in medicine : journal of the British Medical Acupuncture Society, 31(1), 81-87 (2013-01-12)
The purpose of this study was to determine how calcitonin gene related peptide (CGRP) via axon reflex participates in increasing local muscle blood flow (MBF) following manual acupuncture (MA). Male Sprague-Dawley rats (N=56, 270-350 g) were used. We examined (1)
Calcitonin gene-related peptide (CALCA) is a proangiogenic growth factor in the human placental development
Dong Y L, et al.
Biology of Reproduction, 76(5), 892-899 (2007)
Kandace Bonner et al.
The Journal of allergy and clinical immunology, 126(6), 1277-1283 (2010-10-12)
Epithelial cell expression of calcitonin gene-related peptide (CGRP) is a feature of provoked asthma. Receptor activity modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor combine to form the CGRP1 receptor. To determine whether functional RAMP1 is expressed by airway
K J Escott et al.
British journal of pharmacology, 110(2), 772-776 (1993-10-01)
1. The effect of the calcitonin gene-related peptide antagonist (CGRP8-37, 400 nmol kg-1, i.v.) on the increased blood flow induced by calcitonin gene related peptide (CGRP), vasodilator prostaglandins, and topical capsaicin was measured with a laser Doppler blood flow meter
Xian-Wei Li et al.
European journal of pharmacology, 679(1-3), 117-126 (2012-02-07)
Calcitonin gene-related peptide (CGRP) inhibits angiotensin II-induced proliferation of aortic smooth muscle cells via inactivation of extracellular signal-regulated protein kinase 1/2 (ERK1/2). ERK1/2 is necessary for the degradation or down-regulation of the cell cycle inhibitor p27, and is also crucial
Andressa Perin-Martins et al.
Journal of the peripheral nervous system : JPNS, 18(1), 62-74 (2013-03-26)
The aim of this study was to investigate the mechanisms that contribute to hyperalgesia and edema induced by TRPA1 activation. The injection of allyl isothiocyanate (AITC, 50, 100, or 300 µg/paw) into the rat's hind paw induced dose and time-dependent hyperalgesia
S P Han et al.
Biochemical and biophysical research communications, 168(2), 786-791 (1990-04-30)
We provide the first functional evidence that calcitonin gene-related peptide (8-37) induces a direct vasoconstriction and reversibly antagonizes vasodilation of the mesenteric arterial bed induced by calcitonin gene-related peptide (CGRP) suggesting that CGRP (8-37) is a competitive antagonist of vascular
Ye-Bo Zhou et al.
Hypertension (Dallas, Tex. : 1979), 63(2), 330-337 (2013-11-13)
Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide family, which shares the receptor system consisting of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs). This study investigated the effects of IMD in paraventricular nucleus (PVN) on renal sympathetic
M Dias et al.
International angiology : a journal of the International Union of Angiology, 30(5), 424-428 (2011-08-02)
Calcitonin gene-related peptide (CGRP) is a potential mediator of neurogenic inflammation in eczema, psoriasis and rosacea, and also contributes to vasodilatation and oedema in complex regional pain disorder. We investigated the feasibility of administering CGRP and its antagonist CGRP8-37 by
Calcitonin gene-related peptide antagonism attenuates the haemodynamic and glycaemic responses to acute hypoxaemia in the late gestation sheep fetus
Thakor A S, et al.
The Journal of Physiology, 566(2), 587-597 (2005)
Esther Sastre et al.
Clinical science (London, England : 1979), 122(7), 337-348 (2011-10-18)
In the present study, we analysed possible alterations in adrenergic, nitrergic and sensory functioning in mesenteric arteries from rats at 1 and 21 months after partial portal vein ligation, and the mechanisms involved in these alterations, if any. For this
Procalcitonin measurement to screen medullary thyroid carcinoma: A prospective evaluation in a series of 2705 patients with thyroid nodules
Giovanella L, et al.
European Journal of Clinical Investigation, 48(6), e12934-e12934 (2018)
Lei Li et al.
Reproductive biology and endocrinology : RB&E, 9, 111-111 (2011-08-10)
Adrenomedullin (ADM), a novel vasorelaxant peptide, was found in human/rat ovaries. The present study investigated the interaction of ADM and endothelin-1 (ET-1) in follicles and newly formed corpora lutea (CL) and the actions of ADM on progesterone production in CL
Phillip Edward Kunkler et al.
Pain, 152(1), 38-44 (2010-11-16)
The TRPA1 receptor is a member of the transient receptor potential (TRP) family of ion channels expressed in nociceptive neurons. TRPA1 receptors are targeted by pungent compounds from mustard and garlic and environmental irritants such as formaldehyde and acrolein. Ingestion
Association study of calcitonin gene-related polypeptide-alpha (CALCA) gene polymorphism with migraine
Menon S, et al.
Brain Research, 1378(5), 119-124 (2011)
Ana Luísa Pires et al.
American journal of physiology. Heart and circulatory physiology, 302(5), H1131-H1137 (2012-01-10)
Intermedin (IMD) is a novel vasoactive peptide from the calcitonin gene-related peptide (CGRP) implicated in cardiac regulation, yet the contractile effects of IMD remain controversial, since previous studies in vivo and isolated cardiomyocytes documented contradictory results. We hypothesized cardiac endothelial
T Chiba et al.
The American journal of physiology, 256(2 Pt 1), E331-E335 (1989-02-01)
From this study, we predicted that the human calcitonin gene-related peptide (hCGRP) fragment hCGRP-(8-37) would be a selective antagonist for CGRP receptors but an agonist for calcitonin (CT) receptors. In rat liver plasma membrane, where CGRP receptors predominate and CT
Hiroki Fujiwara et al.
Journal of pharmacological sciences, 119(3), 260-270 (2012-07-13)
Rat mesenteric arteries were maintained by both adrenergic vasoconstrictor nerves and calcitonin gene-related peptide (CGRP) vasodilator nerves. However, functions of these nerves in a pathophysiological state have not fully been analyzed. The use of disease models developed genetically in mice
Jalal Izadi Mobarakeh et al.
Biomedical research (Tokyo, Japan), 32(3), 195-201 (2011-06-16)
Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception. The aim of the present study is to clarify the interaction of histamine and CGRP in the perception of inflammatory pain. The effects of a histamine H1 receptor antagonist
Susannah J Sample et al.
PloS one, 6(6), e20386-e20386 (2011-06-23)
Calcitonin gene related peptide (CGRP) is a neuropeptide that is abundant in the sensory neurons which innervate bone. The effects of CGRP on isolated bone cells have been widely studied, and CGRP is currently considered to be an osteoanabolic peptide
Toshiaki Mishima et al.
American journal of physiology. Heart and circulatory physiology, 300(2), H431-H439 (2010-12-07)
It is known that the neural system plays a fundamental role in neovascularization. A neuropeptide, calcitonin gene-related peptide (CGRP), is widely distributed in the central and peripheral neuronal systems. However, it remains to be elucidated the role of CGRP in
Javier Blanco-Rivero et al.
Experimental physiology, 96(3), 275-286 (2010-12-15)
Our study determines alterations in the vasoconstrictor response elicited by electric field stimulation (EFS) in mesenteric arteries from cirrhotic rats treated with CCl(4), and how calcitonin gene-related peptide (CGRP) participates in this response. Vasoconstriction induced by EFS was analysed in
LianSheng Liu et al.
JOP : Journal of the pancreas, 12(4), 389-394 (2011-07-09)
Calcitonin gene-related peptide (CGRP), substance P and nerve growth factor play an important role in inflammatory pain in various somatic pain models but their role in chronic pancreatitis has not been well studied. The aim of this study was to
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