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Yuan-Hui Li et al.
Cell death discovery, 7(1), 239-239 (2021-09-15)
Mesenchymal stem cell (MSC) therapy has become a promising treatment for liver fibrosis due to its predominant immunomodulatory performance in hepatic stellate cell inhibition and fibrosis resolution. However, the cellular and molecular mechanisms underlying these processes remain limited. In the
Yu Katata et al.
Cell death & disease, 11(8), 617-617 (2020-08-15)
Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations. Patients with Costello syndrome present craniofacial abnormalities, cardiac defects, and cancer predisposition, as well as skin abnormalities, including papillomas, keratosis pilaris, and eczematous dermatitis. However, the
Yunzhe Lu et al.
Cell reports, 33(2), 108246-108246 (2020-10-15)
Collective migration is essential for development, wound repair, and cancer metastasis. For most collective systems, "leader cells" determine both the direction and the power of the migration. It has remained unclear, however, how the highly polarized vertebrate epithelium migrates directionally
Jingtao Guo et al.
Cell stem cell, 26(2), 262-276 (2020-01-14)
The human testis undergoes dramatic developmental and structural changes during puberty, including proliferation and maturation of somatic niche cells, and the onset of spermatogenesis. To characterize this understudied process, we profiled and analyzed single-cell transcriptomes of ∼10,000 testicular cells from
Jody Groenendyk et al.
PloS one, 15(8), e0236457-e0236457 (2020-08-14)
Transgenic mice with selective induction of calreticulin transgene expression in cardiomyocytes (CardiacCRT+) were analyzed. CardiacCRT+ cardiomyocytes showed increased contractility and Ca2+ transients. Yet, in vivo assessment of cardiac performance, and ischemic tolerance of CardiacCRT+ mice demonstrated right ventricle dilation and
Fanny Herisson et al.
Nature neuroscience, 21(9), 1209-1217 (2018-08-29)
Innate immune cells recruited to inflammatory sites have short life spans and originate from the marrow, which is distributed throughout the long and flat bones. While bone marrow production and release of leukocyte increases after stroke, it is currently unknown
Jaime Onofre et al.
Reproductive biomedicine online, 37(1), 6-17 (2018-05-20)
From a clinical perspective, which parameters grant optimal cryopreservation of mouse testicular cell suspensions? We studied the effect of different cryopreservation rates, the addition of sugars, different vessels and the addition of an apoptotic inhibitor on the efficiency of testicular
Sara Cardellini et al.
BMJ open diabetes research & care, 8(1) (2020-04-18)
Insulin resistance, defined as tissue inflammation leading to type 2 diabetes, is a feature of obesity. The immune system has been implicated in its pathogenesis, but the role of adaptive immunity in humans remains uncertain. Here, we aim to determine
Anne-Claire Langlois et al.
Scientific reports, 10(1), 13509-13509 (2020-08-13)
Sporozoite forms of the Plasmodium parasite, the causative agent of malaria, are transmitted by mosquitoes and first infect the liver for an initial round of replication before parasite proliferation in the blood. The molecular mechanisms involved during sporozoite invasion of
Xiaowen Sun et al.
Cell death & disease, 11(9), 737-737 (2020-09-12)
Primordial follicle pool provides all available oocytes throughout the whole reproductive life span. Abnormal regulation in primordial follicle assembly leads to abnormal size of primordial follicle pool, even causes infertility. Here, miR-378-3p was proved to regulate mouse primordial follicle assembly
Zuqiang Liu et al.
Nature communications, 9(1), 4682-4682 (2018-11-10)
The complex immune tumour microenvironment requires an equally complex immunotherapy approach, especially when the cancer-immune set point is non-inflamed. Oncolytic viruses expressing immune activating cytokines might optimally modify the immune microenvironment and improve the antitumour effects. In this study, we
Fang Zhang et al.
Virologica Sinica, 34(5), 538-548 (2019-06-20)
Japanese encephalitis (JE) is a viral encephalitis disease caused by Japanese encephalitis virus (JEV) infection. Uncontrolled inflammatory responses in the central nervous system (CNS) are a hallmark of severe JE. Although the CCR2-CCL2 axis is important for monocytes trafficking during
Wen-Jin Chen et al.
Cell death & disease, 13(1), 50-50 (2022-01-13)
Non-clear renal cell carcinomas (nccRCCs) are less frequent in kidney cancer with histopathological heterogeneity. A better understanding of the tumor biology of nccRCC can provide more effective treatment paradigms for different subtypes. To reveal the heterogeneity of tumor microenvironment (TME)
Claudia Robles-Planells et al.
BioMed research international, 2020, 4045760-4045760 (2020-07-07)
Reovirus is known to have an anticancer effect in both the preclinical and clinical assays. Current evidence suggests that the reovirus-mediated impact on tumor growth depends on the activation of specific antitumor immune responses. A feasible explanation for the oncolytic
Qin He et al.
Theranostics, 11(12), 5759-5777 (2021-04-27)
Background: Since metastasis remains the main reason for HCC-associated death, a better understanding of molecular mechanism underlying HCC metastasis is urgently needed. Here, we elucidated the role of Homeobox B5 (HOXB5), a member of the HOX transcriptional factor family, in
Nicole Hollingshead et al.
Cellular immunology, 360, 104275-104275 (2021-01-10)
The liver contains a rich mix of T cells, including activated T cells, tissue-resident memory T cells and cells undergoing apoptosis. When antigens are presented in this milieu the default result is functional tolerance. T cell tolerance in the liver
Ben Warren et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(15), 3741-3752 (2018-03-16)
Insect auditory receivers provide an excellent comparative resource to understand general principles of auditory transduction, but analysis of the electrophysiological properties of the auditory neurons has been hampered by their tiny size and inaccessibility. Here we pioneer patch-clamp recordings from
Mónica Enguita et al.
Cell death & disease, 10(1), 14-14 (2019-01-10)
Liver cirrhosis results from chronic hepatic damage and is characterized by derangement of the organ architecture with increased liver fibrogenesis and defective hepatocellular function. It frequently evolves into progressive hepatic insufficiency associated with high mortality unless liver transplantation is performed.
Yanling Gou et al.
Human reproduction (Oxford, England), 34(4), 646-658 (2019-03-07)
How is the activation of estrogen receptor β (ERβ) in endometriotic stromal cells (ESCs) involved in macrophage recruitment to promote the pathogenesis of endometriosis? ERβ modulates the production of C-C motif chemokine ligand 2 (CCL2) via nuclear factor kappa-light-chain-enhancer of
R Foissac et al.
Chirurgie de la main, 32(4), 199-205 (2013-07-17)
Dupuytren's disease is a disorder of the palmar aponeurosis responsible for apparition of pathological collagen cords that will gradually lead to a digital retraction. These cords cause functional disability to the hand with a real handicap for the patient. No
Amanda J Martinot et al.
PLoS pathogens, 16(12), e1009096-e1009096 (2020-12-15)
Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to protect against pulmonary tuberculosis. We previously reported that Mtb lacking
Wen-Long Lei et al.
Cell death & disease, 12(10), 883-883 (2021-09-29)
Protein phosphatase 6 (PP6) is a member of the PP2A-like subfamily, which plays significant roles in numerous fundamental biological activities. We found that PPP6C plays important roles in male germ cells recently. Spermatogenesis is supported by the Sertoli cells in
Sung-Jin Kim et al.
Bone, 138, 115497-115497 (2020-07-01)
Adult bone homeostasis requires a fine-tuned balance between the activity of osteoblasts and osteoclasts. This osteoblast-osteoclast coupling is therapeutically important because it limits the efficacy of most anabolic or anti-resorptive treatments for osteoporosis. Sirtuin6 (SIRT6), a histone deacetylase, was implicated
Gaëlle Breton et al.
The Journal of experimental medicine, 212(3), 401-413 (2015-02-18)
Two subsets of conventional dendritic cells (cDCs) with distinct cell surface markers and functions exist in mouse and human. The two subsets of cDCs are specialized antigen-presenting cells that initiate T cell immunity and tolerance. In the mouse, a migratory
Yoon-Young Sung et al.
Frontiers in pharmacology, 9, 578-578 (2018-06-19)
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Bleomycin (BLM) contributes to the induction of pulmonary inflammation and fibrosis in animals. Although skin and lung tissue inflammation is closely related in the pathogenesis of allergic diseases, a proper animal
Mattia Gallizioli et al.
Cell reports, 33(3), 108291-108291 (2020-10-22)
Brain CD11c+ cells share features with microglia and dendritic cells (DCs). Sterile inflammation increases brain CD11c+ cells, but their phenotype, origin, and functions remain largely unknown. We report that, after cerebral ischemia, microglia attract DCs to the inflamed brain, and
Jian Shi et al.
Frontiers in cell and developmental biology, 9, 646214-646214 (2021-04-20)
Meiosis is essential for genetic stability and diversity during sexual reproduction in most eukaryotes. Chromatin structure and gene expression are drastically changed during meiosis, and various histone modifications have been reported to participate in this unique process. However, the dynamic
Cancan Du et al.
Journal of cellular and molecular medicine, 24(14), 7802-7813 (2020-05-26)
Tumour-derived exosomes have been shown to induce pre-metastatic niche formation, favoring metastatic colonization of tumour cells, but the underlying molecular mechanism is still not fully understood. In this study, we showed that exosomes derived from the LLC cells could indeed
Yanqin Liu et al.
Journal of cellular and molecular medicine, 25(16), 7690-7708 (2021-06-20)
The maternal-foetal interface is an immune-privileged site where the semi-allogeneic embryo is protected from attacks by the maternal immune system. Uterine macrophages are key players in establishing and maintaining pregnancy, and the dysregulation of the M1-M2 subpopulation balance causes abortion.
Carmelo Luci et al.
Cellular and molecular gastroenterology and hepatology, 13(1), 173-191 (2021-08-20)
Spleen tyrosine kinase (SYK) signaling pathway regulates critical processes in innate immunity, but its role in parenchymal cells remains elusive in chronic liver diseases. We investigate the relative contribution of SYK and its substrate c-Abl Src homology 3 domain-binding protein-2
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