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C E Serna-Jiménez et al.
International journal of pharmaceutics, 492(1-2), 223-232 (2015-07-22)
The aim of this study was to develop and evaluate a transdermal delivery system of pizotifen malate. Pizotifen is frequently used in the preventive treatment of migraine, but is also indicated in eating disorders. In the course of the project
Thirapit Subongkot et al.
International journal of nanomedicine, 10, 4581-4592 (2015-08-01)
The purpose of this study was to investigate the effect of ultradeformable liposome components, Tween 20 and terpenes, on vesicle fluidity. The fluidity was evaluated by electron spin resonance spectroscopy using 5-doxyl stearic acid and 16-doxyl stearic acid as spin
Johannes F-W Greiner et al.
Biochimica et biophysica acta, 1833(12), 2866-2878 (2013-07-23)
Natural plant-derived products are commonly applied to treat a broad range of human diseases, including cancer as well as chronic and acute airway inflammation. In this regard, the monoterpene oxide 1,8-cineol, the active ingredient of the clinically approved drug Soledum®
Hee-jin Jun et al.
Bioorganic & medicinal chemistry letters, 23(2), 579-583 (2012-12-19)
We investigated the effect of cineole on the expression of genes related to reverse cholesterol transport and hepatic fatty acid metabolism. Cineole, a small aroma compound in teas and herbs, significantly stimulated the transactivation of liver X receptor modulator (LXR)-α
Dirk W Lachenmeier et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 173-178 (2012-10-09)
Mouthwash ingestion has been observed in settings of restricted availability to alcoholic beverages such as in hospitals, prisons or military establishments. The literature offers limited evidence that ingredients of mouthwash may have health effects above the effects of ethanol. This
Ana Marco-Medina et al.
Cryo letters, 34(2), 119-127 (2013-04-30)
Cryopreservation is at present the most reliable strategy to preserve plant germplasm. When aromatic plants are the object of conservation it is necessary to assess not only the genetic but also the phytochemical stability to ensure that plant material maintains
María H del Loandos et al.
Natural product communications, 7(9), 1117-1122 (2012-10-19)
Rabbit liver carboxylesterase (rCE) was evaluated as the catalyst for the enantioselective hydrolysis of (+/-)-3-endo-acetyloxy-1 ,8-cineole [(+/-)-4], which yields (1S,3S,4R)-(+)-3-acetyloxy-1,8-cineole [(+)-4] and (1R,3R,4S)-(-)-3-hydroxy-1,8-cineole [(-)-3]. Enantioselective asymmetrization of meso-3,5-diacetoxy-1,8-cineol (5) gives (1S,3S,4R,5R)-(-)-3-acetyloxy-5-hydroxy-1,8-cineole (6), with high enantioselectivity. rCE has been chosen to
Abdul Ahad et al.
Expert opinion on drug delivery, 11(8), 1149-1162 (2014-05-17)
The aim of this study was to develop and optimize a transdermal gel formulation of valsartan using Box-Behnken design and to evaluate it for pharmacokinetic study. The independent variables were Carbopol 940 (X1), PEG 400 (X2) and ethanol (X3) while
Patricia Rodrigues Lima et al.
Life sciences, 92(24-26), 1195-1201 (2013-05-25)
Acute pancreatitis (AP) is an inflammatory condition wherein pro-inflammatory mediators, oxidative stress, and NF-κB signaling play a key role. Currently, no specific therapy exists and treatment is mainly supportive and targeted to prevent local pancreatic injury and systemic inflammatory complications.
Thitiya Mangprayool et al.
Fitoterapia, 89, 68-73 (2013-05-21)
The extract of ginger, the rhizomes of Zingiber officinale Roscoe (Zingiberaceae), has been reported to possess anti-hyperactivity and anti-inflammation on airway. The present study described brochodilatory activity of ginger oil and identified its active compound. Ginger oil was extracted by
Jeanette E Stok et al.
Biochimica et biophysica acta, 1834(3), 688-696 (2013-01-12)
P450(cin) (CYP176A) is a rare bacterial P450 in that contains an asparagine (Asn242) instead of the conserved threonine that almost all other P450s possess that directs oxygen activation by the heme prosthetic group. However, P450(cin) does have the neighbouring, conserved
E-Hyun Shin et al.
Journal of medical entomology, 50(3), 579-584 (2013-06-28)
Leptotrombidium pallidum (Nagoya, Miyagawa, Mitamura & Tamiya) is a primary vector of Orientia tsutsugamushi (Hyashi), the causative agent of scrub typhus. An assessment is made of the repellency to L. pallidum larvae (chiggers) of cassia bark, eucalyptus, and star anise
Soumaya Bourgou et al.
TheScientificWorldJournal, 2012, 528593-528593 (2012-05-31)
The present work investigates the effect of ripening stage on the chemical composition of essential oil extracted from peel of four citrus: bitter orange (Citrus aurantium), lemon (Citrus limon), orange maltaise (Citrus sinensis), and mandarin (Citrus reticulate) and on their
Hiroki Kawasaki et al.
Life sciences, 92(6-7), 359-367 (2013-01-29)
Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrations inhibit action potential conduction in the neurons and thus have a local anesthetic effect. The
Zerihun A Demissie et al.
Plant molecular biology, 79(4-5), 393-411 (2012-05-18)
Several members of the genus Lavandula produce valuable essential oils (EOs) that are primarily constituted of the low molecular weight isoprenoids, particularly monoterpenes. We isolated over 8,000 ESTs from the glandular trichomes of L. x intermedia flowers (where bulk of
Chokri Messaoud et al.
Journal of food science, 77(9), C941-C947 (2012-08-15)
In traditional medicine, myrtle (Myrtus communis L.) is frequently consumed as an infusion and decoction. In this study, we investigate the phenolic and volatile compositions and antioxidant and antibacterial activities of leaf infusions prepared during 3 different times. The total
Ling Chai et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(7), 1102-1104 (2012-12-21)
To analyze the compositions of the essential oil from the rhizome of Curcuma aromatica in Guangxi. The essential oil from the rhizome of Curcuma aromatica was extrated by steam distillation and analysed by GC-MS. 50 chemical constituents accounting for 93.11%
Geanne K N Santos et al.
Molecules (Basel, Switzerland), 19(10), 16573-16587 (2014-10-16)
Although numerous reports are available concerning the larvicidal potential of essential oils, very few investigations have focused on their mechanisms of action. In the present study, we have investigated the chemical composition of the leaf oil of Croton rhamnifolioides during
Soichiro Murata et al.
International journal of molecular sciences, 16(6), 12051-12063 (2015-05-30)
Hepatocyte-specific Phosphatase and tensin homolog (Pten)-knockout (KO) mice exhibit hepatic lesions analogous to non-alcoholic steatohepatitis (NASH). 1,8-cineole is a monoterpene oxide and it has several biological effects including hepatoprotective effects. In this study we revealed that 1,8-cineole ameliorates NASH of
Production of p-cymene and hydrogen from a bio-renewable feedstock-1, 8-cineole (eucalyptus oil).
Leita, Benjamin A et al.
Green Chemistry, 12(1), 70-76 (2010)
Gabriela Antunes et al.
PloS one, 9(8), e105531-e105531 (2014-08-22)
Olfactory adaptation is a fundamental process for the functioning of the olfactory system, but the underlying mechanisms regulating its occurrence in intact olfactory sensory neurons (OSNs) are not fully understood. In this work, we have combined stochastic computational modeling and
Abdolkarim Chehregani et al.
Pharmaceutical biology, 51(2), 246-252 (2012-11-07)
Artemisia spicigera C. Koch (Asteraceae) is a perennial shrubby herb and is generally distributed in Armenia, Iran, and Middle Anatolia. This species traditionally has been used in medicines. The aim of this research is to study the chemical composition and
Karine Rech Begnini et al.
Journal of medicinal food, 17(10), 1129-1133 (2014-09-18)
Cancer is a leading cause of death and is responsible for one in eight deaths worldwide. The use of herbs as complementary medicine for cancer, especially advanced cancer, has recently increased. The aim of this study was to evaluate in
Sara Invitto et al.
Respiratory physiology & neurobiology, 259, 37-44 (2018-07-15)
Obstructive Sleep Apnea Syndrome (OSA) is characterized by snoring associated with repeated apnea and/or obstructive hypopnea. The nasal airways of OSA patients, measured via acoustic rhinometry, could be significantly narrower than healthy subjects and this reduced nasal structure can impair
Yi Lan et al.
Journal of Zhejiang University. Science. B, 15(11), 940-952 (2014-11-05)
Our previous studies had confirmed that the essential oil from Zanthoxylum bungeanum Maxim. (Z. bungeanum oil) could effectively enhance the percutaneous permeation of drug molecules as a natural transdermal penetration enhancer. The aim of the present study is to investigate
Preparation of biologically active substances and animal and microbial metabolites from menthols, cineoles and kauranes.
Asakawa, Yoshinori et al.
Phytochemistry, 27(12), 3861-3869 (1988)
Boris Rodenak Kladniew et al.
Chemico-biological interactions, 214, 57-68 (2014-03-13)
Monoterpenes are naturally occurring plant hydrocarbons with multiple effects on the mevalonate pathway (MP), while statins competitively inhibit hydroxymethylglutarylcoenzyme-A reductase (HMGCR), the rate-limiting enzyme in the MP. Monoterpenes and statins proved capable of inhibiting both proliferation and cholesterogenesis. In the
Yu-Feng Wu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(17), 2803-2806 (2014-01-02)
The vapour distillation was used to extract the volatile oil of Chimonanthus salicifolius with different storage time, determine the content of cineole in volatile oil by GC, to study the influence of storage time on the content of volatile oil
Yalda Moayedi et al.
Molecular carcinogenesis, 58(5), 722-734 (2018-12-26)
Bioactive derivatives from the camphor laurel tree, Cinnamomum camphora, are posited to exhibit chemopreventive properties but the efficacy and mechanism of these natural products are not fully understood. We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity
Nelson Justino Gomes Neto et al.
Canadian journal of microbiology, 58(8), 973-981 (2012-07-20)
Listeria monocytogenes has the capability of adapting to 1 or more antimicrobial compounds or procedures applied by the food industry to control the growth and survival of microorganisms in foods. In this study, the effects of Rosmarinus officinalis essential oil
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